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1. 发明申请

US20060115485A1 Methods of preventing and treating RSV infections and related conditions 审中-公开
标题翻译：预防和治疗RSV感染和相关病症的方法
公开(公告)号：US20060115485A1
公开(公告)日：2006-06-01
申请号：US11263230
申请日：2005-10-31
申请人： Genevieve Losonsky , Edward Connor , James Young , Herren Wu , William Dall'Acqua
发明人： Genevieve Losonsky , Edward Connor , James Young , Herren Wu , William Dall'Acqua
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/543 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/92 , C07K2317/94
摘要： The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (kon) of at least 2×105 M−1s−1 and a dissociation rate (koff) of less than 5×10−4 s−1.
摘要翻译：本发明提供了用于预防，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URI））和/或下呼吸道感染（LRI）的方法，），中耳炎（优选来源于，由RSV感染引起或与RSV感染相关联，例如RSV URI和/或LRI），和/或与其相关的症状或呼吸病症（例如，哮喘，喘鸣和/或反应性气道疾病（RAD）），包括向所述人施用有效量的一种或多种以高亲和力和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体。在一些实施方案中，一种或多种抗体包含修饰的IgG恒定结构域或其FcRn结合片段，导致更长的体内血清半衰期。在具体实施方案中，本发明的方法包括施用有效量的一种或多种经免疫特异性结合一种或多种RSV抗原的修饰的抗体，其具有至少2×10 6的结合速率（kNI）小于5×10-6的解离速率（k >） 4 -1 。

2. 发明申请

US20070196916A1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 有权
公开(公告)号：US20070196916A1
公开(公告)日：2007-08-23
申请号：US11643982
申请日：2006-12-20
申请人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
发明人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
IPC分类号： C07H21/04 , A61K39/395 , C12N5/06 , C12N5/16
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis of a RSV infection.

3. 发明申请

US20050147616A1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 有权
标题翻译：给予/给予抗RSV抗体进行预防和治疗的方法
公开(公告)号：US20050147616A1
公开(公告)日：2005-07-07
申请号：US10962285
申请日：2004-10-08
申请人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
发明人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
IPC分类号： C07K16/10 , C12P21/08 , A61K39/42 , C07H21/04 , C07K16/08 , C12N5/06 , C12Q1/70
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection
摘要翻译：本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为所述抗体或抗体片段在所述人受试者中实现。本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定所述抗体或抗体片段的血清滴度在所述人受试者中实现。本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法

4. 发明申请

US20050196749A1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
公开(公告)号：US20050196749A1
公开(公告)日：2005-09-08
申请号：US10403180
申请日：2003-03-31
申请人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
发明人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
IPC分类号： C07K16/10 , C12Q1/70 , C07K16/08
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection

5. 发明申请

US20050002926A1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
公开(公告)号：US20050002926A1
公开(公告)日：2005-01-06
申请号：US10900230
申请日：2004-07-26
申请人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
发明人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
IPC分类号： C07K16/10 , A61K39/395 , A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection

6. 发明授权

US07543325B2 System for remotely controlling client recording and storage behavior 有权
标题翻译：用于远程控制客户端记录和存储行为的系统
公开(公告)号：US07543325B2
公开(公告)日：2009-06-02
申请号：US10339700
申请日：2003-01-08
申请人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
发明人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
IPC分类号： H04N7/173
CPC分类号： H04N21/6543 , H04N5/76 , H04N5/765 , H04N5/782 , H04N5/91 , H04N7/025 , H04N7/162 , H04N21/2181 , H04N21/2407 , H04N21/4147 , H04N21/4331 , H04N21/4334 , H04N21/4335 , H04N21/44222 , H04N21/4516 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/466 , H04N21/4667 , H04N21/47214 , H04N21/4755 , H04N21/8586
摘要： A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests.
摘要翻译：用于远程控制客户端记录和存储行为的系统在客户端系统存储设备上调度多媒体内容的记录，存储和删除。本发明接受作为输入的节目观看偏好的优先列表，其与指示感兴趣的节目实际上被广播的节目指南对象的数据库进行比较。生成时间与可用存储空间的时间表，对于观看者的显式或派生的优选内容是最佳的。观众可以请求捕获某些内容，这导致那些内容的最高可能的优先级。本发明提供了被称为由服务发送给客户端系统的捕获请求的对象。捕获请求反映了关于客户端系统存储分区的本地存储管理决策。捕获请求还允许服务以与观众请求某些内容被记录但是比观看者可以请求更强大的相同的方式确定由客户端系统记录的内容。拍摄请求的记录请求可以抢占查看器请求或以与查看器请求相同或较低的优先级输入。捕获请求可以调整记录请求的所有方面并影响捕获请求本身。客户端系统的操作功能也由服务使用捕获请求来操纵。

