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1. 发明申请

US20050085424A1 Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof 失效
标题翻译：具有弹性蛋白酶抑制活性的杂环化合物及其中间体
公开(公告)号：US20050085424A1
公开(公告)日：2005-04-21
申请号：US10502768
申请日：2003-02-05
申请人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
发明人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
IPC分类号： A61K38/00 , A61P11/00 , A61P43/00 , C07K5/06 , A61K38/04 , C07K5/04 , C07D43/02
CPC分类号： C07K5/06191 , A61K38/00
摘要： Heterocyclic compounds represented by the general formula (I) and having elastase inhibiting activity; and intermediates for the synthesis thereof: (I) wherein R1 is a heterocyclic group represented by the general formula (II): (II) [wherein A represents the presence or absence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogen or CH], and the heterocyclic group may be substituted with one to three substituents which may be the same or different and are selected from the group consisting of lower alkyl, lower alkoxy, and phenyl which may be substituted with optionally halogenated lower alkyl, lower alkoxy or halogeno; and R2 and R3 are each hydrogen or hydroxyl, or R2 and R3 may be united to form an oxo group, with the proviso that both are not hydrogen.
摘要翻译：由通式（I）表示的具有弹性蛋白酶抑制活性的杂环化合物; 及其合成中间体：（I）其中R 1为由通式（II）表示的杂环基：（II）[其中A表示苯环的存在或不存在; X是氧，硫或NH; 并且Y是氮或CH]，并且杂环基可以被一至三个可以相同或不同并且选自低级烷基，低级烷氧基和苯基的取代基取代，所述取代基可被任选卤代低级烷基，低级烷氧基或卤素; R 2和R 3各自为氢或羟基，或R 2和R 3可以结合到形成氧代基，条件是两者都不是氢。

2. 发明授权

US07067491B2 Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof 失效
标题翻译：具有弹性蛋白酶抑制活性的杂环化合物及其中间体
公开(公告)号：US07067491B2
公开(公告)日：2006-06-27
申请号：US10502768
申请日：2003-02-05
申请人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
发明人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
IPC分类号： A61K38/00
CPC分类号： C07K5/06191 , A61K38/00
摘要： Heterocyclic compounds represented by the general formula (I) and having elastase inhibiting activity; and intermediates for the synthesis thereof: (I) wherein R1 is a heterocyclic group represented by the general formula (II): (II) [wherein A represents the presence or absence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogen or CH], and the heterocyclic group may be substituted with one to three substituents which may be the same or different and are selected from the group consisting of lower alkyl, lower alkoxy, and phenyl which may be substituted with optionally halogenated lower alkyl, lower alkoxy or halogeno; and R2 and R3 are each hydrogen or hydroxyl, or R2 and R3 may be united to form an oxo group, with the proviso that both are not hydrogen.
摘要翻译：由通式（I）表示的具有弹性蛋白酶抑制活性的杂环化合物; 及其合成中间体：（I）其中R 1为由通式（II）表示的杂环基：（II）[其中A表示苯环的存在或不存在; X是氧，硫或NH; 并且Y是氮或CH]，并且杂环基可以被一至三个可以相同或不同并且选自低级烷基，低级烷氧基和苯基的取代基取代，所述取代基可被任选卤代低级烷基，低级烷氧基或卤素; R 2和R 3各自为氢或羟基，或R 2和R 3可以结合到形成氧代基，条件是两者都不是氢。

