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1. 发明申请

US20080050726A1 Methods for diagnosing pancreatic cancer 审中-公开
标题翻译：诊断胰腺癌的方法
公开(公告)号：US20080050726A1
公开(公告)日：2008-02-28
申请号：US11523496
申请日：2006-09-19
申请人： Yixin Wang , Dmitri Talantov
发明人： Yixin Wang , Dmitri Talantov
IPC分类号： C12Q1/68 , C07H21/04 , C40B40/08
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/5091 , G16H10/40 , Y02A90/26
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
摘要翻译：本发明提供了通过获得含有转移细胞的样品来鉴定未知来源的转移起点的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成算法，其中算法使生物标志物反对参考标准化; 并强加了一个优化每个生物标志物的灵敏度和特异性的临界值，对癌症的患病率进行加权，并根据算法确定的最高概率选择确定起源的组织，或者确定癌不是从特定的一组癌; 并且任选地测量对一种或多种另外的不同癌特异性的生物标志物，并重复其它生物标志物的步骤。

2. 发明申请

US20110009288A1 METHODS AND REAGENTS FOR THE EARLY DETECTION OF MELANOMA 审中-公开
标题翻译：早期检测MELANOMA的方法和试剂
公开(公告)号：US20110009288A1
公开(公告)日：2011-01-13
申请号：US12832462
申请日：2010-07-08
申请人： Dmitri TALANTOV , John F. Palma , Tatiana Vener , Tim Jatkoe , Haiying Wang , Yixin Wang
发明人： Dmitri TALANTOV , John F. Palma , Tatiana Vener , Tim Jatkoe , Haiying Wang , Yixin Wang
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： An assay for identifying early stage malignant melanocyte in biopsy tissues is provided by determining whether differential expression of a particular gene indicative of melanoma exceed a cut-off value.
摘要翻译：通过确定指示黑素瘤的特定基因的差异表达是否超过临界值来提供用于鉴定活检组织中的早期恶性黑素细胞的测定法。

3. 发明申请

US20070065859A1 Methods and materials for identifying the origin of a carcinoma of unknown primary origin 审中-公开
标题翻译：用于鉴定原发性原发癌的起源的方法和材料
公开(公告)号：US20070065859A1
公开(公告)日：2007-03-22
申请号：US11523495
申请日：2006-09-19
申请人： Yixin Wang , Abhijit Mazumder , Dmitri Talantov , Timothy Jatkoe , Jonathan Baden
发明人： Yixin Wang , Abhijit Mazumder , Dmitri Talantov , Timothy Jatkoe , Jonathan Baden
IPC分类号： C12Q1/68 , G01N33/574 , G06F19/00 , C12M1/34
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/5091 , G16H10/40 , Y02A90/26
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
摘要翻译：本发明提供了通过获得含有转移细胞的样品来鉴定未知来源的转移起点的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成算法，其中算法使生物标志物反对参考标准化; 并强加了一个优化每个生物标志物的灵敏度和特异性的临界值，对癌症的患病率进行加权，并根据算法确定的最高概率选择确定起源的组织，或者确定癌不是从特定的一组癌; 并且任选地测量对一种或多种另外的不同癌特异性的生物标志物，并重复其它生物标志物的步骤。

4. 发明申请

US20060166258A1 Preservation of RNA in a biological sample 审中-公开
标题翻译：在生物样品中保存RNA
公开(公告)号：US20060166258A1
公开(公告)日：2006-07-27
申请号：US11389923
申请日：2006-03-27
申请人： Fredrik Kamme , Bernhard Meurers , Dmitri Talantov , Jingxue Yu
发明人： Fredrik Kamme , Bernhard Meurers , Dmitri Talantov , Jingxue Yu
IPC分类号： C12Q1/68 , G01N1/30 , G01N33/48
CPC分类号： C12Q1/6841 , C12N15/1003 , G01N1/30
摘要： To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or tris-(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods.
摘要翻译：为了保存生物样品中的RNA用于分析，将样品与能够在水溶液中沉淀RNA的RNA防腐剂一起温育，例如三苯基甲烷染料（例如甲基绿，结晶紫，对羟基苯胺或三 - （4-氨基苯基））甲烷），甲酚紫或钴离子。 RNA保存可用于免疫染色测定和其他组织化学方法。

5. 发明申请

US20100021886A1 Methods and Materials for Identifying the Origin of a Carcinoma of Unknown Primary Origin 审中-公开
标题翻译：识别原发性原发性癌的原因的方法和材料
公开(公告)号：US20100021886A1
公开(公告)日：2010-01-28
申请号：US12024134
申请日：2008-02-01
申请人： YIXIN WANG , ABHIJIT MAZUMDER , DMITRI TALANTOV , TIMOTHY JATKOE , JONATHAN F. BADEN
发明人： YIXIN WANG , ABHIJIT MAZUMDER , DMITRI TALANTOV , TIMOTHY JATKOE , JONATHAN F. BADEN
IPC分类号： C12Q1/68 , C12Q1/02 , C07H21/00 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
摘要翻译：本发明提供了通过获得含有转移细胞的样品来鉴定未知来源的转移起点的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成线性鉴别分析，其中线性鉴别分析使生物标志物反对参考标准化; 并强加了一个优化每个生物标志物的灵敏度和特异性的切断点，重视癌症的流行，并且基于通过线性鉴别分析确定的最高概率来选择确定起源的组织，或者确定癌症不是从特定的一套癌; 并且任选地测量对一种或多种另外的不同癌特异性的生物标志物，并重复其它生物标志物的步骤。

6. 发明授权

US07056673B2 Preservation of RNA in a biological sample 失效
公开(公告)号：US07056673B2
公开(公告)日：2006-06-06
申请号：US10826834
申请日：2004-04-15
申请人： Fredrik C. Kamme , Bernhard H Meurers , Dmitri Talantov , Jingxue Yu
发明人： Fredrik C. Kamme , Bernhard H Meurers , Dmitri Talantov , Jingxue Yu
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6841 , C12N15/1003 , G01N1/30
摘要： To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or tris-(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods.

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