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1. 发明授权

US5987352A Minimally invasive implantable device for monitoring physiologic events 失效
标题翻译：用于监测生理事件的微创植入式装置
公开(公告)号：US5987352A
公开(公告)日：1999-11-16
申请号：US33678
申请日：1998-03-03
申请人： George J. Klein , Dwight H. Warkentin , Kenneth M. Riff , Brian B. Lee , James K. Carney , Gregg Turi , Anthony J. Varrichio
发明人： George J. Klein , Dwight H. Warkentin , Kenneth M. Riff , Brian B. Lee , James K. Carney , Gregg Turi , Anthony J. Varrichio
IPC分类号： A61B5/0492 , A61B5/0404 , A61B5/0408 , A61B5/0478 , A61N1/375 , A61B5/0402
CPC分类号： A61N1/375
摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described n several embodiments. This implant preferably has a segmented looping memory for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.
摘要翻译：在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。该植入物优选地具有用于存储触发的生理事件的分段循环存储器。设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。优选地，该装置可以在没有微处理器的情况下工作。包括外部设备或其他患者激活的手动触发器。自动触发器和手动设置触发器可能具有不同的大小。优选的生理事件是ECG信号。电极间距可能很重要。可以向设备提供附加的传感器。与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

2. 发明授权

US5535752A Implantable capacitive absolute pressure and temperature monitor system 失效
标题翻译：可植入电容绝对压力和温度监控系统
公开(公告)号：US5535752A
公开(公告)日：1996-07-16
申请号：US394860
申请日：1995-02-27
申请人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
发明人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
IPC分类号： A61B5/00 , A61B5/01 , A61B5/0215 , A61N1/08 , A61N1/365 , A61N1/362
CPC分类号： A61B5/0215 , A61N1/08 , A61N1/3655 , A61N1/36564 , A61B2560/0257 , Y10S977/90 , Y10S977/905
摘要： A capacitive pressure and temperature sensing system for providing signals representative of the magnitude of body fluid absolute pressure at a selected site and ambient operating conditions, including body temperature, at the site. An implantable lead having a sensor module formed in its distal end is coupled to a monitor that powers a sensor circuit in the sensor module and demodulates and stores absolute pressure and temperature data derived from signals generated by the sensor circuit. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.
摘要翻译：一种电容式压力和温度感测系统，用于提供代表在现场的所选位置和环境操作条件（包括体温）的体液绝对压力的大小的信号。具有形成在其远端的传感器模块的可植入引线被耦合到对传感器模块中的传感器电路供电的监视器，并且解调并存储由传感器电路产生的信号导出的绝对压力和温度数据。传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如，血气，EGM和患者活动。

3. 发明授权

US06236882B1 Noise rejection for monitoring ECG's 有权
标题翻译：监测心电图的噪声抑制
公开(公告)号：US06236882B1
公开(公告)日：2001-05-22
申请号：US09353167
申请日：1999-07-14
申请人： Brian B. Lee , Michael R. Kane , Gregg Turi
发明人： Brian B. Lee , Michael R. Kane , Gregg Turi
IPC分类号： A61B50402
CPC分类号： A61B5/0402 , A61B5/0432 , A61B5/0456 , A61B5/7203 , A61B5/7232
摘要： An implantable medical device which preferably has a segmented looping memory for storing triggered physiologic events also has autotriggers to record the ECGs and any other relevant physiologic signals occurring during triggering events. The problem is that in the far field R-wave sensing is difficult because of noise. Denial and extensible accommodation periods are introduced into the R-wave sensing registration for triggering data storage. If the event is sensed during an accommodation period the sense will not add an R-wave sense to the trigger's count of R-waves. It may cause resetting of the trigger count in some circumstnaces. Typical triggering events may include arrhythmia's and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger may be included. Auto triggers and manually set triggers may be of different sizes. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.
摘要翻译：优选地具有用于存储触发的生理事件的分段循环存储器的可植入医疗装置还具有记录ECG的自动触发器以及在触发事件期间发生的任何其它相关生理信号。问题在于，在远场R波传感由于噪声困难。拒绝和可延伸的住宿期被引入到R波感测注册中以触发数据存储。如果在住宿期间感测到事件，感觉不会在触发器的R波数量上增加R波感。在某些情况下可能会导致触发计数的重置。典型的触发事件可能包括心律失常和晕厥事件。优选地，该装置可以在没有微处理器的情况下工作。可以包括外部设备或其他患者激活的手动触发器。自动触发器和手动设置触发器可能具有不同的大小。电极间距可能很重要。可以向设备提供附加的传感器。与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

4. 发明授权

US5331966A Subcutaneous multi-electrode sensing system, method and pacer 失效
标题翻译：皮下多电极感应系统，方法和起搏器
公开(公告)号：US5331966A
公开(公告)日：1994-07-26
申请号：US168725
申请日：1993-12-16
申请人： Tom D. Bennett , William J. Combs , Kallok, Michael J. , Brian B. Lee , Rahul Mehra , George J. Klein
发明人： Tom D. Bennett , William J. Combs , Kallok, Michael J. , Brian B. Lee , Rahul Mehra , George J. Klein
IPC分类号： A61N1/365 , A61B5/0402 , A61N1/362 , A61N1/375 , A61B5/0428
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/3622 , A61N1/0504 , A61N1/3756 , Y10S128/903
摘要： A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, and memory to process the electrical cardiac signals between any selected pair or pairs of the electrode array in order to provide a leadless, orientation insensitive means for receiving the electrical signal from the heart. This far-field EGM may be used to provide storage and analysis of arrhythmic events and to provide control signals for the delivery of various therapies including pacing, cardioversion and defibrillation therapies as well as the delivery of antiarrhythmic drugs, and, in the pacing context, to effect capture detection and automatic stimulation threshold adaption, recording of PMT episodes, measurement of refractory periods in order to set timing windows for antitachy pacing therapies, and as a control signal for use in adjusting pacing rate to physiologic demand.
摘要翻译：一种用于提供通过相对紧密间隔的皮下电极（位于植入装置的主体上）的阵列来检测和收集电心电信号的增强能力的方法和装置，其可以与合适的开关电路，信号处理器和存储器一起使用处理任何所选择的一对或一对电极阵列之间的电心脏信号，以便提供用于从心脏接收电信号的无引导方向不敏感的装置。这种远场EGM可用于提供心律失常事件的存储和分析，并提供用于递送各种疗法的控制信号，包括起搏，心脏复律和除颤疗法以及递送抗心律失常药物，并且在起搏背景下，以实现捕获检测和自动刺激阈值适应，记录PMT发作，测量不良期以设置反向起搏治疗的时间窗口，以及用作调整生理需求起搏速率的控制信号。

