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    • 1. 发明授权
    • Polyamide derivatives having unsaturated terminal amic acid groups
    • 具有不饱和末端酰胺酸基团的聚酰胺衍生物
    • US4377536A
    • 1983-03-22
    • US322075
    • 1981-11-16
    • Phillip A. WaitkusGaetano F. D'Alelio
    • Phillip A. WaitkusGaetano F. D'Alelio
    • C07D209/48C08G73/14C07C101/68
    • C07D209/48C08G73/14
    • Novel compositions comprising unsaturated polyhemi-amic acid compositions and processes for their preparation are disclosed herein. These new compositions are primarily derivatives of anhydride-terminated aromatic polyimides from which they are prepared by amidation to provide unsaturated amide groups having terminal --CH.dbd.CH.sub.2 groups as hemi-amic acid groups or their derivatives. These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation thereby extending greatly the applications for which the aromatic polyimides can be employed. Also included are monomeric compounds containing unsaturated amide groups derived from monomeric tetracarboxylic dianhydrides. These are particularly useful as crosslinking agents.
    • 本文公开了包含不饱和聚氨基甲酸组合物的新型组合物及其制备方法。 这些新组合物主要是酸酐封端的芳族聚酰亚胺的衍生物,它们通过酰胺化制备,以提供具有末端-CH = CH 2基团的不饱和酰胺基团作为半 - 酰胺基团或其衍生物。 这些新组合物比原来的酸酐封端的聚酰亚胺更易于处理,并且可以在适当的较低温度下转化成交联的不溶性的可熔融的聚合物,而不会产生副产物形成,从而大大延伸了可以使用芳族聚酰亚胺的应用。 还包括含有源自单体四羧酸二酐的不饱和酰胺基团的单体化合物。 这些作为交联剂特别有用。
    • 4. 发明授权
    • Aminobenzyl-amides and salts thereof
    • 氨基苄基酰胺及其盐
    • US3950393A
    • 1976-04-13
    • US458099
    • 1974-04-05
    • Johannes KeckKlaus-Reinhold NollHelmut PieperGerd KrugerSigfrid Puschmann
    • Johannes KeckKlaus-Reinhold NollHelmut PieperGerd KrugerSigfrid Puschmann
    • C07C211/52A61K31/135A61K31/19C07C209/10C07C209/50C07C209/62C07C209/74C07C211/29C07C211/49C07C211/53C07C221/00C07C225/22C07C231/12C07C233/43C07C255/58C07D221/24C07D295/135C07C101/48C07C101/68
    • C07D295/135A61K31/135A61K31/19C07D221/24Y10S514/849
    • Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##EQU1## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-ulcergenics, secretolytics, antitussive, and stimulants of the production of the surfactant or antiatelectasis factor of the alveoli.
    • 式WHEREIN R 1的化合物是氢或脂族或芳族羧酸酰基,R 2是氢,氯或溴,R 3是氟,1至4个碳原子的烷基,三氟甲基,氰基,氨基甲酰基,羧基,烷氧基,烷氧基,乙酰基, 羟乙基或R6 -CH2-N ANGLE R7,其中R6和R7各自为烷基,环烷基,羟基 - 环烷基或彼此连接的氮原子,吡咯烷基,哌啶子基或吗啉代,R4和R5各自为 氢,1至5个碳原子的烷基,一或二羟基(1至5个碳原子的烷基),2至4个碳原子的烯基,5至7个碳原子的环烷基,一或二羟基(环烷基 5至7个碳原子),苄基,吗啉代羰基甲基或彼此连接的氮原子,吡咯烷基,哌啶子基,六亚甲基亚氨基,吗啉代,N-甲基哌嗪基或卡宾多,以及非毒性,药理学上可接受的 其添加量: 化合物作为其生物利用作为抗生素,秘密,抗生素和生物活性成分或抗生素因子的有效途径。
    • 5. 发明授权
    • Process for the preparation of 2,5-di-phenylamino-terephthalic acid and
its dialkyl esters
    • 制备2,5-二苯基氨基 - 对苯二甲酸及其二烷基酯的方法
    • US5616779A
    • 1997-04-01
    • US397733
    • 1995-03-02
    • Otto Arndt
    • Otto Arndt
    • C07C229/62B01J31/04C07B61/00C07C227/06C07C227/08C07C227/16C07C227/18C07C101/38C07C101/68C07C103/76
    • C07C227/08C07C227/16
    • The present invention relates to a process for the preparation of 2,5-di-phenylamino-terephthalic acid and its dialkyl esters of the formula ##STR1## in which R is a hydrogen atom or a methyl or an ethyl group, by reaction of a succinic acid dialkyl ester with a sodium alcoholate in xylene, treatment of the resulting 2,5-dihydroxy-cyclohexadiene-1,4-di-carboxylic acid dialkyl ester with acid and aniline, dehydrogenation of the resulting 2,5-di-phenylamino-dihydro-(3,6)-terephthalic acid dialkyl ester by means of oxygen, if appropriate hydrolysis of the 2,5-di-phenylamino-terephthalic acid dialkyl ester formed and liberation of the 2,5-di-phenylamino-terephthalic acid from the di-sodium salt formed. The 2,5-di-phenylamino-dihydro-(3,6)-terephthalic acid dialkyl ester is reacted with pure oxygen in the presence of an alkali metal ion and/or an alkaline earth metal ion. This significantly decreases undesirable impurities.
    • 本发明涉及通过琥珀酸二烷基酯与二甲苯醇钠反应制备2,5-二苯基氨基 - 对苯二甲酸及其通式为乙基的二烷基酯的方法,处理 的所得的2,5-二羟基 - 环己二烯-1,4-二羧酸二烷基酯与酸和苯胺,所得的2,5-二苯基氨基 - 二氢 - (3,6) - 对苯二甲酸二烷基酯 如果合适的水解形成的2,5-二苯基氨基 - 对苯二甲酸二烷基酯和形成的二钠盐释放2,5-二苯基氨基 - 对苯二甲酸,通过氧气。 2,5-二苯基氨基 - 二氢 - (3,6) - 对苯二甲酸二烷基酯在碱金属离子和/或碱土金属离子存在下与纯氧反应。 这显着降低了不需要的杂质。