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1. 发明授权

US07397904B2 Asymmetric flattening filter for x-ray device 有权
标题翻译：用于x射线装置的非对称平坦化滤光片
公开(公告)号：US07397904B2
公开(公告)日：2008-07-08
申请号：US11127343
申请日：2005-05-11
申请人： Gary Virshup , James Boye , Edward J. Seppi , Heinrich Riem , Govin Dasani , Edward Shapiro
发明人： Gary Virshup , James Boye , Edward J. Seppi , Heinrich Riem , Govin Dasani , Edward Shapiro
IPC分类号： G21K3/00
CPC分类号： G21K1/10
摘要： Devices and methods for implementing selective, or asymmetric, attenuation of an x-ray beam. In one example, a filter is provided that is substantially in the form of a wedge where some portions of the filter are thicker, and thus provide greater attenuation, than other, thinner portions of the filter. The filter is situated between the target surface of the anode and the x-ray subject so that x-rays generated by the target pass through the filter before reaching the x-ray subject. Specifically, the filter is oriented so that the thicker portion of the filter receives the higher intensity portion of the x-ray beam, while the thinner portion of the filter receives the relatively lower intensity portion of the x-ray beam. Thus, the gain profile of the x-ray beam is flattened so that the intensity, or flux, of the x-ray beam is relatively uniform throughout a substantial portion of the beam profile.
摘要翻译：用于实现X射线束的选择性或不对称衰减的装置和方法。在一个示例中，提供基本上为楔形件的过滤器，其中过滤器的一些部分比过滤器的其它较薄部分更厚，因此提供更大的衰减。过滤器位于阳极的目标表面和X射线对象之间，使得由目标产生的x射线在到达x射线物体之前通过过滤器。具体地，过滤器被定向成使得过滤器的较厚部分接收x射线束的较高强度部分，而过滤器的较薄部分接收x射线束的较低强度部分。因此，x射线束的增益分布被平坦化，使得x射线束的强度或通量在光束轮廓的整个实质部分中相对均匀。

2. 发明授权

US08311185B2 Multi-energy x-ray source 有权
标题翻译：多能量X射线源
公开(公告)号：US08311185B2
公开(公告)日：2012-11-13
申请号：US12684069
申请日：2010-01-07
申请人： Edward J. Seppi , Gary Virshup
发明人： Edward J. Seppi , Gary Virshup
IPC分类号： H05G1/64
CPC分类号： H01J35/101 , A61B5/7289 , A61B5/7292 , A61B6/032 , A61B6/4035 , A61B6/405 , A61B6/482 , A61B6/502 , A61B6/5288 , A61B6/541 , H01J35/14 , H01J35/28 , H01J35/305 , H01J2235/088 , H01J2235/1006
摘要： A system for generating image data includes a voltage supply configured for applying a first voltage to generate radiation at a first energy level, and for applying a second voltage to generate radiation at a second energy level, an imager for generating a first set of image data based at least in part on the radiation at the first energy level, and for generating a second set of image data based at least in part on the radiation at the second energy level, and a processor for creating composite image data using the first and the second sets of image data.
摘要翻译：一种用于产生图像数据的系统包括：电压源，被配置为施加第一电压以产生处于第一能级的辐射，并且用于施加第二电压以产生第二能量级的辐射;成像器，用于产生第一组图像数据至少部分地基于第一能量级别的辐射，以及用于至少部分地基于第二能级的辐射产生第二组图像数据，以及处理器，用于使用第一和第二能量水平产生合成图像数据第二组图像数据。

