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1. 发明授权

US08008046B2 Thermal cycling method 有权
标题翻译：热循环法
公开(公告)号：US08008046B2
公开(公告)日：2011-08-30
申请号：US12335413
申请日：2008-12-15
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12P19/34 , C12M1/00
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity.
摘要翻译：本发明提供了一种用于进行核酸扩增反应的方法，其涉及使用包含液体的热块加热和冷却样品容器中的样品。该方法可以同时进行多个核酸扩增反应，其中进行每个反应以具有温度分布。该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。

2. 发明申请

US20090275014A1 THERMAL CYCLING METHOD 有权
标题翻译：热循环方法
公开(公告)号：US20090275014A1
公开(公告)日：2009-11-05
申请号：US12335413
申请日：2008-12-15
申请人： George MALTEZOS , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George MALTEZOS , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12Q1/70 , C12Q1/68 , C12P19/34
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity.
摘要翻译：本发明提供了一种用于进行核酸扩增反应的方法，其涉及使用包含液体的热块加热和冷却样品容器中的样品。该方法可以同时进行多个核酸扩增反应，其中进行每个反应以具有温度分布。该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。

3. 发明授权

US09316586B2 Apparatus for thermal cycling 有权
标题翻译：热循环装置
公开(公告)号：US09316586B2
公开(公告)日：2016-04-19
申请号：US13417121
申请日：2012-03-09
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： G01N21/64 , B01L7/00 , B01L3/00
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

4. 发明授权

US08232091B2 Thermal cycling system 有权
标题翻译：热循环系统
公开(公告)号：US08232091B2
公开(公告)日：2012-07-31
申请号：US11750326
申请日：2007-05-17
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12M1/00 , C12P19/34
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

5. 发明授权

US08003370B2 Thermal cycling apparatus 有权
标题翻译：热循环装置
公开(公告)号：US08003370B2
公开(公告)日：2011-08-23
申请号：US12335448
申请日：2008-12-15
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12M1/00 , C12P19/34
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer heat to and from reaction vessels.
摘要翻译：本发明提供了一种用于在具有均匀温度分布的样品容器中提供样品的加热和冷却的装置。该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。该系统采用含有液体组合物的热块以有效地将热量传递到反应容器和从其返回。

6. 发明申请

US20080003649A1 THERMAL CYCLING SYSTEM 有权
标题翻译：热循环系统
公开(公告)号：US20080003649A1
公开(公告)日：2008-01-03
申请号：US11750326
申请日：2007-05-17
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher Walker
IPC分类号： C12P19/34 , C12M1/38
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

7. 发明申请

US20090011417A1 Testing Device 审中-公开
标题翻译：测试设备
公开(公告)号：US20090011417A1
公开(公告)日：2009-01-08
申请号：US12044922
申请日：2008-03-07
申请人： George Maltezos , Axel Scherer , Jingqing Huang , Alex Dickinson , Matthew Johnston
发明人： George Maltezos , Axel Scherer , Jingqing Huang , Alex Dickinson , Matthew Johnston
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/24 , G06Q90/00 , C12M1/33 , C07H21/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/143 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/0809 , B01L2300/0838 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G06Q99/00
摘要： The invention provides, in different aspects, a system, sample preparation device, sample processing cartridge, kit, methods of use, business methods, and computer program product.
摘要翻译：本发明在不同方面提供了系统，样品制备装置，样品处理盒，试剂盒，使用方法，商业方法和计算机程序产品。

