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1. 发明授权

US06224570B1 Rheolytic thrombectomy catheter and method of using same 有权
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US06224570B1
公开(公告)日：2001-05-01
申请号：US09188633
申请日：1998-11-09
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。公开了几个实施例。所有实施例包括具有内腔和内部高压管的外导管，其尺寸使其能够穿过导管的内腔。内部高压管的远端延伸超过导管的远端，并且携带用于将一个或多个盐水向近端引导到导管的远端的喷射帽。在一些实施例中，导管具有远侧定位的向内指向的固定止动件，并且内部高压管包括远侧定位的向外指向的过渡止动件，用于接合向内指向的固定止动件，从而将喷射盖定位在距离导管。在其他实施例中，静止止动件位于导管的近端处，并且过渡停止件承载在内部高压管的近端上。在具有位于近侧的静止和过渡止动件的实施例中，内部高压管在其远端包括导流器。在使用中，血栓被移出，夹带并通过盐水喷射器破碎成碎片，并通过导管的内腔向近端排出。

2. 发明授权

US06676637B1 Single operator exchange fluid jet thrombectomy method 有权
标题翻译：单操作者交换流体喷射血栓切除术
公开(公告)号：US06676637B1
公开(公告)日：2004-01-13
申请号：US09888454
申请日：2001-06-25
申请人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.
摘要翻译：单个操作者交换流体喷射血栓切除术方法，其使用具有外部导管组件的单个操作者交换流体喷射血栓切除装置，以及允许作为溶血性血栓切除术导管或横流血栓切除术导管起作用的内部导管组件形式的可分离和可更换部件。外导管组件对于任何使用模式都是共同的，并且包括具有内腔的引导导管，通过该导管将导丝和携带喷射发生器和导流器的下管的较大部分通过并前进。在该方法中，通过流体射流将血栓移出，夹带并分裂成碎片，并通过引导导管的内腔排出。

3. 发明授权

US06755803B1 Single operator exchange fluid jet thrombectomy device 有权
标题翻译：单一操作者交换流体喷射血栓切除装置
公开(公告)号：US06755803B1
公开(公告)日：2004-06-29
申请号：US09888455
申请日：2001-06-25
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.
摘要翻译：单个操作者交换流体喷射血栓切除装置，其具有外导管组件和内导管组件形式的可分离和可更换组件，其允许作为溶血性血栓切除术导管或横流血栓切除术导管。实施例包括与任何使用模式共同的外导管组件，其具有具有内腔的引导导管，引导线和携带导流器的下管的较大部分通过该内腔通过并前进。为了用作溶解性血栓切除术导管，血栓被移出，夹带并通过射流破碎成碎片，并通过导管的内腔排出。为了用作横流血栓切除术导管，提供了具有流出和流入孔的导流器。

4. 发明授权

US06355027B1 Flexible microcatheter 有权
标题翻译：柔性微导管
公开(公告)号：US06355027B1
公开(公告)日：2002-03-12
申请号：US09328761
申请日：1999-06-09
申请人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M2500
CPC分类号： A61M25/0054 , A61M25/005 , A61M25/0053 , A61M2025/0042
摘要： Flexible microcatheter having regions of different flexibility integrally and strategically placed along and about the length of a one-piece composite catheter tube. Distally the flexible microcatheter exhibits pronounced flexibility with respect to locations or regions of flexibility located proximally for navigation along tortuous vascular paths. Different regions of flexibility are formed by applying resins of different Shore hardness readings either singularly or in combination along and about a braid which overlies an inner resin layer. The encapsulated braid provides resistance to kinking and bending of the flexible microcatheter as well as providing for torque transmission and pushability along the length of the flexible microcatheter.
摘要翻译：柔性微导管具有不同柔性的区域，整体地并且沿着并且围绕一体式复合导管的长度有策略地放置。远端地，柔性微导管相对于靠近曲折的血管路径导航的近端位置或柔性区域具有显着的灵活性。不同的柔性区域通过单独或组合地施加不同邵氏硬度读数的树脂形成，并且围绕着位于内层树脂层上的编织物。封装的编织物提供柔性微导管的扭结和弯曲的抗性，以及沿着柔性微导管的长度提供扭矩传递和推压性。

5. 发明授权

US5989210A Rheolytic thrombectomy catheter and method of using same 失效
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US5989210A
公开(公告)日：1999-11-23
申请号：US19728
申请日：1998-02-06
申请人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
发明人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
IPC分类号： A61B17/22 , A61B19/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/32075 , A61B2090/034
摘要： A surgical device and method for removal of tissue, such as thrombus, from a vessel in the body. The device has a first tube with a distal open end and an inward directed stop and a second tube with an outward directed stop for engaging the inward directed stop and thereby regulating the relationship between a retrograde jet and the distal open end. Thrombus is dislodged, entrained, and broken into pieces which are evacuated through the first tube.
摘要翻译：用于从体内的血管中去除诸如血栓的组织的手术装置和方法。该装置具有第一管，其具有远端开口端和向内指向的止动件，以及具有向外定向止动件的第二管，用于接合向内指向的止动件，从而调节逆行射流与远端开口端之间的关系。血栓被移出，夹带并分解成通过第一管排出的碎片。

