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1. 发明申请

US20110004265A1 MEDICAL DEVICE PACKAGING SYSTEM 有权
标题翻译：医疗器械包装系统
公开(公告)号：US20110004265A1
公开(公告)日：2011-01-06
申请号：US12825798
申请日：2010-06-29
申请人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
发明人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294
摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.
摘要翻译：一种包括可灭菌包装的系统; 可植入医疗器械放置在可灭菌包装内; 以及电接口，其电耦合到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，接口可以包括电耦合到可植入医疗装置上的电极端子的封装接点，在封装触点和患者端子之间延伸的患者端子和导体。

2. 发明授权

US08224447B2 Medical device packaging system 有权
标题翻译：医疗器械包装系统
公开(公告)号：US08224447B2
公开(公告)日：2012-07-17
申请号：US11291030
申请日：2005-11-30
申请人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
发明人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
IPC分类号： A61N1/375
CPC分类号： A61N1/372 , A61N2001/37294
摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.
摘要翻译：一种包括可灭菌包装的系统; 可植入医疗器械放置在可灭菌包装内; 以及电接口，其电耦合到所述可植入医疗装置并且从所述可灭菌包装内部延伸到所述可灭菌包装之外。在各种实施例中，接口可以包括电耦合到可植入医疗装置上的电极端子的封装接点，在封装触点和患者端子之间延伸的患者端子和导体。

3. 发明授权

US08219200B2 Medical device packaging system 有权
公开(公告)号：US08219200B2
公开(公告)日：2012-07-10
申请号：US12825798
申请日：2010-06-29
申请人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
发明人： William K. Wenger , Paul G. Krause , William J. Plombon , Steven N. Lu , Sean B. McAdams , Brian B. Lee , Lee Stylos , Judy B. Salzer , G. Jordan Montgomery
IPC分类号： A61N1/375
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294
摘要： A system, comprising a sterilizable package; an implantable medical device placed inside the sterilizable package; and an electrical interface electrically coupled to the implantable medical device and extending from inside the sterilizable package to outside the sterilizable package. In various embodiments, the interface may include package contacts electrically coupled to electrode terminals on the implantable medical device, patient terminals and conductors extending between the package contacts and the patient terminals.

4. 发明授权

US07912537B2 Telemetry-synchronized physiological monitoring and therapy delivery systems 有权
标题翻译：遥测同步生理监测和治疗传播系统
公开(公告)号：US07912537B2
公开(公告)日：2011-03-22
申请号：US11380435
申请日：2006-04-27
申请人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
发明人： Brian B. Lee , Eric J. Panken , Can Cinbis , Gerard J. Hill , John J. Grevious
IPC分类号： A61N1/06
CPC分类号： A61N1/37288 , A61N1/3611 , A61N1/36135 , A61N1/36585 , Y10S128/903
摘要： A physiological monitoring or therapy delivery system includes autonomous, wirelessly linked, implantable devices located at different areas to sense physiologic signals and deliver therapy. At least one of the implantable devices can trigger synchronized action (e.g. data capture or therapy delivery) by other implantable devices via a telemetry link.
摘要翻译：生理监测或治疗递送系统包括位于不同区域的自主的，无线连接的可植入装置，以感测生理信号并递送治疗。可植入装置中的至少一个可以经由遥测链路触发其它可植入装置的同步动作（例如数据捕获或治疗传递）。

5. 发明授权

US06496715B1 System and method for non-invasive determination of optimal orientation of an implantable sensing device 有权
标题翻译：用于非侵入性确定可植入感测装置的最佳取向的系统和方法
公开(公告)号：US06496715B1
公开(公告)日：2002-12-17
申请号：US09718689
申请日：2000-11-22
申请人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
发明人： Brian B. Lee , Michael R. Kane , Eric J. Panken , James D. Reinke
IPC分类号： A61B504
CPC分类号： A61N1/375
摘要： A system and method for determining the optimal positioning of an implantable system for sensing physiologic signals within a body. According to a one embodiment of the system, electrodes are positioned on an external surface of a body, and an ECG monitoring device is used to measure cardiac signals between various pairs of the electrodes. One or more of the electrodes may be re-positioned until an electrode pair position and orientation is located that provides a maximum signal reading. This position and orientation may then be used as the position and orientation in which to implant a corresponding device.
摘要翻译：一种用于确定用于感测身体内的生理信号的可植入系统的最佳定位的系统和方法。根据系统的一个实施例，电极定位在身体的外表面上，并且使用ECG监测装置来测量各对电极之间的心脏信号。一个或多个电极可以被重新定位，直到位于提供最大信号读数的电极对位置和取向。然后可以将该位置和取向用作植入相应装置的位置和取向。