7. 发明申请

US20050183740A1 Process and apparatus for removing residues from semiconductor substrates 审中-公开
标题翻译：用于从半导体衬底去除残留物的方法和设备
公开(公告)号：US20050183740A1
公开(公告)日：2005-08-25
申请号：US10783249
申请日：2004-02-19
申请人： John Fulton , Daniel Gaspar , Clement Yonker , James Young , Alan Lea , Mark Engelhard
发明人： John Fulton , Daniel Gaspar , Clement Yonker , James Young , Alan Lea , Mark Engelhard
IPC分类号： B08B7/00 , C11D1/12 , C11D1/14 , C11D1/34 , C11D11/00 , H01L21/02 , H01L21/306 , H01L21/311 , H01L21/768 , B08B3/00
CPC分类号： H01L21/02063 , B08B7/0021 , C11D1/123 , C11D1/146 , C11D1/345 , C11D11/0047 , H01L21/02101 , H01L21/76814
摘要： The present invention generally relates to a system for cleaning substrates. More particularly, the present invention relates to process(es) for effecting chemical removal of residues from semiconductor substrates, including silicon wafers, using a system of reactive reverse micelle(s) or microemulsions in a densified carbon dioxide matrix. Various reactive chemical agents in the reactive micelle system may be used to effect cleaning and removal of etch and metal residues to levels sufficient for commercial wafer production and processing.
摘要翻译：本发明一般涉及一种用于清洁衬底的系统。更具体地，本发明涉及使用在致密化二氧化碳基质中的反应性反胶束或微乳液系统来实现化学去除包括硅晶片在内的半导体衬底的残留物的方法。可以使用反应性胶束系统中的各种反应性化学试剂来实现清洁和去除蚀刻和金属残留物，使其达到商业晶片生产和加工的水平。

8. 发明授权

US06524742B1 Electrically conductive, freestanding microporous polymer sheet 有权
标题翻译：导电，独立的微孔聚合物片材
公开(公告)号：US06524742B1
公开(公告)日：2003-02-25
申请号：US09507174
申请日：2000-02-18
申请人： James Emanuel , James Young , Richard W. Pekala
发明人： James Emanuel , James Young , Richard W. Pekala
IPC分类号： H01M214
CPC分类号： H01G9/042 , H01G9/155 , H01M2/1653 , H01M2/1673 , H01M4/00 , H01M4/02 , H01M4/04 , H01M4/13 , H01M4/134 , H01M4/139 , H01M4/50 , H01M4/505 , H01M4/52 , H01M4/56 , H01M4/587 , H01M4/622 , H01M4/623 , H01M4/661 , H01M4/8647 , H01M4/96 , H01M6/10 , H01M6/188 , H01M6/40 , H01M10/04 , H01M10/0436 , H01M10/0525 , H01M10/06 , H01M10/24 , H01M10/345 , H01M2300/0082 , H01M2300/0085 , Y02E60/13 , Y10T29/49112 , Y10T29/49114
摘要： A freestanding, microporous polymer sheet (52, 56) is composed of a polymer matrix binding and electrically conductive matrix. The polymer matrix preferably includes UHMWPE, and the electrically conductive matrix preferably is in powder form. The UHMWPE is of a molecular weight that provides sufficient molecular chain entanglement to form a sheet, with freestanding characteristics. Multiple microporous sheets (30) can be wound or stacked in a package filled with an electrolyte to function as electrodes in an energy storage device (86), such as a battery. Metallic layers (81, 83) can be applied to the microporous sheets to function as current collectors in such devices.
摘要翻译：独立的微孔聚合物片（52,56）由聚合物基质结合和导电基质组成。聚合物基质优选包括UHMWPE，并且导电基质优选为粉末形式。 UHMWPE具有提供足够的分子链缠结以形成具有独立特性的片材的分子量。可以将多个微孔板（30）卷绕或堆叠在填充有电解质的包装中，以用作诸如电池的能量存储装置（86）中的电极。可以将金属层（81,83）施加到微孔板上，用作这种装置中的集流器。

