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1. 发明申请

US20100105109A1 MULTIPLY-PRIMED AMPLIFICATION OF CIRCULAR NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：圆形核酸序列的多重增殖放大
公开(公告)号：US20100105109A1
公开(公告)日：2010-04-29
申请号：US12532228
申请日：2008-03-18
申请人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
发明人： Haiguang Xiao , John R. Nelson , Galina Chernaya , Haiying Wang , Paul Mitsis , Gyanendra Kumar , Carl F. Fuller , Yuyang Christine Cai
IPC分类号： C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2531/125 , C12Q2521/319
摘要： Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme digestion or DNA sequencing and other analyses that involve hybridization. Kits containing components for use in the method are also described. Also described are further uses of this amplified DNA in sequencing, genotyping and haplotyping, and other molecular biology applications.
摘要翻译：公开了使用多个特异性和/或随机序列寡核苷酸引物扩增单链或双链环状DNA分子，特别是存在于菌落和斑块提取物中的靶DNA序列的改进方法。该扩增产物用于通过限制酶消化或DNA测序和涉及杂交的其他分析进行分析。还描述了包含用于该方法的组分的试剂盒。还描述了这种扩增的DNA在测序，基因分型和单元分型以及其他分子生物学应用中的进一步使用。

2. 发明授权

US06215992B1 Universal dictation input apparatus and method 失效
标题翻译：通用听写输入装置及方法
公开(公告)号：US06215992B1
公开(公告)日：2001-04-10
申请号：US08902589
申请日：1997-07-29
申请人： Dennis S. Howell , Donald E. Latson , Jason D. Gaines , Richard Ford , Franklin B. Parks , Robert W. Ross , John R. Nelson
发明人： Dennis S. Howell , Donald E. Latson , Jason D. Gaines , Richard Ford , Franklin B. Parks , Robert W. Ross , John R. Nelson
IPC分类号： H04B106
CPC分类号： H04M11/10 , G10L15/30 , G10L2015/225 , H04M1/7255 , H04M1/733
摘要： The universal dictation input apparatus and method disclosed employs multiple wireless dictation devices (“WDD”) and base stations each of which include a 900 MHz radio for communicating with one another over selected radio frequency (“RF”) channel pairs to conduct dictation sessions on centralized dictation systems (“CDSs”). Each base station is uniquely assigned a single channel pair. The WDDs are programmed with code representing the exclusive channels of a select number of base stations. When a user takes a WDD off-hook, a WDD sequentially and cyclically scans for carrier transmitted by authorized base stations until an idle base station is identified and linked to over the authorized channel. The user of a WDD must be authorized to conduct dictation sessions on one or more CDSs. To this end the WDDs includes a dialing address keypad to address authorized CDSs. The CDSs are third party systems addressed from a WDD by DTMF dialing digits. Dictation sessions are conducted by sending dictation commands, for example “record” and “play” in the form of DTMF digits to the CDSs. The WDDs send data as ASCII codes in packets to a base station. The transmitted data includes dialing digits and system commands for the base station. The WDDs generate data from the dialing keypad, programmable keys customized to send frequently used dictation commands to a CDS and to provide other specialized features and a barcode reader. Specific setup data is downloaded to a base station to enable it to execute commands and dialing, digits unique to CDS of different vendors and to prepare for receipt of verbal dictation commands. A base station includes a voice recognition algorithm to translate verbal commands spoken at a WDD, such as “record” and “play,” into codes forwarded to a CDS as DTMF digits.
摘要翻译：所公开的通用听写输入装置和方法使用多个无线听写设备（“WDD”）和基站，每个基站包括900MHz无线电装置，用于在选定的射频（“RF”）信道对上彼此进行通信，以进行听写会话集中听写系统（“CDS”）。每个基站被唯一分配一个通道对。 WDD用代表选定数量的基站的排他通道的代码进行编程。当用户采取WDD摘机状态时，WDD会顺序循环扫描授权基站发送的载波，直到空闲基站识别并通过授权信道进行链接。必须授权WDD的用户在一个或多个CDS上执行听写会话。为此，WDD包括一个拨号地址小键盘来解决授权的CDS。 CDS是通过DTMF拨号数字从WDD寻址的第三方系统。通过发送听写命令来进行听写会话，例如以CDF的DTMF数字形式的“录音”和“播放”。 WDD将数据作为ASCII码以数据包的形式发送到基站。所发送的数据包括用于基站的拨号数字和系统命令。 WDD从拨号键盘生成数据，可定制的可编程键将经常使用的听写命令发送到CDS，并提供其他专门功能和条形码读取器。特定的设置数据被下载到基站以使其能够执行命令和拨号，不同供应商的CDS特有的数字，并准备接收口头听写命令。基站包括语音识别算法，用于将转发到CDS的代码的语音命令（例如“记录”和“播放”）转换为作为DTMF数字的CDS。

