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1. 发明申请

US20050055063A1 Method and apparatus for the treatment of urinary tract dysfunction 审中-公开
标题翻译：用于治疗尿路功能障碍的方法和装置
公开(公告)号：US20050055063A1
公开(公告)日：2005-03-10
申请号：US10890504
申请日：2004-07-12
申请人： Gerald Loeb , Hilton Kaplan
发明人： Gerald Loeb , Hilton Kaplan
IPC分类号： A61N1/36 , A61N1/372 , A61N1/18
CPC分类号： A61N1/36007 , A61N1/37205
摘要： The subject invention teaches the use of electrical stimulation of specific sensory nerves, such as the proximal urethral afferents to control urination. A wireless, injectable microstimulator may implanted into the soft tissues through which the sensory nerves pass. The sensory nerves supplying the proximal urethra are stimulated by a microstimulator implanted adjacent to the prostatic urethra within the substance of the prostate gland in males, and distal to the bladder neck in females. The activity induced in these nerves causes the spinal cord to generate reflex responses that result in contractions of the detrusor muscle and relaxation of the sphincter, emptying the bladder. The invention also includes methods of implanting and/or testing microstimulators at a target location. The invention also includes the use of sensory devices to effect the microstimulators or alert the user as to the status of the bladder.
摘要翻译：本发明教导了使用特定感觉神经（例如近端尿道传入）的电刺激来控制排尿。无线注射微型刺激器可以植入感觉神经通过的软组织中。供应近端尿道的感觉神经通过在雄性前列腺的物质内和雌性膀胱颈远端的前列腺尿道附近植入的微型刺激器来刺激。在这些神经中诱导的活动导致脊髓产生反射反应，导致逼尿肌的收缩和括约肌的松弛，排空膀胱。本发明还包括在目标位置植入和/或测试微刺激器的方法。本发明还包括使用感觉装置来实现微刺激器或者向用户警告膀胱的状态。

2. 发明申请

US20070265582A1 Injection Devices for Unimpeded Target Location Testing 审中-公开
标题翻译：用于无阻碍目标位置测试的注射装置
公开(公告)号：US20070265582A1
公开(公告)日：2007-11-15
申请号：US11680363
申请日：2007-02-28
申请人： Hilton Kaplan , Gerald Loeb
发明人： Hilton Kaplan , Gerald Loeb
IPC分类号： A61M25/14
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2090/034 , A61B2090/035 , A61B2090/3987 , A61N1/37205
摘要： Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.
摘要翻译：用于将植入物定位在体内目标位置的装置和方法。所述方法包括在目标位置的注射装置内测试植入物以确定植入物是否有效地起作用。所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。该装置可以被配置为允许在植入期间相对于注射装置保持植入物的纵向和/或轴向位置。该装置还可以被配置为允许对植入物进行测试。还可以包括配置用于注射装置中的植入物。

3. 发明申请

US20070118197A1 Probe for Identifying Injection Site for Deep Brain Neural Prostheses 审中-公开
标题翻译：探测深部脑神经假体注射部位
公开(公告)号：US20070118197A1
公开(公告)日：2007-05-24
申请号：US11457004
申请日：2006-07-12
申请人： Gerald Loeb
发明人： Gerald Loeb
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/0539
摘要： Devices and systems for recording and/or stimulating electrical signals in order to identify a target site within a patient's brain for further electrical stimulation and chemical treatments of the brain. The deep brain stimulation devices and methods include implantable devices having various microelectrode configurations and drug delivery mechanisms. The devices can be used to treat a variety of neurological conditions.
摘要翻译：用于记录和/或刺激电信号的装置和系统，以便识别患者脑内的目标部位，以进一步进行电刺激和大脑的化学治疗。深脑刺激装置和方法包括具有各种微电极配置和药物递送机制的可植入装置。该装置可用于治疗各种神经病症。

