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1. 发明申请

US20060020087A1 Method for surface modification, a novel support matrix and the use of the matrix 失效
标题翻译：表面修饰方法，新型支撑矩阵和矩阵的使用
公开(公告)号：US20060020087A1
公开(公告)日：2006-01-26
申请号：US11224550
申请日：2005-09-12
申请人： Helene Derand , Jan Nasman , Rose Nasman , Harry Nasman
发明人： Helene Derand , Jan Nasman , Rose Nasman , Harry Nasman
IPC分类号： C08G65/32 , C08L71/02
CPC分类号： C08F8/00 , B01J20/28042 , B01J20/286 , B01J20/321 , B01J20/3272 , Y10T428/2998 , C08F12/00 , C08F16/00 , C08F20/00
摘要： A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P′) carrying nucleophilic groups X′. The method is characterized in (a) ethoxylating a plurality of said X′ thereby transforming them to groups comprising —(CH2CH2O)nH, or (b) (i) ethoxylating a polymer (P″) carrying nucleophilic groups X″ thereby transforming P″ to a polyhydroxy polymer (P′″) carrying a plurality of —(CH2CH2O)nH groups, whereafter (ii) P′″ is attached to the base matrix. n is an integer≧1. A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity>5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug. The use of the support matrix defined in liquid chromatography, cell culturing, stepwise solid phase synthesis of organic molecules, affinity adsorption in suspensions, solid phase catalysis with an immobilized catalyst.
摘要翻译：一种多孔基质基质的亲水化和/或表面积增大的方法，其在其内表面和/或外表面上包含携带亲核基团X'的聚合物（P'）。该方法的特征在于（a）使多个所述X'乙氧基化，从而将它们转化成包含 - （CH 2 CH 2 CH 2 O）n H，或（b）（i）乙氧基化携带亲核基团X“的聚合物（P”），从而将P“转化成多羟基聚合物（P”），其携带多个 - （CH 2 H基团，然后（ii）P“'连接到基础基质上。 n是整数> = 1。可通过该方法获得的支撑矩阵。支撑基质具有足够的刚度和溶胀性，以允许当以颗粒形式填充到床上或以多孔整体塞的形式通过基质时，流速> 5cm / h的液体流动。使用在液相色谱，细胞培养，有机分子的逐步固相合成，悬浮液中的亲和吸附，固定化催化剂的固相催化中定义的载体基质。

2. 发明授权

US07553393B2 Method for covering a microfluidic assembly 有权
标题翻译：覆盖微流体组件的方法
公开(公告)号：US07553393B2
公开(公告)日：2009-06-30
申请号：US10182792
申请日：2001-01-22
申请人： Helene Derand , Anders Larsson
发明人： Helene Derand , Anders Larsson
IPC分类号： B29C65/00
CPC分类号： B01L3/502707 , B01J2219/00783 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B29C65/02 , B29C65/14 , B29C65/4815 , B29C65/483 , B29C66/1122 , B29C66/53461 , B29C66/71 , B29C66/72321 , B29C66/73172 , B29C66/73176 , B29L2031/756 , B32B37/0023 , B32B2037/1215 , Y10T436/2575 , B29K2067/003 , B29K2069/00
摘要： A method for covering a set of open microchannel structures which are fabricated on a planar surface made of plastics and which comprise two or more part areas that have different surface characteristics. The method comprises the steps of: a) providing the surface comprising the set of microchannel structures; b) providing a lid-forming sheet having on one side an even layer of a thermoglue; c) applying the side of the sheet having the thermoglue against the surface carrying the microchannel structure; d) heating the assembly created in step (c) to selectively liquefy the hot-melt adhesive while at the same time pressing the sheet material and the planar surface of the substrate together; e) permitting the resulting laminate-covered microchannel structure to cool. An assembly comprising (a) a planar substrate, the surface of which has a set of one or more open microchannel structures each of which comprises part areas representing different functionalities, and (b) a lid-forming material covering said set of microchannel structures and having one or more openings going from a microchannel structure to ambient atmosphere. The assembly is characterized in that the joint between said surface and said sheet material is a thermoglue that possibly has been cured.
摘要翻译：一种用于覆盖一组开放式微通道结构的方法，其制造在由塑料制成的平面上，并且包括具有不同表面特性的两个或多个部分区域。该方法包括以下步骤：a）提供包括一组微通道结构的表面; b）提供在一侧具有均匀的热镀层层的盖形成片; c）将具有热胶粘层的片材的侧面施加在承载微通道结构的表面上; d）加热步骤（c）中产生的组件以选择性地液化热熔粘合剂，同时将片材和基片的平面表面压在一起; e）允许所得层压物覆盖的微通道结构冷却。一种组件，其包括（a）平面基板，其表面具有一组一个或多个开放微通道结构，每个开放微通道结构包括表示不同功能的部分区域，以及（b）覆盖所述一组微通道结构的盖形成材料，具有从微通道结构到环境气氛的一个或多个开口。该组件的特征在于，所述表面和所述片材之间的接合是可能已经固化的热电胶。

