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1. 发明授权

US11965154B2 Detection of nuclease edited sequences in automated modules and instruments 有权
公开(公告)号：US11965154B2
公开(公告)日：2024-04-23
申请号：US16545097
申请日：2019-08-20
申请人： Inscripta, Inc.
发明人： Eileen Spindler , Isaac Wagner , Clint Davis , Julia Swavola , Phillip Belgrader
IPC分类号： C12N1/20 , B01L3/00 , C12M1/00 , C12M1/42 , C12M3/00 , C12M3/04 , C12N9/22 , C12N13/00 , G01N35/00 , G01N35/10
CPC分类号： C12N1/20 , B01L3/502 , C12M27/10 , C12M29/04 , C12M35/00 , C12M35/02 , C12M45/00 , C12N9/22 , C12N13/00 , G01N35/00722 , G01N35/10 , B01L2200/16 , B01L2300/087 , C12M23/44 , G01N2035/009
摘要： The present disclosure provides modules, instruments and methods to enrich for cells edited via nucleic acid-guided nuclease editing of live cells.

2. 发明授权

US10501716B2 Device for mechanical and hydrodynamic microfluidic transfection 有权
公开(公告)号：US10501716B2
公开(公告)日：2019-12-10
申请号：US15885766
申请日：2018-01-31
申请人： Indee. Inc.
发明人： Ryan Pawell
IPC分类号： B01L3/00 , C12M3/00 , C12M1/42 , C12N15/87 , C12M1/00 , B81B1/00 , C12M3/06
CPC分类号： C12M35/04 , B81B1/00 , C12M23/16 , C12M27/18 , C12M35/00 , C12N15/87 , B81B2201/058 , B81B2203/0338 , C12N2510/00 , C12N2521/00 , C12N2740/15043
摘要： Methods for introducing exogenous material into a cell are provided, which include exposing the cell to a transient decrease in pressure in the presence of the exogenous material. Also provided are devices for performing the method of the invention.

3. 发明申请

US20190185846A1 AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS 审中-公开
公开(公告)号：US20190185846A1
公开(公告)日：2019-06-20
申请号：US16269671
申请日：2019-02-07
申请人： Inscripta, Inc.
发明人： Don Masquelier , Phillip Belgrader , Jorge Bernate , Ryan Gill , Kevin Ness
IPC分类号： C12N15/10 , C40B40/02 , C12M1/36 , C12N15/11 , C12M3/00 , C12M1/12 , C12M1/00 , C12N9/22
CPC分类号： C12N15/1082 , C12M23/44 , C12M33/14 , C12M35/00 , C12M37/04 , C12M41/36 , C12M41/48 , C12M43/00 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80 , C40B40/02
摘要： In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.

4. 发明申请

US20190048364A1 Methods, tip assemblies and kits for introducing material into cells 审中-公开
公开(公告)号：US20190048364A1
公开(公告)日：2019-02-14
申请号：US16159185
申请日：2018-10-12
申请人： Tufts University
发明人： Thomas J. Diefenbach
IPC分类号： C12N15/87 , C12N15/89 , C12N13/00 , C12M1/42 , C12M1/26 , B01L3/02
CPC分类号： C12N15/87 , B01L3/021 , C12M33/04 , C12M35/00 , C12M35/04 , C12N13/00 , C12N15/89
摘要： Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.

5. 发明申请

US20180273891A1 PLURIPOTENT STEM CELL MANUFACTURING SYSTEM AND METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS 审中-公开
公开(公告)号：US20180273891A1
公开(公告)日：2018-09-27
申请号：US15756029
申请日：2016-08-30
申请人： Koji TANABE , I PEACE, INC.
发明人： Koji TANABE , Brendan KELLY , Kenta SUTO
IPC分类号： C12M1/36 , C12N5/074 , C12M1/00 , C12M1/34 , C12N5/078 , C12M3/00 , C12M1/02 , C12M1/12
CPC分类号： C12M41/48 , C12M23/28 , C12M23/44 , C12M27/00 , C12M29/00 , C12M29/04 , C12M35/00 , C12M37/02 , C12M41/12 , C12M41/36 , C12M45/02 , C12M47/04 , C12N5/0634 , C12N5/0696
摘要： The present invention provides a stem cell manufacturing system comprising: a sending channel (20) through which a solution containing cells flows; an apparatus (30) which is connected to the sending channel (20) and transfers a pluripotency inducer into the cells to produce cells harboring the inducer; and an apparatus (40) which cultures the cells harboring the inducer to produce cell clusters consisting of stem cells.

6. 发明申请

US20180245041A1 PLURIPOTENT STEM CELL PRODUCTION SYSTEM 审中-公开
公开(公告)号：US20180245041A1
公开(公告)日：2018-08-30
申请号：US15756031
申请日：2016-08-31
申请人： Koji TANABE , I PEACE, INC.
发明人： Koji TANABE , Brendan KELLY , Kenta SUTO , Hidenori SHIMODA , Ryoji HIRAIDE
IPC分类号： C12N5/078 , C12M1/00 , C12M1/34 , C12M1/36
CPC分类号： C12M41/48 , C12M23/28 , C12M23/44 , C12M27/00 , C12M29/00 , C12M29/04 , C12M35/00 , C12M37/02 , C12M41/12 , C12M41/36 , C12M45/02 , C12M47/04 , C12N5/0634 , C12N5/0696
摘要： A stem cell production system provided with a preintroduction cell-feeding solution channel 20 through which a solution containing cells passes, an induction factor-feeding solution mechanism 21 for feeding a pluripotency induction factor to the preintroduction cell-feeding solution channel 20, a factor introduction device 30 connected to the preintroduction cell-feeding solution channel 20 for making cells with induction factor introduced by introducing the pluripotency induction factor into the cells, a cell mass-making device 40 for making multiple cell masses comprising stem cells by culturing the cells with induction factor introduced, and a packaging device 100 for sequentially packaging each of the multiple cell masses.

