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1. 发明授权

US06329069B1 Composite structure and devices made from same and method 失效
标题翻译：复合结构和器件由相同和方法制成
公开(公告)号：US06329069B1
公开(公告)日：2001-12-11
申请号：US08900088
申请日：1997-07-24
申请人： Gholam Reza Zadno Azizi , Raj Subramaniam , Mir A. Imran , Jeffrey W. Simpson
发明人： Gholam Reza Zadno Azizi , Raj Subramaniam , Mir A. Imran , Jeffrey W. Simpson
IPC分类号： B32B1502
CPC分类号： C22F1/006 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , H01Q1/242 , H01Q1/362 , H01Q11/08 , Y10T428/12389 , Y10T428/12438 , Y10T428/12806 , Y10T428/12979
摘要： A composite structure comprising a body having a surface and cladding covering at least a part of said surface of the body and being in intimate contact with the surface. The body and cladding are formed of different materials.
摘要翻译：一种复合结构，包括具有覆盖所述主体的所述表面的至少一部分并与所述表面紧密接触的表面和包层的主体。身体和包层由不同的材料形成。

2. 发明授权

US5772105A Clad shape memory alloy composite structure and method 失效
标题翻译：包层形状记忆合金复合结构及方法
公开(公告)号：US5772105A
公开(公告)日：1998-06-30
申请号：US767631
申请日：1996-12-17
申请人： Gholam Reza Zadno-Azizi , Raj Subramaniam , Mir A. Imran
发明人： Gholam Reza Zadno-Azizi , Raj Subramaniam , Mir A. Imran
IPC分类号： B21C37/04 , B32B15/01 , C22F1/00 , H01Q1/24 , H01Q1/36 , H01Q11/08 , B23K31/02
CPC分类号： H01Q1/242 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , C22F1/006 , H01Q1/362 , H01Q11/08
摘要： A composite structure comprising a body having a surface. Cladding covers at least a part of the surface. The body and the cladding are formed of different materials, at least one of which is a shape memory alloy having a recoverable strain in excess of 1.0%.
摘要翻译：一种复合结构，包括具有表面的主体。包层至少覆盖表面的一部分。主体和包层由不同的材料形成，其中至少一种是具有超过1.0％的可恢复应变的形状记忆合金。

3. 发明授权

US5766203A Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method 失效
标题翻译：具有可扩展的远端末端和气囊导管和与其一起使用的支架的护套和方法
公开(公告)号：US5766203A
公开(公告)日：1998-06-16
申请号：US728769
申请日：1996-10-10
申请人： Mir A. Imran , Deepak R. Gandhi , Anant V. Hegde , Gholam-Reza Zadno-Azizi
发明人： Mir A. Imran , Deepak R. Gandhi , Anant V. Hegde , Gholam-Reza Zadno-Azizi
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61F2/958 , A61M2025/0063 , A61M2025/1086 , A61M25/005 , A61M25/0053 , A61M25/0668
摘要： A sheath for advancement into a vessel of a patient having a stenosis therein which at least partially occludes the flow of blood in the vessel. A flexible elongate tubular member has proximal and distal extremities with a lumen extending from the proximal extremity to the distal extremity. A portion of the distal extremity of the flexible elongate tubular member is radially expandable. The expandable portion carries stiffening elements that impart pushability and column strength to the expandable portion.
摘要翻译：用于进入其中具有狭窄的患者的血管的护套，其至少部分地封闭血管中的血液流。柔性细长管状构件具有近端和远端，其末端具有从近端延伸到远端的内腔。柔性细长管状构件的远端的一部分是可径向扩张的。可膨胀部分承载加强元件，其赋予可膨胀部分的推压性和柱强度。

4. 发明授权

US5349964A Device having an electrically actuatable section with a portion having a current shunt and method 失效
标题翻译：具有电致动部分的装置，具有一个具有电流分路和方法的部分
公开(公告)号：US5349964A
公开(公告)日：1994-09-27
申请号：US57098
申请日：1993-05-05
申请人： Mir A. Imran , Gholam-Reza Zadno-Azizi , Mark L. Pomeranz
发明人： Mir A. Imran , Gholam-Reza Zadno-Azizi , Mark L. Pomeranz
IPC分类号： A61B1/00 , A61M25/01 , A61B5/00
CPC分类号： A61M25/0158 , A61M2025/0161 , A61M25/09033
摘要： Device comprising an elongate tubular member having proximal and distal extremities and having a section with a plurality of lumens extending from the proximal extremity to the section. At least two conductive elements are disposed in the lumens in said section of the elongate tubular member. The conductive elements are formed of a conductive metal alloy having a recoverable strain in excess of 1% and exhibiting a martensitic phase transformation. Electrical current is supplied to the at least one conductive element. The section has at least one portion. A current conductor is carried by said at least one conductive element for shunting current flow around the at least one portion of said at least one conductive element.
摘要翻译：装置包括具有近端和远端的细长管状构件，并具有具有从近端延伸至所述区段的多个内腔的区段。至少两个导电元件设置在细长管状构件的所述部分中的内腔中。导电元件由具有超过1％的可恢复应变并显示马氏体相变的导电金属合金形成。电流被提供给至少一个导电元件。该部分至少有一部分。电流导体由所述至少一个导电元件承载，用于分流围绕所述至少一个导电元件的至少一部分的电流。