3. 发明授权

US07869862B2 Systems and methods for functional imaging using contrast-enhanced multiple-energy computed tomography 有权
标题翻译：使用对比度增强多能计算机断层扫描的功能成像的系统和方法
公开(公告)号：US07869862B2
公开(公告)日：2011-01-11
申请号：US10687522
申请日：2003-10-15
申请人： Edward J. Seppi , Larry Partain , Michael Green , Gary Virshup
发明人： Edward J. Seppi , Larry Partain , Michael Green , Gary Virshup
IPC分类号： A61B6/00
CPC分类号： A61B6/405 , A61B5/7289 , A61B5/7292 , A61B6/032 , A61B6/0435 , A61B6/4035 , A61B6/4042 , A61B6/4241 , A61B6/4441 , A61B6/4488 , A61B6/466 , A61B6/481 , A61B6/482 , A61B6/502 , A61B6/504 , A61B6/5288 , A61B6/541 , G01N23/046 , G01N2223/419 , G01N2223/612 , H01J2235/081
摘要： A method of generating images of a portion of a body includes introducing a contrast agent into the body, generating a first set of image data using radiation at a first energy level after the contrast agent is introduced into the body, generating a second set of image data using radiation at a second energy level after the contrast agent is introduced into the body, and creating a volumetric composite image using the first and the second sets of image data.
摘要翻译：产生身体部分的图像的方法包括将造影剂引入体内，在将造影剂引入体内之后，以第一能量级别的辐射产生第一组图像数据，产生第二组图像在将造影剂引入身体之后，使用在第二能量级别的辐射的数据，以及使用第一和第二组图像数据创建体积合成图像。

4. 发明授权

US07649981B2 Multi-energy x-ray source 有权
标题翻译：多能量X射线源
公开(公告)号：US07649981B2
公开(公告)日：2010-01-19
申请号：US10687573
申请日：2003-10-15
申请人： Edward J. Seppi , Gary Virshup
发明人： Edward J. Seppi , Gary Virshup
IPC分类号： G21K3/00
CPC分类号： H01J35/101 , A61B5/7289 , A61B5/7292 , A61B6/032 , A61B6/4035 , A61B6/405 , A61B6/482 , A61B6/502 , A61B6/5288 , A61B6/541 , H01J35/14 , H01J35/28 , H01J35/305 , H01J2235/088 , H01J2235/1006
摘要： An apparatus for use in a radiation procedure includes a radiation filter having a first portion and a second portion, the first and the second portions forming a layer for filtering radiation impinging thereon, wherein the first portion is made from a first material having a first x-ray filtering characteristic, and the second portion is made from a second material having a second x-ray filtering characteristic. An apparatus for use in a radiation procedure includes a first target material, a second target material, and an accelerator for accelerating particles towards the first target material and the second target material to generate x-rays at a first energy level and a second energy level, respectively.
摘要翻译：用于辐射过程的装置包括具有第一部分和第二部分的辐射过滤器，第一和第二部分形成用于过滤辐射的辐射层，其中第一部分由具有第一部分和第二部分的第一材料制成，射线滤波特性，第二部分由具有第二x射线滤波特性的第二材料制成。用于辐射过程的装置包括：第一靶材料，第二靶材料和用于将颗粒朝向第一靶材料加速的加速器和第二靶材料，以在第一能级和第二能级产生X射线，分别。

5. 发明授权

US07737972B2 Systems and methods for digital volumetric laminar tomography 有权
标题翻译：数字体积层析成像系统和方法
公开(公告)号：US07737972B2
公开(公告)日：2010-06-15
申请号：US11403377
申请日：2006-04-13
申请人： Edward J. Seppi
发明人： Edward J. Seppi
IPC分类号： G06T17/00
CPC分类号： A61B6/02 , A61B6/027 , A61B6/466 , A61B6/583 , G06T11/006 , G06T2211/424
摘要： Systems and methods are provided for implementing an analytical approach to digital volumetric laminar tomography. The volumetric data visualizations generally take the form of volumetric images which approximate the spatial distribution of an x-ray attenuation coefficient throughout the region of interest in the object, such as a person, under examination. These visualizations are produced from a set of basic two dimensional data. One numerical technique employed in this regard takes the form of a process of convolution and back projection, where the convolution function is determined through the use of various analytic and empirical techniques.
摘要翻译：提供了系统和方法来实现数字体积层析成像的分析方法。体数据可视化通常采取体积图像的形式，其近似于正在检查的对象（例如人）中的感兴趣区域的x射线衰减系数的空间分布。这些可视化是由一组基本二维数据产生的。在这方面采用的一种数值技术是卷积和反投影过程的形式，其中卷积函数通过使用各种分析和经验技术来确定。

