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1. 发明申请

US20100105109A1 MULTIPLY-PRIMED AMPLIFICATION OF CIRCULAR NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：圆形核酸序列的多重增殖放大
公开(公告)号：US20100105109A1
公开(公告)日：2010-04-29
申请号：US12532228
申请日：2008-03-18
申请人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
发明人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
IPC分类号： C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2531/125 , C12Q2521/319
摘要： Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme digestion or DNA sequencing and other analyses that involve hybridization. Kits containing components for use in the method are also described. Also described are further uses of this amplified DNA in sequencing, genotyping and haplotyping, and other molecular biology applications.
摘要翻译：公开了使用多个特异性和/或随机序列寡核苷酸引物扩增单链或双链环状DNA分子，特别是存在于菌落和斑块提取物中的靶DNA序列的改进方法。该扩增产物用于通过限制酶消化或DNA测序和涉及杂交的其他分析进行分析。还描述了包含用于该方法的组分的试剂盒。还描述了这种扩增的DNA在测序，基因分型和单元分型以及其他分子生物学应用中的进一步使用。

2. 发明申请

US20100003670A1 CHARACTERIZING PROSTATE CANCER 审中-公开
标题翻译：表征前列腺癌
公开(公告)号：US20100003670A1
公开(公告)日：2010-01-07
申请号：US11929206
申请日：2007-10-30
申请人： Haiying Wang , Shobha Varde , Dondapati Chowdary , Jyoti Mehrotra , Tatiana Nener , Abhijit Mazumder
发明人： Haiying Wang , Shobha Varde , Dondapati Chowdary , Jyoti Mehrotra , Tatiana Nener , Abhijit Mazumder
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： Methods and kits for predicting the course or aggressiveness of prostate cancer include detecting the methylation status of various genes.
摘要翻译：用于预测前列腺癌病程或侵袭性的方法和试剂盒包括检测各种基因的甲基化状态。

3. 发明申请

US20120276132A1 Atoxic recombinant holotoxins of Clostridium difficile as immunogens 审中-公开
标题翻译：艰难梭菌作为免疫原的无毒重组全毒素
公开(公告)号：US20120276132A1
公开(公告)日：2012-11-01
申请号：US13486550
申请日：2012-06-01
申请人： Hanping Feng , Haiying Wang , Saul Tzipori
发明人： Hanping Feng , Haiying Wang , Saul Tzipori
IPC分类号： A61K39/08 , A61P31/04 , C12N9/52 , A61P37/04 , C12N15/57 , C12N15/63
CPC分类号： A61K39/08 , C07K14/33 , C07K2319/20 , C12N15/62 , C12N15/75 , Y02A50/469
摘要： Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens evaluated as potential vaccine candidates are mutated toxin A (encoded by TcdA) and toxin B (TcdB), and a rationally designed chimeric protein containing full-length TcdB protein except that the receptor binding domain is replaced with that of TcdA (designated as cTxAB). A small deletion (97 amino acids) in the transmembrane domain was used to reduce or eliminate toxicity.
摘要翻译：无毒性艰难梭菌毒素蛋白在无内毒素的芽孢杆菌系统中表达，开发出一种疫苗，以减少艰难梭菌感染（CDI）的发病率和严重程度。评估为潜在疫苗候选物的免疫原是突变的毒素A（由TcdA编码）和毒素B（TcdB），以及合理设计的含有全长TcdB蛋白的嵌合蛋白，不同之处在于受体结合域被TcdA替代（命名为cTxAB ）。使用跨膜结构域的小缺失（97个氨基酸）来减少或消除毒性。

4. 发明申请

US20120307604A1 IMPLEMENTATION METHOD, IMPLEMENTATION DEVICE FOR ELECTRONIC ALARM CLOCK, AND MOBILE COMMUNICATION TERMINAL THEREOF 有权
标题翻译：电子报警时钟的实现方法，实现装置及其移动通信终端
公开(公告)号：US20120307604A1
公开(公告)日：2012-12-06
申请号：US13576500
申请日：2011-01-25
申请人： Haiying Wang
发明人： Haiying Wang
IPC分类号： G04G13/02
CPC分类号： G04G13/023 , H04M1/21 , H04M1/72566
摘要： The present invention provides an implementation method, implementation device for electronic alarm clock, and a mobile communication terminal thereof, the main content of which includes: determining a first time length capable of achieving the alert purpose by learning the time when a user inputs an instruction of stopping shaking and/or ringing during a plurality of shaking and/or ringing processes, and keeping, in a time period, the shaking and/or ringing intensity when the first time length is over, thus enabling the quick alert in the case which avoids frightening the user by abrupt shaking and/or ringing.
摘要翻译：本发明提供一种实现方法，电子闹钟实现装置及其移动通信终端，其主要内容包括：通过学习用户输入指令的时间来确定能够实现警报目的的第一时间长度在多个振动和/或振铃过程期间停止振动和/或振铃，并且在第一时间长度结束时在一段时间内保持振动和/或振铃强度，从而在以下情况下能够快速警报：避免用户突然晃动和/或振铃。