3. 发明申请

US20060002825A1 Microfludic devices with new inner surfaces 审中-公开
标题翻译：具有新内表面的微流体装置
公开(公告)号：US20060002825A1
公开(公告)日：2006-01-05
申请号：US11213362
申请日：2005-08-26
申请人： Helene Derand , Frida Jernstrom
发明人： Helene Derand , Frida Jernstrom
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01L2200/12 , B01L2300/165
摘要： A microfluidic disc having one or more enclosed microchannel structures, and the microchannel structures are intended to be used for transport of transporting liquids. The device is characterized in that at least a part of the inner walls of each of one or more microchannel structures are treated with a gas plasma having one or more organic precursor compounds.
摘要翻译：具有一个或多个封闭微通道结构的微流体盘，并且微通道结构旨在用于运输液体。该装置的特征在于，用具有一种或多种有机前体化合物的气体等离子体处理一个或多个微通道结构中的每一个的至少一部分内壁。

4. 发明申请

US20050153431A1 Retaining microfluidic microcavity and other microfluidic structures 有权
公开(公告)号：US20050153431A1
公开(公告)日：2005-07-14
申请号：US11010869
申请日：2004-12-13
申请人： Per Andersson , Gunnar Ekstrand , Helene Derand
发明人： Per Andersson , Gunnar Ekstrand , Helene Derand
IPC分类号： B01F5/06 , B01F13/00 , B01F15/02 , B01J19/00 , B01L3/00 , C40B40/10 , G01N30/46 , G01N30/60 , G01N33/543 , G01N35/00 , H01J49/04 , C12M1/34
CPC分类号： G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

5. 发明授权

US07429354B2 Structural units that define fluidic functions 失效
标题翻译：定义流体功能的结构单元
公开(公告)号：US07429354B2
公开(公告)日：2008-09-30
申请号：US10472255
申请日：2002-03-19
申请人： Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
发明人： Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
IPC分类号： G01N21/00
CPC分类号： G01N33/54366 , B01J19/0093 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0678 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , G01N35/00069
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion >5 mN/m with centrifugal force.
摘要翻译：一种微流体装置，其包括几个微通道结构，其中存在入口端口，出口以及其间具有流体功能的子结构。该装置具有对称轴，微通道结构围绕该轴布置为两个或更多个同心的环形区域。对于相同微通道结构的入口和出口，入口通常比出口更接近对称轴。每个微通道结构包括一个子结构，其可以在圆盘围绕轴线旋转时保持液体，和/或入口端口与路径分离，离开开放废料出口的废液在旋转时将跟随盘的表面。对于环形区域的微通道结构，相应的子结构基本上处于相同的径向距离，而不同环形区域的微通道结构中的相应子结构处于不同的径向距离。本发明还涉及几个其他子结构。子结构主要适用于输送具有离心力的表面尺寸> 5mN / m的液体等分试样。

6. 发明授权

US07104517B1 Polymer valves 有权
标题翻译：聚合物阀门
公开(公告)号：US07104517B1
公开(公告)日：2006-09-12
申请号：US10030297
申请日：2000-06-30
申请人： Helene Derand , Per Andersson , Anders Larsson
发明人： Helene Derand , Per Andersson , Anders Larsson
IPC分类号： F16K31/00
CPC分类号： F16K99/0001 , B01J19/0093 , B01J2219/00783 , B01J2219/00891 , B01L3/502738 , B01L2200/12 , B01L2300/0806 , B01L2300/1861 , B01L2400/0661 , F15C5/00 , F16K13/10 , F16K99/0019 , F16K99/0034 , F16K99/0036
摘要： The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs (34) of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way (32) for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (34). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.
摘要翻译：本发明涉及一种控制微通道结构中液体流动的方法。它包括在所述微通道结构中提供在所述结构中的聚合物材料的塞子（34），所述聚合物材料处于第一状态，从而阻止所述通道从液体流动，并且在第二状态下提供用于液体流动的自由通路（32）。选择性地施加能量以使所述聚合物进入所述第一或第二状态中的期望的一种。它还涉及一种微通道阀系统，其包括多个这样的塞子（34）。另外，它包括化学反应器，包括通过微通道互连的多个微室，具有根据本发明的阀系统。