5. 发明授权

US07912537B2 Telemetry-synchronized physiological monitoring and therapy delivery systems 有权
标题翻译：遥测同步生理监测和治疗传播系统
公开(公告)号：US07912537B2
公开(公告)日：2011-03-22
申请号：US11380435
申请日：2006-04-27
申请人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
发明人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
IPC分类号： A61N1/06
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

6. 发明申请

US20110004265A1 MEDICAL DEVICE PACKAGING SYSTEM 有权
标题翻译：医疗器械包装系统
公开(公告)号：US20110004265A1
公开(公告)日：2011-01-06
申请号：US12825798
申请日：2010-06-29
申请人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
发明人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294
摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.
摘要翻译：一种包括可灭菌包装的系统; 可植入医疗器械放置在可灭菌包装内; 以及电接口，其电耦合到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，接口可以包括电耦合到可植入医疗装置上的电极端子的封装接点，在封装触点和患者端子之间延伸的患者端子和导体。

7. 发明授权

US06496715B1 System and method for non-invasive determination of optimal orientation of an implantable sensing device 有权
标题翻译：用于非侵入性确定可植入感测装置的最佳取向的系统和方法
公开(公告)号：US06496715B1
公开(公告)日：2002-12-17
申请号：US09718689
申请日：2000-11-22
申请人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
发明人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
IPC分类号： A61B504
CPC分类号： A61N1/375
摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.
摘要翻译：一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。然后可以将该位置和取向用作植入相应装置的位置和取向。

8. 发明授权

US6163723A Circuit and method for implantable dual sensor medical electrical lead 失效
标题翻译：可植入双传感器医用电线的电路和方法
公开(公告)号：US6163723A
公开(公告)日：2000-12-19
申请号：US177540
申请日：1998-10-22
申请人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
发明人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensor while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.
摘要翻译：公开了一种用于可植入医疗装置和控制方法的可植入双传感器装置。双传感器组件包括经由一对引线导体耦合到医疗装置的两个生理传感器。切换电路由医疗设备控制，以通过施加适当极性的电源电压来选择性地激活和去激活两个生理传感器。双传感器组件的每个传感器通过相应的电源开关连接到一对引线导体。响应于施加到引线导体的电源电压的极性，功率开关以交替方式激活或去激活它们各自的传感器。在同时禁用双重传感器组件的另一个传感器的同时，选择性地激活传感器之一，可以降低传感器数据和通过一对引线导体传输的其他信息的功耗和可靠的通信。功率开关可以使用二极管构成，包括分立或衬底二极管，或晶体管，例如n沟道和p沟道晶体管。可以将多种生理传感器并入双重换能器组件中。

9. 发明申请

US20120283705A1 PERCUTANEOUS DELIVERY TOOL 审中-公开
标题翻译： PERCUTANEOUS DELIVERY工具
公开(公告)号：US20120283705A1
公开(公告)日：2012-11-08
申请号：US13101613
申请日：2011-05-05
申请人： Brian B. Lee , Sara M. Hoeppner
发明人： Brian B. Lee , Sara M. Hoeppner
IPC分类号： A61B17/00
CPC分类号： A61N1/372 , A61B17/28 , A61B17/30 , A61B2017/00738 , A61B2017/305 , A61N1/37205 , A61N1/3756
摘要： A percutaneous delivery tool may be used to implant a medical device, for example, within a subcutaneous space. The percutaneous delivery tool may include a handle, first and second attachment members, and first and second connecting members connecting the attachment members to the handle. In some examples, the first and second attachment members are configured to receive the medical device such that the medical device is positioned between the attachment members. In some additional examples, the first and second connecting members are angled with respect to the handle, the first connecting member is angled with respect to the first attachment member, and the second connecting member is angled with respect to the second attachment member.
摘要翻译：可以使用经皮递送工具来植入医疗装置，例如在皮下空间内。经皮递送工具可以包括手柄，第一和第二附接构件以及将附接构件连接到手柄的第一和第二连接构件。在一些示例中，第一和第二附接构件构造成接收医疗装置，使得医疗装置位于附接构件之间。在一些附加示例中，第一和第二连接构件相对于手柄成一定角度，第一连接构件相对于第一附接构件成角度，并且第二连接构件相对于第二附接构件成角度。

10. 发明申请

US20080188764A1 METHOD AND APPARATUS FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 有权
标题翻译：基于静脉循环长度的ATRIAL FIBRILLATION检测方法与装置
公开(公告)号：US20080188764A1
公开(公告)日：2008-08-07
申请号：US11554275
申请日：2006-10-30
申请人： Brian B. Lee , Eric J. Panken
发明人： Brian B. Lee , Eric J. Panken
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

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