4. 发明申请

US20060004424A1 Charge-metered biomedical stimulator 审中-公开
标题翻译：电荷计量生物医学刺激器
公开(公告)号：US20060004424A1
公开(公告)日：2006-01-05
申请号：US11146761
申请日：2005-06-06
申请人： Gerald Loeb , Jack Wills
发明人： Gerald Loeb , Jack Wills
IPC分类号： A61N1/18
CPC分类号： A61N1/08 , A61N1/3605 , A61N1/37205 , A61N1/378
摘要： Disclosed are biomedical stimulators and systems that deliver stimulus power efficiently to electrodes and tissues, provide reliable control of stimulus efficacy over a wide dynamic range of available power and voltage, avoid damaging net direct current flow through tissue, minimize the amount of data that must be transmitted to specify a particular stimulus strength, and extend the range of received field strengths for which stimulators can function safely and reliably. These biomedical stimulators and systems provide reliable stimulation of known intensity by measuring charging currents and discharging predetermined quantities of charge.
摘要翻译：公开了生物医学刺激器和系统，可以有效地向电极和组织提供刺激功率，在可用功率和电压的宽动态范围内提供可靠的刺激功效控制，避免损害通过组织的净直流电流，从而最大限度地减少必须传输以指定特定的刺激强度，并且扩展刺激器可以安全可靠地起作用的接收场强的范围。这些生物医学刺激器和系统通过测量充电电流和放电预定量的电荷来提供已知强度的可靠刺激。

5. 发明申请

US20070227267A1 Biomimetic Tactile Sensor 有权
标题翻译：仿生触觉传感器
公开(公告)号：US20070227267A1
公开(公告)日：2007-10-04
申请号：US11692718
申请日：2007-03-28
申请人： Gerald Loeb , Roland Johansson
发明人： Gerald Loeb , Roland Johansson
IPC分类号： G01D7/00
CPC分类号： G01D5/2417 , B25J13/084 , G01D5/1655 , G01L5/228
摘要： Disclosed is a tactile sensory system consisting of set of sensors that work by measuring impedance among plurality of electrodes. The electrodes are deployed on a substantially rigid structure that is protected form the direct contact with external objects by overlying deformable structures. These mechanical structures have similarities to the biological relationships among the distal phalanx, overlying finger pulp and covering skin and nail. Signal information is extracted form these sensors that is related to canonical physical representations used to describe stimuli to be sensed.
摘要翻译：公开了一种触觉感觉系统，其由通过测量多个电极之间的阻抗而工作的一组传感器组成。电极部署在基本上刚性的结构上，该结构通过覆盖可变形结构而被形成与外部物体的直接接触。这些机械结构与远端指骨，上覆手指纸和覆盖皮肤和指甲之间的生物学关系具有相似性。从与用于描述要感测的刺激的规范物理表示相关的这些传感器提取信号信息。

6. 发明申请

US20050245969A1 Identification of target site for implantation of a microstimulator 有权
标题翻译：识别微型刺激器植入的靶位点
公开(公告)号：US20050245969A1
公开(公告)日：2005-11-03
申请号：US11103197
申请日：2005-04-11
申请人： Gerald Loeb
发明人： Gerald Loeb
IPC分类号： A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/08
摘要： Devices and methods for locating a target site for the electrical stimulation of muscles are disclosed. The intensity of a search stimulus is varied continuously near the threshold to evoke an M-wave recorded by EMG electrodes. A feedback signal allows the clinician to judge when the threshold is sufficiently low to warrant the implantation of the stimulation electrodes at that site.
摘要翻译：公开了用于定位用于肌肉电刺激的目标部位的装置和方法。搜索刺激的强度在阈值附近变化，以引起由EMG电极记录的M波。反馈信号允许临床医生判断阈值何时足够低，以保证在该位置植入刺激电极。

7. 发明申请

US20070048226A1 Biochemical marker detection device 审中-公开
标题翻译：生化标记检测装置
公开(公告)号：US20070048226A1
公开(公告)日：2007-03-01
申请号：US11350695
申请日：2006-02-08
申请人： Gerald Loeb , Laura Marcu , Sanmao Kang , Kuo-Chih Liao
发明人： Gerald Loeb , Laura Marcu , Sanmao Kang , Kuo-Chih Liao
IPC分类号： A61K49/00 , C12Q1/00
CPC分类号： G01N21/6428 , A61B5/0071 , A61B5/0084 , A61B5/4848 , A61K49/0021 , A61K49/0056 , G01N1/30 , G01N21/645 , G01N2021/6484 , G01N2510/00
摘要： A probe device for detecting chemotherapy effectiveness, and methods of use are disclosed. The device includes a fiber optic probe element that can be injected into a tumor. The probe element is connected to an external controlling/measurement element, which injects a reagent through the probe and into the tumor. The reagent reacts with biological markers indicative of chemotherapy effectiveness.
摘要翻译：公开了一种用于检测化疗效果的探针装置及其使用方法。该装置包括可注入肿瘤的光纤探针元件。探针元件连接到外部控制/测量元件，其通过探针注入试剂并进入肿瘤。试剂与指示化疗有效性的生物标志物反应。