6. 发明授权

US07103137B2 Radiation scanning of objects for contraband 有权
标题翻译：违禁物品的辐射扫描
公开(公告)号：US07103137B2
公开(公告)日：2006-09-05
申请号：US10202273
申请日：2002-07-24
申请人： Edward J. Seppi , Marcel Marc , John Ford
发明人： Edward J. Seppi , Marcel Marc , John Ford
IPC分类号： G01N23/00
CPC分类号： G01V5/005 , G01N23/04 , G01N2223/423 , G01T1/2985
摘要： A scanning unit for identifying contraband within objects, such as cargo containers and luggage, moving through the unit along a first path comprises at least one source of a beam of radiation movable across a second path that is transverse to the first path and extends partially around the first path. A stationary detector transverse to the first path also extends partially around the first path, positioned to detect radiation transmitted through the object during scanning. In one example, a plurality of movable X-ray sources are supported by a semi-circular rail perpendicular to the first path and the detector, which may be a detector array is also semi-circular and perpendicular to the path. A fan beam may also be used. Radiographic images may be obtained and/or computed tomography (“CT”) images may be reconstructed. The images may be analyzed for contraband. Methods of scanning objects are also disclosed.
摘要翻译：用于识别物体内的违禁品的扫描单元，例如货物集装箱和行李箱，沿着第一路径移动通过该单元包括至少一个辐射源的源，该辐射束可跨越横向于第一路径的第二路径并部分地围绕第一条路。横向于第一路径的固定式检测器也部分地围绕第一路径延伸，定位成在扫描期间检测透过物体的辐射。在一个示例中，多个可移动X射线源由垂直于第一路径的半圆形轨道支撑，并且可以是检测器阵列的检测器阵列也是半圆形的并且垂直于路径。也可以使用扇形光束。可以获得放射照相图像和/或计算机断层摄影（“CT”）图像。图像可能被分析为违禁品。还公开了扫描对象的方法。

7. 发明授权

US5692507A Computer tomography apparatus using image intensifier detector 失效
标题翻译：使用图像增强器检测器的计算机断层摄影装置
公开(公告)号：US5692507A
公开(公告)日：1997-12-02
申请号：US352269
申请日：1994-12-07
申请人： Edward J. Seppi , Edward G. Shapiro , Robert L. Anderson
发明人： Edward J. Seppi , Edward G. Shapiro , Robert L. Anderson
IPC分类号： A61B6/03 , H04N5/32 , H05G1/64 , A61B6/00
CPC分类号： H05G1/64 , A61B6/032 , A61B6/583 , H04N5/32 , A61B6/548 , Y10S128/92
摘要： Disclosed is a low cost computer tomographic (CT) scanner system specifically designed for radiation therapy treatment planning. A 512-channel photo-diode array with digitizing electronics converts image intensifier optical projection data directly into digital signals and has a dynamic range on the order of 100,000:1. The new simulator includes a rotating gantry, an X-ray generator with radiographic and fluoroscopic modes and a therapy style patient support assembly. Results on head and body size phantoms indicate that the simulator X-ray generator and image intensifier tube (IIT) with multi-channel photo-detector can produce photon statistic limited CT images. Software and hardware compensation methods are described which minimize geometrical distortions. Low noise, high input impedance electronics are employed which are phase-locked to the line frequency. A dual sample interval method is employed which effectively increases the range of the digital signal produced by the front-end electronics by three additional bits.
摘要翻译：公开了专门用于放射治疗治疗计划的低成本计算机断层摄影（CT）扫描仪系统。具有数字化电子设备的512通道光电二极管阵列将图像增强器光学投影数据直接转换为数字信号，并具有100,000：1的动态范围。新的模拟器包括旋转机架，具有放射照相和透视模式的X射线发生器和治疗方式的患者支撑组件。头部和体型模型的结果表明，具有多通道光电探测器的模拟器X射线发生器和图像增强管（IIT）可以产生光子统计有限的CT图像。描述了最小化几何失真的软件和硬件补偿方法。使用低噪声，高输入阻抗电子器件，其与线路频率锁相。采用双采样间隔方法，其通过三个附加位有效地增加由前端电子器件产生的数字信号的范围。