5. 发明授权

US06652480B1 Methods for reducing distal embolization 失效
标题翻译：减少远端栓塞的方法
公开(公告)号：US06652480B1
公开(公告)日：2003-11-25
申请号：US09438030
申请日：1999-11-10
申请人： Mir A. Imran , Ketan P. Muni , Gholam-Reza Zadno-Azizi
发明人： Mir A. Imran , Ketan P. Muni , Gholam-Reza Zadno-Azizi
IPC分类号： A61M100
CPC分类号： A61M25/104 , A61B17/22 , A61B18/245 , A61B2017/22067 , A61B2017/22084 , A61M2025/09183 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61M2025/1093
摘要： A method for reducing distal embolization during insertion of devices to treat plaque, thrombi and other intravascular occlusions. Using a guide catheter, a guidewire is delivered to a site proximal to the lesion. An aspiration catheter is then introduced over the guidewire, and the two are moved together in a distal to proximal direction across the occlusion. The aspiration catheter is then moved in a proximal to distal direction while continuously aspirating, which prevents embolization of any particles which may be created during the crossing of the guidewire.
摘要翻译：一种用于在插入装置以治疗斑块，血栓和其他血管内闭塞的过程中减少远端栓塞的方法。使用引导导管将导丝输送到病变附近的部位。然后在引导线上引入抽吸导管，并且两者在跨近闭塞的远端到近端方向一起移动在一起。然后将抽吸导管沿近端方向移动，同时连续抽吸，这可以防止在导线交叉期间产生的任何颗粒的栓塞。

6. 发明授权

US5465717A Apparatus and Method for ventricular mapping and ablation 失效
标题翻译：用于心室图和消融的装置和方法
公开(公告)号：US5465717A
公开(公告)日：1995-11-14
申请号：US290391
申请日：1994-08-15
申请人： Mir A. Imran , Mark L. Pomeranz , Gholam-Reza Zadno-Azizi
发明人： Mir A. Imran , Mark L. Pomeranz , Gholam-Reza Zadno-Azizi
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61N1/05 , A61N1/36 , A61B5/04
CPC分类号： A61B5/6859 , A61B18/1492 , A61B5/0422 , A61B5/6853 , A61B5/6858 , A61N1/056 , A61N1/36014 , A61B18/00 , A61B18/08 , A61B18/1402 , A61B2017/00292 , A61B2017/00867 , A61B2017/22038 , A61B2018/00083 , A61B2018/00107 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839 , A61B2018/00869 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2562/0209 , A61B2562/043 , C08L2201/12
摘要： Apparatus for mapping a wall of a heart forming a chamber in the heart comprising a guiding catheter having a lumen extending therethrough and a mapping catheter having a shaft that is slidably mounted in the lumen of the guiding catheter. A basket assembly is provided and is comprised of a plurality of circumferentially spaced-apart longitudinally extending arms having proximal and distal extremities. The proximal extremities of the arms are secured to the distal extremity of the shaft of the mapping catheter. Each of the arms includes a member formed of a material having a recoverable strain in excess of 1% and has an outwardly bowed shape memory. At least one electrode is provided on each of the arms. Conductors connected to the electrodes are carried by the arms.
摘要翻译：用于映射在心脏中形成腔室的心壁的装置，包括具有延伸穿过其中的内腔的引导导管和具有可滑动地安装在引导导管的内腔中的轴的映射导管。提供篮组件，并且包括具有近端和远端的多个周向间隔开的纵向延伸的臂。臂的近端被固定到映射导管的轴的远端。每个臂包括由具有超过1％的可恢复应变并且具有向外弯曲形状记忆的材料形成的构件。在每个臂上设置至少一个电极。连接到电极的导体由臂承载。

7. 发明授权

US5611874A Clad shape memory alloy composite structure and method 失效
标题翻译：包层形状记忆合金复合结构及方法
公开(公告)号：US5611874A
公开(公告)日：1997-03-18
申请号：US507752
申请日：1995-07-26
申请人： Gholam R. Zadno-Azizi , Raj Subramaniam , Mir A. Imran
发明人： Gholam R. Zadno-Azizi , Raj Subramaniam , Mir A. Imran
IPC分类号： B21C37/04 , B32B15/01 , C22F1/00 , H01Q1/24 , H01Q1/36 , H01Q11/08 , B32B7/02 , C22K1/00
CPC分类号： H01Q1/242 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , C22F1/006 , H01Q1/362 , H01Q11/08
摘要： A composite structure comprising a body having a surface. Cladding covers at least a part of the surface. The body and the cladding are formed of different materials, at least one of which is a shape memory alloy having a recoverable strain in excess of 1.0%.
摘要翻译：一种复合结构，包括具有表面的主体。包层至少覆盖表面的一部分。主体和包层由不同的材料形成，其中至少一种是具有超过1.0％的可恢复应变的形状记忆合金。

