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1. 发明授权

US07169161B2 Guidewire having occlusive device and repeatably crimpable proximal end 有权
标题翻译：导丝具有闭塞装置和可重复卷曲的近端
公开(公告)号：US07169161B2
公开(公告)日：2007-01-30
申请号：US10012891
申请日：2001-11-06
申请人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson , Rick C. Kravic , Hieu V. Le
发明人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson , Rick C. Kravic , Hieu V. Le
IPC分类号： A61M25/10
CPC分类号： A61M25/10184 , A61M25/09 , A61M25/10185 , A61M2025/09008
摘要： A tubular guidewire assembly having a distal occlusive device and an extended crimpable section proximate a proximal end that is adapted to connect to a gas inflation/evacuation system. The extended crimpable section can be selectively sealed at one of a plurality of separate locations to form an airtight seal of the tubular guidewire assembly. Each time a deflation of the occlusive device is desired in order to reestablish blood flow to a vessel downstream of the occlusive device, the extended crimpable section preferably is cut distal to the location of the last seal to quickly deflate the occlusive device.
摘要翻译：一种管状导丝组件，其具有远端闭塞装置和靠近近端的伸缩卷曲部分，其适于连接到气体充气/抽空系统。扩展的可卷曲部分可以选择性地密封在多个分开的位置中的一个处，以形成管状导丝组件的气密密封。每次需要闭塞装置的放气以便重新建立到闭塞装置下游的血管的血液流动时，伸出的可卷曲部分优选地被切割到最后密封的位置的远侧，以快速地缩小闭塞装置。

2. 发明申请

US20080312671A1 Infusion flow guidewire system 有权
标题翻译：输液流导丝系统
公开(公告)号：US20080312671A1
公开(公告)日：2008-12-18
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system including a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a nitinol hypotube, a flexible tip and distally located rearwardly directed orifices for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torquing and for longitudinal actuation along and within the vasculature.
摘要翻译：一种输液流导丝系统，包括输送鞘和输注流导丝。最小横截面柔性输注流导丝包括镍钛诺海波管，柔性尖端和向远侧定位的用于输注纤维蛋白溶解剂的向后的孔，并引入高压流体用于位于曲折的小尺寸血管中的浸渍和向后定向的血栓碎屑流。提供其中一些可移除地附接的装置用于抓握本发明的构件用于旋转扭矩并沿着和在脉管系统内沿纵向致动。

3. 发明授权

US08608703B2 Infusion flow guidewire system 有权
标题翻译：输液流导丝系统
公开(公告)号：US08608703B2
公开(公告)日：2013-12-17
申请号：US11980164
申请日：2007-10-30
申请人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
发明人： John C. Riles , Douglas J. Ball , Michael J. Bonnette , Eric J. Thor , John L. Teschendorf , Hieu V. Le
IPC分类号： A61M5/178 , A61M25/00 , A61B17/22 , A61D1/02
CPC分类号： A61B17/32037 , A61B2017/22038 , A61B2017/22049 , A61M2025/09083
摘要： An infusion flow guidewire system and method of use. The infusion flow guidewire system includes a delivery sheath and an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a flexible tip having a closed distal end, a coil, a core wire and at least one distally located jet orifice for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided for grasping members of the invention for rotational torqueing and for longitudinal actuation along and within the vasculature.
摘要翻译：一种输液流导丝系统及其使用方法。输注流导丝系统包括输送鞘和输注流导丝。最小横截面柔性灌注流导丝包括柔性末端，其具有封闭的远端，线圈，芯线和用于输注纤维蛋白溶解剂的至少一个位于远端的喷射孔，并且用于引入用于浸渍和向后流动的高压流体血栓碎片位于曲折的小型血管中。提供了一些可拆卸地附接的装置，用于抓握本发明的构件以用于旋转扭矩并沿着和在脉管系统内沿纵向致动。

4. 发明授权

US07334681B2 Packaging system with oxygen sensor for gas inflation/evacuation system and sealing system 失效
标题翻译：用于气体充气/抽空系统和密封系统的氧气传感器的包装系统
公开(公告)号：US07334681B2
公开(公告)日：2008-02-26
申请号：US11654741
申请日：2007-01-18
申请人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson
发明人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson
IPC分类号： B65D85/20 , A61M25/10
CPC分类号： A61M25/002 , A61M25/0009 , A61M25/10182 , A61M25/10184 , A61M25/10185 , A61M2025/09008 , B65D79/02 , B65D81/2076 , Y10S206/807 , Y10T436/207497
摘要： A storable gas inflation/evacuation system and sealing system. The systems are removably connectible to a proximal portion of a guidewire assembly which has an occlusive balloon at a distal portion. The invention includes provision for indicating the presence of oxygen which is undesirable. The storable aspect concerns a sealable container isolating systems components from ambient atmosphere and an oxygen-sensitive material located within the sealable container. The oxygen-sensitive material is initially inactive but activated by exposure to radiation so as to visually change in response to post-radiation oxygen exposure.
摘要翻译：可储存的气体充气/排气系统和密封系统。该系统可拆卸地连接到导丝组件的近端部分，导丝组件在远侧部分具有闭塞气囊。本发明包括用于指示不合乎需要的氧的存在。可存储的方面涉及可密封的容器，隔离系统部件与环境大气和位于可密封容器内的氧敏感材料。氧敏感材料最初是无活性的，但是通过暴露于辐射而被激活，以便根据后辐射氧暴露而视觉上改变。