5. 发明申请

US20110009288A1 METHODS AND REAGENTS FOR THE EARLY DETECTION OF MELANOMA 审中-公开
标题翻译：早期检测MELANOMA的方法和试剂
公开(公告)号：US20110009288A1
公开(公告)日：2011-01-13
申请号：US12832462
申请日：2010-07-08
申请人： Dmitri TALANTOV , John F. Palma , Tatiana Vener , Tim Jatkoe , Haiying Wang , Yixin Wang
发明人： Dmitri TALANTOV , John F. Palma , Tatiana Vener , Tim Jatkoe , Haiying Wang , Yixin Wang
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： An assay for identifying early stage malignant melanocyte in biopsy tissues is provided by determining whether differential expression of a particular gene indicative of melanoma exceed a cut-off value.
摘要翻译：通过确定指示黑素瘤的特定基因的差异表达是否超过临界值来提供用于鉴定活检组织中的早期恶性黑素细胞的测定法。

6. 发明申请

US20090047656A1 Molecular analysis of primary cells 审中-公开
标题翻译：原代细胞的分子分析
公开(公告)号：US20090047656A1
公开(公告)日：2009-02-19
申请号：US11717835
申请日：2007-03-13
申请人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
发明人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , C12Q1/02
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides a method of propagating cells of interest obtained from a biological specimen by a) enriching the cells under conditions that maintain sufficient cell viability; and b) propagating the cells under conditions effective to allow cell viability, proliferation and integrity.
摘要翻译：本发明提供一种通过以下步骤来繁殖生物样品获得的感兴趣的细胞：（a）在维持足够细胞活力的条件下使细胞富集; 和b）在有效允许细胞活力，增殖和完整性的条件下繁殖细胞。

7. 发明授权

US06898593B1 Sorted-paged retrieval of hierarchical data from relational databases 有权
标题翻译：从关系数据库对分级数据进行排序分页检索
公开(公告)号：US06898593B1
公开(公告)日：2005-05-24
申请号：US10072399
申请日：2002-02-05
申请人： Ramkartik Mulukutla , Haiying Wang
发明人： Ramkartik Mulukutla , Haiying Wang
IPC分类号： G06F17/30
CPC分类号： G06F17/30607 , G06F17/30466 , G06F17/30498 , Y10S707/99933 , Y10S707/99943
摘要： A method for sorted-paged retrieval of hierarchical data from a relational database is disclosed, which includes the use of one or more relational table equi-join terms in a query to increase the retrieval efficiency, suitable restrictions imposed on the join terms to further increase the retrieval efficiency, partial de-normalization or replication of information to improve the efficiency of the join operation(s) and thus further increase the retrieval efficiency, and proper cursor management to keep track of the current location of the cursor(s) involved. As a result, specific pages of objects can be efficiently retrieved from a database, while the specified sort orders and restrictions imposed by the original retrieval requests can be maintained.
摘要翻译：公开了一种从关系数据库对分级数据进行分层分页检索的方法，其中包括在查询中使用一个或多个关系表等连接项来提高检索效率，对连接项施加的适当限制进一步增加检索效率，部分解除规范化或复制信息，以提高联合操作的效率，从而进一步提高检索效率，以及适当的光标管理来跟踪所涉及的光标的当前位置。因此，可以从数据库中有效地检索对象的特定页面，同时可以保持由原始检索请求强加的指定排序顺序和限制。

8. 发明申请

US20100081145A1 Detecting Prostate Cancer 审中-公开
标题翻译：检测前列腺癌
公开(公告)号：US20100081145A1
公开(公告)日：2010-04-01
申请号：US12628764
申请日：2009-12-01
申请人： Haiying Wang , Jonathan F. Baden , Tatiana Vener , Dondapati Chowdary , Abhijit Mazumder
发明人： Haiying Wang , Jonathan F. Baden , Tatiana Vener , Dondapati Chowdary , Abhijit Mazumder
IPC分类号： C12Q1/68
CPC分类号： G01N33/57434 , G01N2333/91171
摘要： Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.
摘要翻译：用于检测尿样中前列腺癌的方法和试剂盒包括检测各种基因的甲基化状态。

9. 发明申请

US20080254455A1 DETECTING PROSTATE CANCER 审中-公开
标题翻译：检测前列腺癌
公开(公告)号：US20080254455A1
公开(公告)日：2008-10-16
申请号：US11734763
申请日：2007-04-12
申请人： Haiying Wang , Jonathan F. Baden , Tatiana Vener , Dondapati Chowdary , Abhijit Mazumder
发明人： Haiying Wang , Jonathan F. Baden , Tatiana Vener , Dondapati Chowdary , Abhijit Mazumder
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/50
CPC分类号： G01N33/57434 , G01N2333/91171
摘要： Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.
摘要翻译：用于检测尿样中前列腺癌的方法和试剂盒包括检测各种基因的甲基化状态。

10. 发明授权

US07120896B2 Integrated business process modeling environment and models created thereby 有权
公开(公告)号：US07120896B2
公开(公告)日：2006-10-10
申请号：US09984977
申请日：2001-10-31
申请人： Navin Budhiraja , Marion Dale Skeen , Haiying Wang , Elisa Jill Rubin , Deb Banerjee
发明人： Navin Budhiraja , Marion Dale Skeen , Haiying Wang , Elisa Jill Rubin , Deb Banerjee
IPC分类号： G06F9/44 , G06F17/00 , G06F9/46
CPC分类号： G06F8/20
摘要： An integrated modeling environment for creating integration models of computer architecture for executing business processes. The models include components having ports defining standard interfaces. The components can represent business process models for executing business processes. Connection information is stored in a repository so that binding of communication protocols can occur during deployment after creation of the model and can be looked up during runtime.

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