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1. 发明授权

US08320518B2 Methods, apparatus, and computer-program products for increasing accuracy in cone-beam computed tomography 有权
标题翻译：方法，装置和计算机程序产品，用于提高锥束计算机断层扫描的精度
公开(公告)号：US08320518B2
公开(公告)日：2012-11-27
申请号：US13209323
申请日：2011-08-12
申请人： Larry Partain
发明人： Larry Partain
IPC分类号： A61B6/03 , H05G1/64 , G21K1/04
CPC分类号： A61B6/032 , A61B6/035 , A61B6/06 , A61B6/4085 , G21K1/043 , G21K1/046
摘要： Portions of the radiation source are obscured so that the radiation only passes through the specific areas of the patient related to the regions-of-interest to the doctor. Scattered radiation received by detector pixels that are obscured by direct-line of sight radiation are used to estimate the scattered radiation in the un-obscured portion, which can be used to increase the accuracy of the image taken through the un-obscured portion.
摘要翻译：辐射源的一部分被遮蔽，使得辐射仅通过患者的与感兴趣区域相关的特定区域到医生。被直接视线辐射遮蔽的检测器像素所接收到的散射辐射被用于估计未遮蔽部分中的散射辐射，其可用于增加通过未遮蔽部分拍摄的图像的精度。

2. 发明申请

US20110299652A1 METHODS, APPARATUS, AND COMPUTER-PROGRAM PRODUCTS FOR INCREASING ACCURACY IN CONE-BEAM COMPUTED TOMOGRAPHY 有权
标题翻译：方法，装置和计算机程序产品，用于提高锥形计算机图像中的精度
公开(公告)号：US20110299652A1
公开(公告)日：2011-12-08
申请号：US13209323
申请日：2011-08-12
申请人： Larry Partain
发明人： Larry Partain
IPC分类号： A61B6/03
CPC分类号： A61B6/032 , A61B6/035 , A61B6/06 , A61B6/4085 , G21K1/043 , G21K1/046
摘要： Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography.
摘要翻译：公开了用于增加锥束计算机断层摄影的精度的方法，系统和计算机产品程序。

3. 发明申请

US20090190714A1 Methods, Apparatus, and Computer-Program Products for Increasing Accuracy in Cone-Beam Computed Tomography 有权
标题翻译：方法，装置和计算机程序产品，用于提高锥形计算机断层扫描的精度
公开(公告)号：US20090190714A1
公开(公告)日：2009-07-30
申请号：US12360795
申请日：2009-01-27
申请人： Larry Partain
发明人： Larry Partain
IPC分类号： H05G1/60
CPC分类号： A61B6/032 , A61B6/035 , A61B6/06 , A61B6/4085 , G21K1/043 , G21K1/046
摘要： Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography.
摘要翻译：公开了用于增加锥束计算机断层摄影的精度的方法，系统和计算机产品程序。

4. 发明授权

US07177386B2 Breathing synchronized computed tomography image acquisition 有权
标题翻译：呼吸同步计算机断层摄影图像采集
公开(公告)号：US07177386B2
公开(公告)日：2007-02-13
申请号：US10801947
申请日：2004-03-15
申请人： Hassan Mostafavi , Edward J. Seppi , Larry Partain
发明人： Hassan Mostafavi , Edward J. Seppi , Larry Partain
IPC分类号： H05G1/00
CPC分类号： A61B6/032 , A61B5/1135 , A61B5/7289 , A61B6/4441 , A61B6/541
摘要： A method for collecting computed tomography (CT) image data includes determining a number of intervals N into which a respiratory cycle is to be divided, determining a number of respiratory cycles M to be covered in one gantry rotation, and rotating a gantry to collect at least M×N sets of CT image data of at least a portion of a patient, wherein each set of the CT image data corresponds to a phase of a respiratory cycle.
摘要翻译：收集计算机断层摄影（CT）图像数据的方法包括确定要分割呼吸周期的间隔N的数量，确定在一台架旋转中要覆盖的呼吸周期M的数量，以及旋转台架以收集至少一部分患者的至少M×N组CT图像数据组，其中每组CT图像数据对应于呼吸周期的相位。

