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1. 发明申请

US20150027933A1 SYSTEM FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 有权
标题翻译：执行磁分离步骤的系统
公开(公告)号：US20150027933A1
公开(公告)日：2015-01-29
申请号：US14500584
申请日：2014-09-29
申请人： GEN-PROBE INCORPORATED
发明人： Christopher B. DAVIS , Norbert D. HAGEN , James T. TUGGLE
IPC分类号： B03C1/28 , B03C1/14 , B03C1/12
CPC分类号： B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
摘要： A system for separating an analyte from other components of a sample contained in a receptacle, where the system includes a receptacle holding station and a magnetic separation station. The receptacle holding station is configured to receive and hold a receptacle and includes one or more magnets positioned to apply a magnetic field to the contents of the receptacle. When present in the receptacle holding station, a receptacle remains stationary relative to the one or more magnets. The magnetic separation station includes one or more magnets and is constructed and arranged to perform a magnetic separation procedure on the contents of a receptacle transported from the receptacle holding station to the magnetic separation station by an automated receptacle transport. The magnetic separation procedure includes isolating an analyte immobilized on a magnetically-responsive solid support within the receptacle and removing other components of the sample from the receptacle. The magnetic separation station is configured to provide relative movement between the receptacle and the one or more magnets after the receptacle is transported to the magnetic separation station.
摘要翻译：用于将分析物与包含在容器中的样品的其它组分分离的系统，其中所述系统包括容器保持站和磁分离站。容器保持站被配置为容纳和保持插座，并且包括一个或多个定位成将磁场施加到容器的内容物上的磁体。当存在于容器保持站中时，容器相对于一个或多个磁体保持静止。磁分离站包括一个或多个磁体，并被构造和布置成对通过自动插座传送从容器保持站传送到磁分离站的容器的内容物执行磁分离程序。磁分离程序包括将固定在磁反应性固体支持物上的分析物分离在容器内并从容器中除去样品的其它组分。磁性分离台构造成在容器被传送到磁分离站之后，在容器和一个或多个磁体之间提供相对运动。

2. 发明申请

US20230095546A1 METHOD FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 有权
公开(公告)号：US20230095546A1
公开(公告)日：2023-03-30
申请号：US18061995
申请日：2022-12-05
申请人： GEN-PROBE INCORPORATED
发明人： Christopher B. DAVIS , Norbert D. HAGEN , James T. TUGGLE
IPC分类号： B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
摘要： A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.

3. 发明申请

US20200030805A1 SYSTEM FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 审中-公开
公开(公告)号：US20200030805A1
公开(公告)日：2020-01-30
申请号：US16400752
申请日：2019-05-01
申请人： GEN-PROBE INCORPORATED
发明人： Christopher B. DAVIS , Norbert D. HAGEN , James T. TUGGLE
IPC分类号： B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
摘要： A system for separating an analyte from other components of a sample includes a receptacle holding station and a magnetic separation station. The receptacle holding station includes one or more stationary, permanent magnets positioned to apply a magnetic field to the contents of a receptacle held stationary within the receptacle holding station. The magnetic separation station includes one or more permanent magnets and is configured to perform a magnetic separation procedure on the contents of a receptacle transported from the receptacle holding station to the magnetic separation station. The magnetic separation procedure includes isolating an analyte immobilized on a magnetically-responsive solid support within the receptacle and removing other components of the sample from the receptacle. The magnetic separation station is configured to provide relative movement between the receptacle and the one or more permanent magnets after the receptacle is transported to the magnetic separation station.

4. 发明申请

US20170261431A1 CONTINUOUS PROCESS FOR PERFORMING MULTIPLE NUCLEIC ACID AMPLIFICATION ASSAYS 有权
公开(公告)号：US20170261431A1
公开(公告)日：2017-09-14
申请号：US15600245
申请日：2017-05-19
申请人： GEN-PROBE INCORPORATED
发明人： Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence LI , Byron J. KNIGHT , Robert E. HEINZ , Jerzy A. MACIOSZEK , Christopher B. DAVIS , Robert F. SCALESE
IPC分类号： G01N21/64 , G01N35/02 , C12Q1/68 , G01N35/10 , G01N21/76 , G01N35/00 , G01N35/04
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater.

5. 发明申请

US20200338559A1 METHOD FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 审中-公开
公开(公告)号：US20200338559A1
公开(公告)日：2020-10-29
申请号：US16924966
申请日：2020-07-09
申请人： GEN-PROBE INCORPORATED
发明人： Christopher B. DAVIS , Norbert D. HAGEN , James T. TUGGLE
IPC分类号： B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
摘要： A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.

6. 发明申请

US20190049378A1 CONTINUOUS PROCESS FOR PERFORMING MULTIPLE NUCLEIC ACID AMPLIFICATION ASSAYS 审中-公开
公开(公告)号：US20190049378A1
公开(公告)日：2019-02-14
申请号：US16014139
申请日：2018-06-21
申请人： GEN-PROBE INCORPORATED
发明人： Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence LI , Byron J. KNIGHT , Robert E. HEINZ , Jerzy A. MACIOSZEK , Christopher B. DAVIS , Robert F. SCALESE
IPC分类号： G01N21/64 , G01N35/04 , G01N35/10 , C12Q1/6813 , C12Q1/6851 , G01N21/76 , G01N35/02 , G01N35/00 , B01L7/00
摘要： A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures. In the method, a first plurality of reaction mixtures are provided to a heater and subjected to conditions for performing a first amplification reaction. The presence or amount of a first target nucleic acid in each of the first plurality of reaction mixtures is determined during the first amplification reaction. During the first amplification reaction, a second plurality of reaction mixtures are provided to the heater and subjected to conditions for performing a second amplification reaction. The presence or amount of a second target nucleic acid in each of the second plurality of reaction mixtures is determined during the second amplification reaction. At least a portion of the second plurality of reaction mixtures are removed from the heater during the second amplification reaction.

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