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1. 发明授权

US06817995B1 Reinforced catheter connector and system 失效
标题翻译：加强导管连接器和系统
公开(公告)号：US06817995B1
公开(公告)日：2004-11-16
申请号：US09553743
申请日：2000-04-20
申请人： David Halpern
发明人： David Halpern
IPC分类号： A61M2500
CPC分类号： A61M39/1011 , A61M25/005
摘要： In accordance with the invention, A reinforced catheter is provided comprising an inner layer forming a catheter body, the body having a distal end and a proximal end, the distal end having a closed tip end, a middle reinforcing layer extending over the first inner layer to the distal end and an outer layer extending over the middle reinforcing layer. Additionally, a connector for coupling a catheter to an extension tube or afterloader is provided comprising a first half having a housing with at least one pair of opposing cutout portions of a first depth provided thereon, a second half slidably connectable with the first half and a biasing means for securing the second half within the housing. Additionally, a catheter system is provided comprising a reinforced catheter, including an inner layer forming a catheter body, the body having a distal end and a proximal end, the distal end having a closed tip end, a middle reinforcing layer extending over the first inner layer to the distal end and an outer layer extending over the middle reinforcing layer and a connector for coupling a catheter to an extension tube or afterloader, the connector including a first half having a housing with at least one pair of opposing cutout portions of a first depth provided thereon, a second half slidably connectable with the first half and a biasing means for securing the second half within the housing. A method for performing a surgical procedure on a patient is also provided comprising inserting a reinforced catheter into the body of the patient, the reinforced catheter including an inner layer forming a catheter body, the body having a distal end and a proximal end, the distal end having a closed tip end, a middle reinforcing layer extending over the first inner layer to the distal end and an outer layer extending over the middle reinforcing layer.
摘要翻译：根据本发明，提供一种加强导管，其包括形成导管主体的内层，所述主体具有远端和近端，所述远端具有闭合的末端，在第一内层上延伸的中间加强层并且延伸到中间增强层上的外层。此外，提供一种用于将导管耦合到延伸管或后加载器的连接器，其包括具有壳体的第一半部，该壳体具有设置在其上的第一深度的至少一对相对的切口部分，可与第一半部可滑动连接的第二半部和用于将第二半固定在壳体内的偏压装置。另外，提供了一种导管系统，其包括加强导管，包括形成导管主体的内层，所述主体具有远端和近端，所述远端具有闭合的末端，中间加强层，其延伸越过所述第一内部层和延伸在中间加强层上的外层和用于将导管耦合到延伸管或后加载器的连接器，所述连接器包括具有壳体的第一半部，所述壳体具有至少一对相对的切口部分，其具有第一设置在其上的深度，与第一半可滑动连接的第二半部以及用于将第二半固定在壳体内的偏压装置。还提供了一种用于对患者进行外科手术的方法，包括将加强导管插入患者体内，加强导管包括形成导管主体的内层，该主体具有远端和近端，远端端部具有封闭的尖端，在第一内层延伸到远端的中间增强层和在中间增强层上延伸的外层。

2. 发明授权

US06800073B2 Biocompatible pharmaceutical articles 有权
标题翻译：生物相容的药物制品
公开(公告)号：US06800073B2
公开(公告)日：2004-10-05
申请号：US09845092
申请日：2001-04-27
申请人： Maria Palasis , Wendy Naimark , Timothy Mickley , Justin Crank
发明人： Maria Palasis , Wendy Naimark , Timothy Mickley , Justin Crank
IPC分类号： A61M2500
CPC分类号： A61L31/10 , A61L2/18 , A61L29/08 , A61L29/085 , A61L29/103 , A61L29/106 , A61L29/14 , A61L31/088 , A61L33/0076
摘要： Many conventional pharmaceutical articles contain seemingly inert components that come into contact with a pharmaceutically active material during use, which contact substantially reduces the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to these incompatible components, which are effective to diminish the reduction in pharmaceutical effectiveness.
摘要翻译：许多常规药物制品含有在使用期间与药物活性物质接触的看似惰性的成分，该接触显着降低了药物活性物质的药物有效性。本文描述的发明涉及对这些不相容组分的各种修改，其有效减少药物效力的降低。

