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1. 发明授权

US06847799B2 Mission certification quiz for fundraising campaign 失效
标题翻译：筹款活动中的任务认证测验
公开(公告)号：US06847799B2
公开(公告)日：2005-01-25
申请号：US10388824
申请日：2003-03-13
申请人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
发明人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
IPC分类号： G09B7/02 , G09B5/04
CPC分类号： G09B7/02
摘要： A web-based mission certification quiz for educating various persons involved in a fundraising campaign is disclosed. A web-based method for educating solicitors, donors, participants and others involved in a fundraising campaign about the campaign's mission includes providing, on a website, information about the campaign's mission, taking, on the website, a mission certification quiz by answering one or more questions, wherein the questions are designed to test a participant's knowledge about the campaign's mission. The method further includes determining a final score based on the number of correct answers, and creating a mission certificate on the website based on the final score.
摘要翻译：披露了一个基于网络的任务认证测验，用于对参与筹款活动的各方进行教育。一个基于网络的方法，用于教育涉及该运动的任务的筹款运动的律师，捐助者，参与者和其他参与者包括在网站上提供关于该运动的任务的信息，在网站上通过回答一个或更多问题，其中的问题旨在测试参与者对运动的使命的了解。该方法还包括基于正确答案的数量来确定最终得分，并且基于最终得分在网站上创建任务证书。

2. 发明授权

US06603955B2 Mission certification quiz for fundraising campaign 失效
公开(公告)号：US06603955B2
公开(公告)日：2003-08-05
申请号：US09894190
申请日：2001-06-27
申请人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
发明人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
IPC分类号： G09B504
CPC分类号： G09B7/02
摘要： A web-based mission certification quiz for educating various persons involved in a fundraising campaign is disclosed. A web-based method for educating solicitors, donors, participants and others involved in a fundraising campaign about the campaign's mission includes providing, on a website, information about the campaign's mission, taking, on the website, a mission certification quiz by answering one or more questions, wherein the questions are designed to test a participant's knowledge about the campaign's mission. The method further includes determining a final score based on the number of correct answers, and creating a mission certificate on the website based on the final score. The method includes starting a timer prior to presenting the question, the timer being set for a predetermined amount of time allowed for each question, providing a question, selecting an answer to the question, wherein the answer is selected from one or more answers provided, and if a correct answer is selected before the expiration of the timer, then only awarding a score for each correct answer. The method further includes determining if there are additional questions in the quiz, and if there are additional questions in the quiz, then answering the questions, and if the are no remaining questions in the quiz, then determining a final score, determining a grade on the basis of the final score, and indicating the final score and the grade on the mission certificate.

3. 发明授权

US07120387B2 Mission certification quiz for fundraising campaign 失效
标题翻译：筹款活动中的任务认证测验
公开(公告)号：US07120387B2
公开(公告)日：2006-10-10
申请号：US11042000
申请日：2005-01-24
申请人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
发明人： Harry E. Gruber , Ephraim Feig , Julie Schwartz
IPC分类号： G09B7/00 , G09B3/00
CPC分类号： G09B7/02
摘要： A web-based mission certification quiz for educating various persons involved in a fundraising campaign is disclosed. A web-based method for educating solicitors, donors, participants and others involved in a fundraising campaign about the campaign's mission includes providing, on a website, information about the campaign's mission, taking, on the website, a mission certification quiz by answering one or more questions, wherein the questions are designed to test a participant's knowledge about the campaign's mission. The method further includes determining a final score based on the number of correct answers, and creating a mission certificate on the website based on the final score.
摘要翻译：披露了一个基于网络的任务认证测验，用于对参与筹款活动的各方进行教育。一个基于网络的方法，用于教育涉及该运动的任务的筹款运动的律师，捐助者，参与者和其他参与者包括在网站上提供关于该运动的任务的信息，在网站上通过回答一个或更多问题，其中的问题旨在测试参与者对运动的使命的了解。该方法还包括基于正确答案的数量来确定最终得分，并且基于最终得分在网站上创建任务证书。

4. 发明申请

US20110217267A1 GENE THERAPY VECTORS AND CYTOSINE DEAMINASES 有权
标题翻译：基因治疗载体和细胞因子杀虫剂
公开(公告)号：US20110217267A1
公开(公告)日：2011-09-08
申请号：US13072705
申请日：2011-03-26
申请人： Harry E. Gruber , Douglas J. Jolly , Omar D. Perez , Christopher R. Logg
发明人： Harry E. Gruber , Douglas J. Jolly , Omar D. Perez , Christopher R. Logg
IPC分类号： A61K35/76 , C12N9/78 , C12N15/85 , C12N15/86 , C12N15/867 , C12N5/10 , C12N7/01 , C07H21/00 , A61K48/00 , A61P35/00 , A61P19/02
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译：本公开提供了修饰的胞嘧啶脱氨酶（CDs）。本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。

