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1. 发明授权

US06466818B1 Porous irrigated tip electrode catheter 有权
标题翻译：多孔灌注电极导管
公开(公告)号：US06466818B1
公开(公告)日：2002-10-15
申请号：US09371905
申请日：1999-08-10
申请人： Shahram Moaddeb , Michele M. Fung , Gregory G. Brucker , Steven D. Savage
发明人： Shahram Moaddeb , Michele M. Fung , Gregory G. Brucker , Steven D. Savage
IPC分类号： A61N130
CPC分类号： A61N1/06
摘要： An irrigated tip catheter comprises a catheter body, a tip section, and a porous tip electrode. The catheter body has an outer wall, proximal and distal ends, and a lumen extending therethrough. The tip section comprises a segment of flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The porous tip electrode is fixedly attached to the distal end of the tubing of the tip section. The tip electrode has an outer surface and comprises a body and an insert. The body comprises a porous material through which fluid can pass and has a cavity therein. The insert, which comprises a non-porous material, is contained within the cavity of the shell. The insert has at least one passage extending therethrough in fluid communication with a lumen in the tip section. An infusion tube having proximal and distal ends extends through the central lumen in the catheter body. The distal end of the infusion tube is in fluid communication with the proximal end of the passage in the tip electrode, whereby fluid can flow through the infusion tube, into the passage in the tip electrode and through the porous material of tip electrode to the outer surface of the tip electrode.
摘要翻译：灌注的尖端导管包括导管主体，尖端部分和多孔尖端电极。导管主体具有外壁，近端和远端以及从其延伸穿过的内腔。尖端部分包括具有近端和远端以及穿过其中的至少一个内腔的柔性管段。尖端部分的近端固定地附接到导管主体的远端。多孔尖端电极固定地附接到尖端部分的管道的远端。尖端电极具有外表面并且包括主体和插入件。主体包括多孔材料，流体可穿过该多孔材料并且其中具有空腔。包括无孔材料的插入件被包含在壳的空腔内。插入件具有至少一个通过其延伸穿过其中的通道，其与尖端部分中的内腔流体连通。具有近端和远端的输液管延伸穿过导管主体中的中心腔。输液管的远端与尖端电极中的通道的近端流体连通，由此流体可以流过输注管，进入尖端电极的通道并通过尖端电极的多孔材料到外部尖端电极的表面。

2. 发明授权

US6063080A Linear catheter ablation system 失效
标题翻译：线性导管消融系统
公开(公告)号：US6063080A
公开(公告)日：2000-05-16
申请号：US73651
申请日：1998-05-06
申请人： Dale K. Nelson , Steven D. Savage , Brad D. Pedersen , Whitney A. McFarlin
发明人： Dale K. Nelson , Steven D. Savage , Brad D. Pedersen , Whitney A. McFarlin
IPC分类号： A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B18/1815 , A61B2017/003 , A61B2018/00214 , A61B2018/00916
摘要： A radio frequency (RF) ablation catheter system utilizes a flexible, tubular electrode that is selectively extendable from a distal end of a catheter body. The flexible, tubular electrode creates a continuous linear lesion when a longitudinal side of the electrode is arcuately positioned against an interior wall of the human body and the electrode is energized while a cooling fluid passes through the electrode. The catheter system also includes mechanisms for remotely manipulating and extending the electrode. Preferably, the catheter body include a catheter shaft and a flexible tip section such that the distal end of the catheter is steerable. The invention also includes a method of operating the RF catheter ablation system so as to create arcuate linear lesions.
摘要翻译：射频（RF）消融导管系统利用可从导管主体的远端选择性地延伸的柔性管状电极。当电极的纵向侧面相对于人体的内壁弧形地定位时，柔性管状电极产生连续的线性损伤，并且电极在冷却流体通过电极时通电。导管系统还包括用于远程操纵和延伸电极的机构。优选地，导管主体包括导管轴和柔性尖端部分，使得导管的远端是可操纵的。本发明还包括操作RF导管消融系统以产生弓形线性损伤的方法。

