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1. 发明申请

US20200338559A1 METHOD FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 审中-公开
公开(公告)号：US20200338559A1
公开(公告)日：2020-10-29
申请号：US16924966
申请日：2020-07-09
申请人： GEN-PROBE INCORPORATED
发明人： Christopher B. DAVIS , Norbert D. HAGEN , James T. TUGGLE
IPC分类号： B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
摘要： A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.

2. 发明申请

US20200282403A1 CARRIER FOR HOLDING A PLURALITY OF MULTI-RECEPTACLE UNITS 审中-公开
公开(公告)号：US20200282403A1
公开(公告)日：2020-09-10
申请号：US16811772
申请日：2020-03-06
申请人： Gen-Probe Incorporated
发明人： David H. COMBS , David A. BUSE , Norbert D. HAGEN , David OPALSKY , Jin CHEN
IPC分类号： B01L9/00 , B66F9/07
摘要： A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.

3. 发明申请

US20200271568A1 CLEANING MEMBER FOR USE IN A SAMPLE TESTING SYSTEM 审中-公开
公开(公告)号：US20200271568A1
公开(公告)日：2020-08-27
申请号：US15930131
申请日：2020-05-12
申请人： GEN-PROBE INCORPORATED
发明人： Norbert D. HAGEN , Byron KNIGHT , David OPALSKY
IPC分类号： G01N21/15 , B08B1/00 , B08B9/00 , G01N35/00 , G02B6/38
摘要： A cleaning member including a distal cleaning element and a proximal coupling element, where the coupling element has a proximal end portion dimensioned to form a frictional fit with a working end of an automated transport arm.

4. 发明申请

US20150196915A1 METHOD AND APPARATUS FOR EFFECTING AUTOMATED MOVEMENT OF A MAGNET IN AN INSTRUMENT FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 有权
公开(公告)号：US20150196915A1
公开(公告)日：2015-07-16
申请号：US14669419
申请日：2015-03-26
申请人： GEN-PROBE INCORPORATED
发明人： Norbert D. HAGEN , Byron J. KNIGHT , David OPALSKY
IPC分类号： B01L3/00 , B01L9/00
CPC分类号： B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
摘要： Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

5. 发明申请

US20140263984A1 INDEXING SIGNAL DETECTION MODULE 有权
标题翻译：指示信号检测模块
公开(公告)号：US20140263984A1
公开(公告)日：2014-09-18
申请号：US14200460
申请日：2014-03-07
申请人： GEN-PROBE INCORPORATED
发明人： Norbert D. HAGEN , David OPALSKY
IPC分类号： G01N21/64 , G02B6/08 , G01J1/02 , G02B6/06 , G01J1/42 , G01J1/04
CPC分类号： G02B6/3668 , G01N21/253 , G01N21/6452 , G01N2021/6484 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269
摘要： An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.
摘要翻译：索引信号检测模块被配置为将一个或多个信号检测器转移到多个可检测信号发射源中的每一个上，以检测或测量由每个源发射的信号。多个信号传输管道将源发射的信号从每个管道的第一端传送到每个管道的第二端，其中信号可由信号检测器检测。导管重新配置器被配置为以对应于信号发射源的空间布置的第一空间布置来固定各个信号传输导管的第一端，并且将相应的信号传输导管的第二端固定在不同于第一个空间安排。

6. 发明申请

US20140175168A1 RECEPTACLE RACK HAVING AN ELECTRONIC MEMORY ELEMENT 有权
标题翻译：具有电子记忆元件的接收机架
公开(公告)号：US20140175168A1
公开(公告)日：2014-06-26
申请号：US14195718
申请日：2014-03-03
申请人： GEN-PROBE INCORPORATED
发明人： Norbert D. HAGEN , David OPALSKY
IPC分类号： G06Q10/08
CPC分类号： G06Q10/087 , G01N35/00732 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00831 , G01N2035/00841
摘要： A system and method for tracking items, such as receptacles, during a process employs a rack configured to hold one or more receptacles. Each receptacle includes a machine-readable label providing information regarding the receptacle, such as contents thereof and process(es) to be performed thereon, and each receptacle-receiving position of the rack has associated therewith a machine-readable label identifying the receptacle receiving location. The rack also includes a memory element to which electronic data may be written. A label reading device reads the machine-readable label on each receptacle and the position-indicating, machine-readable labels on the rack. Information obtained from the machine-readable labels is written to the memory element, so that for subsequent processing of the receptacles carried on the rack, information relating to each of the receptacles can be obtained by reading the information written to the memory element. A tamper prevention element provides an indication of whether the rack may have been tampered with after data is written to the memory element.
摘要翻译：在过程期间用于跟踪物品（例如插座）的系统和方法采用配置成容纳一个或多个插座的机架。每个插座包括提供关于插座的信息的机器可读标签，诸如其内容和要在其上执行的处理，并且机架的每个插座接收位置与其相关联地标识容器接收位置的机器可读标签。机架还包括可以写入电子数据的存储元件。标签读取装置读取每个插座上的机器可读标签和机架上的位置指示机器可读标签。从机器可读标签获得的信息被写入存储元件，因此为了随后处理在机架上承载的插座，可以通过读取写入存储元件的信息来获得与每个插座有关的信息。防篡改元件提供了在将数据写入存储器元件之后机架是否可能被篡改的指示。

