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1. 发明申请

US20090108191A1 Mass Spectrometer gain adjustment using ion ratios 审中-公开
标题翻译：使用离子比进行质谱仪增益调整
公开(公告)号：US20090108191A1
公开(公告)日：2009-04-30
申请号：US11927995
申请日：2007-10-30
申请人： George Yefchak , Kenneth L. Staton , Gangqiang Li
发明人： George Yefchak , Kenneth L. Staton , Gangqiang Li
IPC分类号： G12B13/00 , H01J49/00
CPC分类号： H01J49/0009 , H01J49/025
摘要： The gain of the ion detector of a mass spectrometer is calibrated by using the ion detector to measure a ratio of the abundances of at least two ion species having a known abundance ratio. The gain of the ion detector is changed until the measured abundance ratio matches the known abundance ratio.
摘要翻译：通过使用离子检测器来测量质谱仪的离子检测器的增益，以测量具有已知丰度比的至少两种离子种类的丰度的比率。改变离子检测器的增益，直到测量的丰度比与已知的丰度比匹配。

2. 发明授权

US06627874B1 Pressure measurement using ion beam current in a mass spectrometer 失效
标题翻译：在质谱仪中使用离子束电流进行压力测量
公开(公告)号：US06627874B1
公开(公告)日：2003-09-30
申请号：US09520638
申请日：2000-03-07
申请人： George Yefchak
发明人： George Yefchak
IPC分类号： G21K500
CPC分类号： H01J41/12 , H01J49/00
摘要： Method and apparatus for rapid monitoring of pressure in a chamber equipped with a mass spectrometer by using the primary beam current in conjunction with a conventional pressure gauge. The conventional gauge allows frequent calibration of the relationship of the beam current to the chamber pressure, preventing excessive drift in the system. An advantage of the system is that it takes advantage of instruments already present in a typical spectrometry apparatus.
摘要翻译：通过使用一次束流与常规压力计一起快速监测装有质谱仪的室中的压力的方法和装置。常规仪表允许频繁地校准束电流与腔室压力的关系，从而防止系统中的过度漂移。该系统的优点是它利用了已经存在于典型的光谱测定装置中的仪器。

3. 发明申请

US20050022895A1 METHODS AND APPARATUS FOR INTRODUCING LIQUIDS INTO MICROFLUIDIC CHAMBERS 失效
标题翻译：将液体引入微流化床的方法和装置
公开(公告)号：US20050022895A1
公开(公告)日：2005-02-03
申请号：US10632175
申请日：2003-07-30
申请人： Phillip Barth , George Yefchak
发明人： Phillip Barth , George Yefchak
IPC分类号： B01D19/00 , B01L3/00 , B01L3/02 , G01N35/10 , B67C3/00
CPC分类号： B01L3/0268 , B01D19/00 , B01L3/502723 , B01L2200/0642 , B01L2200/0684 , G01N2035/1018 , Y10T137/206
摘要： The present invention is directed to methods and apparatus for removing a gaseous bubble confined in a microvolume of liquid in a chamber. A source of liquid, a barrier region and an exit region are provided in fluid communication with the chamber. The source of liquid has an energy potential as regards movement of the gaseous bubble that is higher than the energy potential of the barrier region, the barrier region has a higher energy potential than the chamber, and the chamber has a higher energy potential than the exit region. The energy potential is reduced within the chamber, the source of liquid, the barrier region, and the exit region by an amount such that the energy within the gaseous bubble is sufficient to displace the gaseous bubble from the chamber through the barrier region and out the exit region and to fill the chamber with the liquid from the source.
摘要翻译：本发明涉及用于去除限制在室中的微量液体中的气泡的方法和装置。提供液体源，阻挡区域和出口区域与腔室流体连通。液体源对气泡的移动具有高于势垒区的能量势的能量势垒，势垒区具有比腔更高的能量势，并且腔具有比出口更高的能量势地区。在室内，液体源，阻挡区域和出口区域中的能量电位减小了一定量，使得气泡内的能量足以使气泡从室通过阻挡区域移出，出口区域并用来自源的液体填充室。

4. 发明授权

US06700118B2 Thermal drift compensation to mass calibration in time-of-flight mass spectrometry 有权
标题翻译：在飞行时间质谱中进行质量校准的热漂移补偿
公开(公告)号：US06700118B2
公开(公告)日：2004-03-02
申请号：US09930835
申请日：2001-08-15
申请人： George Yefchak , Carl Myerholtz , Gangqiang Li
发明人： George Yefchak , Carl Myerholtz , Gangqiang Li
IPC分类号： B01D5944
CPC分类号： H01J49/40
摘要： Adjustment systems, methods, computerized methods and computer readable-mediums that can be used in time-of-flight mass spectrometry (TOFMS) to account for thermal drift or mechanical strain are provided.
摘要翻译：提供了可在飞行时间质谱（TOFMS）中用于考虑热漂移或机械应变的调整系统，方法，计算机化方法和计算机可读介质。

