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1. 发明授权

US4963344A Method to enhance NMR imaging using chelated paramagnetic ions 失效
标题翻译：使用螯合顺磁离子增强核磁共振成像的方法
公开(公告)号：US4963344A
公开(公告)日：1990-10-16
申请号：US370139
申请日：1989-06-23
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
摘要翻译：可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸。

2. 发明授权

US5021236A Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules 失效
标题翻译：使用结合生物分子的螯合顺磁离子增强NMR成像的方法
公开(公告)号：US5021236A
公开(公告)日：1991-06-04
申请号：US20300
申请日：1987-03-02
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid, wherein said chelate complex is bound to a biomolecule.
摘要翻译：可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸，其中所述螯合络合物与生物分子结合。

3. 发明授权

US5648063A Sterile composition comprising a chelate complex for magnetic resonance imaging 失效
标题翻译：包含用于磁共振成像的螯合物的无菌组合物
公开(公告)号：US5648063A
公开(公告)日：1997-07-15
申请号：US101811
申请日：1993-08-04
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/08 , A61K49/10 , A61B5/055
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/16 , A61K51/04 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译：诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地，一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。

4. 发明授权

US5560903A Method of enhancing paramagnetism in chelates for MRI 失效
标题翻译：增强MRI中螯合物顺铂的方法
公开(公告)号：US5560903A
公开(公告)日：1996-10-01
申请号：US462681
申请日：1995-06-05
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07C323/25 , C07D257/02 , C07F9/3817 , C07F9/386 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译：诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地，一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。

5. 发明授权

US5362475A Gadolinium chelates for magnetic resonance imaging 失效
标题翻译：钆螯合物用于磁共振成像
公开(公告)号：US5362475A
公开(公告)日：1994-11-08
申请号：US911800
申请日：1992-07-10
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译：诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸和一种或多种钆离子的阴离子，以及任选的一种或多种无机和/或有机碱或氨基酸的生理学生物相容性阳离子或阳离子，任选地具有常用于盖仑制剂中的添加剂，溶于或悬浮于水性介质中。

6. 发明授权

US5047228A Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives 失效
标题翻译：非离子型5-C取代的2,4,6-三碘代邻苯二甲酸衍生物
公开(公告)号：US5047228A
公开(公告)日：1991-09-10
申请号：US318454
申请日：1989-03-02
申请人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Mutzel
发明人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Mutzel
IPC分类号： C07C69/80 , A61K49/04 , C07C63/68 , C07C67/00 , C07C69/76 , C07C231/00 , C07C231/02 , C07C231/06 , C07C233/65 , C07C233/68 , C07C233/69 , C07C237/30 , C07C237/32
CPC分类号： C07C233/69
摘要： Nonionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --COOR.sub.3, --CH.sub.2 NHR.sub.7 or --CH.sub.2 OH; Y is --1R.sub.1 R.sub.2 or --OR.sub.3 ; and Z is --NR.sub.1 R.sub.2, --NHR.sub.7 or --OR.sub.3 ; and wherein R.sub.1 R.sub.2 and R.sub.3 in X, Y or Z, and R.sub.7 in X and Z, are identical or different, R.sub.1 and R.sub.2, and each is hydrogen, C.sub.1-6 -alkyl or C.sub.2-8 - alkyl substituted by 1-5 OH groups and/or by a C.sub.1-3 -alkoxy group; R.sub.3 is C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-2 OH groups and/or by a C.sub.1-3 -alkoxy group; and R.sub.7 is an acyl group of a C.sub.2-5 OH group and/or by a C.sub.1-3 -alkoxy group are highly advantageous X-ray contrast agents.
摘要翻译：其中X为-CONR1R2，-COOR3，-CH2NHR7或-CH2OH的式（I）的非离子化合物; Y为-1R1R2或-OR3; 并且Z是-NR 1 R 2，-NHR 7或-OR 3; 并且其中X，Y或Z中的R 1和R 3以及X和Z中的R 7相同或不同，R 1和R 2各自为氢，C 1-6 - 烷基或被1-5 OH取代的C 2-8 - 烷基基团和/或被C 1-3 - 烷氧基取代; R3是被1-2个OH基团和/或被C1-3烷氧基取代的C 1-4 - 烷基或C 2-4 - 烷基; R7是C2-5OH基和/或C1-3烷氧基的酰基是非常有利的X射线造影剂。

