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1. 发明授权

US5535752A Implantable capacitive absolute pressure and temperature monitor system 失效
标题翻译：可植入电容绝对压力和温度监控系统
公开(公告)号：US5535752A
公开(公告)日：1996-07-16
申请号：US394860
申请日：1995-02-27
申请人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
发明人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
IPC分类号： A61B5/00 , A61B5/01 , A61B5/0215 , A61N1/08 , A61N1/365 , A61N1/362
CPC分类号： A61B5/0215 , A61N1/08 , A61N1/3655 , A61N1/36564 , A61B2560/0257 , Y10S977/90 , Y10S977/905
摘要： A capacitive pressure and temperature sensing system for providing signals representative of the magnitude of body fluid absolute pressure at a selected site and ambient operating conditions, including body temperature, at the site. An implantable lead having a sensor module formed in its distal end is coupled to a monitor that powers a sensor circuit in the sensor module and demodulates and stores absolute pressure and temperature data derived from signals generated by the sensor circuit. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.
摘要翻译：一种电容式压力和温度感测系统，用于提供代表在现场的所选位置和环境操作条件（包括体温）的体液绝对压力的大小的信号。具有形成在其远端的传感器模块的可植入引线被耦合到对传感器模块中的传感器电路供电的监视器，并且解调并存储由传感器电路产生的信号导出的绝对压力和温度数据。传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如，血气，EGM和患者活动。

2. 发明授权

US5564434A Implantable capacitive absolute pressure and temperature sensor 失效
标题翻译：可植入电容绝对压力和温度传感器
公开(公告)号：US5564434A
公开(公告)日：1996-10-15
申请号：US394870
申请日：1995-02-27
申请人： Louis E. Halperin , Keith A. Miesel , Keith A. Ufford , James R. Svensk , Timothy Patrick , Beth A. Hassler , Anthony J. Varrichio
发明人： Louis E. Halperin , Keith A. Miesel , Keith A. Ufford , James R. Svensk , Timothy Patrick , Beth A. Hassler , Anthony J. Varrichio
IPC分类号： G01L9/12 , A61B5/00 , A61N1/365 , G01K5/32
CPC分类号： A61B5/0031 , A61N1/3655 , A61N1/36564 , A61B2560/0257 , A61B2562/0247 , A61B5/7217 , Y10S977/90 , Y10S977/905
摘要： An endocardial lead for implantation in a right heart chamber for responding to blood pressure and temperature and providing modulated pressure and temperature related signals to an implanted or external hemodynamic monitor and/or cardiac pacemaker or pacemaker/cardioverter/defibrillator. The lead has a sensor module formed in its distal end and is coupled to a monitor that powers a sensor circuit in the sensor module. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.
摘要翻译：用于植入在右心室中以响应血压和温度并且向植入或外部血液动力学监测器和/或心脏起搏器或起搏器/心律转复器/除颤器提供调制的压力和温度相关信号的心内膜引线。引线具有在其远端形成的传感器模块，并且耦合到对传感器模块中的传感器电路供电的监视器。传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如，血气，EGM和患者活动。

3. 发明授权

US5821011A Body implanted device with electrical feedthrough 失效
公开(公告)号：US5821011A
公开(公告)日：1998-10-13
申请号：US47132
申请日：1993-04-09
申请人： William J. Taylor , Joseph F. Lessar , Louis E. Halperin , Robert E. Kraska
发明人： William J. Taylor , Joseph F. Lessar , Louis E. Halperin , Robert E. Kraska
IPC分类号： C03C8/24 , C03C29/00 , H01M2/06 , H01M2/08
CPC分类号： C03C29/00 , C03C8/24 , H01M2/065 , H01M2/08
摘要： A body implanted device including a container having an opening through which extends an electrical feedthrough. The feedthrough includes a terminal of bio-stable material. A glass insulator is positioned around the terminal. The glass insulator is chosen from a CABAL-12 type composition or variation thereof. The terminal is comprised of a material which has thermal expansion characteristics compatible with the glass seal. For glass seals having a thermal expansion in the range of 6.8 to 8.0.times.10.sup.-6 in/in/.degree.C. the terminal is comprised of a thin layer of titanium metallurgically clad over niobium or tantalum. For glass seals having a thermal expansion in the range of 8.0 to 9.0.times.10.sup.-6 in/in/.degree.C. the terminal is comprised of platinum, platinum-iridium or alloys of either, or of pure titanium.

