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1. 发明申请

US20090198113A1 DEDICATED SPECTRAL ILLUMINATION SPECTROSCOPY 审中-公开
标题翻译：专用光谱照射光谱
公开(公告)号：US20090198113A1
公开(公告)日：2009-08-06
申请号：US12303431
申请日：2007-06-05
申请人： Wouter Harry Jacinth Rensen , Golo Von Basum , Markus Laubscher , Gerhardus Wilhelmus Lucassen , Miguel Palacios
发明人： Wouter Harry Jacinth Rensen , Golo Von Basum , Markus Laubscher , Gerhardus Wilhelmus Lucassen , Miguel Palacios
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/314 , G01N21/359
摘要： Apparatus and method for an analyte determination in blood, relying on spectroscopic techniques, in which sample is illuminated with light having dedicated spectral characteristics. The first light source (20) is a broadband light source in the IR-range, the second light source (25) is comprised of one or more monochromatic sources, such as laser diodes. The sources are chosen to correspond to wavelength highly correlated with glucose adsorption.
摘要翻译：依靠光谱技术在血液中进行分析物测定的装置和方法，其中样品用具有专用光谱特征的光照射。第一光源（20）是IR范围内的宽带光源，第二光源（25）由一个或多个单色源（例如激光二极管）组成。选择来源对应于与葡萄糖吸附高度相关的波长。

2. 发明授权

US08406835B2 Probe head for spectroscopic analysis of a fluid 失效
标题翻译：用于流体光谱分析的探头
公开(公告)号：US08406835B2
公开(公告)日：2013-03-26
申请号：US11568363
申请日：2005-02-14
申请人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
发明人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
IPC分类号： A61B5/1455 , A61B5/00 , G02B6/44
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.
摘要翻译：描述了用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括：探头，其具有用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的目标; 具有光谱分析单元和电源的基站; 以及连接探头和基站的电缆，用于将返回辐射从探头传输到基站，并为探头提供来自基站的电源的电力。

3. 发明申请

US20100087739A1 APPARATUS FOR OPTICAL BODY ANALYSIS 审中-公开
标题翻译：用于光学身体分析的装置
公开(公告)号：US20100087739A1
公开(公告)日：2010-04-08
申请号：US12442603
申请日：2007-09-25
申请人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
发明人： Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00 , G01N21/47 , G01J4/00
CPC分类号： A61B5/0059 , A61B5/441 , A61B5/6843 , A61B2562/146
摘要： An apparatus for optical body analysis is built with an illumination and detection head, and an optical coupler. The illumination and detection head comprises a light source for illuminating a body portion to analyze through the optical coupler and a detector for receiving light diffusely reflected by the body portion. The optical coupler is mechanically decoupled from the illumination and detection head and is adapted to be in contact with an outer surface of the body portion while the contact between the optical coupler and the body portion minimally affects physical properties of the body portion. The apparatus may further comprise a position unit adapted to adjust the position of the illumination and detection head relative to the optical coupler so that the detector receives through the optical coupler light generated by the light source and diffusely reflected by the body portion.
摘要翻译：用于光学体分析的装置由照明和检测头以及光耦合器构成。照明和检测头包括用于照亮身体部分以通过光耦合器分析的光源和用于接收由身体部分漫反射的光的检测器。光耦合器与照明和检测头机械地分离，并且适于与主体部分的外表面接触，同时光耦合器和主体部分之间的接触最小程度地影响主体部分的物理特性。该装置还可以包括位置单元，其适于调整照明和检测头相对于光学耦合器的位置，使得检测器通过光耦合器接收由光源产生的并被身体部分漫反射的光。

4. 发明授权

US07486978B2 Catheter head 失效
标题翻译：导管头
公开(公告)号：US07486978B2
公开(公告)日：2009-02-03
申请号：US10554352
申请日：2004-04-23
申请人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
发明人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B6/481 , A61B6/504 , A61B2562/0238
摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320; 322; 326; 338) for directing of radiation to a blood detection volume (220; 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.
摘要翻译：本发明涉及一种导管头，包括：用于将辐射引导到血液检测体积（220; 310）的装置（104,108; 306,304; 320; 322; 326; 338）用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析用于确定血液的至少一种性质的返回辐射。

5. 发明申请

US20110201942A1 DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A BODY PART 审中-公开
标题翻译：用于光学检查身体部分的内部的装置和方法
公开(公告)号：US20110201942A1
公开(公告)日：2011-08-18
申请号：US13125677
申请日：2009-10-21
申请人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
发明人： Marius Iosif Boamfa , Wouter Harry Jacinth Rensen
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/4528 , A61B5/6825
摘要： A device for optically examining the interior of a body part by transillumination is provided. The device comprises: an illumination unit (2) adapted for emitting polarized light (8) towards a body part (5) to be examined; and a detector unit (6) adapted for detecting light in transmission. A polarizer (10) is arranged in front of the detector unit (6).
摘要翻译：提供了通过透照光学检查身体部分的内部的装置。该装置包括：照明单元（2），适于向待检查的身体部分（5）发射偏振光（8）; 以及适于检测透射光的检测器单元（6）。偏振器（10）布置在检测器单元（6）的前面。