7. 发明授权

US5746999A Magnetic particles for diagnostic purposes 失效
公开(公告)号：US5746999A
公开(公告)日：1998-05-05
申请号：US484309
申请日：1995-06-07
申请人： Heinz Gries , Wolfgang Mutzel , Christian Zurth , Hanns-Joachim Weinmann
发明人： Heinz Gries , Wolfgang Mutzel , Christian Zurth , Hanns-Joachim Weinmann
IPC分类号： C08B37/02 , A61B5/055
CPC分类号： C08B37/0021 , G01N2400/14 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/86
摘要： Agents containing magnetic particles are suitable for use in enhancing images in diagnostic procedures, e.g., via x-ray, ultrasound or especially NMR. Preferred particles are based on metals, e.g., iron, cobalt or nickel, double metal oxides/hydroxides or complexes thereof.

8. 发明授权

US4395391A Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides), their preparation, and x-ray contrast media containing same 失效
标题翻译：不对称取代的二羧酸 - 双 - （2,4,6-三碘 - 酰苯胺），其制备物和含有它们的X射线造影剂
公开(公告)号：US4395391A
公开(公告)日：1983-07-26
申请号：US324368
申请日：1981-11-24
申请人： Heinrich Pfeiffer , Wolfgang Mutzel , Ulrich Speck
发明人： Heinrich Pfeiffer , Wolfgang Mutzel , Ulrich Speck
IPC分类号： A61K49/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/00 , C07C233/30 , C07C235/16 , C07C101/68
CPC分类号： C07C233/00 , A61K49/04 , C07C233/30
摘要： Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides) of formula I ##STR1## wherein X is straight-chain or branched alkylene interrupted by one or more oxygen atoms,R.sup.1 is --NHacyl, --CH.sub.2 NHacyl, or --CONHR.sup.3 wherein R.sup.3 is hydrogen or a lower straight-chain or branched optionally mono- or poly-hydroxylated, alkyl residue, and where any hydroxyl groups present may be functionally modified, andR.sup.2 is hydrogen or lower alkyl, and their salts,are extraordinarily well suited, in view of their good pharmacological and physico-chemical properties, as water-soluble x-ray contrast media for all fields of application, in particular for i.v. cholegraphy and for computer tomography.
摘要翻译：式（I）的不对称取代的二羧酸 - 双 - （2,4,6-三碘 - 酰苯胺）其中X是被一个或多个氧原子间隔的直链或支链亚烷基，R 1是-NHacyl， -CH 2 N-酰基或-CONHR 3，其中R 3是氢或低级直链或支链任选的单羟基化或多羟基化的烷基残基，并且其中存在的任何羟基可以被功能性修饰，并且R 2是氢或低级烷基，盐，由于其良好的药理学和物理化学性质，特别适用于所有应用领域的水溶性x射线造影剂，特别适用于iv 精神科和计算机断层扫描。