6. 发明授权

US6163723A Circuit and method for implantable dual sensor medical electrical lead 失效
标题翻译：可植入双传感器医用电线的电路和方法
公开(公告)号：US6163723A
公开(公告)日：2000-12-19
申请号：US177540
申请日：1998-10-22
申请人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
发明人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensor while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.
摘要翻译：公开了一种用于可植入医疗装置和控制方法的可植入双传感器装置。双传感器组件包括经由一对引线导体耦合到医疗装置的两个生理传感器。切换电路由医疗设备控制，以通过施加适当极性的电源电压来选择性地激活和去激活两个生理传感器。双传感器组件的每个传感器通过相应的电源开关连接到一对引线导体。响应于施加到引线导体的电源电压的极性，功率开关以交替方式激活或去激活它们各自的传感器。在同时禁用双重传感器组件的另一个传感器的同时，选择性地激活传感器之一，可以降低传感器数据和通过一对引线导体传输的其他信息的功耗和可靠的通信。功率开关可以使用二极管构成，包括分立或衬底二极管，或晶体管，例如n沟道和p沟道晶体管。可以将多种生理传感器并入双重换能器组件中。

7. 发明授权

US5331966A Subcutaneous multi-electrode sensing system, method and pacer 失效
标题翻译：皮下多电极感应系统，方法和起搏器
公开(公告)号：US5331966A
公开(公告)日：1994-07-26
申请号：US168725
申请日：1993-12-16
申请人： Tom D. Bennett , William J. Combs , Kallok, Michael J. , Brian B. Lee , Rahul Mehra , George J. Klein
发明人： Tom D. Bennett , William J. Combs , Kallok, Michael J. , Brian B. Lee , Rahul Mehra , George J. Klein
IPC分类号： A61N1/365 , A61B5/0402 , A61N1/362 , A61N1/375 , A61B5/0428
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/3622 , A61N1/0504 , A61N1/3756 , Y10S128/903
摘要： A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, and memory to process the electrical cardiac signals between any selected pair or pairs of the electrode array in order to provide a leadless, orientation insensitive means for receiving the electrical signal from the heart. This far-field EGM may be used to provide storage and analysis of arrhythmic events and to provide control signals for the delivery of various therapies including pacing, cardioversion and defibrillation therapies as well as the delivery of antiarrhythmic drugs, and, in the pacing context, to effect capture detection and automatic stimulation threshold adaption, recording of PMT episodes, measurement of refractory periods in order to set timing windows for antitachy pacing therapies, and as a control signal for use in adjusting pacing rate to physiologic demand.
摘要翻译：一种用于提供通过相对紧密间隔的皮下电极（位于植入装置的主体上）的阵列来检测和收集电心电信号的增强能力的方法和装置，其可以与合适的开关电路，信号处理器和存储器一起使用处理任何所选择的一对或一对电极阵列之间的电心脏信号，以便提供用于从心脏接收电信号的无引导方向不敏感的装置。这种远场EGM可用于提供心律失常事件的存储和分析，并提供用于递送各种疗法的控制信号，包括起搏，心脏复律和除颤疗法以及递送抗心律失常药物，并且在起搏背景下，以实现捕获检测和自动刺激阈值适应，记录PMT发作，测量不良期以设置反向起搏治疗的时间窗口，以及用作调整生理需求起搏速率的控制信号。