5. 发明授权

US06241982B1 Method for treating brain cancer with a conditionally lethal gene 失效
标题翻译：用有条件致死基因治疗脑癌的方法
公开(公告)号：US06241982B1
公开(公告)日：2001-06-05
申请号：US08468646
申请日：1995-06-06
申请人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
发明人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
IPC分类号： A61K4800
CPC分类号： A01K67/033 , A01K67/0275 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译：本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。

6. 发明授权

US5864033A Adenosine kinase inhibitors 失效
标题翻译：腺苷激酶抑制剂
公开(公告)号：US5864033A
公开(公告)日：1999-01-26
申请号：US451236
申请日：1995-05-26
申请人： Clinton E. Browne , Bheemarao G. Ugarkar , Kevin M. Mullane , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo Castellino
发明人： Clinton E. Browne , Bheemarao G. Ugarkar , Kevin M. Mullane , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo Castellino
IPC分类号： A61K31/00 , C07D487/04 , C07D519/00 , C07H19/04 , C07H19/052 , C07H19/06 , C07H19/14 , C07H19/16
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/7076 , C07D487/04 , C07H19/04 , C07H19/052 , C07H19/06 , C07H19/14 , C07H19/16
摘要： Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various conditions which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
摘要翻译：提供了选择性抑制腺苷激酶的新型化合物和制备腺苷激酶抑制剂的方法。还提供了治疗各种病症的方法，其可以通过使用腺苷激酶抑制剂增加腺苷浓度来改善。

7. 发明授权

US5856185A Method for making reflection defective retroviral vectors for infecting human cells 失效
标题翻译：复制用于感染人细胞的有缺陷的逆转录病毒载体的方法
公开(公告)号：US5856185A
公开(公告)日：1999-01-05
申请号：US472109
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , C07H21/04 , C12N15/48
CPC分类号： A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译：公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。

8. 发明授权

US5646128A Methods for treating adenosine kinase related conditions 失效
标题翻译：治疗腺苷激酶相关病症的方法
公开(公告)号：US5646128A
公开(公告)日：1997-07-08
申请号：US349125
申请日：1994-12-01
申请人： Gary S. Firestein , Bheemarao G. Ugarkar , Leonard P. Miller , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo J. Castellino , Clinton E. Browne
发明人： Gary S. Firestein , Bheemarao G. Ugarkar , Leonard P. Miller , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo J. Castellino , Clinton E. Browne
IPC分类号： A61K31/00 , C07H19/04 , C07H19/052 , A61K31/70
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/7076 , C07H19/04 , C07H19/052 , Y10S514/825 , Y10S514/885 , Y10S514/886
摘要： Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
摘要翻译：提供了选择性抑制腺苷激酶的新型化合物和制备腺苷激酶抑制剂的方法。还提供了治疗各种炎性病症（包括关节炎和SIRS）的方法，其可以通过使用腺苷激酶抑制剂增加腺苷浓度来改善。

9. 发明授权

US08722867B2 Gene therapy vectors and cytosine deaminases 有权
标题翻译：基因治疗载体和胞嘧啶脱氨酶
公开(公告)号：US08722867B2
公开(公告)日：2014-05-13
申请号：US13072705
申请日：2011-03-26
申请人： Harry E. Gruber , Douglas J. Jolly , Omar D. Perez , Christopher R. Logg
发明人： Harry E. Gruber , Douglas J. Jolly , Omar D. Perez , Christopher R. Logg
IPC分类号： A61K48/00 , C07H21/00 , C12N15/867 , A61K35/76 , C12N15/63
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译：本公开提供了修饰的胞嘧啶脱氨酶（CDs）。本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。

10. 发明申请

US20110268720A1 FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF 有权
标题翻译： 5-氟代异喹啉的配方及其用途
公开(公告)号：US20110268720A1
公开(公告)日：2011-11-03
申请号：US13001516
申请日：2009-06-30
申请人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
发明人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
IPC分类号： A61K31/513 , A61K48/00 , A61P35/00 , A61K38/46 , C07D239/47 , A61P31/10
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/50 , A61K38/51 , C12Y305/04001 , A61K2300/00
摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.
摘要翻译：本公开提供5-氟胞嘧啶的延长释放制剂。另一方面，提供了一种治疗真菌病的方法。该方法包括向有需要的受试者施用真菌治疗有效量的包含5-氟胞嘧啶的组合物。另一方面，提供了治疗癌症的方法。该方法包括向有需要的受试者施用足够量的表达载体以诱导能够将5-氟胞嘧啶转化成癌症细胞中的5-氟尿嘧啶的胞嘧啶脱氨酶的表达和癌症治疗有效量的组合物包含5-氟胞嘧啶。

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