8. 发明授权

US09056197B2 Selective stimulation systems and signal parameters for medical conditions 有权
标题翻译：选择性刺激系统和医疗条件的信号参数
公开(公告)号：US09056197B2
公开(公告)日：2015-06-16
申请号：US12607009
申请日：2009-10-27
申请人： Eyad Kishawi , Mir A. Imran , Brian J. Mossop , Jeffery M. Kramer , Richard W. O'Connor
发明人： Eyad Kishawi , Mir A. Imran , Brian J. Mossop , Jeffery M. Kramer , Richard W. O'Connor
IPC分类号： A61N1/08 , A61N1/05 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36157 , A61N1/37247
摘要： Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.
摘要翻译：提供装置，系统和方法用于各种条件的靶向治疗，特别是与神经系统相关或受其影响的条件，例如疼痛。提供这种病症的靶向治疗具有最小的有害副作用，例如不期望的运动反应或不受影响的身体区域的刺激。这是通过直接神经调节与病症相关的目标解剖结构来实现的，同时最小化或排除其他解剖结构的不希望的神经调节。

9. 发明授权

US08914128B2 Methods, devices and systems for programming neurostimulation 有权
标题翻译：用于编程神经刺激的方法，装置和系统
公开(公告)号：US08914128B2
公开(公告)日：2014-12-16
申请号：US13558271
申请日：2012-07-25
申请人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
发明人： Mir A. Imran , Brian J. Mossop , Eyad Kishawi
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/36146 , A61N1/36185
摘要： Methods, devices and systems are provided to efficiently identify, from among a plurality of possible neurostimulation parameter sets, one or more preferred neurostimulation parameter sets that treat a targeted pain of a patient. A plurality of different neurostimulation parameter sets are tested on the patient to thereby identify those tested neurostimulation parameter sets that treat the targeted pain. Each of the tested neurostimulation parameter sets defines an electrode configuration that differs from the other tested neurostimulation parameter sets. If more than one of the tested neurostimulation parameter sets are identified as treating the targeted pain, then neurostimulation parameter sets identified as treating the targeted pain are retested, with the value for a specific neurostimulation signal parameter reduced by a same amount for each of the retested neurostimulation parameter sets, to thereby identify those neurostimulation parameter sets that treat the targeted pain at the reduced power consumption level.
摘要翻译：提供了方法，装置和系统以有效地从多个可能的神经刺激参数组中识别治疗患者的目标疼痛的一个或多个优选的神经刺激参数组。在患者身上测试多个不同的神经刺激参数组，从而识别那些用于治疗目标疼痛的神经刺激参数组。每个测试的神经刺激参数集定义了与其他测试的神经刺激参数组不同的电极配置。如果将多于一个测试的神经刺激参数集合识别为治疗目标疼痛，则重新测定被鉴定为治疗目标疼痛的神经刺激参数集，对于每个重新测试的特定神经刺激信号参数的值减少相同的量神经刺激参数集，从而识别在降低的功耗水平下治疗目标疼痛的神经刺激参数组。

10. 发明申请

US20130085476A1 SYSTEM AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT TO THE INNER EAR 审中-公开
标题翻译：将治疗药物输送到内脏的系统和方法
公开(公告)号：US20130085476A1
公开(公告)日：2013-04-04
申请号：US13627346
申请日：2012-09-26
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61F11/00
CPC分类号： A61F11/00 , A61F11/004 , A61K9/0046
摘要： Embodiments of the invention provide systems and methods for delivering therapeutic compositions to the inner-ear to treat inner-ear disorders. An embodiment of such a system comprises a sheath for insertion into the auditory canal and a cannula which can be inserted through the sheath. The cannula can include a tip for piercing the tympanic membrane and delivering the composition to an inner-ear tissue surface. The system may also include a therapeutic composition comprising a therapeutic agent and a thixotropic material which allows the composition to be delivered (e.g., by injection) through the cannula in liquid form and transition to gel-form once delivered to the tissue surface. A method for using the system comprises introducing the sheath into the ear, introducing the cannula through the sheath to pierce the tympanic membrane and position the tip adjacent an inner-ear tissue surface; and delivering the composition through the cannula to adhere to the tissue surface.
摘要翻译：本发明的实施方案提供了用于将治疗组合物递送至内耳以治疗内耳障碍的系统和方法。这种系统的一个实施例包括用于插入到耳道中的护套和可插入穿过护套的套管。套管可以包括用于刺穿鼓膜并将组合物输送到内耳组织表面的尖端。该系统还可以包括包含治疗剂和触变材料的治疗组合物，其允许组合物以液体形式通过插管递送（例如通过注射），并且一旦递送至组织表面则转变成凝胶形式。使用该系统的方法包括将护套引入耳朵中，通过护套引入套管以刺穿鼓膜并将尖端定位在内耳组织表面附近; 并且通过套管输送组合物以粘附到组织表面。

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