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1. 发明授权

US5611874A Clad shape memory alloy composite structure and method 失效
标题翻译：包层形状记忆合金复合结构及方法
公开(公告)号：US5611874A
公开(公告)日：1997-03-18
申请号：US507752
申请日：1995-07-26
申请人： Gholam R. Zadno-Azizi , Raj Subramaniam , Mir A. Imran
发明人： Gholam R. Zadno-Azizi , Raj Subramaniam , Mir A. Imran
IPC分类号： B21C37/04 , B32B15/01 , C22F1/00 , H01Q1/24 , H01Q1/36 , H01Q11/08 , B32B7/02 , C22K1/00
CPC分类号： H01Q1/242 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , C22F1/006 , H01Q1/362 , H01Q11/08
摘要： A composite structure comprising a body having a surface. Cladding covers at least a part of the surface. The body and the cladding are formed of different materials, at least one of which is a shape memory alloy having a recoverable strain in excess of 1.0%.
摘要翻译：一种复合结构，包括具有表面的主体。包层至少覆盖表面的一部分。主体和包层由不同的材料形成，其中至少一种是具有超过1.0％的可恢复应变的形状记忆合金。

2. 发明授权

US06329069B1 Composite structure and devices made from same and method 失效
标题翻译：复合结构和器件由相同和方法制成
公开(公告)号：US06329069B1
公开(公告)日：2001-12-11
申请号：US08900088
申请日：1997-07-24
申请人： Gholam Reza Zadno Azizi , Raj Subramaniam , Mir A. Imran , Jeffrey W. Simpson
发明人： Gholam Reza Zadno Azizi , Raj Subramaniam , Mir A. Imran , Jeffrey W. Simpson
IPC分类号： B32B1502
CPC分类号： C22F1/006 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , H01Q1/242 , H01Q1/362 , H01Q11/08 , Y10T428/12389 , Y10T428/12438 , Y10T428/12806 , Y10T428/12979
摘要： A composite structure comprising a body having a surface and cladding covering at least a part of said surface of the body and being in intimate contact with the surface. The body and cladding are formed of different materials.
摘要翻译：一种复合结构，包括具有覆盖所述主体的所述表面的至少一部分并与所述表面紧密接触的表面和包层的主体。身体和包层由不同的材料形成。

3. 发明授权

US5772105A Clad shape memory alloy composite structure and method 失效
标题翻译：包层形状记忆合金复合结构及方法
公开(公告)号：US5772105A
公开(公告)日：1998-06-30
申请号：US767631
申请日：1996-12-17
申请人： Gholam Reza Zadno-Azizi , Raj Subramaniam , Mir A. Imran
发明人： Gholam Reza Zadno-Azizi , Raj Subramaniam , Mir A. Imran
IPC分类号： B21C37/04 , B32B15/01 , C22F1/00 , H01Q1/24 , H01Q1/36 , H01Q11/08 , B23K31/02
CPC分类号： H01Q1/242 , B21C37/042 , B21C37/045 , B32B15/01 , B32B15/013 , B32B15/015 , C22F1/006 , H01Q1/362 , H01Q11/08
摘要： A composite structure comprising a body having a surface. Cladding covers at least a part of the surface. The body and the cladding are formed of different materials, at least one of which is a shape memory alloy having a recoverable strain in excess of 1.0%.
摘要翻译：一种复合结构，包括具有表面的主体。包层至少覆盖表面的一部分。主体和包层由不同的材料形成，其中至少一种是具有超过1.0％的可恢复应变的形状记忆合金。

4. 发明申请

US20210298764A1 SYSTEM AND METHOD FOR LEFT ATRIAL APPENDAGE CLOSURE 有权
公开(公告)号：US20210298764A1
公开(公告)日：2021-09-30
申请号：US17249979
申请日：2021-03-19
申请人： Raj Subramaniam , Zaya Tun , Robert Quintos
发明人： Raj Subramaniam , Zaya Tun , Robert Quintos
IPC分类号： A61B17/12 , A61B17/04
摘要： A device for sealing a left atrial appendage includes an anchor element, a sealing element, and a coupling element. The anchor element is configured to anchor the device to tissue in or adjacent the left atrial appendage. The sealing element is configured to seal the left atrial appendage and prevent thrombus from embolizing therefrom. The coupling element joins the anchor element with the sealing element. A delivery catheter may be used to deliver the sealing device.