7. 发明申请

US20170306284A1 BUBBLE JETTING CHIP, LOCAL ABLATION DEVICE AND LOCAL ABLATION METHOD, AND INJECTION DEVICE AND INJECTION METHOD 审中-公开
公开(公告)号：US20170306284A1
公开(公告)日：2017-10-26
申请号：US15512618
申请日：2015-09-29
申请人： JAPAN SCIENCE AND TECHNOLOGY AGENCY
发明人： Yoko YAMANISHI , Yohei HAMANO , Takuya KAMBAYASHI
IPC分类号： C12M1/42 , B05B17/06 , A61B18/14 , A61B18/00
CPC分类号： C12M35/04 , A61B18/14 , A61B2018/00577 , A61B2018/00964 , B05B17/0607 , C12M35/00 , C12M35/02 , C12N13/00 , C12N15/89
摘要： The present invention enables fabrication and mass production of a bubble-jetting chip that includes a desired number of bubble jetting portions of the same size having bubble-jetting outlets of the same size.Mass production is enabled by fabricating a bubble-jetting chip comprising a substrate and a bubble-jetting portion formed on the substrate, the bubble-jetting portion comprising: an electrode that is formed of a conductive material; an insulating portion that is formed of an insulating photosensitive resin, is provided so as to sandwich the electrode, and includes an extended section that extends beyond the tip of the electrode; and a space that is formed between the extended section of the insulating portion and the tip of the electrode.

8. 发明授权

US09382530B2 Method and device for enhancing a directional migration of stem cells 有权
标题翻译：用于增强干细胞定向迁移的方法和装置
公开(公告)号：US09382530B2
公开(公告)日：2016-07-05
申请号：US14068969
申请日：2013-10-31
申请人： TAIPEI MEDICAL UNIVERSITY
发明人： Jennifer Hui-Chun Ho
IPC分类号： C12N13/00 , C12M1/00 , C12M1/42 , C12M1/34 , C12N5/0775
CPC分类号： C12N13/00 , C12M31/00 , C12M35/00 , C12M41/46 , C12N5/0667 , C12N2510/00 , C12N2529/10
摘要： The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells.
摘要翻译：本发明提供了增强干细胞定向迁移的方法，其包括提供一个或多个干细胞并用绿光的有效能量照射干细胞，从而增强干细胞定向迁移，其中茎的迁移取向细胞与绿色光源相对。还提供了通过本发明的方法处理的干细胞和用于增强干细胞的定向迁移的装置。

9. 发明申请

US20160146797A1 SYSTEMS AND METHODS FOR THE CAPTURE AND SEPARATION OF MICROPARTICLES 审中-公开
标题翻译：用于收集和分离微生物的系统和方法
公开(公告)号：US20160146797A1
公开(公告)日：2016-05-26
申请号：US14743303
申请日：2015-06-18
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Qiao Lin , Yao Zhou
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , B01D21/0009 , B03C1/288 , B03C2201/26 , C07K1/14 , C12M35/00 , C12M47/04 , C12Q1/6883 , G01N35/0098
摘要： Systems and methods are provided for capturing and/or isolating target microparticles. In one aspect, a method for capturing target microparticles is disclosed. The method includes: forming a fluid including the target microparticles, non-target microparticles, and magnetic beads, the magnetic beads having a stronger affinity with the target microparticles than with the non-target microparticles; flowing the fluid through a multidirectional microchannel; and applying a magnetic field to the fluid while the fluid is flowing through at least a portion of the microchannel to effect capture of at least a portion of the target microparticles onto the magnetic beads. Such a method can further includes passing the fluid having exited from the microchannel through a separator while subjecting the fluid to a second magnetic field so as to isolate the target microparticles. In addition, devices and systems are disclosed for capturing and/or isolating target microparticles based on magnetic manipulation.
摘要翻译：提供用于捕获和/或分离靶微粒的系统和方法。一方面，公开了一种捕获目标微粒的方法。该方法包括：与目标微粒相比，形成包含目标微粒，非目标微粒和磁珠的流体，与目标微粒具有更强亲合力的磁珠; 使流体流过多向微通道; 以及当所述流体流过所述微通道的至少一部分以使所述目标微粒的至少一部分捕获到所述磁珠上时，向所述流体施加磁场。这种方法可以进一步包括使流过微通道的流体通过分离器，同时使流体进入第二磁场以分离目标微粒。此外，公开了用于基于磁操作捕获和/或隔离目标微粒的装置和系统。

10. 发明授权

US09017991B2 Methods tip assemblies and kits for introducing material into cells 有权
标题翻译：方法用于将材料引入细胞的尖端组件和试剂盒
公开(公告)号：US09017991B2
公开(公告)日：2015-04-28
申请号：US13231592
申请日：2011-09-13
申请人： Thomas J. Diefenbach
发明人： Thomas J. Diefenbach
IPC分类号： C12M3/00 , C12N15/89 , C12M1/26 , B01L3/02
CPC分类号： C12N15/87 , B01L3/021 , C12M33/04 , C12M35/00 , C12M35/04 , C12N13/00 , C12N15/89
摘要： Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.
摘要翻译：提供了方法，尖端组件和试剂盒，用于将材料引入细胞。尖端组件包括附接部分，通道部分和收缩部，其作用是当流体从通道部分通过收缩部分时降低流体压力，由此尖端组件在细胞膜中形成孔并将材料引入到细胞。该材料包括例如选自以下的一种：无机化合物，药物，遗传物质，蛋白质，碳水化合物，合成聚合物和药物组合物。

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