5. 发明申请

US20080073499A1 Peak finding in low-resolution mass spectrometry by use of chromatographic integration routines 审中-公开
标题翻译：通过使用色谱集成程序在低分辨率质谱中进行峰值检测
公开(公告)号：US20080073499A1
公开(公告)日：2008-03-27
申请号：US11492368
申请日：2006-07-25
申请人： George Yefchak , James H. Crabtree
发明人： George Yefchak , James H. Crabtree
IPC分类号： B01D59/44
CPC分类号： H01J49/0036
摘要： Methods for processing low resolution mass spectrometry data, including providing the low resolution mass spectrometry data as abundance versus flight time data, converting the flight time axis of the low resolution mass spectrometry data to a calibrated mass axis, and converting that to retention time-based chromatographic data. The time-based data may then be converted back to abundance versus mass data and processed to create a mass spectrum.
摘要翻译：用于处理低分辨率质谱数据的方法，包括提供低分辨率质谱数据作为丰度与飞行时间数据，将低分辨率质谱数据的飞行时间轴转换为校准质量轴，并将其转换为保留时间色谱数据。然后可以将基于时间的数据转换回丰度与质量数据并进行处理以产生质谱。

6. 发明申请

US20050126905A1 High-precision feedback control for ion sculpting of solid state features 审中-公开
标题翻译：高精度反馈控制，用于固态特征的离子雕刻
公开(公告)号：US20050126905A1
公开(公告)日：2005-06-16
申请号：US10960176
申请日：2004-10-07
申请人： Jene Golovchenko , Derek Stein , George Yefchak , Richard Pittaro , Curt Flory
发明人： Jene Golovchenko , Derek Stein , George Yefchak , Richard Pittaro , Curt Flory
IPC分类号： B01L3/00 , B81B1/00 , B81C1/00 , B81C99/00 , G01N27/28 , G01N27/416 , H01L21/66 , C23C14/32
CPC分类号： G01N33/48721 , B01L3/5027 , B24B37/013 , B81C99/004 , B81C99/0065 , H01L22/26 , H01L2924/0002 , H01L2924/00
摘要： The invention provides a method for controlled fabrication of a solid state structural feature. In the method, a solid state structure is provided and the structure is exposed to an ion beam, under fabrication process conditions for producing the structural feature. A physical detection species is directed toward a designated structure location, and the rate at which the detection species proceeds from the designated structure location is measured. Detection species rate measurements are fit to a mathematical model, and the fabrication process conditions are controlled, based on the fitted detection species rate measurements, to fabricate the structural feature.
摘要翻译：本发明提供了一种用于控制制造固态结构特征的方法。在该方法中，在用于产生结构特征的制造工艺条件下，提供固态结构并且将结构暴露于离子束。物理检测物质指向指定的结构位置，并且测量检测物种从指定的结构位置进行的速率。检测物种率测量符合数学模型，并且基于拟合的检测物种速率测量来控制制造工艺条件以制造结构特征。

7. 发明授权

US06455845B1 Ion packet generation for mass spectrometer 有权
标题翻译：离子包生成用于质谱仪
公开(公告)号：US06455845B1
公开(公告)日：2002-09-24
申请号：US09552959
申请日：2000-04-20
申请人： Ganggiang Li , Carl A. Myerholtz , George Yefchak
发明人： Ganggiang Li , Carl A. Myerholtz , George Yefchak
IPC分类号： H01J4940
CPC分类号： H01J49/401 , H01J49/403
摘要： A method of providing an ion packet to an analyzer section of a mass spectrometer from an ion beam, a pulser which can execute such a method, and a mass spectrometer which includes such a pulser. In the method, a field pulse is applied to extract an ion packet from the beam at a sideways direction to the beam and provide it to a mass analyzer section of the mass spectrometer, which pulse simultaneously causes non-extracted ions of the beam to be deflected onto an electrode of opposite charge. The pulse ON time is significantly longer than conventionally used. For example, the pulse ON time may be longer than the pulse OFF time or at least twice as long as or several times longer than required to extract the ion packet and provide it to the mass analyzer section, so as to reduce stray ions entering the mass analyzer section. Preferably, the pulse ON time is the time required for ions of a predetermined highest mass of interest to be analyzed by the analyzer section, minus the time required to refill the region of the beam from which the ion packet is extracted with ions of the predetermined highest mass. Ion leakage into the mass spectrometer section between packet extractions, and hence detected noise, can be reduced.
摘要翻译：从离子束向质谱仪的分析器部分提供离子包的方法，可以执行这种方法的脉冲发生器和包括这种脉冲发生器的质谱仪。在该方法中，施加场脉冲以从横梁向束提取离子束，并将其提供给质谱仪的质量分析器部分，该脉冲同时使未提取的离子束成为偏转到相反电荷的电极上。脉冲接通时间比常规使用的时间长得多。例如，脉冲接通时间可以比脉冲关闭时间长，或者比提取离子包所需的时间长至少两倍或几倍，并将其提供给质量分析器部分，以便减少进入质量分析仪。优选地，脉冲接通时间是由分析器部分分析预定最高感兴趣质量的离子所需的时间，减去用预定的离子的离子重新填充离子分组被提取的束的区域所需的时间最高质量。可以减少在包提取之间进入质谱仪部分的离子泄漏，并因此检测噪声。

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