5. 发明申请

US20070023853A1 Megavoltage imaging with a photoconductor based sensor 有权
标题翻译：用基于感光体的传感器进行Megavoltage成像
公开(公告)号：US20070023853A1
公开(公告)日：2007-02-01
申请号：US11193162
申请日：2005-07-29
申请人： Larry Partain , George Zentai
发明人： Larry Partain , George Zentai
IPC分类号： H01L31/00
CPC分类号： G01T1/24
摘要： A photodetector for detecting megavoltage (MV) radiation comprises a semiconductor conversion layer having a first surface and a second surface disposed opposite the first surface, a first electrode coupled to the first surface, a second electrode coupled to the second surface, and a low density substrate including a detector array coupled to the second electrode opposite the semiconductor conversion layer. The photodetector includes a sufficient thickness of a high density material to create a sufficient number of photoelectrons from incident MV radiation, so that the photoelectrons can be received by the conversion layer and converted to a sufficient of recharge carriers for detection by the detector array.
摘要翻译：用于检测兆伏特（MV）辐射的光电检测器包括半导体转换层，其具有与第一表面相对布置的第一表面和第二表面，耦合到第一表面的第一电极，耦合到第二表面的第二电极和低密度衬底，包括耦合到与半导体转换层相对的第二电极的检测器阵列。光电检测器包括足够厚度的高密度材料以从入射的MV辐射产生足够数量的光电子，使得光电子能够被转换层接收并转换成足够的再充电载体，以便由检测器阵列检测。

6. 发明申请

US20130071333A1 METHOD AND SYSTEM FOR IDENTIFYING, ASSESSING, AND MANAGING CANCER GROWTH RATES AND POTENTIAL METASTASIS 有权
标题翻译：识别，评估和管理癌症生长率和潜在的细胞因子的方法和系统
公开(公告)号：US20130071333A1
公开(公告)日：2013-03-21
申请号：US13623098
申请日：2012-09-19
申请人： Larry PARTAIN , Mingshan SUN , Edward J. SEPPI , Raisa PAVLYUCHKOVA , Arundhuti GANGULY , Stavros PRIONAS , James E. CLAYTON
发明人： Larry PARTAIN , Mingshan SUN , Edward J. SEPPI , Raisa PAVLYUCHKOVA , Arundhuti GANGULY , Stavros PRIONAS , James E. CLAYTON
IPC分类号： A61K49/04
CPC分类号： G06F19/3431 , G06F19/00 , G06K9/6277 , G06K2209/053 , G16H50/30
摘要： Techniques described herein generally relate to identifying, assessing, and managing cancer growth rates and potential metastasis. Some example methods may include constructing one or more quantitative metrics for the potential metastasis in a selected population of other patients, acquiring a first set of numeric biomarker data for the patient before having placed a biomarker in the patient, acquiring a second set of numeric biomarker data for the patient after having placed the biomarker in the patient, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, and predicting quantitative and objective risk for the cancer growth rates and potential metastasis and adjusting a treatment plan based on the biomarker surrogate values and at least one of the one or more quantitative metrics.
摘要翻译：本文描述的技术通常涉及鉴定，评估和管理癌症生长速度和潜在转移。一些示例性方法可以包括为所选择的其他患者群体中的潜在转移构建一个或多个定量度量，在将患者的生物标志物置于患者体内之前获取患者的第一组数值生物标志物数据，获取第二组数值生物标志物基于从第一组数字生物标志物数据和第二组数值生物标志物数据导出的平均数值生物标志物差异，确定用于微血管密度信息的生物标记替代值的集合，确定患者的数据;确定基于从第一组数值生物标志物数据和第二组数值生物标志物数据得出的平均数值生物标志物差异的微血管密度信息的一组生物标志物替代值，并预测癌症生长速率和潜在转移的定量和客观风险，根据生物标志物代理调整治疗计划值和至少一个一个或多个定量度量。

