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1. 发明申请

US20090227572A1 TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES 审中-公开
标题翻译：治疗糖尿病和外周神经病变
公开(公告)号：US20090227572A1
公开(公告)日：2009-09-10
申请号：US12405915
申请日：2009-03-17
申请人： Jack R. Barber , Shi Chung Ng
发明人： Jack R. Barber , Shi Chung Ng
IPC分类号： A61K31/5395 , A61K31/4545 , A61K31/15 , C07D413/14 , C07D401/12 , C07C251/16
CPC分类号： A61K31/165 , A61K31/4545 , A61K31/5395
摘要： The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provides methods of treating or preventing peripheral nervous system neuropathies. Peripheral nervous system neuropathies may but need not be diabetic neuropathies, and may but need not be associated with a diabetic wound. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions and methods, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供增强与糖尿病相关的伤口愈合的方法，包括向有需要的受试者施用有效量的一种或多种某些羟胺衍生物。另一方面，本发明提供治疗或预防周围神经系统神经病的方法。外周神经系统神经病可能不需要是糖尿病性神经病，并且可能不需要与糖尿病伤口相关联。本发明还提供药物组合物，其包含某些羟胺衍生物或其药学上可接受的盐，任选地与一种或多种另外的治疗剂组合。在某些组合物和方法中，另外的治疗剂是第二羟胺衍生物或其药学上可接受的盐。

2. 发明授权

US07070994B2 Packaging cells 失效
公开(公告)号：US07070994B2
公开(公告)日：2006-07-04
申请号：US10205179
申请日：2002-07-24
申请人： Jack R. Barber , Douglas J. Jolly , James G. Respess , Stephen M. W. Chang
发明人： Jack R. Barber , Douglas J. Jolly , James G. Respess , Stephen M. W. Chang
IPC分类号： C12N5/10 , C12N5/08 , C12N5/00 , C12N15/867 , C12N15/48
CPC分类号： C12N15/8509 , A01K67/033 , A01K2217/05 , A01K2267/01 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C07K2319/32 , C12N7/00 , C12N9/1211 , C12N15/86 , C12N2740/13022 , C12N2740/13023 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16222
摘要： The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

3. 发明授权

US06787646B1 Tumor suppressor molecules and methods of use 失效
标题翻译：肿瘤抑制分子及其使用方法
公开(公告)号：US06787646B1
公开(公告)日：2004-09-07
申请号：US09438917
申请日：1999-11-12
申请人： Peter J. Welch , Jack R. Barber
发明人： Peter J. Welch , Jack R. Barber
IPC分类号： C07H2104
CPC分类号： C07K14/4703
摘要： The invention provides substantially pure tumor suppressor nucleic acid molecules and tumor suppressor polypeptides. The invention also provides hairpin ribozymes and antibodies selective for these tumor suppressor molecules. Also provided are methods of detecting a neoplastic cell in a sample using detectable agents specific for the tumor suppressor nucleic acids and polypeptides.
摘要翻译：本发明提供基本上纯的肿瘤抑制核酸分子和肿瘤抑制多肽。本发明还提供了针对这些肿瘤抑制分子选择性的发夹核酶和抗体。还提供了使用对肿瘤抑制核酸和多肽特异性的可检测试剂检测样品中的肿瘤细胞的方法。

4. 发明授权

US06605429B1 Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries 失效
标题翻译：使用随机或靶特异性核酶基因载体文库的基因功能分析和发现
公开(公告)号：US06605429B1
公开(公告)日：2003-08-12
申请号：US09355221
申请日：1999-07-23
申请人： Jack R. Barber , Peter Welch , Soonpin Yei , Richard Tritz
发明人： Jack R. Barber , Peter Welch , Soonpin Yei , Richard Tritz
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A01K2217/05 , C12N15/1048 , C12N2310/122 , C12N2799/025 , C12Q1/6811 , C12Q1/6897
摘要： The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
摘要翻译：本发明提供了具有随机识别序列的发夹核酶库，其包装在载体中并可操作地连接到适合于在多种细胞中高水平表达的启动子。本发明包括使用多种选择方案中的文库来鉴定，分离和表征已知或未知的靶RNA，以揭示这种切割的表型效应，并鉴定产生这些表型效应的基因产物。

5. 发明授权

US06410326B1 Method for inhibiting human tumor cells 失效
标题翻译：抑制人肿瘤细胞的方法
公开(公告)号：US06410326B1
公开(公告)日：2002-06-25
申请号：US08486683
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： C12N1563
CPC分类号： A01K67/033 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译：公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。