3. 发明授权

US06796976B1 Establishing access to the body 有权
标题翻译：建立对身体的访问
公开(公告)号：US06796976B1
公开(公告)日：2004-09-28
申请号：US09263897
申请日：1999-03-05
申请人： Yem Chin , Clifford M. Liu , Benjamin J. Bottcher , John B. Adams
发明人： Yem Chin , Clifford M. Liu , Benjamin J. Bottcher , John B. Adams
IPC分类号： A61M2500
CPC分类号： A61M25/01 , A61M25/0108 , A61M25/0662
摘要： An apparatus and method for access to the inside of a body includes a transparent sheath with a radiopaque marking and fastener for securing a guidewire or catheter. The transparent sheath permits objects located within and near the sheath to be visualized with an external imaging system. Objects located near the sheath can also be observed with an imaging device disposed inside the sheath. The radiopaque marker permits accurate positioning of the sheath in the body. The sheath can be inserted into the body over an interventional device. A fastener prevents migration of a guidewire or catheter during the procedure.
摘要翻译：用于进入身体内部的装置和方法包括具有用于固定导丝或导管的不透射线标记和紧固件的透明护套。透明护套允许位于鞘内和附近的物体用外部成像系统可视化。位于护套附近的物体也可以用设置在鞘内的成像装置观察。不透射线的标记允许护套在体内的精确定位。鞘可以通过介入装置插入体内。紧固件防止了在该过程中导丝或导管的迁移。

4. 发明授权

US06770059B1 Curved tip for an insertion device 失效
标题翻译：用于插入装置的弯曲尖端
公开(公告)号：US06770059B1
公开(公告)日：2004-08-03
申请号：US09698621
申请日：2000-10-27
申请人： Thomas L. Spinks , Kevin H. Pike
发明人： Thomas L. Spinks , Kevin H. Pike
IPC分类号： A61M2500
CPC分类号： A61M25/0068 , A61M5/3286 , A61M25/0631
摘要： The present invention is directed to an insertion device, such as a catheter, including a tip having a hollow, substantially radial cross sectional configuration and a substantially parabolic longitudinal configuration with a circular tip curvature. The outer wall of the novel tip of the invention is completely curved, and contains no straight or angled outer walls within the length of the tip. The inner wall of the tip defines a substantially straight passageway through which a piercing device such as a needle may be inserted.
摘要翻译：本发明涉及一种诸如导管的插入装置，其包括具有中空的，基本上径向的横截面形状的尖端和具有圆形尖端曲率的基本抛物线的纵向构造。本发明的新型尖端的外壁是完全弯曲的，并且在尖端的长度内不包含直的或成角度的外壁。尖端的内壁限定了基本上直的通道，诸如针的穿刺装置可以穿过该通道插入。

5. 发明授权

US06764484B2 C-channel to o-channel converter for a single operator exchange biliary catheter 失效
标题翻译： C通道至o通道转换器，用于单个操作者交换胆管导管
公开(公告)号：US06764484B2
公开(公告)日：2004-07-20
申请号：US09822708
申请日：2001-03-30
申请人： Kevin Richardson , Michael Mangano
发明人： Kevin Richardson , Michael Mangano
IPC分类号： A61M2500
CPC分类号： A61M25/0029 , A61M25/0023 , A61M25/0032 , A61M2025/018 , A61M2025/0183 , A61M2025/09125 , A61M2025/1056 , A61M2210/1071 , A61M2210/1075
摘要： A catheter system for use during biliary procedures, including a first elongate member carrying a guidewire lumen, and a channel extending longitudinally along the member which provides access to the guidewire lumen and defines two edge surfaces. A second elongate member is also included which is disposed within the guidewire lumen and mates with the cross-sectional profile of the guidewire lumen of the first elongate member, thereby converting a guidewire lumen having a C-shaped design into one having an O-shaped design. The catheter may be used in rapid exchange catheter procedures requiring the use of small diameter guidewires which would otherwise slip out of the channel during use.
摘要翻译：一种在胆汁手术期间使用的导管系统，包括承载导丝管腔的第一细长构件和沿构件纵向延伸的通道，其提供对导丝管腔的通路并限定两个边缘表面。还包括第二细长构件，其布置在导丝管腔内并且与第一细长构件的导丝管腔的横截面轮廓配合，从而将具有C形设计的导丝管腔转换为具有O形设计。导管可用于快速更换导管方法，需要使用小直径导丝，否则在使用过程中滑动通道。

