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1. 发明授权

US07717952B2 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US07717952B2
公开(公告)日：2010-05-18
申请号：US11586285
申请日：2006-10-25
申请人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
发明人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

2. 发明申请

US20080255580A1 MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH SEPARATION 有权
标题翻译：医疗器械输送系统与分离
公开(公告)号：US20080255580A1
公开(公告)日：2008-10-16
申请号：US12059241
申请日：2008-03-31
申请人： GRANT T. HOFFMAN , Brian C. Case
发明人： GRANT T. HOFFMAN , Brian C. Case
IPC分类号： A61B17/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97
摘要： Medical device delivery systems and associated methods are provided. Delivery systems according to the invention include an elongated tubular member and a body member, such as a dilator, disposed therein. An intraluminal medical device is disposed on the dilator and within the tubular member prior to deployment. The delivery system includes a means for separating two or more portions of the distal end of the tubular member that aids in deploying the intraluminal medical device from the delivery system by separating two or more portions of the tubular member from each other to facilitate release of the intraluminal medical device from the body member. Various structures can be used for means for separating, including a cutting ring, activateable material on the tubular member, or other suitable structure. The provided devices and methods reduce friction occuring from relative movement between the sheath and dilator during deployment.
摘要翻译：提供医疗器械输送系统及相关方法。根据本发明的递送系统包括细长的管状构件和设置在其中的诸如扩张器的主体构件。在展开之前，将管腔内医疗装置设置在扩张器上并在管状构件内。递送系统包括用于分离管状构件的远端的两个或更多个部分的装置，其通过将管状构件的两个或更多个部分彼此分离来有助于将管腔内医疗装置从输送系统展开以便于释放管腔内医疗器械从身体成员。各种结构可以用于分离的装置，包括切割环，管状构件上的可激活材料或其他合适的结构。所提供的装置和方法减少在展开期间由护套和扩张器之间的相对运动发生的摩擦力。

3. 发明授权

US09421096B2 Artificial valve prosthesis with improved flow dynamics 有权
标题翻译：具有改善流动动力学的人造瓣膜假体
公开(公告)号：US09421096B2
公开(公告)日：2016-08-23
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

4. 发明授权

US08852140B2 System and method for adjustment of blood separation procedure parameters 有权
标题翻译：血液分离手术参数调整系统及方法
公开(公告)号：US08852140B2
公开(公告)日：2014-10-07
申请号：US13345305
申请日：2012-01-06
申请人： John W. Barry, Jr. , Brian C. Case , Lan T. Nguyen
发明人： John W. Barry, Jr. , Brian C. Case , Lan T. Nguyen
IPC分类号： B01D17/12 , B01D17/00 , B01D43/00 , A61M1/36
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3672 , A61M2202/0427
摘要： Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.
摘要翻译：提供了用于自动调整血液分离程序的操作参数的系统和方法。血液分离装置具有用于使流体流入的入口和用于从其中除去流体的出口。提供用于将流体移入和移出设备的泵系统。在使用中，将血液输送到装置中，其中血小板与至少一部分血液分离。控制器确定设备中血小板的量。至少部分地基于装置中的血小板的量，采取纠正措施以避免装置中的血小板聚集。纠正措施可能是将升高量的抗凝血剂输送到血液和/或装置中，并且可以在所确定的血小板接近，满足或超过血小板聚集的阈值预测可能性时开始。

5. 发明申请

US20120297255A1 SYSTEM AND METHOD TO BETTER ASSURE CORRECT USE OF PRE-PROGRAMMED MEDICAL DEVICES 审中-公开
标题翻译：更好地确保预编程医疗设备的正确使用的系统和方法
公开(公告)号：US20120297255A1
公开(公告)日：2012-11-22
申请号：US13110520
申请日：2011-05-18
申请人： Brian C. Case , Lan T. Nguyen
发明人： Brian C. Case , Lan T. Nguyen
IPC分类号： G06F11/07
CPC分类号： G16H40/60 , A61B34/10 , A61M1/34 , A61M1/3403 , A61M2205/33 , A61M2205/3334 , G06F19/00 , G06F21/31 , G08B3/10 , G08B5/22 , G16H10/60 , H05K999/99
摘要： Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject.
摘要翻译：提供了用于执行关于受试者的医疗程序的系统和方法。系统的数据存储位置用多个对象数据条目进行预编程，每个对象数据条目具有与其相关联的对象特定信息。用户界面从对象接收与被摄体的身份相对应的身份输入。控制器与数据库和用户界面相关联，并被编程为将身份输入与主题数据条目进行比较。如果身份输入对应于对象数据条目的被摄体特定信息，则控制器命令治疗装置对被摄体进行医疗处理。否则，如果身份输入不对应于任何主题数据条目的主题特定信息，则控制器产生阻止相对于被摄体执行医疗程序的错误信号。

6. 发明授权

US08157857B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08157857B2
公开(公告)日：2012-04-17
申请号：US12605585
申请日：2009-10-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