6. 发明授权

US06310045B1 Compositions and methods for cancer immunotherapy 失效
标题翻译：癌症免疫治疗的组成和方法
公开(公告)号：US06310045B1
公开(公告)日：2001-10-30
申请号：US08474636
申请日：1995-06-06
申请人： Jack R. Barber , Douglas J. Jolly , James G. Respess
发明人： Jack R. Barber , Douglas J. Jolly , James G. Respess
IPC分类号： A01N4304
CPC分类号： C12N15/86 , A01K67/0271 , A01K67/0275 , A01K67/033 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/55 , C07K14/57 , C07K14/70514 , C07K14/70535 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062 , C12N2740/15022 , C12N2760/16122 , Y02A50/472
摘要： The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
摘要翻译：本发明提供了利用重组病毒载体抑制所选择的肿瘤生长的方法。简言之，在本发明的一个方面，提供了抑制所选择的肿瘤生长的方法，其包括直接向温血动物施用指导至少一种抗肿瘤剂表达的载体构建体的步骤，使得所述肿瘤的生长被抑制。抗肿瘤剂的代表性实例包括免疫激活剂和肿瘤增殖抑制剂。

7. 发明授权

US5662896A Compositions and methods for cancer immunotherapy 失效
标题翻译：癌症免疫治疗的组成和方法
公开(公告)号：US5662896A
公开(公告)日：1997-09-02
申请号：US32846
申请日：1993-03-17
申请人： Jack R. Barber , Douglas J. Jolly , James G. Respess
发明人： Jack R. Barber , Douglas J. Jolly , James G. Respess
IPC分类号： C12N15/09 , A01K67/027 , A01K67/033 , A61K35/13 , A61K35/76 , A61K38/00 , A61K38/16 , A61K38/20 , A61K38/21 , A61K38/46 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/55 , C07K14/57 , C07K14/73 , C07K14/735 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/23 , C12N15/85 , C12N15/867 , C12N15/86 , C12N15/26
CPC分类号： C12N15/86 , A01K67/0271 , A01K67/0275 , A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , C07K14/005 , C07K14/55 , C07K14/57 , C07K14/70514 , C07K14/70535 , C12N15/8509 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N2740/13022 , C12N2740/13043 , C12N2740/13052 , C12N2740/13062 , C12N2740/15022 , C12N2760/16122
摘要： The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
摘要翻译：本发明提供了利用重组病毒载体抑制所选择的肿瘤生长的方法。简言之，在本发明的一个方面，提供了抑制所选择的肿瘤生长的方法，其包括直接向温血动物施用指导至少一种抗肿瘤剂表达的载体构建体的步骤，使得所述肿瘤的生长被抑制。抗肿瘤剂的代表性实例包括免疫激活剂和肿瘤增殖抑制剂。

8. 发明授权

US06569679B1 Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene 失效
标题翻译：生成编码细胞因子和条件致死基因的腺病毒载体的细胞
公开(公告)号：US06569679B1
公开(公告)日：2003-05-27
申请号：US08471645
申请日：1995-06-06
申请人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
发明人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
IPC分类号： C12N1586
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C12N7/00 , C12N9/1211 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/16622 , C12N2740/13043 , C12N2740/15022 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译：本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。

9. 发明授权

US06458567B1 Hepatitis C Virus ribozymes 失效
标题翻译：丙型肝炎病毒核酶
公开(公告)号：US06458567B1
公开(公告)日：2002-10-01
申请号：US09431419
申请日：1999-11-01
申请人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
发明人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
IPC分类号： C07H2104
CPC分类号： C12N15/1131 , A61K38/00 , C07H21/04 , C12N2310/111 , C12N2310/122 , C12N2799/022 , C12N2799/025 , C12N2799/027
摘要： This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.
摘要翻译：本发明提供用于治疗或预防生物体或受试者中的丙型肝炎病毒（“HCV”）感染或疾病的核酶以及治疗HCV感染或疾病的方法。还提供了诸如载体，宿主细胞，编码这些核酶的DNA分子的试剂在治疗和预防HCV感染或疾病的方法中有用。

10. 发明授权

US5997859A Method for treating a metastatic carcinoma using a conditionally lethal gene 失效
标题翻译：使用条件致死基因治疗转移性癌症的方法
公开(公告)号：US5997859A
公开(公告)日：1999-12-07
申请号：US467034
申请日：1995-06-06
申请人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
发明人： Jack R. Barber , Harry E. Gruber , Douglas J. Jolly
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/035 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , A61K31/70
CPC分类号： A01K67/033 , A01K67/0275 , A61K38/2013 , A61K38/217 , A61K39/0011 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译：本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。

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