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1. 发明授权

US08406835B2 Probe head for spectroscopic analysis of a fluid 失效
标题翻译：用于流体光谱分析的探头
公开(公告)号：US08406835B2
公开(公告)日：2013-03-26
申请号：US11568363
申请日：2005-02-14
申请人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
发明人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
IPC分类号： A61B5/1455 , A61B5/00 , G02B6/44
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.
摘要翻译：描述了用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括：探头，其具有用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的目标; 具有光谱分析单元和电源的基站; 以及连接探头和基站的电缆，用于将返回辐射从探头传输到基站，并为探头提供来自基站的电源的电力。

2. 发明申请

US20080262324A1 Measurement Head For Non-Invasive Blood Analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US20080262324A1
公开(公告)日：2008-10-23
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

3. 发明授权

US07817268B2 Alignment system for spectroscopic analysis 失效
标题翻译：光谱分析校准系统
公开(公告)号：US07817268B2
公开(公告)日：2010-10-19
申请号：US11574161
申请日：2005-08-24
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gérald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gérald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
IPC分类号： G01J3/30
CPC分类号： G01J3/02 , G01J1/4228 , G01J3/0229 , G01J3/0289
摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.
摘要翻译：本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。以这种方式，可以有效地检测光谱系统的横向偏移。通常，多个不同的检测方案是可实现的，允许分光系统的自主调谐并且用于自动消除光谱系统的未对准。

4. 发明申请

US20080129991A1 Alignment System for Spectroscopic Analysis 失效
标题翻译：光谱分析校准系统
公开(公告)号：US20080129991A1
公开(公告)日：2008-06-05
申请号：US11574161
申请日：2005-08-24
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J1/4228 , G01J3/0229 , G01J3/0289
摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous, tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.
摘要翻译：本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。以这种方式，可以有效地检测光谱系统的横向偏移。通常，多个不同的检测方案是可实现的，允许对分光系统进行自主调谐，并自动消除光谱系统的未对准。

5. 发明申请

US20080249380A1 Protection Mechanism for Spectroscopic Analysis of Biological Tissue 审中-公开
标题翻译：生物组织光谱分析保护机制
公开(公告)号：US20080249380A1
公开(公告)日：2008-10-09
申请号：US11568549
申请日：2005-04-19
申请人： Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen , Marjolein Van Der Voort
发明人： Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen , Marjolein Van Der Voort
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0531 , A61B2090/065
摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.
摘要翻译：本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。测量头的测量位置可以有效地通过使用例如测量头来确定。压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。

6. 发明授权

US07663748B2 Autofocus mechanism for spectroscopic system 有权
标题翻译：光谱系统的自动对焦机制
公开(公告)号：US07663748B2
公开(公告)日：2010-02-16
申请号：US11570132
申请日：2005-06-07
申请人： Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen , Durk Jolmer De Vries
发明人： Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen , Durk Jolmer De Vries
IPC分类号： G01J3/30
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.
摘要翻译：用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如，毛细血管的中心。

7. 发明授权

US07761129B2 Measurement head for non-invasive blood analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US07761129B2
公开(公告)日：2010-07-20
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： A measurement head has an objective for imaging of a target area such as including a capillary vessel in the skin. The measurement head does not require a lateral shifting of the optical axis of the objective. Transverse relative movements between the objective and a capillary vessel in the skin are performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors for measuring the contact pressure between the measurement head and the skin. Pressure information may be exploited in order to calibrate a spectroscopic analyzer, and/or to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：测量头具有用于对目标区域进行成像的目的，例如在皮肤中包括毛细血管。测量头不需要物镜光轴的横向偏移。通过相对于测量头的目标机械地移动皮肤来执行物体和皮肤中的毛细血管之间的横向相对运动。此外，测量头适于承载用于测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以利用压力信息来校准光谱分析仪，和/或调节预定边界内的接触压力，指定用于毛细血管的光谱检查的最佳接触压力范围。

8. 发明授权

US07486978B2 Catheter head 失效
标题翻译：导管头
公开(公告)号：US07486978B2
公开(公告)日：2009-02-03
申请号：US10554352
申请日：2004-04-23
申请人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
发明人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B6/481 , A61B6/504 , A61B2562/0238
摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320; 322; 326; 338) for directing of radiation to a blood detection volume (220; 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.
摘要翻译：本发明涉及一种导管头，包括：用于将辐射引导到血液检测体积（220; 310）的装置（104,108; 306,304; 320; 322; 326; 338）用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析用于确定血液的至少一种性质的返回辐射。

9. 发明申请

US20100087739A1 APPARATUS FOR OPTICAL BODY ANALYSIS 审中-公开
标题翻译：用于光学身体分析的装置
公开(公告)号：US20100087739A1
公开(公告)日：2010-04-08
申请号：US12442603
申请日：2007-09-25
申请人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
发明人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00 , G01N21/47 , G01J4/00
CPC分类号： A61B5/0059 , A61B5/441 , A61B5/6843 , A61B2562/146
摘要： An apparatus for optical body analysis is built with an illumination and detection head, and an optical coupler. The illumination and detection head comprises a light source for illuminating a body portion to analyze through the optical coupler and a detector for receiving light diffusely reflected by the body portion. The optical coupler is mechanically decoupled from the illumination and detection head and is adapted to be in contact with an outer surface of the body portion while the contact between the optical coupler and the body portion minimally affects physical properties of the body portion. The apparatus may further comprise a position unit adapted to adjust the position of the illumination and detection head relative to the optical coupler so that the detector receives through the optical coupler light generated by the light source and diffusely reflected by the body portion.
摘要翻译：用于光学体分析的装置由照明和检测头以及光耦合器构成。照明和检测头包括用于照亮身体部分以通过光耦合器分析的光源和用于接收由身体部分漫反射的光的检测器。光耦合器与照明和检测头机械地分离，并且适于与主体部分的外表面接触，同时光耦合器和主体部分之间的接触最小程度地影响主体部分的物理特性。该装置还可以包括位置单元，其适于调整照明和检测头相对于光学耦合器的位置，使得检测器通过光耦合器接收由光源产生的并被身体部分漫反射的光。

10. 发明申请

US20090198113A1 DEDICATED SPECTRAL ILLUMINATION SPECTROSCOPY 审中-公开
标题翻译：专用光谱照射光谱
公开(公告)号：US20090198113A1
公开(公告)日：2009-08-06
申请号：US12303431
申请日：2007-06-05
申请人： Wouter Harry Jacinth Rensen , Golo Von Basum , Markus Laubscher , Gerhardus Wilhelmus Lucassen , Miguel Palacios
发明人： Wouter Harry Jacinth Rensen , Golo Von Basum , Markus Laubscher , Gerhardus Wilhelmus Lucassen , Miguel Palacios
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/314 , G01N21/359
摘要： Apparatus and method for an analyte determination in blood, relying on spectroscopic techniques, in which sample is illuminated with light having dedicated spectral characteristics. The first light source (20) is a broadband light source in the IR-range, the second light source (25) is comprised of one or more monochromatic sources, such as laser diodes. The sources are chosen to correspond to wavelength highly correlated with glucose adsorption.
摘要翻译：依靠光谱技术在血液中进行分析物测定的装置和方法，其中样品用具有专用光谱特征的光照射。第一光源（20）是IR范围内的宽带光源，第二光源（25）由一个或多个单色源（例如激光二极管）组成。选择来源对应于与葡萄糖吸附高度相关的波长。

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