8. 发明授权

US4452081A Measurement of velocity and tissue temperature by ultrasound 失效
标题翻译：通过超声测量速度和组织温度
公开(公告)号：US4452081A
公开(公告)日：1984-06-05
申请号：US429579
申请日：1982-09-30
申请人： Edward J. Seppi
发明人： Edward J. Seppi
IPC分类号： A61B8/00 , G01H5/00 , G01K11/24 , G01N29/07 , G01S15/88 , G01N29/00 , G01K11/22
CPC分类号： G01H5/00 , G01K11/24 , G01N29/07 , G01N2291/02881
摘要： Temperature inside a tissue volume is noninvasively determined on the basis of its known relationship with the velocity of ultrasound inside the volume. The velocity of ultrasound between two field points inside the volume of interest is calculated from measurements of differences in transit times of sound beams scattered in substantially opposite directions at these field points.
摘要翻译：基于其与体积内的超声波速度的已知关系，非组织地确定组织体积内的温度。通过在这些场点处以基本相反方向散射的声束的传播时间差的测量来计算感兴趣体积内的两个场点之间的超声波速度。

9. 发明授权

US08000436B2 Radiation scanning units including a movable platform 失效
标题翻译：辐射扫描装置包括可移动平台
公开(公告)号：US08000436B2
公开(公告)日：2011-08-16
申请号：US12080860
申请日：2008-04-07
申请人： Edward J. Seppi , John Ford , Marcel Marc
发明人： Edward J. Seppi , John Ford , Marcel Marc
IPC分类号： G01N23/00
CPC分类号： G01V5/005 , G01N23/046 , G01N2223/419
摘要： A scanning unit for inspecting objects comprises in one example a radiation source, a movable platform to support an object, and a detector positioned to receive radiation after interaction of radiation with the object. The platform is movable at least partially within a cavity defined, at least partially, below at least one of the source or the detector. In another scanning unit, a first conveyor conveys an object to a movable platform, and second and third conveyors convey the object from the platform. The second and third conveyors are at different vertical heights. In another scanning unit, images from an energy sensitive detector and a spatial detector are fused. In a method, scanning parameters during CT scanning are changed and images reconstructed before and after the change. In another method, an object is scanned with X-ray beams having first and second energy distributions, generated by the same X-ray source.
摘要翻译：用于检查物体的扫描单元在一个示例中包括辐射源，用于支撑物体的可移动平台以及定位成在辐射与物体相互作用之后接收辐射的检测器。该平台至少部分地在至少部分地在源或检测器中的至少一个之下限定的空腔内移动。在另一个扫描单元中，第一输送器将物体传送到可移动平台，第二和第三输送机从平台传送物体。第二和第三输送机处于不同的垂直高度。在另一个扫描单元中，来自能量敏感检测器和空间检测器的图像被融合。在一种方法中，CT扫描期间的扫描参数被改变，并且在改变之前和之后重建图像。在另一种方法中，用具有由相同X射线源产生的第一和第二能量分布的X射线束扫描物体。

10. 发明授权

US07945021B2 Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager 有权
标题翻译：多模锥束CT放射治疗模拟器和平板成像机的治疗机
公开(公告)号：US07945021B2
公开(公告)日：2011-05-17
申请号：US10324227
申请日：2002-12-18
申请人： Edward G. Shapiro , Edward J. Seppi , John M. Pavkovich , Peter Munro , Stanley W. Johnsen , Richard E. Colbeth
发明人： Edward G. Shapiro , Edward J. Seppi , John M. Pavkovich , Peter Munro , Stanley W. Johnsen , Richard E. Colbeth
IPC分类号： A61N5/10 , H05G1/64 , A61B6/03
CPC分类号： A61N5/1049 , A61B6/032 , A61B6/0457 , A61B6/4085 , A61B6/42 , A61B6/4208 , A61B6/4233 , A61B6/4241 , A61B6/461 , A61B6/487 , A61N5/10 , A61N5/103 , A61N5/1031 , A61N5/1039 , A61N5/1048 , A61N5/1064 , A61N2005/1054 , A61N2005/1061 , G01T1/202
摘要： A multi-mode cone beam computed tomography radiotherapy simulator and treatment machine is disclosed. The radiotherapy simulator and treatment machine both include a rotatable gantry on which is positioned a cone-beam radiation source and a flat panel imager. The flat panel imager captures x-ray image data to generate cone-beam CT volumetric images used to generate a therapy patient position setup and a treatment plan.
摘要翻译：公开了一种多模式锥束计算机断层摄影放射治疗模拟器和治疗机。放射治疗模拟器和处理机都包括可旋转的台架，其上定位有锥束辐射源和平板成像器。平板成像仪捕获X射线图像数据以产生用于产生治疗患者位置设置和治疗计划的锥束CT体积图像。

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