7. 发明申请

US20140038170A1 APPARATUS, SYSTEMS, AND METHODS FOR PERFORMING THERMAL MELT ANALYSES AND AMPLIFICATIONS 有权
标题翻译：用于执行热熔胶分析和放大的装置，系统和方法
公开(公告)号：US20140038170A1
公开(公告)日：2014-02-06
申请号：US13956060
申请日：2013-07-31
申请人： Gen-Probe Incorporated
发明人： David OPALSKY , Norbert D. HAGEN , Rolf SILBERT , Sean Siyao CHIU , Haitao LI
IPC分类号： G01N25/04
CPC分类号： G01N25/04 , B01L7/5255 , B01L9/06 , B01L2200/028 , B01L2300/0627 , B01L2300/1827 , G01N21/6428 , G01N2021/6432 , G01N2021/6439
摘要： The present disclosure provides apparatus, systems, and methods for conducting rapid, accurate, and consistent heated amplifications and/or thermal melt analyses.
摘要翻译：本公开提供用于进行快速，准确和一致的加热放大和/或热熔融分析的装置，系统和方法。

8. 发明申请

US20210002705A1 APPARATUS FOR APPLYING THERMAL ENERGY TO A RECEPTACLE AND DETECTING AN EMISSION SIGNAL FROM THE RECEPTACLE 有权
公开(公告)号：US20210002705A1
公开(公告)日：2021-01-07
申请号：US17027433
申请日：2020-09-21
申请人： Gen-Probe Incorporated
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. Knight
IPC分类号： C12Q1/686 , B01L7/00 , G01N21/64
摘要： An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with multiple receptacle wells. Each well has a through-hole extending from an inner surface of the well to an outer surface of the holder. A cover is rotatable between an open position and a closed position relative to the holder and is configured to exert a force onto any receptacles in the wells when the cover is in the closed position. The apparatus includes multiple optical fibers, and each of the optical fibers provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A thermal element is positioned between a thermally-conductive support and the receptacle holder.

9. 发明申请

US20200319107A1 SYSTEM AND METHOD FOR MONITORING A REACTION WITHIN A RECEPTACLE VESSEL 审中-公开
公开(公告)号：US20200319107A1
公开(公告)日：2020-10-08
申请号：US16910414
申请日：2020-06-24
申请人： Gen-Probe Incorporated
发明人： Haitao LI , David OPALSKY , R. Eric HEINZ , Norbert D. HAGEN
IPC分类号： G01N21/64 , G01N21/27
摘要： A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.

10. 发明申请

US20190079248A1 METHOD OF MEASURING A TIME-VARYING SIGNAL EMISSION 审中-公开
公开(公告)号：US20190079248A1
公开(公告)日：2019-03-14
申请号：US16179609
申请日：2018-11-02
申请人： GEN-PROBE INCORPORATED
发明人： Norbert D. HAGEN , David OPALSKY
IPC分类号： G02B6/36 , G02B6/06 , G02B6/08 , G01N21/25 , G01N21/64 , G02B6/42
摘要： A method of measuring a time-varying signal emission, the method including subjecting the contents of a receptacle to a thermal cycling process. During the thermal cycling process, measuring a signal emission from the contents of the receptacle at regular time intervals and recording the measured signal emission and a time stamp at each time interval. Also during the thermal cycling process, determining a temperature of the thermal cycling process at regular time intervals and recording the determined temperature and a time stamp at each time interval. The measured signal emissions are synchronized with a specific temperature of the thermal cycling process by comparing the time stamps of the measured emission signals with the time stamps of the determined temperatures.

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