5. 发明授权

US5300561A Solution containing amphiphilic molecules 失效
标题翻译：含有两亲分子的溶液
公开(公告)号：US5300561A
公开(公告)日：1994-04-05
申请号：US924921
申请日：1992-08-05
申请人： Brij P. Singh , Raj Subramaniam , Scott E. Rickert
发明人： Brij P. Singh , Raj Subramaniam , Scott E. Rickert
IPC分类号： B05B17/06 , B05D1/02 , B05D1/18 , C03C17/00 , C03C17/30 , C08K5/05
CPC分类号： C03C17/30 , B05B17/0623 , B05B17/063 , B05D1/02 , C03C17/004 , B05D1/185 , Y10T428/31612 , Y10T428/31663
摘要： A solution of amphiphilic molecules and water is atomized to form a mist of droplets which are deposited on a substrate surface to completely cover same with a coating of the solution. The amphiphilic molecules in the coating self-assemble on the surface into a continuous thin film that is less than 500 nanometers thick. The water is evaporated from the coating to leave only the film chemically bonded to the surface.
摘要翻译：两相分子和水的溶液被雾化以形成沉积在基材表面上以完全覆盖溶液涂层的液滴雾。涂层中的两亲分子在表面上自组装成小于500纳米厚的连续薄膜。水从涂层蒸发，仅留下化学键合到表面的膜。

6. 发明授权

US09125668B2 Ablation device with multiple ablation modes 有权
标题翻译：消融装置具有多种消融模式
公开(公告)号：US09125668B2
公开(公告)日：2015-09-08
申请号：US13613931
申请日：2012-09-13
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/18 , A61B17/20 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00065 , A61B2018/00232 , A61B2018/00238 , A61B2018/00345 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon is configured to transmit the RF energy in a direction distally towards a leading end of the ablation device. Multiple ablation electrodes on the device can be used for providing lesions of different size or shape.
摘要翻译：公开了用于对身体组织进行消融治疗的装置，系统和方法。用于治疗身体组织的示例性消融装置包括离子导电球囊和将RF能量递送到气囊的远端部分的射频电极。气囊被配置为在远离消融装置的前端的方向上传送RF能量。器件上的多个消融电极可用于提供不同大小或形状的病灶。

7. 发明授权

US08827952B2 Biasing mechanism for a balloon catheter 有权
标题翻译：球囊导管的偏心机制
公开(公告)号：US08827952B2
公开(公告)日：2014-09-09
申请号：US13312725
申请日：2011-12-06
申请人： Raj Subramaniam , Zaya Tun , Desmond Cheung , Robert Quintos
发明人： Raj Subramaniam , Zaya Tun , Desmond Cheung , Robert Quintos
IPC分类号： A61M29/00 , A61M25/10
CPC分类号： A61M25/10 , A61M2025/1068
摘要： Methods and devices for biasing a balloon catheter are disclosed. In one example, a medical device may include a catheter shaft and a balloon assembly coupled to a distal region of the catheter shaft. The balloon assembly can define a chamber configured to be inflated and deflated using a fluid supplied from the catheter shaft. A biasing member may be positioned in the chamber of the balloon assembly and may be configured to bias the balloon assembly to a longitudinally extended state without obstructing an exhaust lumen of the catheter shaft. In some cases, the biasing member may be a spring. In other cases, the biasing member may be a coiled portion of a fluid supply line.
摘要翻译：公开了用于偏压球囊导管的方法和装置。在一个示例中，医疗装置可以包括联接到导管轴的远侧区域的导管轴和球囊组件。球囊组件可以限定使用从导管轴供应的流体而被构造成膨胀和放气的腔室。偏置构件可以定位在球囊组件的腔室中，并且可以被配置成将球囊组件偏压到纵向延伸状态，而不会妨碍导管轴的排气腔。在一些情况下，偏置构件可以是弹簧。在其他情况下，偏置构件可以是流体供应管线的卷绕部分。

