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1. 发明授权

US08008046B2 Thermal cycling method 有权
标题翻译：热循环法
公开(公告)号：US08008046B2
公开(公告)日：2011-08-30
申请号：US12335413
申请日：2008-12-15
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12P19/34 , C12M1/00
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity.
摘要翻译：本发明提供了一种用于进行核酸扩增反应的方法，其涉及使用包含液体的热块加热和冷却样品容器中的样品。该方法可以同时进行多个核酸扩增反应，其中进行每个反应以具有温度分布。该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。

2. 发明申请

US20080151249A1 HIGH EFFICIENCY COUPLING OPTICS FOR PUMPING AND DETECTION OF FLUORESCENCE 有权
标题翻译：用于泵送和检测荧光的高效耦合光学
公开(公告)号：US20080151249A1
公开(公告)日：2008-06-26
申请号：US11876211
申请日：2007-10-22
申请人： Christopher I. Walker , Axel Scherer
发明人： Christopher I. Walker , Axel Scherer
IPC分类号： G01N21/55
CPC分类号： G01N21/0303 , G01N21/645 , G01N2021/6482
摘要： The invention provides a high efficiency coupling structure for extracting illumination such as fluorescent radiation from a chemical reaction vessel such as a cuvette. The cuvette is provided with a mirrored surface. An end cap for the cuvette includes a probe portion that exhibits total internal reflection. Lenses are provided in various embodiments that improve the light collection and directing properties of the end cap. A fast optical system for free space coupling of optical radiation emanating from a chemical processing cuvette that uses the end cap as an element is also described.
摘要翻译：本发明提供了一种高效率耦合结构，用于提取诸如比色皿等化学反应容器的荧光辐射照明。比色杯配有镜面。用于比色杯的端盖包括具有全内反射的探针部分。在改善端盖的光收集和引导性能的各种实施例中提供了透镜。还描述了用于使用端盖作为元件的化学处理试管发出的光辐射的自由空间耦合的快速光学系统。

3. 发明授权

US08378689B2 Electrostatic sensor device and matrix 有权
标题翻译：静电传感器和矩阵
公开(公告)号：US08378689B2
公开(公告)日：2013-02-19
申请号：US12836365
申请日：2010-07-14
申请人： James T. Walker , Christopher I. Walker , Tony G. Tadin , Arjen Sundman
发明人： James T. Walker , Christopher I. Walker , Tony G. Tadin , Arjen Sundman
IPC分类号： G01R31/02 , G01R29/22
CPC分类号： G01R29/12
摘要： An electrostatic sensor device including a first sensor element and a second sensor element; a dielectric substrate material formed in two layers, and a sensing hole which penetrates the dielectric substrate material from its upper surface to its lower surface. The first sensor element is receivable in the sensing hole; and second sensor element includes a first conducting ring disposed on an upper surface of said dielectric substrate and surrounding said sensing hole. The second conducting ring is disposed on a lower surface of the dielectric substrate and surrounds the sensing hole. The first sensor element and the second sensor are capable of producing a variable response when the first sensor element is disposed in the sensing hole.
摘要翻译：一种静电传感器装置，包括第一传感器元件和第二传感器元件; 形成为两层的电介质基板材料，以及从上表面向下表面贯通电介质基板材料的检测孔。第一传感器元件可接收在传感孔中; 并且第二传感器元件包括设置在所述电介质基板的上表面上并围绕所述感测孔的第一导电环。第二导电环设置在电介质基板的下表面上，并围绕传感孔。当第一传感器元件设置在感测孔中时，第一传感器元件和第二传感器能够产生可变响应。

4. 发明授权

US08232091B2 Thermal cycling system 有权
标题翻译：热循环系统
公开(公告)号：US08232091B2
公开(公告)日：2012-07-31
申请号：US11750326
申请日：2007-05-17
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12M1/00 , C12P19/34
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

5. 发明授权

US08003370B2 Thermal cycling apparatus 有权
标题翻译：热循环装置
公开(公告)号：US08003370B2
公开(公告)日：2011-08-23
申请号：US12335448
申请日：2008-12-15
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： C12M1/00 , C12P19/34
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer heat to and from reaction vessels.
摘要翻译：本发明提供了一种用于在具有均匀温度分布的样品容器中提供样品的加热和冷却的装置。该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。该系统采用含有液体组合物的热块以有效地将热量传递到反应容器和从其返回。

