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1. 发明授权

US6017338A Fluid cooled and perfused tip for a catheter 失效
标题翻译：用于导管的流体冷却和灌注末端
公开(公告)号：US6017338A
公开(公告)日：2000-01-25
申请号：US496947
申请日：1995-06-30
申请人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
发明人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00 , A61B17/39
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a catheter body. The ablation catheter also includes a tip for monitoring electrical potentials, and applying electrical energy to a biological tissue. A fluid source is positioned at one end of the catheter for supplying a fluid flow through the catheter to the tip means. Passages are positioned within the tip in a variety of manners for directing the fluid flow through the tip means to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip structure for measurement of the electrical potentials in a biological tissue. Ablation structure is also positioned within the tip for application of ablative energy to the biological tissue.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管尖端上的生物流体的凝结，防止与导管尖端接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许消融产生的损伤尺寸增加。消融导管包括导管体。消融导管还包括用于监测电势并将电能施加到生物组织的尖端。流体源位于导管的一端，用于将通过导管的流体流提供给尖端装置。通道以各种方式定位在尖端内，用于将流体流动通过尖端装置引导到尖端的外表面，以控制温度并在尖端周围形成保护性流体层。监测结构也位于尖端结构内，用于测量生物组织中的电位。消融结构也位于用于向生物组织施加烧蚀能量的尖端内。

2. 发明授权

US5643197A Fluid cooled and perfused tip for a catheter 失效
标题翻译：用于导管的流体冷却和灌注末端
公开(公告)号：US5643197A
公开(公告)日：1997-07-01
申请号：US361329
申请日：1994-12-21
申请人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
发明人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00 , A61B17/20
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a tip for applying electrical energy to biological tissue. Passages are positioned within the tip in a variety of manners for directing a fluid flow through the tip to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip for measurement of the electrical potentials in a biological tissue. Ablation electrode structure is also positioned within the tip for application of ablative energy to the biological tissue. A flexible, extended embodiment electrode provides the capability to form deep, linear lesions along a portion of a heart wall during ablation for the treatment of particular arrhythmias.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管尖端上生物流体的凝结，防止与导管尖端接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。消融导管包括用于向生物组织施加电能的尖端。通道以各种方式定位在尖端内，用于将流体流动通过尖端到顶部的外表面，以控制温度并在尖端周围形成保护性流体层。监测结构也位于尖端内，用于测量生物组织中的电位。消融电极结构也位于尖端内，用于向生物组织施加烧蚀能量。灵活的，延伸的实施例电极提供了在消融期间沿着心壁的一部分形成深的线性损伤以用于治疗特定心律失常的能力。

3. 发明授权

US5830209A Multi-fiber laser catheter 失效
标题翻译：多光纤激光导管
公开(公告)号：US5830209A
公开(公告)日：1998-11-03
申请号：US529810
申请日：1995-09-18
申请人： Steven D. Savage , Gregory G. Brucker
发明人： Steven D. Savage , Gregory G. Brucker
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24 , A61B17/36
CPC分类号： A61B18/24 , A61B2017/00092 , A61B2017/00243 , A61B2017/22038 , A61B2018/00011
摘要： Laser catheters according to the invention include multiple optical fibers for delivery of laser energy to a pre-determined treatment site in the therapeutic treatment of cardiac tissue. A fixation device fixes the distal end of the catheter to the treatment site. Temperature sensing devices disposed on the fixation device provide a temperature depth profile of the tissue treatment site, which can be used to control the treatment. Multi-piece, single-piece and porous tip catheters are disclosed.
摘要翻译：根据本发明的激光导管包括用于在心脏组织的治疗性治疗中将激光能量传递到预定治疗部位的多根光纤。固定装置将导管的远端固定到治疗部位。设置在固定装置上的温度感测装置提供可用于控制处理的组织处理部位的温度深度分布。公开了多片，单件和多孔尖端导管。

