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1. 发明申请

US20080262324A1 Measurement Head For Non-Invasive Blood Analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US20080262324A1
公开(公告)日：2008-10-23
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

2. 发明授权

US07761129B2 Measurement head for non-invasive blood analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US07761129B2
公开(公告)日：2010-07-20
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： A measurement head has an objective for imaging of a target area such as including a capillary vessel in the skin. The measurement head does not require a lateral shifting of the optical axis of the objective. Transverse relative movements between the objective and a capillary vessel in the skin are performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors for measuring the contact pressure between the measurement head and the skin. Pressure information may be exploited in order to calibrate a spectroscopic analyzer, and/or to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：测量头具有用于对目标区域进行成像的目的，例如在皮肤中包括毛细血管。测量头不需要物镜光轴的横向偏移。通过相对于测量头的目标机械地移动皮肤来执行物体和皮肤中的毛细血管之间的横向相对运动。此外，测量头适于承载用于测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以利用压力信息来校准光谱分析仪，和/或调节预定边界内的接触压力，指定用于毛细血管的光谱检查的最佳接触压力范围。

3. 发明申请

US20080129991A1 Alignment System for Spectroscopic Analysis 失效
标题翻译：光谱分析校准系统
公开(公告)号：US20080129991A1
公开(公告)日：2008-06-05
申请号：US11574161
申请日：2005-08-24
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J1/4228 , G01J3/0229 , G01J3/0289
摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous, tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.
摘要翻译：本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。以这种方式，可以有效地检测光谱系统的横向偏移。通常，多个不同的检测方案是可实现的，允许对分光系统进行自主调谐，并自动消除光谱系统的未对准。

4. 发明授权

US07663748B2 Autofocus mechanism for spectroscopic system 有权
标题翻译：光谱系统的自动对焦机制
公开(公告)号：US07663748B2
公开(公告)日：2010-02-16
申请号：US11570132
申请日：2005-06-07
申请人： Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen , Durk Jolmer De Vries
发明人： Michael Cornelis Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen , Durk Jolmer De Vries
IPC分类号： G01J3/30
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.
摘要翻译：用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如，毛细血管的中心。

5. 发明授权

US07511812B2 Aberration correction for spectroscopic analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US07511812B2
公开(公告)日：2009-03-31
申请号：US11570133
申请日：2005-06-13
申请人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
发明人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
IPC分类号： G01J3/30
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.
摘要翻译：确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

6. 发明申请

US20080002199A1 Aberration Correction for Spectroscopic Analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US20080002199A1
公开(公告)日：2008-01-03
申请号：US11570133
申请日：2005-06-13
申请人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
发明人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
IPC分类号： G01J3/30 , G06F19/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

7. 发明申请

US20070293766A1 Transmission Based Imaging for Spectroscopic Analysis 审中-公开
标题翻译：基于透射的光谱分析成像
公开(公告)号：US20070293766A1
公开(公告)日：2007-12-20
申请号：US11574163
申请日：2005-08-24
申请人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
发明人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
IPC分类号： G01J3/28
CPC分类号： A61B5/489 , A61B5/0059 , A61B2562/0238 , G01J3/36 , G01J3/42 , G01N21/31 , G01N21/35 , G01N21/59
摘要： The present invention provides a spectroscopic system and a transmission based imaging system for a spectroscopic system as well as a probe head for a transmission based imaging system for a spectroscopic system and a corresponding transmission based imaging method. The spectroscopic system is preferably applicable to in vivo noninvasive blood analysis. Transmission based imaging makes use of a transmitted portion of an imaging or monitoring beam that has been transmitted through biological tissue. By means of transmission based imaging, a contrast decreasing impact of scattered radiation can be effectively reduced. Additionally, by arranging the imaging light source opposite to an objective lens of the spectroscopic system, unintended propagation of spectroscopic excitation radiation into free space can be effectively prevented.
摘要翻译：本发明提供了一种用于分光系统的光谱系统和基于透射的成像系统以及用于分光系统的基于透射的成像系统和相应的基于透射的成像方法的探针头。光谱系统优选适用于体内非侵入性血液分析。基于传输的成像利用已经通过生物组织传输的成像或监视光束的透射部分。通过基于传输的成像，可以有效降低散射辐射的对比度减小的影响。此外，通过将成像光源与分光系统的物镜相对设置，可以有效地防止光谱激发辐射的非预期传播进入自由空间。

8. 发明申请

US20070252984A1 Autofocus Mechanism for Spectroscopic System 有权
标题翻译：光谱系统的自动聚焦机制
公开(公告)号：US20070252984A1
公开(公告)日：2007-11-01
申请号：US11570132
申请日：2005-06-07
申请人： Michael Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Rensen , Durk De Vries
发明人： Michael Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Rensen , Durk De Vries
IPC分类号： G01B11/14 , G01J3/00
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： The present invention provides an autofocus mechanism for a spectroscopic system that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam into the determined volume of interest and for collecting return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel.
摘要翻译：本发明提供一种用于分光系统的自动对焦机构，其适于确定感兴趣体积的性质。感兴趣的体积随着时间而变化。本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。光谱系统还适于将激发光束聚焦到所确定的感兴趣体积中，并用于收集从感兴趣体积发出的用于光谱分析的返回辐射。优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度，毛细血管的中心。

9. 发明申请

US20060293728A1 Device and method for low intensity optical hair growth control 审中-公开
公开(公告)号：US20060293728A1
公开(公告)日：2006-12-28
申请号：US11165987
申请日：2005-06-24
申请人： Michiel Roersma , Antonius Nuijs , Guido Roosen , Paul Ackermans , Rieko Verhagen , Gerald Lucassen , Jan van Herk
发明人： Michiel Roersma , Antonius Nuijs , Guido Roosen , Paul Ackermans , Rieko Verhagen , Gerald Lucassen , Jan van Herk
IPC分类号： A61N5/06
CPC分类号： A61N5/0617 , A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00476 , A61B2018/00904 , A61N2005/0644 , A61N2005/0651 , A61N2005/0654 , A61N2005/0659 , A61N2005/067
摘要： The present invention discloses a device and a method for controlling growth of hair on human skin with low doses of electromagnetic radiation, and a device for carrying out the method. In the method, radiation of a suitable spectrum is applied to the skin, in one or more pulses of between 1 and 100 ms, and with maximum fluencies on the skin between 1 and 12 J/cm2. By applying such low fluencies and at controlled pulse durations, follicles of the hairs are induced to the catagen phase. This means that the growth of the hairs of those follicles will stop. Although the method is not primarily aimed at immediate hair removal, hairs may be shed subsequently. In any case, further growth may be stopped for prolonged periods of time. The main advantage of the method is that the risk of damage to the skin is minimized.

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