6. 发明授权

US08414785B2 Methods for fabrication of microfluidic systems on printed circuit boards 有权
标题翻译：在印刷电路板上制造微流体系统的方法
公开(公告)号：US08414785B2
公开(公告)日：2013-04-09
申请号：US12572211
申请日：2009-10-01
申请人： Christopher I. Walker , Aditya Rajagopal , Axel Scherer
发明人： Christopher I. Walker , Aditya Rajagopal , Axel Scherer
IPC分类号： H05K3/06
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/16 , H05K1/0272 , H05K3/06 , H05K3/068 , H05K2203/0285
摘要： Methods for fabrication of microfluidic systems on printed circuit boards (PCB) are described. The PCB contains layers of insulating material and a layer or layers of metal buried within layers of insulating material. The metal layers are etched away, leaving fully enclosed microfluidic channels buried within the layers of insulating material.
摘要翻译：描述了在印刷电路板（PCB）上制造微流体系统的方法。 PCB包含绝缘材料层和埋在绝缘材料层内的一层或多层金属。金属层被蚀刻掉，留下完全封闭的微流体通道掩埋在绝缘材料层内。

7. 发明授权

US09316586B2 Apparatus for thermal cycling 有权
标题翻译：热循环装置
公开(公告)号：US09316586B2
公开(公告)日：2016-04-19
申请号：US13417121
申请日：2012-03-09
申请人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
发明人： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
IPC分类号： G01N21/64 , B01L7/00 , B01L3/00
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

8. 发明申请

US20120264202A1 SYSTEM FOR PERFORMING POLYMERASE CHAIN REACTION NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：用于执行聚合酶链反应核酸扩增的系统
公开(公告)号：US20120264202A1
公开(公告)日：2012-10-18
申请号：US13423674
申请日：2012-03-19
申请人： Christopher I. WALKER , Aditya RAJAGOPAL
发明人： Christopher I. WALKER , Aditya RAJAGOPAL
IPC分类号： C12M1/40 , B05D1/36 , B05D3/00 , B05D5/12
CPC分类号： B01L3/502707 , B01L7/52 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/1827
摘要： A printed circuit structure containing a fluidic chamber configured to receive an aqueous solution containing a sample to be analyzed and fluorophore for polymerase chain reaction analysis. The printed circuit structure also contains a heating element that provides for temperature cycling of the fluidic chamber to support polymerase chain reaction analysis.
摘要翻译：一种包含流化室的印刷电路结构，其配置为接收含有待分析样品的水溶液和用于聚合酶链式反应分析的荧光团。印刷电路结构还包含加热元件，其提供流体室的温度循环以支持聚合酶链式反应分析。

9. 发明授权

US07992587B2 Microfluidic autoregulator devices and arrays for operation with newtonian fluids 有权
标题翻译：用于牛顿流体操作的微流控自动调节器和阵列
公开(公告)号：US07992587B2
公开(公告)日：2011-08-09
申请号：US11606312
申请日：2006-11-28
申请人： Emil Kartalov , Axel Scherer , W. French Anderson , Christopher I. Walker
发明人： Emil Kartalov , Axel Scherer , W. French Anderson , Christopher I. Walker
IPC分类号： F16K31/36
CPC分类号： G05D7/0694 , B01L3/5027 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , Y10T137/218 , Y10T137/2202 , Y10T137/7796
摘要： By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.
摘要翻译：通过使用通孔，制造微流体自动调节器，该微流控自动调节器包括流体的来源，用于流体的水槽，连接原点和水槽的主流动通道，连通到主流动通道的阀，以选择性地控制流体的流动，并且取决于通过主流动通道的流动的装置，用于在阀门两端产生压差，至少部分地启动阀门，以控制通过主流动通道的流体流动。用于产生压力差的用于依赖于流动的装置包括从流动通道到阀门的死端迂回通道或反馈到阀的控制室的回路通道。

10. 发明申请

US20100309112A1 COLOR DISPLAY MATERIALS AND RELATED METHODS AND DEVICES 审中-公开
标题翻译：彩色显示材料及相关方法和装置
公开(公告)号：US20100309112A1
公开(公告)日：2010-12-09
申请号：US12796628
申请日：2010-06-08
申请人： Aditya Rajagopal , Christopher I. Walker , Saurabh Vyawahare , Axel Scherer , Thomas A. Tombrello
发明人： Aditya Rajagopal , Christopher I. Walker , Saurabh Vyawahare , Axel Scherer , Thomas A. Tombrello
IPC分类号： G09G3/34
CPC分类号： G09G3/344 , G09G3/2003 , G09G3/2007 , G09G2300/0439
摘要： Pixel devices, comprising ink particles differing in electrical charge, mass and/or shape contained within a fluidic structure, and related arrays methods and systems.
摘要翻译：像素装置，包括不同电荷，流体结构中所含的质量和/或形状的墨颗粒，以及相关的阵列方法和系统。

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