3. 发明授权

US06852744B2 Pyrrolidine derivatives and their use as chymase inhibitor 失效
标题翻译：吡咯烷衍生物及其作为胃促胰酶抑制剂的用途
公开(公告)号：US06852744B2
公开(公告)日：2005-02-08
申请号：US10363036
申请日：2001-08-21
申请人： Takashi Deguchi , Ryotaro Shiratake , Fuminori Sato , Buichi Fujitani , Yayoi Honda , Akihiko Kiyoshi , Mitsue Notake , Graham Andrew Showell , Robert George Boyle , Sukhbinder Singh Klair
发明人： Takashi Deguchi , Ryotaro Shiratake , Fuminori Sato , Buichi Fujitani , Yayoi Honda , Akihiko Kiyoshi , Mitsue Notake , Graham Andrew Showell , Robert George Boyle , Sukhbinder Singh Klair
IPC分类号： C12N9/99 , A61K38/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/08 , C07K5/10 , A61K31/42 , A61K31/41 , C07D261/18 , C07D285/06
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06034 , C07K5/06191 , C07K5/0827 , C07K5/1027
摘要： Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R1 is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substituted or unsubstituted indolyl, benzofuryl, substituted or unsubstituted benzothienyl, etc.; R2 is H, alkyl, phenyl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; R3 is (i) substituted or unsubstituted monocyclic heterocyclic group, (ii) substituted or unsubstituted benzene- or pyridine-fused heterocyclic group, or (iii) a group (a): R4 and R5 are independently H or OH, but R4 and R5 are not simultaneously H, or both form oxo; n is 0, 1, 2 or 3; or a salt thereof.
摘要翻译：新型吡咯烷衍生物可用作合成活性化合物的胃促胰酶抑制剂或中间体，其具有式（I）：其中R 1是环烷基，取代或未取代的苯基或萘基，茚满基，噻吩基，呋喃基，取代或未取代的吲哚基，苯并呋喃基，取代或未取代的苯并噻吩基等; R 2是H，烷基，苯基 - 低级烷基，环烷基或环烷基 - 低级烷基; R 3是（i）取代或未取代的单环杂环基，（ii）取代或未取代的苯 - 或吡啶稠合杂环基，或（iii）基团（a）：R 4和R 5是独立地是H或OH，但R 4和R 5不同时为H，或两者都形成氧代; n为0,1,2或3; 或其盐。

4. 发明授权

US06646150B1 Processes for producing (aminomethyl)trifluorocarbinol derivatives 失效
标题翻译：（氨基甲基）三氟甲醇衍生物的制备方法
公开(公告)号：US06646150B1
公开(公告)日：2003-11-11
申请号：US10149674
申请日：2002-06-13
申请人： Fuminori Sato , Tomoki Omodani , Ryotaro Shiratake , Yasunao Inoue , Takashi Deguchi
发明人： Fuminori Sato , Tomoki Omodani , Ryotaro Shiratake , Yasunao Inoue , Takashi Deguchi
IPC分类号： C07C21302
CPC分类号： C07C213/02 , C07C269/06 , Y02P20/55 , C07C215/08 , C07C271/16
摘要： The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as starting compounds for drugs such as protease inhibitors, etc.
摘要翻译：本发明提供工业上制备（氨基甲基）三甲基甲醇衍生物的方法，特别是其光学活性化合物，其可用作药物如蛋白酶抑制剂等的起始化合物。

5. 发明授权

US06198494B1 Image recording apparatus with plural print heads 失效
标题翻译：具有多个打印头的图像记录装置
公开(公告)号：US06198494B1
公开(公告)日：2001-03-06
申请号：US09039897
申请日：1998-03-16
申请人： Tsuyoshi Haraguchi , Takashi Deguchi , Tuyosi Hattori , Takashi Igarashi
发明人： Tsuyoshi Haraguchi , Takashi Deguchi , Tuyosi Hattori , Takashi Igarashi
IPC分类号： B41C104
CPC分类号： H04N1/506 , B41J2/47
摘要： In a color image recording apparatus provided with plural print heads and a conveyor, each print head includes a plurality of recording elements aligned along at least a single line in a primary scanning direction and the plural print heads are arranged in parallel to each other in the primary scanning direction so that plural component images of the color image are formed parallel respectively by the plural print heads. A reference component image forming device controls the plural pieces of print heads so as to form and superimpose plural reference component images based on the reference component image data and timing setting values. A timing correcting unit analyzes positional deviations in the secondary scanning direction among the plural superimposed reference component images and corrects the timing setting values on the basis of the positional deviations in the secondary scanning direction.
摘要翻译：在设置有多个打印头和传送带的彩色图像记录装置中，每个打印头包括沿着主扫描方向沿着至少一条直线排列的多个记录元件，并且多个打印头在主扫描方向，使得彩色图像的多个分量图像分别由多个打印头形成为平行。参考分量图像形成装置控制多个打印头，以便基于参考分量图像数据和定时设置值来形成和叠加多个参考分量图像。定时校正单元分析多个叠加基准分量图像中的副扫描方向的位置偏差，并根据二次扫描方向的位置偏差校正定时设定值。

