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1. 发明授权

US06224570B1 Rheolytic thrombectomy catheter and method of using same 有权
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US06224570B1
公开(公告)日：2001-05-01
申请号：US09188633
申请日：1998-11-09
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。公开了几个实施例。所有实施例包括具有内腔和内部高压管的外导管，其尺寸使其能够穿过导管的内腔。内部高压管的远端延伸超过导管的远端，并且携带用于将一个或多个盐水向近端引导到导管的远端的喷射帽。在一些实施例中，导管具有远侧定位的向内指向的固定止动件，并且内部高压管包括远侧定位的向外指向的过渡止动件，用于接合向内指向的固定止动件，从而将喷射盖定位在距离导管。在其他实施例中，静止止动件位于导管的近端处，并且过渡停止件承载在内部高压管的近端上。在具有位于近侧的静止和过渡止动件的实施例中，内部高压管在其远端包括导流器。在使用中，血栓被移出，夹带并通过盐水喷射器破碎成碎片，并通过导管的内腔向近端排出。

2. 发明授权

US06719718B2 Thrombectomy catheter and system 失效
公开(公告)号：US06719718B2
公开(公告)日：2004-04-13
申请号：US09930794
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

3. 发明授权

US06764483B1 Thrombectomy catheter and system 失效
公开(公告)号：US06764483B1
公开(公告)日：2004-07-20
申请号：US09915875
申请日：2001-07-26
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

4. 发明授权

US06945951B1 Thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06945951B1
公开(公告)日：2005-09-20
申请号：US09930796
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B17/22 , A61B17/32 , A61M1/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

5. 发明授权

US06805684B2 Thrombectomy catheter and system 失效
公开(公告)号：US06805684B2
公开(公告)日：2004-10-19
申请号：US09930795
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

6. 发明授权

US06676627B1 Crossflow thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06676627B1
公开(公告)日：2004-01-13
申请号：US09417395
申请日：1999-10-13
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

7. 发明授权

US06355027B1 Flexible microcatheter 有权
标题翻译：柔性微导管
公开(公告)号：US06355027B1
公开(公告)日：2002-03-12
申请号：US09328761
申请日：1999-06-09
申请人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M2500
CPC分类号： A61M25/0054 , A61M25/005 , A61M25/0053 , A61M2025/0042
摘要： Flexible microcatheter having regions of different flexibility integrally and strategically placed along and about the length of a one-piece composite catheter tube. Distally the flexible microcatheter exhibits pronounced flexibility with respect to locations or regions of flexibility located proximally for navigation along tortuous vascular paths. Different regions of flexibility are formed by applying resins of different Shore hardness readings either singularly or in combination along and about a braid which overlies an inner resin layer. The encapsulated braid provides resistance to kinking and bending of the flexible microcatheter as well as providing for torque transmission and pushability along the length of the flexible microcatheter.
摘要翻译：柔性微导管具有不同柔性的区域，整体地并且沿着并且围绕一体式复合导管的长度有策略地放置。远端地，柔性微导管相对于靠近曲折的血管路径导航的近端位置或柔性区域具有显着的灵活性。不同的柔性区域通过单独或组合地施加不同邵氏硬度读数的树脂形成，并且围绕着位于内层树脂层上的编织物。封装的编织物提供柔性微导管的扭结和弯曲的抗性，以及沿着柔性微导管的长度提供扭矩传递和推压性。

8. 发明授权

US5989210A Rheolytic thrombectomy catheter and method of using same 失效
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US5989210A
公开(公告)日：1999-11-23
申请号：US19728
申请日：1998-02-06
申请人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
发明人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
IPC分类号： A61B17/22 , A61B19/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/32075 , A61B2090/034
摘要： A surgical device and method for removal of tissue, such as thrombus, from a vessel in the body. The device has a first tube with a distal open end and an inward directed stop and a second tube with an outward directed stop for engaging the inward directed stop and thereby regulating the relationship between a retrograde jet and the distal open end. Thrombus is dislodged, entrained, and broken into pieces which are evacuated through the first tube.
摘要翻译：用于从体内的血管中去除诸如血栓的组织的手术装置和方法。该装置具有第一管，其具有远端开口端和向内指向的止动件，以及具有向外定向止动件的第二管，用于接合向内指向的止动件，从而调节逆行射流与远端开口端之间的关系。血栓被移出，夹带并分解成通过第一管排出的碎片。

9. 发明授权

US5989271A Flexible tip rheolytic thrombectomy catheter and method of constructing same 失效
标题翻译：柔性尖端溶解性血栓切除术导管及其构建方法
公开(公告)号：US5989271A
公开(公告)日：1999-11-23
申请号：US188631
申请日：1998-11-09
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Cindy M. Setum , Robert C. Dutcher , William J. Drasler
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Cindy M. Setum , Robert C. Dutcher , William J. Drasler
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22045
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. The rheolytic thrombectomy catheter has a first tube with a distal open end and a second tube aligned within the first tube and having a flexible tip assembly. A tapered and flexible tip follows a guidewire within and along tortuous and difficult vasculature paths to the site of thrombus. The flexible tip assembly, includes a soft flexible tip and also includes a hard plastic shell offering structural integrity and rigid alignment between a toroidal loop and an inner body to prevent lever arm distortion and to maintain spray gap alignment for saline jet flow emanating from the toroidal loop. Saline jets dislodge, entrain, and break thrombus into pieces which are evacuated through the dual lumen tube. A construction method is also included for mounting of the toroidal loop within the hard plastic shell and attachment of the soft tapered and flexible tip with sufficient bond strength to function as intended for use.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。所述溶解性血栓切除术导管具有第一管，所述第一管具有远端开口端，所述第二管在所述第一管内对准并且具有柔性末端组件。锥形和柔性的尖端跟随导线，并沿着曲折和困难的脉管系统通向血栓部位。柔性尖端组件包括软柔性尖端并且还包括硬塑料外壳，其在环形环和内部主体之间提供结构完整性和刚性对准，以防止杠杆臂变形并且保持喷射间隙对准用于从环形管发出的盐水喷射流循环。盐水喷射器移动，夹带并将血栓破坏成通过双腔管排出的碎片。还包括用于将环形环安装在硬塑料外壳内的结构方法，以及软的锥形和挠性端部的附着，其具有足够的粘合强度，以达到预期的目的。

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