5. 发明授权

US06942678B2 Gas inflation/evacuation system and sealing system for guidewire assembly having occlusive device 失效
标题翻译：用于具有闭塞装置的导丝组件的气体充气/排气系统和密封系统
公开(公告)号：US06942678B2
公开(公告)日：2005-09-13
申请号：US10007788
申请日：2001-11-06
申请人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson
发明人： Michael J. Bonnette , Eric J. Thor , Mark L. Jenson
IPC分类号： A61F2/958 , A61M25/10
CPC分类号： A61M25/10184 , A61M25/09 , A61M25/10185 , A61M25/104 , A61M29/02 , A61M39/06 , A61M2025/09008
摘要： A gas inflation/evacuation system and sealing system for use with occlusive devices such as occlusive balloons in vascular procedures. The gas inflation/evacuation system is removably connectible to a proximal portion of a guidewire assembly and includes an evacuation system to evacuate the guidewire assembly and an inflation system for introducing a biocompatible gas under pressure into the guidewire assembly to inflate an occlusive device a plurality of times. A sealing system is also removably connectible to the proximal portion of the guidewire assembly and selectively seals an extended sealable section at the proximal portion of the guidewire assembly at one of a plurality of separate locations to form an airtight seal of the guidewire assembly. Each time a deflation of the occlusive device is desired in order to reestablish blood flow to the vessel downstream of the occlusive device, the extended sealable section at the proximal portion of the guidewire assembly preferably is cut distal to the location of the last seal to quickly deflate the occlusive device.
摘要翻译：用于闭塞装置的气体充气/抽空系统和密封系统，例如血管手术中的闭塞气囊。气体充气/抽空系统可移除地连接到导丝组件的近端部分，并且包括抽空系统以抽出导丝组件和用于将压力下的生物相容性气体引入导丝组件的膨胀系统，以使闭塞装置多个次密封系统也可移除地连接到导丝组件的近端部分，并且在多个分开的位置之一处选择性地密封导丝组件的近端部分处的延伸的可密封部分，以形成导丝组件的气密密封。每次需要闭塞装置的放气以便重新建立到闭塞装置下游的血管的血流时，导丝组件的近端部分处的延伸的可密封部分优选地被切割成远离最后密封的位置，以快速放气闭塞装置。

6. 发明申请

US20080275383A1 Miniature cross stream thrombectomy catheter 有权
标题翻译：微型交叉血栓切除术导管
公开(公告)号：US20080275383A1
公开(公告)日：2008-11-06
申请号：US10910108
申请日：2004-08-02
申请人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
发明人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
IPC分类号： A61M1/00 , B23P11/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译：一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料血管

7. 发明授权

US07220269B1 Thrombectomy catheter system with occluder and method of using same 有权
标题翻译：具有闭塞器的血栓切除导管系统及其使用方法
公开(公告)号：US07220269B1
公开(公告)日：2007-05-22
申请号：US10702815
申请日：2003-11-06
申请人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
发明人： Gary M. Ansel , Michael J. Bonnette , Dan T. Janse , Hieu V. Le
IPC分类号： A61B17/3203 , A61B17/3207 , A61M25/14
CPC分类号： A61B17/22031 , A61B17/22032 , A61B17/221 , A61B17/32037 , A61B2017/22035 , A61B2017/22067 , A61B2017/2215
摘要： A thrombectomy catheter system with occluder and method of using same for removal of tissue, such as thrombus and the like, from a vessel in the body. Multiple catheters and an occluder-bearing guidewire tube at a thrombus site provide for expandable deployment of a compliant occluder against the vasculature walls distal to the thrombus. The expanded occluder is maneuvered proximally to urge thrombus into close proximity with a retractable capture cone located distally on a capture catheter where the thrombus is dislodged, entrained, and broken into pieces by the action of a fluid jet emanator and then evacuated through the capture catheter.
摘要翻译：具有闭塞器的血栓切除术导管系统及其用于从身体中的血管中去除组织（例如血栓等）的方法。多个导管和位于血栓位置处的封堵器导丝管提供了将顺应性封堵器可扩展地部署在远离血栓的脉管系统壁上。扩张的闭塞器在近侧被操纵以促使血栓紧邻位于远端位于捕获导管上的可伸缩捕获锥体，其中血栓被移出，夹带并通过流体喷射发生器的作用而分裂成碎片，然后通过捕获导管抽真空。