9. 发明授权

US5665488A Method of making a battery separator and the battery separator produced thereby 失效
标题翻译：制造电池隔板的方法和由此制造的电池隔板
公开(公告)号：US5665488A
公开(公告)日：1997-09-09
申请号：US515855
申请日：1995-08-16
申请人： James Young , Gregory T. Humphrey , Daniel K. Lee
发明人： James Young , Gregory T. Humphrey , Daniel K. Lee
IPC分类号： H01M2/16 , H01M2/18
CPC分类号： H01M2/18 , H01M2/1606 , H01M2/1653
摘要： A method of making a battery separator useful in flooded cell type lead acid batteries comprising providing a sheet of microporous polyolefin material having two planar surfaces, forming at least one hollow rib extending from one of the planar surfaces, and wholly or partially filling the hollow rib with a rib core material. The forming of the hollow rib and the filling of the hollow rib with rib core material may be effected in separate steps or simultaneously. Where the formation and filling of the hollow rib take place simultaneously, the process involves applying at least one bead of a rib core material to one planar surface of the sheet of microporous polyolefin material, pressing the bead of rib core material into said microporous polyolefin sheet to thereby displace the microporous polyolefin material located thereunder outwardly from the other planar surface to thereby form a rib member projecting from said other planar surface. The separator thus produced is a sheet of microporous polyolefin material having at least one rib projecting from one planar surface thereof, the rib having an outer surface of the microporous polyolefin material and a core of a rib core material. The microporous polyolefin material is preferably microporous polyethylene. The rib core material is a polymeric material selected from the group consisting of thermoplastics, thermosetting polymers and reactive hot melts.
摘要翻译：一种制造电池隔膜的方法，其用于淹槽电池型铅酸蓄电池，其包括提供具有两个平坦表面的微孔聚烯烃材料片，形成从一个平面表面延伸的至少一个中空肋，以及全部或部分填充中空肋具有肋芯材料。中空肋条的形成和具有肋芯材料的中空肋条的填充可以在单独的步骤中或同时进行。在中空肋条的形成和填充同时进行的情况下，该方法包括将至少一个肋芯材料的珠粒施加到微孔聚烯烃材料片的一个平坦表面上，将肋芯材料的珠粒压入所述微孔聚烯烃片材从而将位于其下方的微孔聚烯烃材料从另一个平面表面向外移位，从而形成从所述另一平坦表面突出的肋构件。如此制造的分离器是一片微孔聚烯烃材料，其具有从其一个平坦表面突出的至少一个肋，所述肋具有微孔聚烯烃材料的外表面和肋芯材料的芯。微孔聚烯烃材料优选为微孔聚乙烯。肋芯材料是选自热塑性塑料，热固性聚合物和反应性热熔体的聚合材料。

10. 发明授权

US5634683A Slideout room for vehicle 失效
标题翻译： Slideout车间
公开(公告)号：US5634683A
公开(公告)日：1997-06-03
申请号：US598349
申请日：1996-02-08
申请人： James Young
发明人： James Young
IPC分类号： B60P3/34 , B62D33/08 , B60D3/34
CPC分类号： B60P3/34 , B62D33/08
摘要： An extendible slideout room having a roof, floor, and sidewalls is moveable between a retracted position and an extended position within a lateral wall of a vehicle such as a motorhome, a boat, or virtually any type of trailer. In the retracted position, the roof, floor and two side walls of the slideout room are disposed within the vehicle, with a third outer side wall positioned in sealed contact with the vehicle's lateral wall about the periphery of the slideout room. When extended, the slideout room's roof, floor and sidewalls project outwardly from the vehicle's lateral wall in sealed contact with the vehicle's wall. Elongated screws rotationally coupled to the slideout room's outer side wall at their respective distal ends are inserted through respective threaded fittings fixedly attached to the vehicle's lateral wall, with each screw disposed adjacent a respective corner of the room. A toothed sprocket is attached to the distal end of each screw, with the sprockets coupled together by means of an endless chain. A drive sprocket connected to a drive motor is also coupled to the chain for displacing the chain and rotating the screws in unison. Rotation of the drive sprocket in a first direction extends the slideout room, while rotation of the drive sprocket in a second, opposed direction retracts the room within the vehicle. The drive mechanism including motor, sprockets and chain are coupled to and move with the slideout room during extension and retraction.
摘要翻译：具有屋顶，地板和侧壁的可延伸的遮光室可在缩回位置和车辆侧壁之间的延伸位置（例如摩托车，船或几乎任何类型的拖车）之间移动。在缩回位置，滑动室的屋顶，地板和两个侧壁设置在车辆内，第三外侧壁与围绕围栏室周边的车辆侧壁密封接触。当延长时，遮光室的屋顶，地板和侧壁从车辆的侧壁向外突出，与车辆的墙壁密封接触。在它们各自的远端处旋转地联接到狭缝室的外侧壁的细长螺钉通过固定地附接到车辆的侧壁的相应的螺纹配件插入，每个螺钉邻近房间的相应角部设置。齿轮的链轮连接到每个螺杆的远端，链轮通过环形链条连接在一起。连接到驱动马达的驱动链轮也联接到链条上，用于移动链条并一致地旋转螺钉。驱动链轮在第一方向上的旋转使得狭缝室延伸，同时驱动链轮在第二相对方向上的旋转使车辆内的房间缩回。包括马达，链轮和链条在内的驱动机构在延伸和缩回期间与凹槽室耦合并移动。

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