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1. 发明授权

US5646128A Methods for treating adenosine kinase related conditions 失效
标题翻译：治疗腺苷激酶相关病症的方法
公开(公告)号：US5646128A
公开(公告)日：1997-07-08
申请号：US349125
申请日：1994-12-01
申请人： Gary S. Firestein , Bheemarao G. Ugarkar , Leonard P. Miller , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo J. Castellino , Clinton E. Browne
发明人： Gary S. Firestein , Bheemarao G. Ugarkar , Leonard P. Miller , Harry E. Gruber , David A. Bullough , Mark D. Erion , Angelo J. Castellino , Clinton E. Browne
IPC分类号： A61K31/00 , C07H19/04 , C07H19/052 , A61K31/70
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/7076 , C07H19/04 , C07H19/052 , Y10S514/825 , Y10S514/885 , Y10S514/886
摘要： Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.
摘要翻译：提供了选择性抑制腺苷激酶的新型化合物和制备腺苷激酶抑制剂的方法。还提供了治疗各种炎性病症（包括关节炎和SIRS）的方法，其可以通过使用腺苷激酶抑制剂增加腺苷浓度来改善。

2. 发明授权

US5853321A Fish processing machine having refrigerated wheels 失效
标题翻译：具有冷藏轮的鱼加工机
公开(公告)号：US5853321A
公开(公告)日：1998-12-29
申请号：US943042
申请日：1997-10-01
申请人： Leonard P. Miller
发明人： Leonard P. Miller
IPC分类号： A22C25/16
CPC分类号： A22C25/16
摘要： A fish processing machine that uses a large pair of refrigerated wheels to hold a fish for processing. The wheels rotate in a clockwise direction. A fish is introduced at the top of the wheels, where it is pressed against the refrigerated wheels. By the phenomenon of frost adhesion, the fish adheres to the wheels. The wheels are angled so that they are spaced closer at the top and farther apart at the bottom. As the wheels rotate, a pair of filleting knives cut the fillets from the carcass. As the wheels continue to rotate, the fillets are automatically separated by adhering to the refrigerated wheels. The remainder of the fish falls down between the wheels to a conveyer for disposal or further processing. As the wheels continue to turn, the fillets can be further processed before the fillets are removed from the skin and the skin is cleaned from the wheels.
摘要翻译：一种使用大量冷藏轮来养鱼的鱼加工机。轮子顺时针旋转。在车轮的顶部引入鱼，并将其压在冷藏轮上。由于霜附着现象，鱼类附着在轮子上。轮子成角度，使得它们在顶部间隔得较近，并且在底部处更远。当轮子旋转时，一对切片刀从胎体上切下鱼片。当轮子继续旋转时，通过粘附到冷藏轮子上自动分离圆角。鱼的其余部分在车轮之间落到输送机处理或进一步加工。当轮子继续转动时，可以在将鱼片从皮肤上取出并从皮肤上清除皮肤之前进一步加工鱼片。

3. 发明授权

US5236908A Methods of treating injury to the central nervous system 失效
标题翻译：对中枢神经系统进行伤害的方法
公开(公告)号：US5236908A
公开(公告)日：1993-08-17
申请号：US712158
申请日：1991-06-07
申请人： Harry E. Gruber , Leonard P. Miller
发明人： Harry E. Gruber , Leonard P. Miller
IPC分类号： A61K31/70 , A61K20060101 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/7076 , A61P25/00 , C07H19/052 , C07H19/167
CPC分类号： A61K31/70
摘要： The invention provides methods for preventing neural tissue damage caused by injury to the central nervous system (CNS) by the administration of a therapeutically effective amount of an adenosinergic agent. One aspect of the invention is directed toward continuous administration of a therapeutically effective amount of an adenosinergic agent for a period of time sufficient to prevent neural tissue damage. In another aspect of the present invention, the adenosinergic agents may be administered on several occasions during the prolonged period of treatment, so long as the doses of adenosinergic agents are spaced in time so that a therapeutically effective concentration of adenosinergic agent is maintained for a period of time sufficient to prevent neural tissue damage.
摘要翻译：本发明提供了通过施用治疗有效量的腺苷能药物来预防由中枢神经系统（CNS）损伤引起的神经组织损伤的方法。本发明的一个方面是针对连续施用治疗有效量的腺苷能药物足以防止神经组织损伤的时间。在本发明的另一方面，腺苷能药物可以在长时间的治疗期间多次施用，只要腺苷能剂的剂量在时间上间隔，使得腺苷能药物的治疗有效浓度保持一段时间的时间足以防止神经组织损伤。

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