8. 发明申请

US20070010726A1 Internal biochemical sensing device 审中-公开
标题翻译：内部生化检测装置
公开(公告)号：US20070010726A1
公开(公告)日：2007-01-11
申请号：US11351158
申请日：2006-02-08
申请人： Gerald Loeb , Thomas George , Cesar Blanco , Laura Marcu
发明人： Gerald Loeb , Thomas George , Cesar Blanco , Laura Marcu
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/14532 , A61B5/1459 , A61B5/415 , A61B5/418 , G01N21/7703 , G01N2021/7786
摘要： A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer receives light from the reaction of fluorescent molecules in the biosensing element. The biosensing device can be used to detect and analyze the effectiveness of chemotherapy agents and molecules associated with various diseases.
摘要翻译：公开了用于检测生物分析物的生物传感装置及其使用和制造方法。该装置包括可以长时间保持植入的生物传感元件。生物传感元件连接到终端外部的光纤。光纤也连接到信息分析仪。信息分析器从生物传感元件中的荧光分子的反应接收光。生物传感装置可用于检测和分析与各种疾病相关的化疗药物和分子的有效性。

9. 发明申请

US20070129772A1 Cochlear Implant Fitting 失效
标题翻译：人工耳蜗植入物
公开(公告)号：US20070129772A1
公开(公告)日：2007-06-07
申请号：US11469357
申请日：2006-08-31
申请人： Gerald Loeb
发明人： Gerald Loeb
IPC分类号： A61N1/00
CPC分类号： A61N1/36036 , H04R25/606
摘要： Systems and methods for fitting cochlear implants. The cochlear implant fitting systems and methods can be used to generate various stimulus patterns for fitting patients with speech processors for cochlear implants. The fitting systems and methods provide means to identify rapidly which of several speech processing strategies could function effectively in cochlear implant patients.
摘要翻译：耳蜗植入物的系统和方法。耳蜗植入物适配系统和方法可用于产生各种刺激模式，用于使具有用于耳蜗植入物的语音处理器的患者拟合。拟合系统和方法提供了快速识别哪些语音处理策略在人工耳蜗患者中有效发挥作用的手段。

10. 发明申请

US20070016265A1 Method and system for training adaptive control of limb movement 审中-公开
标题翻译：训练肢体运动适应性控制的方法和系统
公开(公告)号：US20070016265A1
公开(公告)日：2007-01-18
申请号：US11350482
申请日：2006-02-09
申请人： Rahman Davoodi , Gerald Loeb , Junkwan Lee
发明人： Rahman Davoodi , Gerald Loeb , Junkwan Lee
IPC分类号： A61N1/18
CPC分类号： G06F3/011 , A61F2/68 , A61F2/72 , A61F2/76 , A61N1/08 , A61N1/36003 , G09B19/003 , G16H50/50
摘要： Disclosed are methods and systems for a virtual reality simulation and display of limb movement that facilitate the development and fitting of prosthetic control of a paralyzed or artificial limb. The user generates command signals that are then processed by the control system. The output of the control system drives a physics-based simulation of the limb that simulates the limb to be controlled. The computed movements of the model limb are displayed to the user as a 3D animation from the perspective of the user so as to give the impression that the user is watching the actual movements of his/her own limb. The user learns to adjust his/her command signals to perform tasks successfully with the virtual limb. Alternatively or additionally, the errors produced by the virtual limb and/or the responses of the user during the training process can provide information for adapting the properties of the control system itself.
摘要翻译：公开了用于虚拟现实模拟和显示肢体运动的方法和系统，其有助于瘫痪或假肢的假肢控制的开发和拟合。用户产生然后由控制系统处理的命令信号。控制系统的输出驱动肢体的基于物理的仿真来模拟要控制的肢体。从用户的角度，将计算出的模型肢体的运动作为3D动画显示给用户，以给出用户正在观看他/她自己的肢体的实际运动的印象。用户学习调整他/她的命令信号，使用虚拟肢体成功地执行任务。或者或另外，虚拟肢体产生的错误和/或用户在训练过程中的响应可以提供用于调整控制系统本身的属性的信息。

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