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1. 发明授权

US06825035B1 Compositions and methods for modulating expression within smooth muscle cells 有权
标题翻译：调节平滑肌细胞内表达的组成和方法
公开(公告)号：US06825035B1
公开(公告)日：2004-11-30
申请号：US09807757
申请日：2001-04-17
申请人： Gary K. Owens , Christopher Mack , Randall Blank
发明人： Gary K. Owens , Christopher Mack , Randall Blank
IPC分类号： C12N510
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0375 , A61K48/00 , C07K14/4716 , C12N15/8509
摘要： The present invention relates to promoters, enhancers and other regulatory elements that direct expression within SMC, comprising nucleotide sequences from the 5′ regulatory region and the first intron, and transcriptionally active fragments thereof, that control expression of an SM &agr;-A. Specifically provided are expression vectors, host cells and transgenic animals wherein an SM &agr;-A regulatory region is capable of controlling expression of a heterologous gene, over-expressing an endogenous SMC gene or an inhibitor of a pathological process or knocking out expression of a specific gene believed to be important for an SM-related disease in SMC. The invention also relates to methods for using said vectors, cells and animals for screening candidate molecules for agonists and antagonists of disorders involving SMC. The invention further relates to compositions and methods for modulating expression of compounds within SMC, and to screening compounds that modulate expression within SMC. Methods for using the molecules and compounds identified by the screening assays for therapeutic treatments also are provided.
摘要翻译：本发明涉及在SMC内直接表达的启动子，增强子和其它调控元件，其包含控制SMα-A表达的来自5'调控区和第一内含子的转录活性片段。具体提供的是表达载体，宿主细胞和转基因动物，其中SMα-A调节区能够控制异源基因的表达，过表达内源性SMC基因或病理过程的抑制剂或敲除特异性基因被认为对SMC中SM相关疾病很重要。本发明还涉及使用所述载体，细胞和动物筛选用于激动剂的候选分子和涉及SMC的病症拮抗剂的方法。本发明还涉及用于调节SMC内化合物表达的组合物和方法，以及筛选调节SMC内的表达的化合物。还提供了通过筛选测定法鉴定的分子和化合物用于治疗性治疗的方法。

2. 发明授权

US07713573B2 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US07713573B2
公开(公告)日：2010-05-11
申请号：US11352436
申请日：2006-02-10
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

3. 发明授权

US06914136B2 Methods and compositions for expressing polynucleotides specifically in smooth muscle cells in vivo 有权
标题翻译：在体内在平滑肌细胞中特异性表达多核苷酸的方法和组合物
公开(公告)号：US06914136B2
公开(公告)日：2005-07-05
申请号：US10057726
申请日：2002-01-24
申请人： Gary K. Owens , Ichiro Manabe
发明人： Gary K. Owens , Ichiro Manabe
IPC分类号： A61K48/00 , C12N15/85 , C07H21/04 , A01K67/027 , C12N5/16 , C12N15/63
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C12N2830/008 , C12N2830/85
摘要： The present invention generally relates to promoters, enhancers and other regulatory elements of smooth muscle cells (“SMC”). The invention more particularly relates to methods for the targeted knockout, or over-expression, of genes of interest within smooth muscle cells or within a subtype of smooth muscle cells. The invention further relates to methods of conferring polynucleotide expression in vivo specifically in smooth muscle cells or in subtypes of smooth muscle cells.
摘要翻译：本发明一般涉及平滑肌细胞（“SMC”）的启动子，增强子和其他调控元件。本发明更具体地涉及在平滑肌细胞内或平滑肌细胞亚型内目标敲除或过度表达感兴趣的基因的方法。本发明还涉及在体内特异性地赋予平滑肌细胞或平滑肌细胞亚型的多核苷酸表达的方法。