3. 发明授权

US5500012A Ablation catheter system 失效
标题翻译：消融导管系统
公开(公告)号：US5500012A
公开(公告)日：1996-03-19
申请号：US272268
申请日：1994-07-08
申请人： Gregory G. Brucker , Steven D. Savage
发明人： Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/18 , A61B18/24 , A61M3/02 , A61B17/36
CPC分类号： A61B5/6855 , A61B18/1492 , A61B18/24 , A61B5/0422 , A61B18/1402 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00039 , A61B2017/00092 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/22038 , A61B2018/00196 , A61B2018/00279 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/1467 , A61B2218/002 , A61B2562/0209 , A61B2562/043 , A61M2230/04 , A61M3/0279
摘要： An ablation catheter system, including a guiding/mapping catheter assembly and a laser catheter. The guiding/mapping catheter includes ring electrodes, tip electrodes, a moveable fixation wire, and a central catheter lumen for an ablation catheter. A laser catheter includes an optical fiber for passing laser energy, tip electrodes, an optical fiber port, and thermocouples on the end of hypodermic tubing.
摘要翻译：消融导管系统，包括导向/映射导管组件和激光导管。引导/映射导管包括环形电极，尖端电极，可移动固定线和用于消融导管的中心导管腔。激光导管包括用于在皮下管道末端传递激光能量，尖端电极，光纤端口和热电偶的光纤。

4. 发明授权

US5462521A Fluid cooled and perfused tip for a catheter 失效
公开(公告)号：US5462521A
公开(公告)日：1995-10-31
申请号：US171213
申请日：1993-12-21
申请人： Greg G. Brucker , Jerome P. Saul , Steven D. Savage
发明人： Greg G. Brucker , Jerome P. Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a catheter body. The ablation catheter also includes a tip for monitoring electrical potentials, and applying electrical energy to a biological tissue. A fluid source is positioned at one end of the catheter for supplying a fluid flow through the catheter to the tip means. Passages are positioned within the tip in a variety of manners for directing the fluid flow through the tip means to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip structure for measurement of the electrical potentials in a biological tissue. Ablation structure is also positioned within the tip for application of ablative energy to the biological tissue.

5. 发明授权

US5271932A Xanthomonas campestris isolates and methods of use 失效
标题翻译：野油菜黄单胞菌分离株和使用方法
公开(公告)号：US5271932A
公开(公告)日：1993-12-21
申请号：US983183
申请日：1992-11-30
申请人： Steven D. Savage , Robert A. Haygood
发明人： Steven D. Savage , Robert A. Haygood
IPC分类号： A01N63/00 , G01N33/569 , A61K37/00 , C12N1/00
CPC分类号： A01N63/00 , G01N33/569 , G01N33/56911
摘要： The subject invention pertains to novel microorganisms useful for the control of unwanted grasses and other weeds. The microorganisms of the subject invention are discovered through a unique process which involves isolating plant pathogens from asymptomatic plants.
摘要翻译：本发明涉及可用于控制不需要的草和其他杂草的新型微生物。通过独特的方法发现本发明的微生物，其涉及从无症状植物中分离植物病原体。

6. 发明授权

US5192541A Weed killing Xanthomonas campestris 失效
标题翻译： WEED KILLING XANTHOMONAS CAMPESTRIS
公开(公告)号：US5192541A
公开(公告)日：1993-03-09
申请号：US753270
申请日：1991-08-30
申请人： Steven D. Savage , Robert A. Haygood
发明人： Steven D. Savage , Robert A. Haygood
IPC分类号： A01N63/02 , A01N63/00 , C12N1/20 , C12R1/64 , G01N33/569
CPC分类号： A01N63/00 , G01N33/569 , G01N33/56911 , Y10S435/911
摘要： The subject invention pertains to novel microorganisms useful for the control of unwanted grasses and other weeds. The microorganisms of the subject invention are discovered through a unique process which involves isolating plant pathogens from asymptomatic plants.

7. 发明授权

US6017338A Fluid cooled and perfused tip for a catheter 失效
标题翻译：用于导管的流体冷却和灌注末端
公开(公告)号：US6017338A
公开(公告)日：2000-01-25
申请号：US496947
申请日：1995-06-30
申请人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
发明人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00 , A61B17/39
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a catheter body. The ablation catheter also includes a tip for monitoring electrical potentials, and applying electrical energy to a biological tissue. A fluid source is positioned at one end of the catheter for supplying a fluid flow through the catheter to the tip means. Passages are positioned within the tip in a variety of manners for directing the fluid flow through the tip means to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip structure for measurement of the electrical potentials in a biological tissue. Ablation structure is also positioned within the tip for application of ablative energy to the biological tissue.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管尖端上的生物流体的凝结，防止与导管尖端接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许消融产生的损伤尺寸增加。消融导管包括导管体。消融导管还包括用于监测电势并将电能施加到生物组织的尖端。流体源位于导管的一端，用于将通过导管的流体流提供给尖端装置。通道以各种方式定位在尖端内，用于将流体流动通过尖端装置引导到尖端的外表面，以控制温度并在尖端周围形成保护性流体层。监测结构也位于尖端结构内，用于测量生物组织中的电位。消融结构也位于用于向生物组织施加烧蚀能量的尖端内。