4. 发明授权

US5507725A Steerable catheter 失效
标题翻译：导向导管
公开(公告)号：US5507725A
公开(公告)日：1996-04-16
申请号：US173250
申请日：1993-12-22
申请人： Steven D. Savage , Gregory G. Brucker
发明人： Steven D. Savage , Gregory G. Brucker
IPC分类号： A61M25/01 , A61M25/092 , A61M37/00
CPC分类号： A61M25/0144 , A61M25/0147
摘要： The invention relates to a steering system for a catheter tip. The system includes wire members that extend through a catheter wall that are used to pull a distal portion of the catheter tip causing controlled, predetermined bending at the tip. Anchoring members located near the catheter tip connect the distal end of the catheter with wire members. The steering system also contains control members which are located at a proximal portion of the catheter and are used to control the pull on the wire members. Steering enhancement members are also included in the steering system which facilitate the bending of the catheter wall.
摘要翻译：本发明涉及一种用于导管尖端的转向系统。该系统包括延伸通过导管壁的线构件，其用于拉动导管末端的远端部分，从而在尖端处引起受控的预定弯曲。位于导管尖端附近的锚固构件将导管的远端与导线构件连接。转向系统还包含位于导管的近端部分的控制构件，并用于控制线构件上的拉动。转向增强构件也包括在便于导管壁弯曲的转向系统中。

5. 发明授权

US5409008A Process and apparatus for mapping of tachyarrhythmia 失效
标题翻译：快速性心律失常的过程和仪器
公开(公告)号：US5409008A
公开(公告)日：1995-04-25
申请号：US83200
申请日：1993-06-25
申请人： Robert H. Svenson , Gregory G. Brucker , Steven D. Savage
发明人： Robert H. Svenson , Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B5/0408 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B17/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/24 , A61M3/02 , A61M25/00 , A61N1/05 , A61B5/04 , A61N1/04
CPC分类号： A61B5/0422 , A61B18/1492 , A61N1/056 , A61B18/02 , A61B18/1402 , A61B18/24 , A61B2017/00243 , A61B2017/00292 , A61B2018/1266 , A61M3/0279
摘要： Process and apparatus for mapping of tachyarrhythmia, such as ventricular tachycardia. The apparatus is a mapping catheter which is a polymer member including a plurality of electrodes at a distal end. An upper ring is divided into at least bipolar poles for sensing endocardial potentials. A spaced lower unipolar ring senses intercardic potentials. The process provides for sensing of a QRS signal with the upper bipolar electrodes, and the unipolar ring provides for sensing of the EKG signal. The mapping catheter is of such a size that the mapping catheter can be inserted up and through a hand-held probe to steer and guide the mapping catheter. An interventional catheter will fit within the mapping catheter for ablation of arrhythmogenic sites. One embodiment is a laser delivery catheter which can include a fiber optic cable, a fixation wire, a metal sensing tip and an internal flushing lumen.
摘要翻译：快速心律失常的定位过程和装置，如室性心动过速。该装置是映射导管，其是在远端包括多个电极的聚合物构件。至少双极极分为上环，用于感应心内膜电位。间隔较低的单极环感知心电位。该过程提供了利用上双极电极感测QRS信号，并且单极环提供用于感测EKG信号。映射导管的尺寸使得映射导管可以插入上方并通过手持探针来引导和引导映射导管。介入导管将适合于映射导管，用于消融致心律失常部位。一个实施例是激光输送导管，其可以包括光纤电缆，固定线，金属感测尖端和内部冲洗腔。