3. 发明申请

US20080287305A1 Method for Nucleic Acid Analysis 有权
标题翻译：核酸分析方法
公开(公告)号：US20080287305A1
公开(公告)日：2008-11-20
申请号：US11570347
申请日：2005-06-09
申请人： Carl W. Fuller , John R. Nelson
发明人： Carl W. Fuller , John R. Nelson
IPC分类号： C40B20/04 , C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6869 , C12Q2565/519 , C12Q2565/301 , C12Q2563/137 , C12Q2527/127 , C12Q2523/113
摘要： This invention provides methods for nucleic acid analysis. A closed complex of nucleic acid template, nucleotide and polymerase can be formed during polymerase reaction, absent divalent metal ion. This is used to trap the labeled nucleotide complementary to the next template nucleotide in the closed complex. Detection of the label allows determination of the identity of this next correct nucleotide. Identification can be either in place, as part of the complex, or as the dye is eluted from the complex when the reaction cycle is completed by the addition of divalent metal ion. In this way, sequential nucleotides of a DNA can be identified, effectively determining the DNA sequence. This method can be applied to nucleic acid single molecules or to collections of identical or nearly identical sequence such as PCR products or clones. Multiple templates can be sequenced in parallel, particularly if they are immobilized on a solid support.
摘要翻译：本发明提供核酸分析方法。可以在聚合酶反应期间形成核酸模板，核苷酸和聚合酶的闭合复合物，不存在二价金属离子。这用于捕获与封闭复合物中下一个模板核苷酸互补的标记核苷酸。标签的检测允许确定下一个正确的核苷酸的身份。识别可以作为复合物的一部分就位，或当通过添加二价金属离子完成反应循环时染料从络合物中洗脱出来。以这种方式，可以鉴定DNA的连续核苷酸，有效地确定DNA序列。该方法可以应用于核酸单分子或相同或几乎相同序列的集合，例如PCR产物或克隆。多个模板可以并行测序，特别是如果它们固定在固体支持物上。

4. 外观设计

USD311062S Housing for medical instrument 失效
公开(公告)号：USD311062S
公开(公告)日：1990-10-02
申请号：US109249
申请日：1987-10-15
申请人： John R. Nelson
设计人： John R. Nelson

5. 外观设计

USD292610S IV fluid flow rate meter 失效
公开(公告)号：USD292610S
公开(公告)日：1987-11-03
申请号：US714634
申请日：1985-03-21
申请人： John R. Nelson
设计人： John R. Nelson

6. 发明授权

US2426275A Apparatus for swedging screws on ophthalmic mountings 失效
标题翻译：用于在眼科装置上卷曲螺丝的装置
公开(公告)号：US2426275A
公开(公告)日：1947-08-26
申请号：US46313842
申请日：1942-10-23
申请人： LESLIE W MYERS , WILL R ANDERSON , JOHN R NELSON , ALBERT L ANDERSON , N P BENSON , CHARLES L WALDO , ROBERT E LINDMARK
发明人： KREBS DANIEL D
IPC分类号： G02C13/00
CPC分类号： G02C13/001 , Y10T29/49915 , Y10T29/4992 , Y10T29/5105

7. 发明授权

US07452698B2 Terminal phosphate blocked nucleoside polyphosphates 有权
标题翻译：磷酸末端封闭核苷多磷酸盐
公开(公告)号：US07452698B2
公开(公告)日：2008-11-18
申请号：US11781986
申请日：2007-07-24
申请人： Anup Sood , Shiv Kumar , Carl W. Fuller , John R. Nelson
发明人： Anup Sood , Shiv Kumar , Carl W. Fuller , John R. Nelson
IPC分类号： C12P19/34 , C12Q1/68 , C07H19/04 , C07H21/00
CPC分类号： C07H19/20 , C07H19/10 , C07H21/00 , C12Q1/6816 , C12Q1/6851 , C12Q1/6869 , C12Q2525/186
摘要： The present invention describes terminal phosphate blocked nucleoside polyphosphates that are stable at high temperature and their use in nucleic acid amplification and analysis. Current invention further describes charge modified terminal phosphate blocked nucleoside polyphosphates for improved incorporation and direct loading of nucleic acid sequencing reactions onto separating media.
摘要翻译：本发明描述了在高温下稳定的磷酸封端的磷酸核苷多磷酸，并且其用于核酸扩增和分析。本发明进一步描述了电荷修饰的末端磷酸酯封端的核苷多磷酸酯，用于改进核酸测序反应在分离介质上的掺入和直接加载。

8. 外观设计

USD379265S Portable computer carrying case 失效
公开(公告)号：USD379265S
公开(公告)日：1997-05-20
申请号：US47057
申请日：1995-11-08
申请人： David T. Wathen , John R. Nelson
设计人： David T. Wathen , John R. Nelson