8. 发明授权

US5830209A Multi-fiber laser catheter 失效
标题翻译：多光纤激光导管
公开(公告)号：US5830209A
公开(公告)日：1998-11-03
申请号：US529810
申请日：1995-09-18
申请人： Steven D. Savage , Gregory G. Brucker
发明人： Steven D. Savage , Gregory G. Brucker
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24 , A61B17/36
CPC分类号： A61B18/24 , A61B2017/00092 , A61B2017/00243 , A61B2017/22038 , A61B2018/00011
摘要： Laser catheters according to the invention include multiple optical fibers for delivery of laser energy to a pre-determined treatment site in the therapeutic treatment of cardiac tissue. A fixation device fixes the distal end of the catheter to the treatment site. Temperature sensing devices disposed on the fixation device provide a temperature depth profile of the tissue treatment site, which can be used to control the treatment. Multi-piece, single-piece and porous tip catheters are disclosed.
摘要翻译：根据本发明的激光导管包括用于在心脏组织的治疗性治疗中将激光能量传递到预定治疗部位的多根光纤。固定装置将导管的远端固定到治疗部位。设置在固定装置上的温度感测装置提供可用于控制处理的组织处理部位的温度深度分布。公开了多片，单件和多孔尖端导管。

9. 发明申请

US20150272669A1 Temperature-Responsive Irrigated Ablation Electrode with Reduced Coolant Flow and related methods for making and using 有权
标题翻译：具有降低冷却剂流量的温度响应性灌注消融电极及其制造和使用的相关方法
公开(公告)号：US20150272669A1
公开(公告)日：2015-10-01
申请号：US14676789
申请日：2015-04-01
申请人： Gregory G. Brucker , Steven D. Savage
发明人： Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00714 , A61B2018/00791
摘要： The present invention provides an irrigated ablation electrode that includes a plurality of high L/d interior fluid passageways and/or slit-shaped apertures to provide for a lower rate of fluid flow and a more uniform distribution of fluid over an exterior surface of the electrode and reduce propensity for aperture blockage. In some embodiments, the slit-shaped apertures have an aspect ratio of at least three, at least five, at least ten, or at least fifteen. Some embodiments include maintaining a pressure drop of at least 345 pascals between irrigation fluid inside the irrigated ablation electrode and fluid immediately outside the electrode when the irrigation fluid has a flow rate of no more than five milliliters per minute (5 ml/min). Some embodiments include a low-density insert with a plurality of fluid channels on its exterior surface to more efficiently cool the electrode and provide a faster thermal response.
摘要翻译：本发明提供了一种灌溉消融电极，其包括多个高L / d内部流体通道和/或狭缝形孔，以提供更低的流体流速和在电极的外表面上更均匀的流体分布并减少孔径堵塞的倾向。在一些实施例中，狭缝状孔具有至少三个，至少五个，至少十个，或至少十五个的纵横比。一些实施方案包括当冲洗流体的流速不超过5毫升每分钟（5ml / min）时，保持冲洗消融电极内部的冲洗流体和紧邻电极外部的流体之间的至少345帕斯卡的压降。一些实施例包括在其外表面上具有多个流体通道的低密度插入件，以更有效地冷却电极并提供更快的热响应。

10. 发明申请

US20130018309A1 TEAR-AWAY SHEATH WITH INTEGRAL STOP 审中-公开
标题翻译： TEAR-AWAY SHEATH与INTEGRAL STOP
公开(公告)号：US20130018309A1
公开(公告)日：2013-01-17
申请号：US13516003
申请日：2010-12-20
申请人： Benjamin T. Ewing , Scott A. Bednar , Brian P. Dickerson , Steven D. Savage , Gregory G. Brucker
发明人： Benjamin T. Ewing , Scott A. Bednar , Brian P. Dickerson , Steven D. Savage , Gregory G. Brucker
IPC分类号： A61M25/01 , A61M25/10
CPC分类号： A61M25/0668 , A61M25/001 , A61M25/0013 , A61M25/002 , A61M25/0068 , A61M25/0074 , A61M25/0082 , A61M25/10 , A61M2025/0098 , A61M2025/0675 , A61M2025/105 , A61M2025/1081
摘要： A tear-away sheath (8) having a tubular element (10) with a distal end and a proximal end, at least one axial fault line (12), and an integral stop (16) is disclosed. The tear-away sheath may also have a handle (14) or closing element at the proximal end. An angioplasty balloon catheter (22) having the disclosed tear-away sheath is also disclosed.
摘要翻译：公开了一种具有远端和近端的管状元件（10），至少一个轴向断裂线（12）和整体止动件（16）的撕开护套（8）。撕开护套还可以在近端具有手柄（14）或闭合元件。还公开了具有公开的撕开鞘的血管成形术球囊导管（22）。

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