6. 发明授权

US6072596A Image recording apparatus 失效
标题翻译：图像记录装置
公开(公告)号：US6072596A
公开(公告)日：2000-06-06
申请号：US855233
申请日：1997-05-13
申请人： Tuyosi Hattori , Toru Kawabe , Takashi Igarashi , Atsushi Suzuki , Tsuyoshi Haraguchi , Takashi Deguchi , Ken Okauchi
发明人： Tuyosi Hattori , Toru Kawabe , Takashi Igarashi , Atsushi Suzuki , Tsuyoshi Haraguchi , Takashi Deguchi , Ken Okauchi
IPC分类号： G03B27/58 , H04N1/23 , H04N1/00 , G03G15/00
CPC分类号： H04N1/00676 , G03B27/588 , H04N1/2307 , H04N1/2338 , G03B2227/005 , H04N2201/3242
摘要： When a digital image recording means records digital image on an image recording medium based on order information or on digital image data, a computing means calculates digital image layout information, and calculates, based on the digital image layout information, X-cut size information used for cutting the image recording medium in the direction perpendicular to the conveyance direction of the conveyance means and Y-cut size information used for cutting the image recording medium in the direction perpendicular to the cutting direction for the X-cut. A cutting means which cuts the image recording medium into a prescribed size has an X-cut means to cut the image recording medium in the direction perpendicular to the conveyance direction of the conveyance means in accordance with the X-cut size information and a Y-cut means to cut the image recording medium in the direction perpendicular to the cutting direction of the X-cut in accordance with the Y-cut size information.
摘要翻译：当数字图像记录装置基于订单信息或数字图像数据将数字图像记录在图像记录介质上时，计算装置计算数字图像布局信息，并且基于数字图像布局信息计算使用的X切割尺寸信息用于在垂直于输送装置的输送方向的方向上切割图像记录介质，以及用于在与X切割的切割方向垂直的方向上切割图像记录介质的Y切割尺寸信息。将图像记录介质切割成规定尺寸的切割装置具有X切割装置，用于根据X切割尺寸信息沿着与输送装置的输送方向垂直的方向切割图像记录介质，并且Y- 切割装置根据Y切割尺寸信息沿垂直于X切割的切割方向的方向切割图像记录介质。