4. 发明授权

US06234973B1 Implantable medical device for sensing absolute blood pressure and barometric pressure 有权
标题翻译：用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US06234973B1
公开(公告)日：2001-05-22
申请号：US09442855
申请日：1999-11-18
申请人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
发明人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
IPC分类号： A61B502
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译：与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室压力传感器。大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

5. 发明授权

US6024704A Implantable medical device for sensing absolute blood pressure and barometric pressure 失效
标题翻译：用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US6024704A
公开(公告)日：2000-02-15
申请号：US70310
申请日：1998-04-30
申请人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
发明人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
IPC分类号： A61B5/0215 , A61B5/03 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译：与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室压力传感器。大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

6. 发明授权

US6090503A Body implanted device with electrical feedthrough 失效
标题翻译：身体植入装置带电馈通
公开(公告)号：US6090503A
公开(公告)日：2000-07-18
申请号：US61402
申请日：1998-04-16
申请人： William J. Taylor , Joseph F. Lessar , Louis E. Halperin , Robert E. Kraska
发明人： William J. Taylor , Joseph F. Lessar , Louis E. Halperin , Robert E. Kraska
IPC分类号： C03C8/24 , C03C29/00 , H01M2/06 , H01M2/08
CPC分类号： C03C29/00 , C03C8/24 , H01M2/065 , H01M2/08
摘要： A body implanted device including a container having an opening through which extends an electrical feedthrough. The feedthrough includes a terminal of bio-stable material. A glass insulator is positioned around the terminal. The glass insulator is chosen from a CABAL-12 type composition or variation thereof. The terminal is comprised of a material which has thermal expansion characteristics compatible with the glass seal. For glass seals having a thermal expansion in the range of 6.8 to 8.0.times.10.sup.-6 in/in/.degree. C. the terminal is comprised of a thin layer of titanium metallurgically clad over niobium or tantalum. For glass seals having a thermal expansion in the range of 8.0 to 9.0.times.10.sup.-6 in/in/.degree. C. the terminal is comprised of platinum, platinum-iridium or alloys of either, or of pure titanium.
摘要翻译：一种体植入装置，包括具有开口的容器，所述开口延伸有电馈通孔。馈通包括生物稳定材料的终端。玻璃绝缘子位于端子周围。玻璃绝缘体选自CABAL-12型组合物或其变体。端子由具有与玻璃密封相容的热膨胀特性的材料构成。对于热膨胀在6.8至8.0×10 -6 in / in /℃范围内的玻璃密封件，该端子由冶金地覆盖在铌或钽上的钛薄层构成。对于热膨胀范围为8.0至9.0×10 -6 in / in /℃的玻璃密封件，该端子由铂，铂 - 铱或纯钛的合金组成。

7. 发明授权

US5810735A External patient reference sensors 失效
标题翻译：外部患者参考传感器
公开(公告)号：US5810735A
公开(公告)日：1998-09-22
申请号：US848764
申请日：1997-05-01
申请人： Louis E. Halperin , James K. Carney , Robert C. Beck , Michael Turi
发明人： Louis E. Halperin , James K. Carney , Robert C. Beck , Michael Turi
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/03 , G01L19/02 , A61B5/02
CPC分类号： A61B5/7475 , A61B5/0002 , A61B5/02156 , A61B5/03 , G01L19/02 , A61B2560/0257 , A61B5/0031 , A61B5/1455
摘要： A system for long term monitoring of an internal patient medical parameter having an external reference and means to correct the internal measurements of the parameter via external measurements taken by the external reference. A coordinating device makes the correction and makes available a histogram-based record of the parameter over time. This information can be used to reprogram an implantable device or for other therapeutic or diagnostic purposes. Pressure sensor embodiment is detailed.
摘要翻译：用于长期监测具有外部参考的内部患者医疗参数的系统，以及通过外部参考获得的外部测量来校正参数的内部测量的装置。协调设备进行校正，并使随时间推移参数的直方图记录。该信息可用于重新编程可植入装置或用于其他治疗或诊断目的。压力传感器的实施例详细说明。

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