8. 发明申请

US20090157069A1 Systems and methods for thermal treatment of body tissue 审中-公开
标题翻译：身体组织热处理系统和方法
公开(公告)号：US20090157069A1
公开(公告)日：2009-06-18
申请号：US12315360
申请日：2008-12-02
申请人： Curtis Tom , Raj Subramaniam , Mathieu Herbette , Chrysbe Madayag
发明人： Curtis Tom , Raj Subramaniam , Mathieu Herbette , Chrysbe Madayag
IPC分类号： A61B18/18 , A61B6/00 , A61F7/12
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/4216 , A61B2018/1861 , A61B2090/3925 , A61K41/0052 , A61K49/1818 , A61N1/406 , B82Y5/00
摘要： Apparatus and methods for treating body tissue by use of thermal treatment material. The thermal treatment material to be injected into target tissue of a body includes: a carrier substrate; a plurality of first particles operative to generate thermal energy in response to an alternating electromagnetic field applied external to the body; and a plurality of second particles, each of the second particles having a core and a coating surrounding the core. The coating is dissolved at a preset temperature by the thermal energy so that the visibility of the core in an external imaging system is affected as the coating is dissolved to expose the core. The variation of the visibility can be used as an indicator to determine if the material has reached the preset temperature.
摘要翻译：使用热处理材料处理身体组织的装置和方法。要注射到身体的靶组织中的热处理材料包括：载体基底; 多个第一粒子，用于响应于施加在身体外部的交变电磁场而产生热能; 和多个第二颗粒，所述第二颗粒中的每一个具有芯和围绕所述芯的涂层。涂层通过热能在预设温度下溶解，使得当涂层溶解以暴露核心时，外部成像系统中的芯的可视性受到影响。可见度的变化可以用作指示物，以确定材料是否达到预设温度。

9. 发明授权

US5520683A Medical electrode and method 失效
标题翻译：医用电极及方法
公开(公告)号：US5520683A
公开(公告)日：1996-05-28
申请号：US243226
申请日：1994-05-16
申请人： Raj Subramaniam , Christopher R. Clare , Donald E. Barnett, Jr.
发明人： Raj Subramaniam , Christopher R. Clare , Donald E. Barnett, Jr.
IPC分类号： A61N1/04 , A61B17/39
CPC分类号： A61N1/0492 , A61B2562/125 , A61N1/048
摘要： A medical electrode for use with a power supply for providing a more uniform current distribution for contacting an exposed surface of skin of a living body comprising a flexible carrier layer formed of an insulating material. A layer of conductive material is carried by the carrier layer. The layer of conductive material is separated into at least two segments with a space therebetween so that the two segments are electrically isolated from each other. A continuous layer of hydrogel material overlies the segments and is disposed in said space. The hydrogel material has a resistivity greater than the resistivity of the skin of the patient. A connector is adapted to be connected to the source of power whereby substantially equal current flow can be achieved from each segment through the skin of the patient without sharp transitions in current flow between the segments and the space between the segments.
摘要翻译：一种用于电源的医用电极，用于提供更均匀的电流分布，用于接触包含由绝缘材料形成的柔性载体层的活体的暴露表面。导电材料层由载体层承载。导电材料层被分离成至少两个具有间隔的部分，使得两个部分彼此电隔离。水凝胶材料的连续层叠在片段上并且设置在所述空间中。水凝胶材料的电阻率大于患者皮肤的电阻率。连接器适于连接到动力源，从而可以通过患者的皮肤从每个部分获得基本上相等的电流，而在片段之间的电流和片段之间的空间没有尖锐的转变。

10. 发明申请

US20210031006A1 STEERABLE SHEATH 有权
公开(公告)号：US20210031006A1
公开(公告)日：2021-02-04
申请号：US16944997
申请日：2020-07-31
申请人： Raj Subramaniam , Zaya Tun , Robert Quintos
发明人： Raj Subramaniam , Zaya Tun , Robert Quintos
IPC分类号： A61M25/01 , A61M25/00 , A61M29/00
摘要： A steerable sheath includes an elongate shaft, a handle, an actuator element on the handle, and a plurality of control wires operably coupled to the elongate shaft and the actuator element. Actuation of the actuator element adjusts a shape of a proximal curve and a distal curve on the elongate shaft.

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