7. 发明申请

US20070054270A1 Preloaded microfluidic devices 审中-公开
标题翻译：预装微流体装置
公开(公告)号：US20070054270A1
公开(公告)日：2007-03-08
申请号：US10550137
申请日：2004-03-23
申请人： Mats Inganas , Susanna Lindman , Helene Derand
发明人： Mats Inganas , Susanna Lindman , Helene Derand
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , G01N33/558
CPC分类号： B01L3/50273 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/069 , B01L2300/0806 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487
摘要： A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a dry state together with a bed-preserving agent comprising one or more compounds having bed-preserving activity.
摘要翻译：一种微流体装置，包括一个，两个或更多个微通道结构（101a-h），每个微通道结构（101a-h）包括旨在保持呈湿多孔床形式的固相材料的反应微腔（104a-h）。所述一个，两个或更多个微通道结构中的每一个包含处于干燥状态的固相材料以及包含一种或多种具有床保存活性的化合物的保存剂。

8. 发明申请

US20050186685A1 Protecting agent 有权
标题翻译：保护剂
公开(公告)号：US20050186685A1
公开(公告)日：2005-08-25
申请号：US11038712
申请日：2005-01-20
申请人： Rickard Kange , Mats Inganas , Magnus Gustafsson , Johan Engstrom , Bo Ek , Helene Derand , Ann-Kristin Honerud
发明人： Rickard Kange , Mats Inganas , Magnus Gustafsson , Johan Engstrom , Bo Ek , Helene Derand , Ann-Kristin Honerud
IPC分类号： B01F17/00 , B01L3/00 , B01L3/02 , G01N1/10 , G01N27/447
CPC分类号： B01F17/0028 , B01F17/005 , B01F17/0064 , B01L3/0241 , B01L3/502746 , B01L2400/084 , G01N27/44752 , Y10T436/25 , Y10T436/2525 , Y10T436/25625 , Y10T436/2575
摘要： A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.
摘要翻译：在微流体导管中输送可能含有物质I的液体等分试样的方法，其溶解在液体中并且通常表现出带电基团和/或疏水基团。该方法的特征在于液体含有两亲性大分子物质。

9. 发明申请

US20050042770A1 Fluidic functions based on non-wettable surfaces 审中-公开
标题翻译：基于非润湿表面的流体功能
公开(公告)号：US20050042770A1
公开(公告)日：2005-02-24
申请号：US10849321
申请日：2004-05-19
申请人： Helene Derand , Matthew Fielden , Cecillia Hellermark , Rickard Kange , Therese Sennefors
发明人： Helene Derand , Matthew Fielden , Cecillia Hellermark , Rickard Kange , Therese Sennefors
IPC分类号： G01N1/10
CPC分类号： B01L3/502738 , B01L2200/0605 , B01L2200/0631 , B01L2200/0647 , B01L2200/0684 , B01L2200/12 , B01L2200/142 , B01L2300/0806 , B01L2300/0864 , B01L2300/161 , B01L2400/086 , B01L2400/088 , Y10T436/2575
摘要： A method for processing two or more liquid aliquots in a microchannnel structure of a microfluidic device. The microchannel structure comprises a hydrophilic microconduit with a fluidic function and a local non-wettable surface associated with the fluidic function/microconduit. Other aspects comprise a method for producing the fluidic function, which comprises introducing non-wettability on a local surface area S that is associated with the microconduit.
摘要翻译：一种用于在微流体装置的微通道结构中处理两个或更多个液体等分试样的方法。微通道结构包括具有流体功能的亲水微管道和与流体功能/微管道相关联的局部不可润湿表面。其它方面包括用于产生流体功能的方法，其包括将非润湿性引入与微型管道相关联的局部表面积S上。

10. 发明授权

US06653625B2 Microfluidic system (MS) 有权
公开(公告)号：US06653625B2
公开(公告)日：2003-11-25
申请号：US09811741
申请日：2001-03-19
申请人： Per Andersson , Helene Derand , Magnus Gustafsson , Anders Palm , Susanne Wallenborg
发明人： Per Andersson , Helene Derand , Magnus Gustafsson , Anders Palm , Susanne Wallenborg
IPC分类号： B01D2726
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

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