6. 发明申请

US20090153852A1 OPTICAL FIBER FOR SPECTROSCOPIC ANALYSIS SYSTEM 审中-公开
标题翻译：光纤光谱分析系统
公开(公告)号：US20090153852A1
公开(公告)日：2009-06-18
申请号：US11568198
申请日：2005-04-12
申请人： Wouter Harry Jacinth Rensen
发明人： Wouter Harry Jacinth Rensen
IPC分类号： G01J3/00 , G02B6/26 , G02B6/02
CPC分类号： G01J3/02
摘要： The present invention provides an optical fiber for connecting a probe head and a base station of a spectroscopic analysis system for analyzing the molecular composition of a volume of interest. The optical fiber comprises a core for transmission of excitation radiation from the base station to the probe head and a first cladding for transmission of multi-mode return radiation from the probe head to a spectroscopic analysis unit of the base station. Preferably, the first cladding is surrounded by a second cladding and therefore provides a multi-mode wave guide by itself. Appropriately designing the dimensions of the core, the first cladding and the second cladding provides an optimal collection and coupling efficiency of the optical fiber. Coating of the distal end facet of the optical fiber with multi-layer optical filters allows an effective separation of elastically and inelastically scattered radiation which is of advantage for the spectroscopic analysis.
摘要翻译：本发明提供了用于连接用于分析感兴趣体积的分子组成的光谱分析系统的探针头和基站的光纤。光纤包括用于从基站传输到探头的激发辐射的核心和用于将多模返回辐射从探头传输到基站的光谱分析单元的第一包层。优选地，第一包层被第二包层包围，因此本身提供多模式波导。适当地设计芯的尺寸，第一包层和第二包层提供了光纤的最佳收集和耦合效率。使用多层光学滤光器对光纤的远端面进行涂覆，可有效地分离弹性和非弹性散射的辐射，这对于光谱分析是有利的。

7. 发明授权

US07405825B2 Optical analysis system 失效
标题翻译：光学分析系统
公开(公告)号：US07405825B2
公开(公告)日：2008-07-29
申请号：US10539540
申请日：2003-12-19
申请人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
发明人： Frank Jeroen Pieter Schuurmans , Michael Cornelis Van Beek , Levinus Pieter Bakker , Wouter Harry Jacinth Rensen , Bernardus Hendrikus Wilhelmus Hendriks , Robert Frans Maria Hendriks , Thomas Steffen
IPC分类号： G01J3/32 , G01J3/457 , G02B26/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/10 , G01J3/28 , G01J3/36 , G01N21/274 , G01N21/31 , G01N2021/3196 , G01N2201/129
摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.
摘要翻译：用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。血液分析系统（40）包括根据本发明的光学分析系统（20）。

8. 发明授权

US10791932B2 Optical detection method and device for optical detection of the condition of joints 有权
公开(公告)号：US10791932B2
公开(公告)日：2020-10-06
申请号：US12992609
申请日：2009-05-20
申请人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
发明人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
IPC分类号： A61B5/00 , A61B5/02
摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

9. 发明授权

US07924140B2 Biometrics-based identification method and apparatus 有权
标题翻译：基于生物识别的识别方法和装置
公开(公告)号：US07924140B2
公开(公告)日：2011-04-12
申请号：US11577375
申请日：2005-10-20
申请人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
发明人： Robert Frans Maria Hendriks , Wouter Harry Jacinth Rensen , Antonius Hermanus Maria Akkermans
IPC分类号： G05B19/00
CPC分类号： G06K9/0012 , G06K9/00013 , G06K9/00899 , G06K2009/00932
摘要： The invention relates to an identification method carried out as follows. A surface structure and an inner structure of a body member are measured (ST1-ST4, ST7) so as to obtain a surface-structure measurement result (FPM) and an inner-structure measurement result (BVPM), respectively. The surface-structure measurement result (FPM) is compared (ST5) with a surface-structure reference result (FPR) that distinguishes an individual from other individuals. The inner-structure measurement result (BVPM) is compared (ST8) with an inner-structure reference result (BVPR) that is associated with the same individual and that distinguishes the individual from other individuals. The body member may be, for example, a finger. In that case, the surface structure comprises a fingerprint and the inner structure comprises a blood-vessel pattern.
摘要翻译：本发明涉及如下进行的识别方法。测量体部件的表面结构和内部结构（ST1-ST4，ST7），以获得表面结构测量结果（FPM）和内部结构测量结果（BVPM）。比较表面结构测量结果（FPM）（ST5）与区分个体与其他个体的表面结构参考结果（FPR）。比较内部结构测量结果（BVPM）（ST8）与与同一个人相关联的内部结构参考结果（BVPR），并将个体与其他个体区分开。身体构件可以是例如手指。在这种情况下，表面结构包括指纹，内部结构包括血管图案。

10. 发明授权

US07817268B2 Alignment system for spectroscopic analysis 失效
标题翻译：光谱分析校准系统
公开(公告)号：US07817268B2
公开(公告)日：2010-10-19
申请号：US11574161
申请日：2005-08-24
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gérald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek , Gérald Lucassen , Marjolein Van Der Voort , Wouter Harry Jacinth Rensen
IPC分类号： G01J3/30
CPC分类号： G01J3/02 , G01J1/4228 , G01J3/0229 , G01J3/0289
摘要： The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.
摘要翻译：本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。以这种方式，可以有效地检测光谱系统的横向偏移。通常，多个不同的检测方案是可实现的，允许分光系统的自主调谐并且用于自动消除光谱系统的未对准。

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