9. 发明授权

US4367216A Triiodinated 5-aminoisophthalic acid derivatives 失效
标题翻译：三碘化5-氨基间苯二酸衍生物
公开(公告)号：US4367216A
公开(公告)日：1983-01-04
申请号：US163895
申请日：1980-06-27
申请人： Wolfgang Mutzel , Hans-Martin Siefert , Ulrich Speck , Heinrich Pfeiffer , Paul-Eberhard Schulze , Bernhard Acksteiner
发明人： Wolfgang Mutzel , Hans-Martin Siefert , Ulrich Speck , Heinrich Pfeiffer , Paul-Eberhard Schulze , Bernhard Acksteiner
IPC分类号： C07C391/00 , C07F7/08 , A61K49/04
CPC分类号： C07F7/0854 , C07C391/00 , C07F7/0818
摘要： Compounds of the formula ##STR1## wherein R.sup.1 is hydroxy-C.sub.2-8 -alkyl containing 1-5 OH-groups;R.sup.2 is hydrogen, C.sub.1-4 -alkyl or R.sup.1 ;R.sup.3 and R.sup.4 can be identical or different, and each independently is hydrogen or C.sub.1-4 -alkyl; andX is straight chain or branched C.sub.2-12 alkylene interrupted by sulfur or selenium atoms, and, optionally, additionally interrupted by oxygen atoms, by a di(C.sub.1-4 -alkyl)silyl group or a tetra(C.sub.1-4 -alkyl)disiloxane group;are very useful as X-ray contrast media opaque agents, which can be employed even in lymphography.
摘要翻译：式IMA的化合物，其中R 1是含有1-5个OH基的羟基-C 2-8 - 烷基; R2是氢，C1-4 - 烷基或R1; R 3和R 4可以相同或不同，并且各自独立地是氢或C 1-4 - 烷基; X是由硫或硒原子间隔的直链或支链C 2--12亚烷基，并且任选另外被氧原子间隔的二（C 1-4 - 烷基）甲硅烷基或四（C 1-4 - 烷基）二硅氧烷基团作为X射线造影剂不透明剂是非常有用的，其甚至可用于淋巴造影术。

10. 发明授权

US4522839A 3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents 失效
标题翻译： 3-取代的2,4,6-三卤代苯甲酰胺作为甜味剂
公开(公告)号：US4522839A
公开(公告)日：1985-06-11
申请号：US554654
申请日：1983-11-23
申请人： Heinz Gries , Wolfgang Mutzel
发明人： Heinz Gries , Wolfgang Mutzel
IPC分类号： A23L27/30 , C07C233/00 , A23L1/236
CPC分类号： C07C255/00 , A23L27/30
摘要： The 3-substituted 2,4,6-trihalogenated benzamides having the formula I ##STR1## wherein Hal is chlorine, bromine, or iodine andZ is a carboxyl group or the group ##STR2## wherein P is 1 and L is 0 or 1, with the proviso that L is 0 when K is 0;K is 0, 2, 3 or 4;M is 0, 1, 2 or 3;N is 0 or 1;X is a hydrogen atom;Y is a hydrogen atom or a lower alkyl group of 1-4 carbon atoms, or when either M or N is other than 0, a hydroxy group, a C.sub.1-6 alkoxy group or a C.sub.1-4 acyloxy group, or when N is 1 and M is other than 0, X and Y together represent an additional carbon-carbon bond; orP and L are each 0;K is 0, 2, 3 or 4;M is 0, 1, 2 or 3;N is 0 or 1;X is a hydrogen atom;Y is a hydrogen atom, a lower alkyl group of 1-4 carbon atoms, a hydroxy group, a C.sub.1-6 alkoxy group, a C.sub.1-4 acyloxy group or, when N is 1, X and Y together represent an additional carbon-carbon bond; and salts thereof with inorganic bases, exhibit an extraordinarily high sweetening power and are excellent substitutes for natural sweetening agents.
摘要翻译：具有式I的3-取代的2,4,6-三卤代苯甲酰胺，其中Hal是氯，溴或碘，Z是羧基或基团，其中P是1，L是0或1 条件是当K为0时L为0; K为0,2,3或4; M为0,1,2或3; N为0或1; X是氢原子; Y是氢原子或1-4个碳原子的低级烷基，或当M或N不是0时，羟基，C1-6烷氧基或C1-4酰氧基，或当N为 1和M不是0，X和Y一起代表额外的碳 - 碳键; 或P和L各自为0; K为0,2,3或4; M为0,1,2或3; N为0或1; X是氢原子; Y是氢原子，1-4个碳原子的低级烷基，羟基，C1-6烷氧基，C1-4酰氧基，或当N是1时，X和Y一起代表另外的碳 - 碳键; 及其与无机碱的盐，表现出极高的甜味力，并且是天然甜味剂的优良替代品。

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