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1. 发明申请

US20140224018A1 MEMS Force Sensors Fabricated Using Paper Substrates 有权
标题翻译：使用纸基板制造的MEMS力传感器
公开(公告)号：US20140224018A1
公开(公告)日：2014-08-14
申请号：US13557861
申请日：2012-07-25
申请人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
发明人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
IPC分类号： G01P15/12 , B81B7/02
CPC分类号： B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
摘要： MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.
摘要翻译：提供了使用诸如纸或织物之类的便宜的基底材料制造的MEMS器件。使用纸作为基材，成本低，制备简单，重量轻，一次性压阻式传感器，包括加速度计。信号处理电路也可以在衬底材料上图案化。传感器可以用作二维传感器，或者可以将纸基材料折叠成三维构型。例如，可以将三个传感器图案化在纸基底上并折叠成立方体，使得三个传感器正交地放置在立方体的表面上，允许沿着三个正交方向（x-y-z）同时测量加速度。这些纸基传感器可以通过结合高度开发的自动切纸，折叠和丝网印刷技术进行批量生产。还提供了修改用作MEMS器件中的基底材料的纸的方法。

2. 发明授权

US09682856B2 MEMS force sensors fabricated using paper substrates 有权
公开(公告)号：US09682856B2
公开(公告)日：2017-06-20
申请号：US13557861
申请日：2012-07-25
申请人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
发明人： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
IPC分类号： G01P15/12 , B81B7/02 , G01P15/08 , G01P15/18 , G01L1/18 , B81C1/00 , G01G3/13
CPC分类号： B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
摘要： MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.

3. 发明申请

US20130034869A1 DEVICES AND METHODS FOR MULTIPLEXED ASSAYS 有权
标题翻译：多重测试的设备和方法
公开(公告)号：US20130034869A1
公开(公告)日：2013-02-07
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
IPC分类号： C12M1/34 , G01N21/78 , G01N33/53
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

4. 发明授权

US08821810B2 Devices and methods for multiplexed assays 有权
标题翻译：多重测定的装置和方法
公开(公告)号：US08821810B2
公开(公告)日：2014-09-02
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
IPC分类号： G01N33/52 , B01L3/00
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

5. 发明授权

US08554344B2 Method and apparatus for microscopy 有权
标题翻译：显微术的方法和装置
公开(公告)号：US08554344B2
公开(公告)日：2013-10-08
申请号：US12922211
申请日：2009-03-13
申请人： Yu Sun , Xinyu Liu
发明人： Yu Sun , Xinyu Liu
IPC分类号： G05B19/18
CPC分类号： G05B19/232 , G02B21/26 , G05B19/291 , G05B19/351 , G05B2219/41346 , G05B2219/49368
摘要： The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.
摘要翻译：本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。以小鼠胚胎为例来说明对照方法。开发了识别小鼠胚胎结构的模式识别实用程序。在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。

6. 发明申请

US20080077329A1 HIGH-THROUGHPUT AUTOMATED CELLULAR INJECTION SYSTEM AND METHOD 有权
标题翻译：高通自动化细胞注射系统及方法
公开(公告)号：US20080077329A1
公开(公告)日：2008-03-27
申请号：US11678608
申请日：2007-02-25
申请人： Yu Sun , Wenhui Wang , Xinyu Liu
发明人： Yu Sun , Wenhui Wang , Xinyu Liu
IPC分类号： G01N33/48
CPC分类号： C12M23/50 , C12M35/00 , C12M41/48
摘要： An automated cell injection system and method are described, which can perform automatic, reliable, and high-throughput cell injection of foreign genetic materials, proteins, and other compounds. The system and method overcome the problems inherent in traditional manual injection that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for zebrafish embryo injection but can be readily extended to other biological injection applications such as mouse embryo, drosophila embryo, and C. elegans injections, capable of facilitating high-throughput genetic research at both academic and industry levels. A novel vacuum based cell-holding device is also provided.
摘要翻译：描述了自动细胞注射系统和方法，其可以执行外来遗传物质，蛋白质和其他化合物的自动，可靠和高通量的细胞注射。该系统和方法克服了传统手动注射固有的问题，其特点是重现性差，人体疲劳和生产能力低。本发明特别适用于斑马鱼胚胎注射，但可以容易地扩展到其他生物注射应用例如小鼠胚胎，果蝇胚和秀丽隐杆线虫注射液，其能够促进学术和工业水平的高通量遗传研究。还提供了一种新颖的基于真空的电池保持装置。

7. 发明申请

US20090278420A1 MEMS-BASED NANOPOSITIONERS AND NANOMANIPULATORS 审中-公开
标题翻译：基于MEMS的纳米增塑剂和纳米颗粒
公开(公告)号：US20090278420A1
公开(公告)日：2009-11-12
申请号：US12305478
申请日：2007-06-21
申请人： Yu Sun , Xinyu Liu
发明人： Yu Sun , Xinyu Liu
IPC分类号： H02N1/00
CPC分类号： B25J7/00 , B25J9/0015
摘要： A MEMS-based mano manipulator or nanopositioner is provided that can achieve both sub-nanometer resolution and millimeter force output. The nanomanipulator or nanopositioner comprises a linear amplification mechanism that minifies input displacements and amplifies input forces, microactuators that drive the amplification mechanism to generate forward and backward motion, and position sensors that measure the input displacement of the amplification mechanism. The position sensors obtain position feedback enabling precise closed-loop control during nanomanipulation.
摘要翻译：提供了基于MEMS的马诺机器人或纳米定位器，其可以实现亚纳米分辨率和毫米波力输出。纳米机械手或纳米定位器包括线性放大机构，其缩小输入位移并放大输入力，驱动放大机构以产生向前和向后运动的微致动器以及测量放大机构的输入位移的位置传感器。位置传感器获得位置反馈，可在纳米操作期间实现精确的闭环控制。