6. 发明申请

US20080275383A1 Miniature cross stream thrombectomy catheter 有权
标题翻译：微型交叉血栓切除术导管
公开(公告)号：US20080275383A1
公开(公告)日：2008-11-06
申请号：US10910108
申请日：2004-08-02
申请人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
发明人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
IPC分类号： A61M1/00 , B23P11/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译：一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料血管

7. 发明授权

US07572244B2 Miniature cross stream thrombectomy catheter 有权
标题翻译：微型交叉血栓切除术导管
公开(公告)号：US07572244B2
公开(公告)日：2009-08-11
申请号：US10910108
申请日：2004-08-02
申请人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
发明人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译：一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料血管

8. 发明授权

US07220269B1 Thrombectomy catheter system with occluder and method of using same 有权
标题翻译：具有闭塞器的血栓切除导管系统及其使用方法
公开(公告)号：US07220269B1
公开(公告)日：2007-05-22
申请号：US10702815
申请日：2003-11-06
申请人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
发明人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
IPC分类号： A61B17/3203 , A61B17/3207 , A61M25/14
CPC分类号： A61B17/22031 , A61B17/22032 , A61B17/221 , A61B17/32037 , A61B2017/22035 , A61B2017/22067 , A61B2017/2215
摘要： A thrombectomy catheter system with occluder and method of using same for removal of tissue, such as thrombus and the like, from a vessel in the body. Multiple catheters and an occluder-bearing guidewire tube at a thrombus site provide for expandable deployment of a compliant occluder against the vasculature walls distal to the thrombus. The expanded occluder is maneuvered proximally to urge thrombus into close proximity with a retractable capture cone located distally on a capture catheter where the thrombus is dislodged, entrained, and broken into pieces by the action of a fluid jet emanator and then evacuated through the capture catheter.
摘要翻译：具有闭塞器的血栓切除术导管系统及其用于从身体中的血管中去除组织（例如血栓等）的方法。多个导管和位于血栓位置处的封堵器导丝管提供了将顺应性封堵器可扩展地部署在远离血栓的脉管系统壁上。扩张的闭塞器在近侧被操纵以促使血栓紧邻位于远端位于捕获导管上的可伸缩捕获锥体，其中血栓被移出，夹带并通过流体喷射发生器的作用而分裂成碎片，然后通过捕获导管抽真空。

9. 发明授权

US07169161B2 Guidewire having occlusive device and repeatably crimpable proximal end 有权
标题翻译：导丝具有闭塞装置和可重复卷曲的近端
公开(公告)号：US07169161B2
公开(公告)日：2007-01-30
申请号：US10012891
申请日：2001-11-06
申请人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson , Rick C. Kravic , Hieu V. Le
发明人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson , Rick C. Kravic , Hieu V. Le
IPC分类号： A61M25/10
CPC分类号： A61M25/10184 , A61M25/09 , A61M25/10185 , A61M2025/09008
摘要： A tubular guidewire assembly having a distal occlusive device and an extended crimpable section proximate a proximal end that is adapted to connect to a gas inflation/evacuation system. The extended crimpable section can be selectively sealed at one of a plurality of separate locations to form an airtight seal of the tubular guidewire assembly. Each time a deflation of the occlusive device is desired in order to reestablish blood flow to a vessel downstream of the occlusive device, the extended crimpable section preferably is cut distal to the location of the last seal to quickly deflate the occlusive device.
摘要翻译：一种管状导丝组件，其具有远端闭塞装置和靠近近端的伸缩卷曲部分，其适于连接到气体充气/抽空系统。扩展的可卷曲部分可以选择性地密封在多个分开的位置中的一个处，以形成管状导丝组件的气密密封。每次需要闭塞装置的放气以便重新建立到闭塞装置下游的血管的血液流动时，伸出的可卷曲部分优选地被切割到最后密封的位置的远侧，以快速地缩小闭塞装置。

10. 发明授权

US08608703B2 Infusion flow guidewire system 有权
标题翻译：输液流导丝系统
公开(公告)号：US08608703B2
公开(公告)日：2013-12-17
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
IPC分类号： A61M5/178 , A61M25/00 , A61B17/22 , A61D1/02
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system and method of use. The infusion flow guidewire system includes a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a flexible tip having a closed distal end, a coil, a core wire and at least one distally located jet orifice for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torqueing and for longitudinal actuation along and within the vasculature.
摘要翻译：一种输液流导丝系统及其使用方法。输注流导丝系统包括输送鞘和输注流导丝。最小横截面柔性灌注流导丝包括柔性末端，其具有封闭的远端，线圈，芯线和用于输注纤维蛋白溶解剂的至少一个位于远端的喷射孔，并且用于引入用于浸渍和向后流动的高压流体血栓碎片位于曲折的小型血管中。提供了一些可拆卸地附接的装置，用于抓握本发明的构件以用于旋转扭矩并沿着和在脉管系统内沿纵向致动。

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