6. 发明授权

US5290277A Multi-fiber linear array laser catheter connector 失效
标题翻译：多光纤线阵激光导管连接器
公开(公告)号：US5290277A
公开(公告)日：1994-03-01
申请号：US863098
申请日：1992-04-03
申请人： Charmaine Vercimak , Steven D. Savage , Gregory G. Brucker
发明人： Charmaine Vercimak , Steven D. Savage , Gregory G. Brucker
IPC分类号： A61B18/24 , G02B6/42 , A61B17/36
CPC分类号： G02B6/3624 , A61B18/24 , G02B6/4296 , G02B6/241 , G02B6/3628
摘要： A multi-fiber linear array laser catheter for use in irradiation of biological tissue where a circular laser beam is optically transformed to coincide with the cross-section of a linear array of optical fibers. The transformed laser beams are focused onto a linear connector and transmitted through a plurality of parallel optical fibers. Heat is extracted and drawn from the vicinity of the parallel optic fibers by metallic plates acting as heat sinks on opposing sides of the parallel optic fibers.
摘要翻译：一种用于生物组织照射的多光纤线阵激光导管，其中圆形激光束被光学变换以与光纤的线性阵列的横截面一致。变换的激光束聚焦在线性连接器上，并透过多个平行的光纤。通过在平行光纤的相对侧上作为散热器的金属板，从平行光纤的附近提取热量。

7. 发明授权

US06466818B1 Porous irrigated tip electrode catheter 有权
标题翻译：多孔灌注电极导管
公开(公告)号：US06466818B1
公开(公告)日：2002-10-15
申请号：US09371905
申请日：1999-08-10
申请人： Shahram Moaddeb , Michele M. Fung , Gregory G. Brucker , Steven D. Savage
发明人： Shahram Moaddeb , Michele M. Fung , Gregory G. Brucker , Steven D. Savage
IPC分类号： A61N130
CPC分类号： A61N1/06
摘要： An irrigated tip catheter comprises a catheter body, a tip section, and a porous tip electrode. The catheter body has an outer wall, proximal and distal ends, and a lumen extending therethrough. The tip section comprises a segment of flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The porous tip electrode is fixedly attached to the distal end of the tubing of the tip section. The tip electrode has an outer surface and comprises a body and an insert. The body comprises a porous material through which fluid can pass and has a cavity therein. The insert, which comprises a non-porous material, is contained within the cavity of the shell. The insert has at least one passage extending therethrough in fluid communication with a lumen in the tip section. An infusion tube having proximal and distal ends extends through the central lumen in the catheter body. The distal end of the infusion tube is in fluid communication with the proximal end of the passage in the tip electrode, whereby fluid can flow through the infusion tube, into the passage in the tip electrode and through the porous material of tip electrode to the outer surface of the tip electrode.
摘要翻译：灌注的尖端导管包括导管主体，尖端部分和多孔尖端电极。导管主体具有外壁，近端和远端以及从其延伸穿过的内腔。尖端部分包括具有近端和远端以及穿过其中的至少一个内腔的柔性管段。尖端部分的近端固定地附接到导管主体的远端。多孔尖端电极固定地附接到尖端部分的管道的远端。尖端电极具有外表面并且包括主体和插入件。主体包括多孔材料，流体可穿过该多孔材料并且其中具有空腔。包括无孔材料的插入件被包含在壳的空腔内。插入件具有至少一个通过其延伸穿过其中的通道，其与尖端部分中的内腔流体连通。具有近端和远端的输液管延伸穿过导管主体中的中心腔。输液管的远端与尖端电极中的通道的近端流体连通，由此流体可以流过输注管，进入尖端电极的通道并通过尖端电极的多孔材料到外部尖端电极的表面。

8. 发明授权

US5500012A Ablation catheter system 失效
标题翻译：消融导管系统
公开(公告)号：US5500012A
公开(公告)日：1996-03-19
申请号：US272268
申请日：1994-07-08
申请人： Gregory G. Brucker , Steven D. Savage
发明人： Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/18 , A61B18/24 , A61M3/02 , A61B17/36
CPC分类号： A61B5/6855 , A61B18/1492 , A61B18/24 , A61B5/0422 , A61B18/1402 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00039 , A61B2017/00092 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/22038 , A61B2018/00196 , A61B2018/00279 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/1467 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61M2230/04 , A61M3/0279
摘要： An ablation catheter system, including a guiding/mapping catheter assembly and a laser catheter. The guiding/mapping catheter includes ring electrodes, tip electrodes, a moveable fixation wire, and a central catheter lumen for an ablation catheter. A laser catheter includes an optical fiber for passing laser energy, tip electrodes, an optical fiber port, and thermocouples on the end of hypodermic tubing.
摘要翻译：消融导管系统，包括导向/映射导管组件和激光导管。引导/映射导管包括环形电极，尖端电极，可移动固定线和用于消融导管的中心导管腔。激光导管包括用于在皮下管道末端传递激光能量，尖端电极，光纤端口和热电偶的光纤。