4. 发明授权

US06780610B1 Identification of a smooth muscle cell (SMC) specific smooth muscle heavy chain (SM-MHC) promoter/enhancer 有权
标题翻译：鉴定平滑肌细胞（SMC）特异性平滑肌重链（SM-MHC）启动子/增强子
公开(公告)号：US06780610B1
公开(公告)日：2004-08-24
申请号：US09600319
申请日：2000-07-13
申请人： Gary K. Owens , Cort Madsen
发明人： Gary K. Owens , Cort Madsen
IPC分类号： C12N516
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K48/0058 , C12N2830/008
摘要： The present invention generally relates to promoters, enhancers and other regulatory elements of smooth muscle cells (“SMC”). The invention also generally relates to the use of these promoters, enhancers and other regulatory elements of SMC to create animal models to study SMC physiology and pathophysiology. The invention further relates to a smooth muscle myosin heavy chain (SM-MHC) promoter/enhancer element which is capable of conferring SMC-specific gene expression in vivo. The invention also relates to methods for the targeted knockout, or over-expression, of genes of interest within smooth muscle cells. The invention further relates to methods of conferring smooth muscle cell specific gene expression in vivo.
摘要翻译：本发明一般涉及平滑肌细胞（“SMC”）的启动子，增强子和其他调控元件。本发明还通常涉及SMC的这些启动子，增强子和其他调节元件的用途来产生用于研究SMC生理学和病理生理学的动物模型。本发明还涉及能够在体内赋予SMC特异性基因表达的平滑肌肌球蛋白重链（SM-MHC）启动子/增强子元件。本发明还涉及在平滑肌细胞内目标敲除或过度表达目的基因的方法。本发明还涉及赋予体内平滑肌细胞特异性基因表达的方法。

5. 发明申请

US20100260922A1 Method for loading nanoporous layers with therapeutic agent 有权
公开(公告)号：US20100260922A1
公开(公告)日：2010-10-14
申请号：US12660282
申请日：2010-02-23
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L31/16
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

6. 发明授权

US08623066B2 Cell seeded expandable body 有权
标题翻译：细胞种子扩张体
公开(公告)号：US08623066B2
公开(公告)日：2014-01-07
申请号：US11963624
申请日：2007-12-21
申请人： Kareen Looi , Gary K. Owens
发明人： Kareen Looi , Gary K. Owens
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/0077 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61L31/005 , A61L31/088 , A61L31/146 , A61L2400/12
摘要： Devices, systems and methods for treating medical conditions using cell therapy via body lumens. Localized delivery is achieved with the use of a stent-like expandable body seeded with cells. The expandable body is expanded to contact at least a portion of the inner walls of the body lumen and the cells, cellular products and/or other therapeutic agents are delivered to the surrounding tissue. The therapeutic benefit provided is dependent on the type of cells used and the features of the expandable body.
摘要翻译：用于通过体腔使用细胞治疗来治疗医疗状况的装置，系统和方法。通过使用接种细胞的支架式可扩张体实现局部递送。可膨胀体膨胀以接触体腔的至少一部分内壁，并将细胞，细胞产物和/或其它治疗剂递送至周围组织。所提供的治疗益处取决于所使用的细胞的类型和可扩张体的特征。

7. 发明授权

US08449602B2 Methods for using a stent having nanoporous layers 有权
标题翻译：使用具有纳米多孔层的支架的方法
公开(公告)号：US08449602B2
公开(公告)日：2013-05-28
申请号：US11352426
申请日：2006-02-10
申请人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
发明人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： Implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents are described. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy to create the pores of the porous layer. The porous layer may be adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. The medical device may be a vascular stent having at least one porous layer adapted to resist stenosis or cellular proliferation.
摘要翻译：描述了具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法以及用治疗剂装载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种成分，而不会通常除去混合物或合金的其它组分以产生多孔层的孔。多孔层可适用于粘合非金属涂层，包括药物洗脱聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。医疗装置可以是具有适于抵抗狭窄或细胞增殖的至少一个多孔层的血管支架。

8. 发明申请

US20080138378A1 CELL SEEDED EXPANDABLE BODY 有权
标题翻译：细胞种子可扩展体
公开(公告)号：US20080138378A1
公开(公告)日：2008-06-12
申请号：US11963624
申请日：2007-12-21
申请人： Kareen Looi , Gary K. Owens
发明人： Kareen Looi , Gary K. Owens
IPC分类号： A61F2/06 , A61K35/00
CPC分类号： A61F2/915 , A61F2/0077 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61L31/005 , A61L31/088 , A61L31/146 , A61L2400/12
摘要： Devices, systems and methods for treating medical conditions using cell therapy via body lumens. Localized delivery is achieved with the use of a stent-like expandable body seeded with cells. The expandable body is expanded to contact at least a portion of the inner walls of the body lumen and the cells, cellular products and/or other therapeutic agents are delivered to the surrounding tissue. The therapeutic benefit provided is dependent on the type of cells used and the features of the expandable body.
摘要翻译：用于通过体腔使用细胞治疗来治疗医疗状况的装置，系统和方法。通过使用接种细胞的支架式可扩张体实现局部递送。可膨胀体膨胀以接触体腔的至少一部分内壁，并将细胞，细胞产物和/或其它治疗剂递送至周围组织。所提供的治疗益处取决于所使用的细胞的类型和可扩张体的特征。

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