7. 发明授权

US07660384B2 Contrast-enhanced cone beam X-ray imaging, evaluation, monitoring and treatment delivery 有权
标题翻译：对比增强锥束X射线成像，评估，监测和治疗交付
公开(公告)号：US07660384B2
公开(公告)日：2010-02-09
申请号：US12126224
申请日：2008-05-23
申请人： Larry Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
发明人： Larry Partain , Stavros Prionas , Edward Seppi , Robert Sutherland , David Humber , Hassan Mostafavi , Felix Fernando , John Boone
IPC分类号： A61B6/04
CPC分类号： A61B6/4241 , A61B6/032 , A61B6/4085 , A61B6/482 , A61B6/502 , A61B6/507
摘要： A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.
摘要翻译：使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器生成三维计算机断层摄影图像数据集，其解析尺寸为0.4mm的体素或至少两个正交方向。

8. 发明申请

US20050092925A1 Process to reduce the dark current in semiconducting films 失效
标题翻译：减少半导体薄膜中的暗电流的过程
公开(公告)号：US20050092925A1
公开(公告)日：2005-05-05
申请号：US10701724
申请日：2003-11-04
申请人： George Zentai , Larry Partain , Raisa Pavlyunchkova , Kanai Shah , Paul Bennett
发明人： George Zentai , Larry Partain , Raisa Pavlyunchkova , Kanai Shah , Paul Bennett
IPC分类号： G01J5/20 , H01L21/00 , H01L21/36 , H01L21/368 , H01L27/14 , H01L31/00 , H01L31/115 , H01L31/18
CPC分类号： H01L31/18 , H01L21/02521 , H01L21/02601 , H01L21/02628 , H01L31/115
摘要： A method of coating the joined crystals within a semiconductor conversion layer to reduce the dark current without compromising the sensitivity of the conversion layer is presented. A semiconductor conversion layer comprising a plurality of joined crystals and permeated by a polymer material and having microscopic voids is also presented.
摘要翻译：提出了在半导体转换层内涂覆结合的晶体以减少暗电流而不损害转换层的灵敏度的方法。还提供了包含多个接合晶体并且被聚合物材料渗透并具有微小空隙的半导体转换层。

9. 发明申请

US20050056829A1 Reducing dark current of photoconductor using heterojunction that maintains high x-ray sensitivity 审中-公开
标题翻译：使用保持高X射线灵敏度的异质结降低光电导体的暗电流
公开(公告)号：US20050056829A1
公开(公告)日：2005-03-17
申请号：US10665298
申请日：2003-09-17
申请人： Michael Green , Steve Bandy , George Zentai , Larry Partain
发明人： Michael Green , Steve Bandy , George Zentai , Larry Partain
IPC分类号： H01L20060101 , H01L29/08 , H01L31/115
CPC分类号： H01L31/115
摘要： A photodetector having a heterojunction structure is described that may operate to reduce contact corrosion and/or reduce dark current while maintaining high x-ray sensitivity. The heterojunction structure may be formed by a plurality of halide semiconductor materials.
摘要翻译：描述了具有异质结结构的光电检测器，其可以在保持高的x射线灵敏度的同时降低接触腐蚀和/或降低暗电流。异质结结构可以由多个卤化物半导体材料形成。

10. 发明授权

US08483803B2 Systems and methods for tracking and targeting object in a patient using imaging techniques 有权
标题翻译：使用成像技术跟踪和定位患者对象的系统和方法
公开(公告)号：US08483803B2
公开(公告)日：2013-07-09
申请号：US12210813
申请日：2008-09-15
申请人： Larry Partain , Hassan Mostafavi , Stavros Prionas
发明人： Larry Partain , Hassan Mostafavi , Stavros Prionas
IPC分类号： A61B6/00
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1061 , G06K9/3241 , G06K2209/053 , G06T7/74
摘要： A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, wherein the contrast-enhanced image and the non-contrast-enhanced image are created at different times, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image. A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image, wherein the act of determining the position is performed is substantially real time.
摘要翻译：一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的该部分具有物体，获得该部分的非对比度增强图像，其中对比度增强图像和在不同时间创建非对比度增强图像，并且使用对比度增强图像和非对比度增强图像来确定对象的位置。一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的部分具有物体，获得该部分的非对比度增强图像，以及确定该对象的位置使用对比度增强图像和非对比度增强图像，其中执行确定位置的动作基本上是实时的。

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