8. 发明授权

US08990023B2 High-throughput automated cellular injection system and method 有权
标题翻译：高通量自动细胞注射系统和方法
公开(公告)号：US08990023B2
公开(公告)日：2015-03-24
申请号：US11678608
申请日：2007-02-25
申请人： Yu Sun , Wenhui Wang , Xinyu Liu
发明人： Yu Sun , Wenhui Wang , Xinyu Liu
IPC分类号： C12M1/00 , G01N35/10 , C12M1/42 , C12M1/36
CPC分类号： C12M23/50 , C12M35/00 , C12M41/48
摘要： An automated cell injection system and method are described, which can perform automatic, reliable, and high-throughput cell injection of foreign genetic materials, proteins, and other compounds. The system and method overcome the problems inherent in traditional manual injection that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for zebrafish embryo injection but can be readily extended to other biological injection applications such as mouse embryo, drosophila embryo, and C. elegans injections, capable of facilitating high-throughput genetic research at both academic and industry levels. A novel vacuum based cell-holding device is also provided.
摘要翻译：描述了自动细胞注射系统和方法，其可以执行外来遗传物质，蛋白质和其他化合物的自动，可靠和高通量的细胞注射。该系统和方法克服了传统手动注射固有的问题，其特点是重现性差，人体疲劳和生产能力低。本发明特别适用于斑马鱼胚胎注射，但可以容易地扩展到其他生物注射应用例如小鼠胚胎，果蝇胚和秀丽隐杆线虫注射液，其能够促进学术和工业水平的高通量遗传研究。还提供了一种新颖的基于真空的电池保持装置。

9. 发明申请

US20110009983A1 Method and Apparatus for Microscopy 有权
标题翻译：显微镜的方法和装置
公开(公告)号：US20110009983A1
公开(公告)日：2011-01-13
申请号：US12922211
申请日：2009-03-13
申请人： Yu Sun , Xinyu Liu
发明人： Yu Sun , Xinyu Liu
IPC分类号： G02B21/26 , G05D3/12
CPC分类号： G05B19/232 , G02B21/26 , G05B19/291 , G05B19/351 , G05B2219/41346 , G05B2219/49368
摘要： The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.
摘要翻译：本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。以小鼠胚胎为例来说明对照方法。开发了识别小鼠胚胎结构的模式识别实用程序。在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。

10. 发明申请

US20150128536A1 COOKING MATERIAL DISPENSING METHOD AND DISPENSING SYSTEM 有权
标题翻译：烹饪材料分配方法和分配系统
公开(公告)号：US20150128536A1
公开(公告)日：2015-05-14
申请号：US14373253
申请日：2012-01-19
申请人： Xinyu Liu , Ping Yan
发明人： Xinyu Liu , Ping Yan
IPC分类号： B65B69/00 , A47J43/00 , A47J36/34
CPC分类号： B65B69/0008 , A23L3/001 , A47J36/34 , A47J37/045 , A47J43/00 , B01F11/00 , B01F13/0098 , B01F15/0085 , B65B69/005 , B65B69/0075 , B65G47/248 , B65G47/252
摘要： Disclosed are a cooking material dispensing system and dispensing method. The dispensing method comprises the following steps: setting a material bag (9) clamping station in a position near a cooking pot opening but outside the range of the pot opening, and clamping the material bag (9) containing a cooking material at the material bag (9) clamping station; confining the material bag (9), such that the material bag (9) is kept in a clamped state to control the deformation thereof during the dispensing procedure; flipping and/or tipping the material bag (9), and when in a position near the cooking pot opening, dispensing the cooking material in the material bag (9) into the cooking pot; and once the cooking material has been dispensed, shifting the material bag (9) from the range of the cooking pot opening and releasing the clamping of the material bag (9). The cooking material dispensing system comprises a dispensing device capable of clamping, confining, and transferring the material bag (9) and flipping the opened material bag and/or tipping the cooking material into the cooking pot. The dispensing system and dispensing method take a material packaged in the material bag (9) and can accurately move the material bag (9) into the dispensing position, making the cooking process convenient, fast and simple, and the entire process will not be contaminated.
摘要翻译：公开了烹饪食物分配系统和分配方法。分配方法包括以下步骤：将材料袋（9）夹持站放置在烹饪锅开口附近但在锅开口范围之外的位置，并将含有烹饪材料的材料袋（9）夹在材料袋（9）夹紧台; 限制材料袋（9），使得材料袋（9）保持在夹紧状态以控制在分配过程期间的变形; 翻转和/或倾翻材料袋（9），并且当在烹饪锅开口附近的位置时，将材料袋（9）中的烹饪材料分配到烹饪锅中; 并且一旦分配了烹饪材料，则将材料袋（9）从烹饪锅开口的范围移开并释放材料袋（9）的夹紧。烹饪材料分配系统包括能够夹紧，限制和转移材料袋（9）并翻开打开的材料袋和/或将烹饪材料倾倒到烹饪锅中的分配装置。分配系统和分配方法将材料袋（9）中的材料包装，并且可以将材料袋（9）精确地移动到分配位置，使得烹饪过程方便，快速和简单，并且整个过程将不被污染。

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