8. 发明申请

US20060288708A1 Thermal management techniques, apparatus and methods for use in microfluidic devices 有权
标题翻译：用于微流体装置的热管理技术，装置和方法
公开(公告)号：US20060288708A1
公开(公告)日：2006-12-28
申请号：US11297106
申请日：2005-12-07
申请人： George Maltezos , Matthew Johnston , Axel Scherer
发明人： George Maltezos , Matthew Johnston , Axel Scherer
IPC分类号： F25B21/02
CPC分类号： B01L3/5027 , F25B21/02 , F25B21/04 , H01L35/30
摘要： A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the chamber; a waste heat channel for carrying away waste heat and/or waste cooling; and at least one Peltier junction having first and second opposing faces, the first face thereof facing towards said heating/cooling chamber and being in thermal communication therewith for providing either heat or cooling to the chamber in response to a flow of electrical current through the at least one Peltier junction, the second face thereof facing towards said waste heat channel and being in thermal communication therewith for either receiving heat from or dumping heat to the channel in response to a flow of electrical current through the Peltier junction.
摘要翻译：一种用于具有绝热基底的微流体装置的加热/冷却装置。该装置包括用于加热和/或冷却设置在腔室中的样品的加热/冷却室; 用于浪费废热和/或废物冷却的废热通道; 以及至少一个珀尔帖接头，其具有第一和第二相对面，其第一面朝向所述加热/冷却室并与其热连通，用于响应于电流通过所述的电流而向所述室提供加热或冷却至少一个珀耳帖接头，其第二面朝向所述废热通道并与其热连通，以响应于通过珀尔帖接头的电流流动来接收热量或将热量倾倒至通道。

9. 发明授权

US08695355B2 Thermal management techniques, apparatus and methods for use in microfluidic devices 有权
标题翻译：用于微流体装置的热管理技术，装置和方法
公开(公告)号：US08695355B2
公开(公告)日：2014-04-15
申请号：US11297106
申请日：2005-12-07
申请人： George Maltezos , Matthew Johnston , Axel Scherer
发明人： George Maltezos , Matthew Johnston , Axel Scherer
IPC分类号： B01L3/00 , F25B21/02 , F25B21/04
CPC分类号： B01L3/5027 , F25B21/02 , F25B21/04 , H01L35/30
摘要： A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the chamber; a waste heat channel for carrying away waste heat and/or waste cooling; and at least one Peltier junction having first and second opposing faces, the first face thereof facing towards said heating/cooling chamber and being in thermal communication therewith for providing either heat or cooling to the chamber in response to a flow of electrical current through the at least one Peltier junction, the second face thereof facing towards said waste heat channel and being in thermal communication therewith for either receiving heat from or dumping heat to the channel in response to a flow of electrical current through the Peltier junction.
摘要翻译：一种用于具有绝热基底的微流体装置的加热/冷却装置。该装置包括用于加热和/或冷却设置在腔室中的样品的加热/冷却室; 用于浪费废热和/或废物冷却的废热通道; 以及至少一个珀尔帖接头，其具有第一和第二相对面，其第一面朝向所述加热/冷却室并与其热连通，用于响应于电流通过所述的电流而向所述室提供加热或冷却至少一个珀耳帖接头，其第二面朝向所述废热通道并与其热连通，以响应于通过珀尔帖接头的电流流动来接收热量或将热量倾倒至通道。

10. 发明申请

US20100279299A1 Devices and Methods for Heating Biological Samples 审中-公开
标题翻译：用于加热生物样品的装置和方法
公开(公告)号：US20100279299A1
公开(公告)日：2010-11-04
申请号：US12753806
申请日：2010-04-02
申请人： George Maltezos , Adrian Fawcett , Matthew Johnston , Xing Yang , David Tracy
发明人： George Maltezos , Adrian Fawcett , Matthew Johnston , Xing Yang , David Tracy
IPC分类号： C12Q1/68 , C12M1/02 , C12M1/34 , C12P19/34
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0636 , B01L2300/0829 , B01L2300/1822 , B01L2300/185 , G01N2021/6439 , G01N2035/00356 , G01N2035/00366
摘要： This invention provides a systems and methods for regulating temperature and heat transfer in applications in which it is desirable to maintain temperature uniformity such as thermal cycling applications. A heat block is used to rapidly transfer heat to or from a set of one or more reaction vessels.
摘要翻译：本发明提供一种在需要保持诸如热循环应用的温度均匀性的应用中调节温度和热传递的系统和方法。热块用于将热量快速传递到一组或多个反应容器的一个或多个反应容器。

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