8. 发明授权

US07572244B2 Miniature cross stream thrombectomy catheter 有权
标题翻译：微型交叉血栓切除术导管
公开(公告)号：US07572244B2
公开(公告)日：2009-08-11
申请号：US10910108
申请日：2004-08-02
申请人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
发明人： Stephen E. Weisel , Michael J. Bonnette , Hieu V. Le , Debra M. Kozak
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22084 , Y10T29/49826
摘要： A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
摘要翻译：一种用于小血管血栓切除手术的小型交叉血栓血栓切除术导管。在微型交叉流血栓切除术导管的远端附近的环形成在同心对准的导流管的下管和近端定向的孔之间，其中下管中的喷射孔与环连通以引导盐水的流动围绕和围绕环的其它流体并且从环形物向近侧引导以通过一个或多个流出孔，并且从而穿过一个或多个流入孔，从而在其间产生消融流，从而从其壁的壁上松开并携带血栓形成材料血管

9. 发明授权

US07879022B2 Rapid exchange fluid jet thrombectomy device and method 有权
标题翻译：快速交换液喷射血栓切除装置及方法
公开(公告)号：US07879022B2
公开(公告)日：2011-02-01
申请号：US11096592
申请日：2005-04-01
申请人： Michael J. Bonnette , Michael P. Schrom , Hieu V. Le
发明人： Michael J. Bonnette , Michael P. Schrom , Hieu V. Le
IPC分类号： A61M3/00 , A61M25/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/3203 , A61B2017/00292 , A61B2017/00778 , A61B2017/22041 , A61B2090/034
摘要： A rapid exchange fluid jet thrombectomy device having a streamlined manifold and a catheter having multiple tubular segments where each tubular segment increases in flexibility in a distal direction. Torque response and pushability is enhanced by the arrangement of a proximally located tubular segment composed of a polymer-jacketed spiral metal tube in combination with an intermediate tubular section and a distal tubular section each having different degrees of flexibility. A guidewire tube exit region is provided where the intermediate tubular section joins the distal tubular section for over-the-wire guidewire usage. The polymer-jacketed spiral metal tube can extend along a partial or full length of the catheter and can include a basic continuous spiral cut which has regions of constant pitch or which has progressively increasing pitch, or in the alternative, can include an interlocking spiral cut having constant pitch regions or progressively decreasing pitch.
摘要翻译：具有流线型歧管的快速交换流体喷射血栓切除装置和具有多个管状区段的导管，其中每个管状区段在远端方向上的柔性增加。通过由聚合物夹套的螺旋金属管组成的近端定位的管状部分与中间管状部分和每个具有不同柔性程度的远端管状部分的组合来增强扭矩响应和推动性。提供导丝管出口区域，其中中间管状部分连接远端管状部分用于线上导丝使用。聚合物套管的螺旋金属管可以沿着导管的部分或全长延伸，并且可以包括具有恒定节距或具有逐渐增加的间距的区域的基本连续螺旋切口，或者替代地，可以包括互锁螺旋切口具有恒定的音调区域或逐渐减小音调。

10. 发明申请

US20080275393A1 Isolation thrombectomy catheter system 审中-公开
标题翻译：隔离血栓切除术导管系统
公开(公告)号：US20080275393A1
公开(公告)日：2008-11-06
申请号：US10925113
申请日：2004-08-24
申请人： Michael J. Bonnette , Hieu V. Le
发明人： Michael J. Bonnette , Hieu V. Le
IPC分类号： A61M1/00 , A61M25/10
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084
摘要： An isolation thrombectomy catheter system where thrombus, clotted material, or the like is isolated by distally and proximally placed inflated occlusive balloons sealing a portion of the vasculature for subsequent removal of thrombus by cross stream jets. An isolation catheter accommodates either a jet assembly for ablation of thrombus and for drug or medication delivery, or accommodates a drug delivery device for introduction of lysing fluids, drugs or medications to a thrombus site. Alternating of lysing fluid delivery and ablation can be incorporated for a combined thrombectomy effort.
摘要翻译：隔离血栓切除术导管系统，其中血栓，凝块材料等通过远侧和近端放置的充气闭塞球隔离，密封一部分脉管系统，以便随后通过流动射流除去血栓。隔离导管容纳用于消融血栓和用于药物或药物输送的射流组件，或者容纳用于将裂解液，药物或药物引入血栓部位的药物递送装置。可以并入裂解液输送和消融的交替用于组合的血栓切除术。

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