8. 发明申请

US20120283705A1 PERCUTANEOUS DELIVERY TOOL 审中-公开
标题翻译： PERCUTANEOUS DELIVERY工具
公开(公告)号：US20120283705A1
公开(公告)日：2012-11-08
申请号：US13101613
申请日：2011-05-05
申请人： Brian B. Lee , Sara M. Hoeppner
发明人： Brian B. Lee , Sara M. Hoeppner
IPC分类号： A61B17/00
CPC分类号： A61N1/372 , A61B17/28 , A61B17/30 , A61B2017/00738 , A61B2017/305 , A61N1/37205 , A61N1/3756
摘要： A percutaneous delivery tool may be used to implant a medical device, for example, within a subcutaneous space. The percutaneous delivery tool may include a handle, first and second attachment members, and first and second connecting members connecting the attachment members to the handle. In some examples, the first and second attachment members are configured to receive the medical device such that the medical device is positioned between the attachment members. In some additional examples, the first and second connecting members are angled with respect to the handle, the first connecting member is angled with respect to the first attachment member, and the second connecting member is angled with respect to the second attachment member.
摘要翻译：可以使用经皮递送工具来植入医疗装置，例如在皮下空间内。经皮递送工具可以包括手柄，第一和第二附接构件以及将附接构件连接到手柄的第一和第二连接构件。在一些示例中，第一和第二附接构件构造成接收医疗装置，使得医疗装置位于附接构件之间。在一些附加示例中，第一和第二连接构件相对于手柄成一定角度，第一连接构件相对于第一附接构件成角度，并且第二连接构件相对于第二附接构件成角度。

9. 发明申请

US20080188764A1 METHOD AND APPARATUS FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 有权
标题翻译：基于静脉循环长度的ATRIAL FIBRILLATION检测方法与装置
公开(公告)号：US20080188764A1
公开(公告)日：2008-08-07
申请号：US11554275
申请日：2006-10-30
申请人： Brian B. Lee , Eric J. Panken
发明人： Brian B. Lee , Eric J. Panken
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/02405 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.
摘要翻译：用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。响应于所计算的差异，在第一时间间隔之后检测心房心律失常。响应于心房心律失常检测触发心脏信号的存储。

10. 发明授权

US07035684B2 Method and apparatus for monitoring heart function in a subcutaneously implanted device 有权
标题翻译：用于监测皮下植入装置中的心脏功能的方法和装置
公开(公告)号：US07035684B2
公开(公告)日：2006-04-25
申请号：US10376062
申请日：2003-02-26
申请人： Brian B. Lee
发明人： Brian B. Lee
IPC分类号： A61B5/04
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/7232 , A61N1/05 , A61N1/3702
摘要： A minimally invasive, implantable monitor and associated method for chronically monitoring a patient's hemodynamic function based on signals sensed by one or more acoustical sensors. The monitor may be implanted subcutaneously or submuscularly in relation to the heart to allow acoustic signals generated by heart or blood motion to be received by a passive or active acoustical sensor. Circuitry for filtering and amplifying and digitizing acoustical data is included, and sampled data may be continuously or intermittently written to a looping memory buffer. ECG electrodes and associated circuitry may be included to simultaneously record ECG data. Upon a manual or automatic trigger event acoustical and ECG data may be stored in long-term memory for future uploading to an external device. The external device may present acoustical data visually and acoustically with associated ECG data to allow interpretation of both electrical and mechanical heart function.
摘要翻译：基于由一个或多个声学传感器感测到的信号的用于长期监测患者血液动力学功能的微创可植入监测器和相关方法。监测器可以相对于心脏皮下或肌肉下植入，以允许由心脏或血液运动产生的声信号由被动或主动声学传感器接收。包括用于滤波和放大和数字化声学数据的电路，并且采样数据可以被连续地或间歇地写入循环存储器缓冲器。可以包括ECG电极和相关联的电路以同时记录ECG数据。在手动或自动触发事件中，声学和ECG数据可以存储在长期存储器中，以便将来上传到外部设备。外部设备可以使用相关的ECG数据在视觉和声学上呈现声学数据，以允许解释电和机械心脏功能。

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