9. 发明授权

US10022183B2 Temperature-responsive irrigated ablation electrode with reduced coolant flow and related methods for making and using 有权
公开(公告)号：US10022183B2
公开(公告)日：2018-07-17
申请号：US14676789
申请日：2015-04-01
申请人： Gregory G. Brucker , Steven D. Savage
发明人： Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B18/12 , A61B18/14 , A61B18/00
摘要： The present invention provides an irrigated ablation electrode that includes a plurality of high L/d interior fluid passageways and/or slit-shaped apertures to provide for a lower rate of fluid flow and a more uniform distribution of fluid over an exterior surface of the electrode and reduce propensity for aperture blockage. In some embodiments, the slit-shaped apertures have an aspect ratio of at least three, at least five, at least ten, or at least fifteen. Some embodiments include maintaining a pressure drop of at least 345 pascals between irrigation fluid inside the irrigated ablation electrode and fluid immediately outside the electrode when the irrigation fluid has a flow rate of no more than five milliliters per minute (5 ml/min). Some embodiments include a low-density insert with a plurality of fluid channels on its exterior surface to more efficiently cool the electrode and provide a faster thermal response.

10. 发明授权

US09126025B2 Method of coating a folded catheter balloon 有权
标题翻译：涂覆折叠导管球囊的方法
公开(公告)号：US09126025B2
公开(公告)日：2015-09-08
申请号：US12990157
申请日：2009-05-01
申请人： Benjamin T. Ewing , Gregory G. Brucker , Scott A. Bednar , John R. Periard , Ashok A. Sharma , Steven D. Savage , Arthur E. Uber, III , Brian P. Dickerson
发明人： Benjamin T. Ewing , Gregory G. Brucker , Scott A. Bednar , John R. Periard , Ashok A. Sharma , Steven D. Savage , Arthur E. Uber, III , Brian P. Dickerson
IPC分类号： H01R43/00 , A61M25/18 , A61M25/10 , A61B17/22 , A61L29/16
CPC分类号： A61M25/104 , A61B17/22 , A61B2017/22001 , A61B2017/22051 , A61B2017/22061 , A61L29/08 , A61L29/16 , A61L2420/02 , A61M25/1002 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2210/12 , Y10T29/49826
摘要： Various methods for optimizing coating of medical devices, such as balloon catheters are disclosed. One method configures catheter balloon folds based on balloon diameter and volume. Other methods include using a specifically-sized protective sheath, using a vacuum, using pressure, pulling the balloon through a coating solution, using at least one spacer or a wick between at least one fold for metering a therapeutic coating into the folds of the balloon, placing an intermediate layer between the balloon and the therapeutic coating, placing a soluble film having a therapeutic agent around the catheter balloon or inside the folds, and any combination thereof. Balloon catheters and catheter balloons having a specific folding configuration, a specifically-sized protective sheath, an intermediate layer, or a soluble film are also disclosed.
摘要翻译：公开了用于优化医疗装置如球囊导管的涂覆的各种方法。一种方法根据球囊直径和体积配置导管球囊折叠。其他方法包括使用特定尺寸的保护套，使用真空，使用压力，通过涂覆溶液拉动球囊，使用至少一个间隔件或芯在至少一个折叠之间，用于将治疗性涂层计量到球囊的折叠中将中间层放置在气囊和治疗涂层之间，将具有治疗剂的可溶性膜放置在导管球囊周围或折叠内部，以及其任何组合。还公开了具有特定折叠构造的气球导管和导管气囊，特定尺寸的保护鞘，中间层或可溶性膜。

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