6. 发明授权

US06761708B1 Radiopaque marker for a catheter and method of making 有权
标题翻译：导管的不透射线标记和制作方法
公开(公告)号：US06761708B1
公开(公告)日：2004-07-13
申请号：US09703518
申请日：2000-10-31
申请人： Jessica G. Chiu , Arlene S. Yang
发明人： Jessica G. Chiu , Arlene S. Yang
IPC分类号： A61M2500
CPC分类号： A61M25/0009 , A61M25/0108 , A61M2025/1079
摘要： A catheter having a radiopaque marker and a method of forming the radiopaque marker on the catheter component. One embodiment of the invention is directed to a method of making a radiopaque marker on a catheter component comprising depositing a first layer of radiopaque material onto at least a section of the catheter component, which in a presently preferred embodiment is deposited by thin film deposition, and electroplating a second layer of radiopaque material onto an outer surface of the first layer of radiopaque material. In one embodiment of the invention, a catheter component has a radiopaque marker comprising a first layer of radiopaque material, and a second layer of radiopaque material on the first layer having a thickness greater than the thickness of the first layer. In another embodiment of the invention, a first layer of radiopaque material comprises a blend of polymeric material and radiopaque material and a second layer of radiopaque material is electroplated onto the blended first layer. The radiopaque marker of the invention may be on a variety of catheter components including a catheter shaft or a balloon on a balloon catheter.
摘要翻译：具有不透射线标记的导管和在导管部件上形成不透射线标记的方法。本发明的一个实施例涉及一种在导管部件上制造不透射线的标记的方法，包括将第一层不透射线材料沉积在导管部件的至少一部分上，在目前优选的实施例中，通过薄膜沉积沉积，并将第二层不透射线材料电镀在第一层不透射线材料的外表面上。在本发明的一个实施例中，导管部件具有包括第一层不透射线材料的不透射线标记，第一层上的第二层不透射线材料的厚度大于第一层的厚度。在本发明的另一个实施例中，第一层不透射线材料包括聚合材料和不透射线材料的共混物，并且第二层不透射线材料电镀在混合的第一层上。本发明的不透射线标记可以在各种导管部件上，包括导管轴或球囊导管上的球囊。

7. 发明授权

US06733479B1 Perforated trocar sleeve and method of use 有权
标题翻译：穿孔套管和使用方法
公开(公告)号：US06733479B1
公开(公告)日：2004-05-11
申请号：US09627971
申请日：2000-07-28
申请人： Douglas E. Ott
发明人： Douglas E. Ott
IPC分类号： A61M2500
CPC分类号： A61B17/3421 , A61B17/3474 , A61M13/003
摘要： A perforated trocar sleeve (20) is disclosed. The trocar sleeve has an elongate tubular body member (21) having a proximal end (22) and a spaced distal end (24). An inlet port (25) is defined in the proximal end of the body member, and an outlet port (26) is defined at the distal end thereof. The inlet and outlet ports, in association with the body member, define a continuous fluid flow conduit (28) within the body member. A plurality of openings (29) are defined in the exterior surface of the tubular body member and extend from the distal end of the body member at least partially toward the proximal end thereof. The fluid to be delivered into a body cavity is passed through these openings and dispersed through an arc extending radially about the axis of the body member. The openings may be spaced randomly or regularly along the length of the body member, and may be positioned within at least one recess (40,60) defined within the exterior surface of the body member. The openings defined in the body member may vary in size along the length of the body member.
摘要翻译：公开了一种穿孔套管针套管（20）。套针套管具有细长的管状本体构件（21），其具有近端（22）和间隔开的远端（24）。入口端口（25）限定在主体构件的近端中，并且在其远端限定出口端口（26）。入口和出口与主体构件相关联地限定在主体构件内的连续流体流动导管（28）。多个开口（29）被限定在管状本体构件的外表面中并且从本体构件的远端至少部分地朝向其近端延伸。要输送到体腔内的流体通过这些开口并通过围绕主体构件的轴线径向延伸的弧分散。开口可以沿着主体构件的长度随机或规则地间隔开，并且可以定位在限定在主体构件的外表面内的至少一个凹部（40,60）内。限定在主体构件中的开口可沿主体构件的长度大小变化。