7. 发明授权

US5672252A Method and apparatus for fabrication of dielectric film 失效
标题翻译：电介质膜的制造方法和装置
公开(公告)号：US5672252A
公开(公告)日：1997-09-30
申请号：US483835
申请日：1995-06-15
申请人： Shigenori Hayashi , Kazuki Komaki , Takeshi Kamada , Masatoshi Kitagawa , Takashi Deguchi , Ryoichi Takayama , Takashi Hirao
发明人： Shigenori Hayashi , Kazuki Komaki , Takeshi Kamada , Masatoshi Kitagawa , Takashi Deguchi , Ryoichi Takayama , Takashi Hirao
IPC分类号： C23C14/00 , C23C14/08 , C23C14/58 , G02F1/00 , H01L21/314 , H01L21/316 , H01L37/02 , H01L41/316 , C23C14/34
CPC分类号： C23C14/5853 , C23C14/0078 , C23C14/088 , H01L21/02197 , H01L21/02266 , H01L21/314 , H01L21/31691 , H01L37/025 , H01L41/1875 , H01L41/316 , G02F1/0027
摘要： A method whereby perovskite type oxide dielectric thin films with ABO.sub.3 structure are able to be formed with such features as good stability, uniformity, reproducibility, or the like, with high through-put by having a deposition process, wherein the thin films are deposited on a substrate, and a stabilization process, where no deposition of the thin films takes place, repeated alternatingly while the substrate temperature being kept near the temperature at which perovskite type oxide dielectric thin films are formed. Also, by employing (i) a processing method wherein a decomposing excitation of a reactive gas due to plasma takes place on or near the deposition surface in a gaseous atmosphere comprising a gas that reacts with the elements composing the thin films, (ii) a processing method wherein an oxidation reaction takes place on the deposition surface in a gaseous atmosphere comprising at least ozone (O.sub.3), and (iii) a processing method wherein light of short wave length is irradiated on the deposition surface in a gaseous atmosphere comprising at least reactive elements in the non-deposition process, the oxygen concentration in the deposited thin films is adjusted and dielectric thin films of good quality and an extremely low defect content are realized.
摘要翻译：具有ABO3结构的钙钛矿型氧化物电介质薄膜能够通过具有沉积工艺的高通量形成具有良好的稳定性，均匀性，再现性等特性的方法，其中薄膜沉积在基板和稳定化处理，其中不存在薄膜的沉积，在衬底温度保持接近形成钙钛矿型氧化物电介质薄膜的温度的同时交替重复。此外，通过采用以下处理方法：（i）在包含与组成薄膜的元素反应的气体的气体气氛中，在等离子体发生的反应性气体的分解激发发生在沉积表面上或其附近的处理方法，（ii）处理方法，其中在至少包含臭氧（O 3）的气体气氛中在沉积表面上发生氧化反应，和（iii）其中在至少包括至少包含臭氧（O 3）的气体气氛中在沉积表面上照射短波长的光的处理方法在非沉积工艺中的非活性元素，沉积的薄膜中的氧浓度被调节，并且实现了良好质量和极低缺陷含量的介电薄膜。

8. 发明授权

US5210266A N-substituted mercaptopropanamide derivatives 失效
公开(公告)号：US5210266A
公开(公告)日：1993-05-11
申请号：US609450
申请日：1990-11-05
申请人： Tetsutaro Mimura , Yasuhisa Nakamura , Junko Nishino , Tadahiro Sawayama , Takashi Sasagawa , Takashi Deguchi , Hideo Nakamura
发明人： Tetsutaro Mimura , Yasuhisa Nakamura , Junko Nishino , Tadahiro Sawayama , Takashi Sasagawa , Takashi Deguchi , Hideo Nakamura
IPC分类号： C07C229/08 , C07C229/24 , C07C229/26 , C07C229/34 , C07C229/60 , C07C323/60 , C07C327/06 , C07C327/12 , C07C327/16 , C07C327/24 , C07C327/32 , C07C329/06 , C07C333/06 , C07D213/50 , C07D261/20 , C07D265/30 , C07D295/088 , C07D295/155 , C07D307/68 , C07D333/22 , C07D333/38
CPC分类号： C07D265/30 , C07C229/08 , C07C229/24 , C07C229/26 , C07C229/34 , C07C229/60 , C07C323/60 , C07C327/06 , C07C327/12 , C07C327/16 , C07C327/24 , C07C327/32 , C07C329/06 , C07C333/06 , C07D213/50 , C07D261/20 , C07D295/088 , C07D295/155 , C07D307/68 , C07D333/22 , C07D333/38 , C07C2101/02 , C07C2101/08 , C07C2101/16
摘要： Novel N-substituted mercaptopropanamide derivatives of the formula: ##STR1## wherein R.sub.1 is mercapto or a group convertible into mercapto when cleaved within the biobody, W is hydrogen atom, an alkyl or an aralkyl, R.sub.2 is an aryl which may optionally have substituent(s), a heterocyclic group which may optionally have substituent(s), or an alkyl which may optionally have substituent(s), X is a cycloalkylene, a cycloalkylidene, or a phenylene which may optionally have substituent(s) or may optionally be fused with other ring, and R.sub.3 is carboxyl or a group convertible into carboxyl when cleaved within the biobody, or a pharmaceutically acceptable salt thereof, and a solid solution of said N-substituted mercaptopropanamide derivative with an amino acid, which have excellent enkephalinase inhibitory activity and are useful for the treatment of mild to moderate pain, and a pharmaceutical composition containing said compounds as an active ingredient, and processes for preparing these compounds.

