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1. 发明授权

US07713573B2 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US07713573B2
公开(公告)日：2010-05-11
申请号：US11352436
申请日：2006-02-10
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

2. 发明申请

US20100260922A1 Method for loading nanoporous layers with therapeutic agent 有权
公开(公告)号：US20100260922A1
公开(公告)日：2010-10-14
申请号：US12660282
申请日：2010-02-23
申请人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L31/16
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

3. 发明授权

US08449602B2 Methods for using a stent having nanoporous layers 有权
标题翻译：使用具有纳米多孔层的支架的方法
公开(公告)号：US08449602B2
公开(公告)日：2013-05-28
申请号：US11352426
申请日：2006-02-10
申请人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
发明人： Whye-Kei Lye , Gary K. Owens , Brian R. Wamhoff , Matthew S. Hudson , Joshua Spradlin , Kareen Looi
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： Implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents are described. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy to create the pores of the porous layer. The porous layer may be adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. The medical device may be a vascular stent having at least one porous layer adapted to resist stenosis or cellular proliferation.
摘要翻译：描述了具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法以及用治疗剂装载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种成分，而不会通常除去混合物或合金的其它组分以产生多孔层的孔。多孔层可适用于粘合非金属涂层，包括药物洗脱聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。医疗装置可以是具有适于抵抗狭窄或细胞增殖的至少一个多孔层的血管支架。

4. 发明授权

US08124166B2 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US08124166B2
公开(公告)日：2012-02-28
申请号：US12660282
申请日：2010-02-23
申请人： Gary Owens , Brian Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary Owens , Brian Wamhoff , Matthew S. Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

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