8. 发明授权

US06723083B2 Catheter for percutaneous transradial approach 失效
标题翻译：经皮经桡动脉导管
公开(公告)号：US06723083B2
公开(公告)日：2004-04-20
申请号：US10246270
申请日：2002-09-18
申请人： Ferdinand Kiemeneij
发明人： Ferdinand Kiemeneij
IPC分类号： A61M2500
CPC分类号： A61M25/0041
摘要： A preshaped tubular catheter for percutaneous transradial approach to catheterization, comprises a distal bridge shaped portion having a distal arch defining a primary curve, a top defining a secondary curve, and a proximal arch defining a tertiary curve. The proximal arch is connected to a straight shaft. The shaft is stiff and the bridge shaped portion has a flexibility extending at least up to and including the primary curve and a stiffness extending at least up to and including the tertiary curve.
摘要翻译：用于经皮经桡动脉导管插入术的预成形管状导管包括远端桥状部分，其具有限定初级曲线的远侧弓形，限定次级曲线的顶部和限定第三曲线的近端弓。近端弓连接到直轴。轴是刚性的，并且桥形部分具有至少延伸到并包括初级曲线的弹性和至少延伸到并包括第三曲线的刚度。

9. 发明授权

US06716207B2 Torqueable and deflectable medical device shaft 有权
标题翻译：可扭转和可偏转的医疗设备轴
公开(公告)号：US06716207B2
公开(公告)日：2004-04-06
申请号：US09863152
申请日：2001-05-22
申请人： Roger Farnholtz
发明人： Roger Farnholtz
IPC分类号： A61M2500
CPC分类号： A61M25/0138 , A61M25/0051 , A61M25/0053 , A61M25/0054 , A61M25/0147 , A61M2205/0266
摘要： A medical device shaft for connection with a handle and for insertion within a body includes an elongated, deflectable shaft having a proximal shaft portion, an intermediate shaft portion, and a distal shaft portion. The elongated, deflectable shaft includes a transition in stiffness from the proximal shaft portion to the distal shaft portion. In a preferred implementation, the shaft includes a plurality of slits that extend perpendicular to a longitudinal axis of the shaft. Varying at least one of the number of slits, the location of slits, the frequency of slits, the orientation of the slits, the size of the slits, and the depth of the slits varies the transition of stiffness.
摘要翻译：用于与手柄连接并用于插入到主体内的医疗装置轴包括具有近端轴部分，中间轴部分和远侧轴部分的细长的可偏转轴。细长的可偏转的轴包括刚性从近端轴部分到远端轴部分的过渡。在优选的实施方案中，轴包括垂直于轴的纵向轴线延伸的多个狭缝。改变狭缝数量，狭缝的位置，狭缝的频率，狭缝的取向，狭缝的尺寸和狭缝的深度中的至少一个改变刚度的转变。

10. 发明授权

US06706025B2 Lubricious catheters 失效
标题翻译：润滑导管
公开(公告)号：US06706025B2
公开(公告)日：2004-03-16
申请号：US09796776
申请日：2001-02-28
申请人： Erik T. Engelson , Robert Hergenrother , Joseph Eder
发明人： Erik T. Engelson , Robert Hergenrother , Joseph Eder
IPC分类号： A61M2500
CPC分类号： A61L29/085 , A61L29/14 , A61M25/0045 , A61M2025/0046
摘要： This invention is in the general field of surgical instruments. It relates specifically to catheters which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vaso-occlusive agents to a target site within a human or animal body which is accessible by a system of natural passageways within that body. The catheters are coated in such a way that they are exceptionally slippery and the coating is very durable. The invention also relates to methods of coating the catheters and to methods of applying lubricious coatings.
摘要翻译：本发明在外科器械的一般领域。它具体涉及可用于心血管和血管内程序以将诊断性，治疗性或血管闭塞性药物递送至人或动物体内的目标部位的导管，其可通过该体内的天然通道系统接近。导管以这样的方式涂覆，使得它们非常滑，并且涂层非常耐用。本发明还涉及涂覆导管的方法和应用润滑涂层的方法。

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