9. 发明申请

US20070293621A1 Powdery White Vulcanization Promoter Composition and Rubber Compositions 有权
标题翻译：粉状白色硫化促进剂组合物和橡胶组合物
公开(公告)号：US20070293621A1
公开(公告)日：2007-12-20
申请号：US11661287
申请日：2005-08-31
申请人： Takashi Korenaga , Takashi Deguchi , Shoichi Tsutsui
发明人： Takashi Korenaga , Takashi Deguchi , Shoichi Tsutsui
IPC分类号： C08L21/00 , C08K3/00 , C09C1/02 , C09C3/08 , C08K9/04
CPC分类号： C09C1/021 , C01P2004/62 , C01P2006/12 , C01P2006/19 , C08K3/011 , C08K3/013 , C08K5/0025 , C08K5/548 , C08K9/02 , C08K9/04 , Y10T428/2993 , C08L21/00
摘要： A powdery white vulcanization promoter composition which is excellent in storage stability, the resistance of blends thereof with rubbers or the like to heat build-up, and design; and rubber compositions containing the same. Specifically, a vulcanization promoter composition which comprises a modified calcium carbonate (A) surface-treated with a fatty acid or a resin acid and a silicic acid, an inorganic filler (B) exhibiting an oil absorption of as high as 50 to 300 ml/100 g, and a vulcanization promoter component (C) liquid at ordinary temperatures, characterized in that the (A):(B) mixing ratio is within the range of 30:70 to 95:5 and the content of (C) is 30 to 80 wt % based on the whole of the promoter composition.
摘要翻译：一种粉末状白色硫化促进剂组合物，其储存稳定性优异，与橡胶等的共混物对热积聚的耐受性和设计; 和含有它们的橡胶组合物。具体地说，一种硫化促进剂组合物，其包含用脂肪酸或树脂酸和硅酸表面处理的改性碳酸钙（A），无机填料（B），其表现出高达50〜300ml / 100g和在常温下的硫化促进剂组分（C）液体，其特征在于（A）：（B）的混合比在30:70至95:5的范围内，（C）的含量为30 至80重量％。

10. 发明授权

US07232200B2 Image forming apparatus and method for forming image 失效
标题翻译：用于形成图像的图像形成装置和方法
公开(公告)号：US07232200B2
公开(公告)日：2007-06-19
申请号：US10995504
申请日：2004-11-24
申请人： Manabu Nakahanada , Atsushi Suzuki , Takashi Deguchi
发明人： Manabu Nakahanada , Atsushi Suzuki , Takashi Deguchi
IPC分类号： B41J29/393
CPC分类号： B41J29/393
摘要： An image forming apparatus comprises a recording head having a plurality of recording elements arranged in array, the recording head being utilized for recording a corrective image onto a recording material, an image reading device to acquire readout information by reading the corrective image, an carrying out section to conduct calculation to obtain a correction amount of recording characteristics, from the readout information acquired by the reading device, an image forming section to form an image onto the recording material by the recording head in which a recording characteristics of the plurality of recording elements are compensated based on the correction amount, and a controller to control the recording head so as to record the corrective image on to the recording material, wherein, the readout information in the carrying out section discriminates optical density unevenness caused by a factor not being associated with the recording head.
摘要翻译：一种图像形成装置包括具有排列成阵列的多个记录元件的记录头，记录头用于将校正图像记录在记录材料上，图像读取装置，通过读取校正图像获取读出信息，执行进行计算以获得记录特性的校正量，根据由读取装置获取的读出信息，通过记录头将图像形成在记录材料上的图像形成部分，其中记录多个记录元件的记录特性基于校正量补偿，以及控制器，用于控制记录头，以将校正图像记录在记录材料上，其中，执行部分中的读出信息鉴别由不相关因素引起的光学浓度不均匀性与录音头。

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