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    • 1. 发明申请
      US20130130267A1 REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR 有权
    • REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR
    • 用于PCR装置的反应容器和执行PCR的方法
    • US20130130267A1
    • 2013-05-23
    • US13698805
    • 2011-05-19
    • Gerd Lüdke , Andreas Boos , Hassan Motejadded , Johannes Bacher
    • Gerd Lüdke , Andreas Boos , Hassan Motejadded , Johannes Bacher
    • B01L7/00
    • B01L7/52 , B01L3/502 , B01L2200/0631 , B01L2200/10 , B01L2300/047 , B01L2300/0636 , B01L2300/0681 , B01L2300/087 , B01L2400/0487 , B01L2400/049
    • The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.
    • 本发明提供一种用于PCR装置的反应容器（20）。 反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。 反应室（33）与液体供应口（34）流体连通，用于向反应室（33）供应含有至少一种目标DNA的液体样品。 反应室（33）和储存室（63）通过间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。 间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。 间隔元件（42）的上端位于多孔膜（51）附近，多孔膜（51）由干燥状态和潮湿状态下具有不同物理性质的材料制成。 在干燥状态下，多孔膜（51）允许空气以及液体通过。 在湿状态下，多孔膜（51）仍然允许液体通过其中而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）为 被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。 此外，描述包含这种反应容器（20）的PCR装置以及进行PCR的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 2. 发明授权
      US09592511B2 Reaction vessel for PCR device and method of performing PCR 有权
    • Reaction vessel for PCR device and method of performing PCR
    • 用于PCR装置的反应容器和进行PCR的方法
    • US09592511B2
    • 2017-03-14
    • US13698805
    • 2011-05-19
    • Gerd Lüdke , Andreas Boos , Hassan Motejadded , Johannes Bacher
    • Gerd Lüdke , Andreas Boos , Hassan Motejadded , Johannes Bacher
    • B01L7/00 , B01L3/00
    • B01L7/52 , B01L3/502 , B01L2200/0631 , B01L2200/10 , B01L2300/047 , B01L2300/0636 , B01L2300/0681 , B01L2300/087 , B01L2400/0487 , B01L2400/049
    • The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.
    • 本发明提供一种用于PCR装置的反应容器（20）。 反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。 反应室（33）与液体供应口（34）流体连通，用于向反应室（33）供应含有至少一种目标DNA的液体样品。 反应室（33）和储存室（63）通过间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。 间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。 间隔元件（42）的上端位于多孔膜（51）附近，多孔膜（51）由干燥状态和潮湿状态下具有不同物理性质的材料制成。 在干燥状态下，多孔膜（51）允许空气以及液体通过。 在湿状态下，多孔膜（51）仍然允许液体通过其中而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）为 被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。 此外，描述包含这种反应容器（20）的PCR装置以及进行PCR的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 4. 发明申请
      US20140242678A1 APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE 有权
    • APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE
    • 用于样品分析的装置和方法，特别是用于样品的自动和/或控制分析
    • US20140242678A1
    • 2014-08-28
    • US14232391
    • 2011-07-27
    • Andreas Boos , Gerd Lüdke , Johannes Bacher
    • Andreas Boos , Gerd Lüdke , Johannes Bacher
    • C12M1/00 , C12N1/06
    • C12M47/06 , C12N1/066 , G01N1/286 , G01N1/38 , G01N1/44 , G01N35/025 , G01N2035/00504 , G01N2035/00524 , G01N2035/0441
    • The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and—at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or—at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or—wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.
    • 本发明提供了一种用于裂解程序的装置和方法，特别是用于样品，特别是生物样品的自动和/或受控裂解方法。 该设备包括至少一个旋转圆盘（31），至少一个小瓶支架（90），其构造成接收小瓶（100），其中小瓶支架（90）布置在圆盘（31）上，至少一个 驱动装置（20），其构造成使盘（31）和小瓶保持器（90）旋转;至少一个加热装置（60），其被配置为将样品加热至确定的培养温度;以及 - 至少一个控制 设备（70），其被配置为通过定时和/或步进控制来控制驱动装置（20）和/或加热装置（60），和/或至少一个用于感应耦合的发送装置（80） 用于能量和信号传输，其被配置为将用于加热的能量传输到加热装置（60），和/或 - 其中所述驱动装置（20）被配置为沿第一方向（A1）旋转所述盘（31） 和/或以第一速度旋转，并且在第二方向（A3）和/或以第二速度旋转小瓶保持器（90）。 该装置和方法适用于（自动）裂解程序，其中裂解可以以安全，有效和有效的方式进行。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 6. 发明申请
      US20080269069A1 Method of Performing a Microarray Assay 审中-公开
    • Method of Performing a Microarray Assay
    • 进行微阵列测定的方法
    • US20080269069A1
    • 2008-10-30
    • US12158074
    • 2006-12-11
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • C40B30/10
    • G01N33/54386 , C12Q1/6837 , G01N33/544 , C12Q2565/102 , C12Q2537/143
    • Disclosed is a method for performing a microarray assay on one or more sample fluid(s), said fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.
    • 公开了一种在一种或多种样品流体上进行微阵列测定的方法，所述流体包含靶生物化合物。 该方法包括用标记标记所述靶生物化合物的步骤。 接下来的步骤包括使所述样品流体与基底接触，并在所述基底的表面检测所述标记的存在。 该方法适用于在一个或多个样品流体中在一个微阵列中同时分析一种或多种类型的靶生物化合物。 为此，每种所述类型的生物化合物被标记有不同的标记，使得属于不同样品流体的目标生物化合物具有不同的标记。 所述不同标签在所述基板的表面检测时是可辨别的。 还公开了在进行微阵列测定的方法中使用聚合物底物。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 8. 发明申请
      US20080312105A1 Sensor For Biomolecules and a Method of Analysis Using Said Sensor 审中-公开
    • Sensor For Biomolecules and a Method of Analysis Using Said Sensor
    • 用于生物分子的传感器和使用所述传感器的分析方法
    • US20080312105A1
    • 2008-12-18
    • US12158076
    • 2006-12-15
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • C40B50/18 , C40B60/12
    • B01L3/502 , B01L2300/0636 , B01L2300/0681
    • Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
    • 公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。 该方法包括将所述样品流体引入配备有多孔底物的室中的步骤，将一个或多个探针分子施加到所述多孔底物上，并且所述探针能够特异性结合所述一个或多个靶分子。 该方法还包括相对于彼此移动所述衬底和所述室的步骤，以迫使所述样品流体通过所述多孔衬底的孔并用所述一个或多个探针分子俘获所述一个或多个靶分子。 还公开了用于分析样品流体的传感器。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 9. 发明申请
      US20080300144A1 Sensor for Biomolecules and a Method for Preparing and Using the Same 审中-公开
    • Sensor for Biomolecules and a Method for Preparing and Using the Same
    • 生物分子传感器及其制备和使用方法
    • US20080300144A1
    • 2008-12-04
    • US12158082
    • 2006-12-13
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • Johannes Bacher , Andreas Boos , Gerd Luedke
    • C40B30/04 , C40B60/12
    • G01N33/54366
    • Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.
    • 公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。 该方法包括以探针位置阵列的形式施加非活化多孔有机聚合物膜的步骤，所述探针能够特异性地结合所述一个或多个靶分子。 此外，该方法包括以下步骤：用一种或多种封闭物质阻挡剩余的不含所述多孔有机聚合物膜的探针的区域，并通过所述多孔有机聚合物膜的孔在一个或两个方向上反复强制样品流体。 还公开了用于分析样品流体的传感器。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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