7. 发明授权

US08128682B2 Medical device with tensionably attached remodelable material 有权
标题翻译：具有可张力连接的可重塑材料的医疗装置
公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

8. 发明申请

US20120041777A1 MOBILE APPLICATIONS FOR BLOOD CENTERS 审中-公开
标题翻译：用于血液中心的移动应用程序
公开(公告)号：US20120041777A1
公开(公告)日：2012-02-16
申请号：US13209161
申请日：2011-08-12
申请人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christine M. Larson
发明人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christine M. Larson
IPC分类号： G06Q10/08 , G06Q50/22
CPC分类号： G16H40/63 , G06F19/3418 , G06Q10/087 , G06Q10/1093 , G06Q50/22 , G06T11/206 , G16H10/60
摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood collection instruments via a mobile device. An example method for blood collection instrument management includes providing a graphical representation of one or more blood collection instruments with a visual indication of a status for each instrument. The graphical representation is to visually convey information regarding each of the one or more blood collection instruments and is selectable by a user to provide additional information regarding each of the one or more blood collection instruments. The method includes facilitating access to troubleshoot and interact with the one or more blood collection instruments via the mobile device. The method includes dynamically updating the status for each instrument via communication between the mobile device and one or more blood collection facilities at which the one or more blood collection instruments are located.
摘要翻译：某些实例提供了通过移动设备提供关于采血仪器的信息的系统，方法和装置。用于采血仪器管理的示例性方法包括提供一个或多个采血器具的图形表示，其具有每个器械的状态的视觉指示。图形表示是视觉地传达关于一个或多个采血器具中的每一个的信息，并且可由用户选择以提供关于一个或多个采血器械中的每一个的附加信息。该方法包括便利访问以经由移动设备对一个或多个采血器具进行故障排除和交互。该方法包括通过移动设备与一个或多个采血设备所在的一个或多个血液采集设备之间的通信动态地更新每个仪器的状态。

9. 发明申请

US20120038651A1 MOBILE APPLICATIONS FOR BLOOD CENTERS 有权
标题翻译：用于血液中心的移动应用程序
公开(公告)号：US20120038651A1
公开(公告)日：2012-02-16
申请号：US13209151
申请日：2011-08-12
申请人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Christopher D. Gassman
发明人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Christopher D. Gassman
IPC分类号： G06T11/20
CPC分类号： G16H40/63 , G06F19/00 , G06F19/3418 , G06Q10/087 , G06Q10/1093 , G06Q50/22 , G06T11/206 , G16H10/60
摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood donation. Certain examples include a method for providing blood collection information to a donor. The method includes displaying a graphical representation of a donor's donation progress toward a goal for blood component collection to a donor via an executable application icon on a mobile device. The graphical representation is to provide a visual indication of the donor's donation progress toward a goal. The donor's donation progress toward the goal is based on data from a donation facility provided to the mobile device and is displayed via the graphical representation without the donor executing the application. The method includes facilitating access to additional blood donation information for the donor by executing the application via the graphical representation on the mobile device. The method includes facilitating donor action with respect to the blood donation information via the mobile device.
摘要翻译：某些例子提供了提供有关献血信息的系统，方法和装置。某些实例包括用于向供体提供血液采集信息的方法。该方法包括通过移动设备上的可执行应用程序图标向献血者显示献血者捐赠进展的向血液成分收集的目标的图示。图形表示是提供捐赠者向目标进行捐赠进展的视觉指示。捐助者对目标的捐赠进展是基于提供给移动设备的捐赠设施的数据，并且通过图形表示显示，而捐助者没有执行应用程序。该方法包括通过经由移动设备上的图形表示来执行应用来促进对供体的附加献血信息的访问。该方法包括促进通过移动设备的献血信息的供体动作。

10. 发明授权

US08038708B2 Implantable device with remodelable material and covering material 有权
标题翻译：具有可重塑材料和覆盖材料的植入式装置
公开(公告)号：US08038708B2
公开(公告)日：2011-10-18
申请号：US11640674
申请日：2006-12-18
申请人： Brian C. Case , Charles W. Agnew
发明人： Brian C. Case , Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078
摘要： Medical devices for implantation within a body vessel can include a remodelable material, such as an extracellular matrix material, positioned within a lumen defined by an outer covering material. The covering material is preferably substantially non-remodelable, and can be supported by a radially expandable frame. The medical device can also include a valve means positioned within the covering material. The valve means can include one or more valve leaflets formed from the remodelable material, and a separate valve support frame. One or more therapeutic agents can be associated with the remodelable material or the covering material.
摘要翻译：用于植入体内容器的医疗装置可以包括位于由外覆盖材料限定的内腔内的可重塑材料，例如细胞外基质材料。覆盖材料优选基本上不可重塑，并且可以由可径向扩张的框架支撑。医疗装置还可以包括定位在覆盖材料内的阀装置。阀装置可以包括由可重塑材料形成的一个或多个瓣膜单元和单独的阀支撑框架。一种或多种治疗剂可与可重塑材料或覆盖材料相关联。

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