9. 发明授权

US5568358A Multi-attitude display lid positioning arrangement for craftsperson's portable signal processing and communications unit 失效
标题翻译：多姿态显示盖定位布置技术人员的便携式信号处理和通信单元
公开(公告)号：US5568358A
公开(公告)日：1996-10-22
申请号：US343697
申请日：1994-11-14
申请人： John R. Nelson , David T. Wathen
发明人： John R. Nelson , David T. Wathen
IPC分类号： E05D11/10 , H04M1/02 , H05K5/00 , E05D3/06
CPC分类号： H04M1/0216 , E05D11/1007 , E05Y2900/606 , Y10T16/547
摘要： A contact-sensitive display screen panel of a craft unit is protected by a pivotable lid. The lid is rotatably supported by lid pivot attachments that enable the lid to be pivoted between closed and open positions, and to be stably locked as a support member in its fully extended attitude. Lid pin elements extend from opposite ends of a lid pin support element and engage left side and right side hinge assemblies. Each lid pin element has a tab element translatable along the underside of the lid. Each lid pin element is biased by a compression spring into engagement with a capturing slot in an interior bore of a post of a hinge arm element of a respective one of hinge assemblies. To rotate the lid from its open position, to its fully extended position, the craftsperson translate the tab elements against the biasing of compression springs, so that the lid pin element becomes unlocked from a slot in the interior bore of the hinge arm element of a respective hinge assembly. Once rotated to its fully extended position, finger pressure against the tab elements is released and the tab elements are allowed to again be biased by the compression springs, locking the reduced thickness portions of the lid pin elements in slots of the interior bores of the hinge arm elements of the hinge assemblies, so that the lid will be stably retained as a support element in its fully extended position.
摘要翻译：手术单元的触敏显示屏面板由可枢转的盖子保护。盖子由盖枢轴附件可旋转地支撑，使得盖子能够在闭合位置和打开位置之间枢转，并且作为支撑构件被稳定地锁定在其完全伸出的姿态。盖销元件从盖销支撑元件的相对端延伸并且接合左侧和右侧铰链组件。每个盖销元件具有可沿着盖的下侧平移的拉舌元件。每个盖销元件被压缩弹簧偏压成与铰链组件相应的一个铰链组件的铰链臂元件的柱的内孔中的捕获槽接合。为了将盖子从其打开位置旋转到其完全伸出的位置，工匠克服压缩弹簧的偏压来平移突片元件，使得盖销元件从铰链臂元件的内孔中的槽中解锁相应的铰链组件。一旦旋转到其完全伸出的位置，手指压紧突片元件的压力被释放，并且接片元件被再次被压缩弹簧偏压，将盖销元件的厚度减小的部分锁定在铰链的内孔的槽中铰链组件的臂元件，使得盖子将被稳定地保持为其完全伸出位置的支撑元件。

10. 发明授权

US4877197A Instrument housing with improved paper feed 失效
标题翻译：仪器外壳采用改进的进纸
公开(公告)号：US4877197A
公开(公告)日：1989-10-31
申请号：US223447
申请日：1988-07-22
申请人： John R. Nelson , Thomas F. Lehman
发明人： John R. Nelson , Thomas F. Lehman
IPC分类号： B41J15/04
CPC分类号： B41J15/04
摘要： An instrument housing having an improved means for storing a roll of paper of selected width and maximum diameter for use by a printer in which the housing has a rectangular opening in the top adjacent the housing front and a rectangular opening in the front forward of and below the opening in the top. A paper trough is positioned within the instrument housing below the top opening and rearwardly of the front opening, the trough having an open top and having opposed parallel sides and a rearward wall and a bottom wall which merge into a quarter circular integral intersection, the radius of curvature of the intersection being about one-half of the maximum diameter of the paper roll for which the trough is dimensioned. A trough gate forms a front wall, the trough gate having a downwardly extending inner surface curved at the lower portion thereof toward the trough back wall at a radius of curvature substantially equal to that of the radius of curvature of the intersection of the trough rearward and bottom walls, and the trough gate having a bottom wall spaced slightly above the trough bottom wall providing a slot therebetween whereby when a roll of paper is positioned within the trough the free end of the paper may exit the trough through the slot. An electrically actuated printer mechanism is positioned in the housing forward of the trough gate, the printer having means to receive the paper for pulling paper through the slot as the printer functions.
摘要翻译：一种具有改进的用于存储所选宽度和最大直径的一卷纸的装置的仪器壳体，用于由打印机使用，其中壳体在靠近壳体前部的顶部具有矩形开口，并且在前面的前方和前方的矩形开口顶部开放。纸槽定位在仪器壳体的位于前开口的顶部开口和后方的下方，槽具有敞开的顶部并且具有相对的平行侧面，并且后壁和底壁合并成四分之一圆形的整体交叉，半径的交点的曲率大约是槽的尺寸的纸卷的最大直径的一半。槽门形成前壁，槽门具有向下延伸的内表面，其向下延伸的内表面在其下部处朝向槽后壁弯曲，曲率半径基本上等于与槽的后壁和后壁相交的曲率半径底壁和槽门具有稍微在槽底壁上方间隔开的底壁，在其间提供一个槽，由此当一卷纸定位在槽内时，纸的自由端可以通过槽离开槽。电动打印机机构定位在槽门前方的壳体中，打印机具有用于在打印机起作用时接收纸张以将纸张拉过狭槽的装置。

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