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1. 发明授权

US08367113B2 Polymers for functional particles 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US08367113B2
公开(公告)日：2013-02-05
申请号：US11803843
申请日：2007-05-15
申请人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
发明人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

2. 发明申请

US20100323199A1 POLYMERS FOR FUNCTIONAL PARTICLES 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US20100323199A1
公开(公告)日：2010-12-23
申请号：US12873692
申请日：2010-09-01
申请人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
发明人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
IPC分类号： B32B5/00
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

3. 发明授权

US08323698B2 Polymers for functional particles 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US08323698B2
公开(公告)日：2012-12-04
申请号：US12873692
申请日：2010-09-01
申请人： Frank X. Gu , Omid C. Farokhzad , Robert S. Langer , Benjamin A. Teply
发明人： Frank X. Gu , Omid C. Farokhzad , Robert S. Langer , Benjamin A. Teply
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

4. 发明授权

US09333179B2 Amphiphilic compound assisted nanoparticles for targeted delivery 有权
标题翻译：两亲化合物辅助纳米颗粒用于靶向递送
公开(公告)号：US09333179B2
公开(公告)日：2016-05-10
申请号：US12573591
申请日：2009-10-05
申请人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
发明人： Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Frank Alexis , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/51 , A61K47/48 , B82Y5/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译：本发明通常涉及具有两亲性组分的纳米颗粒。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。本发明的其它方面涉及使用纳米颗粒文库的方法。

5. 发明申请

US20100022680A1 Microfluidic Synthesis of Organic Nanoparticles 有权
标题翻译：微流控合成有机纳米颗粒
公开(公告)号：US20100022680A1
公开(公告)日：2010-01-28
申请号：US12306249
申请日：2007-06-22
申请人： Rohit Karnik , Frank X. Gu , Pamela Basto , Chris Cannizzaro , Alireza Khademhosseini , Robert S. Langer , Omid C. Farokhzad
发明人： Rohit Karnik , Frank X. Gu , Pamela Basto , Chris Cannizzaro , Alireza Khademhosseini , Robert S. Langer , Omid C. Farokhzad
IPC分类号： C08J3/14 , B01J2/00
CPC分类号： B01F3/0807 , A61K9/1694 , A61K9/5153 , A61K9/5192 , A61K47/48907 , A61K47/48915 , A61K47/6935 , A61K47/6937 , B01F5/0471 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F11/0071 , B01F13/0059 , B01F13/0062 , B01F2005/0621 , B01F2005/0636 , B01J13/04 , B01J19/0046 , B01J19/0093 , B01J2219/00162 , B01J2219/00164 , B01J2219/00459 , B01J2219/005 , B01J2219/0059 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00889 , B01J2219/0095 , B82Y30/00
摘要： The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
摘要翻译：本发明提供用于制备用于药物递送的颗粒（例如纳米颗粒）的微流体系统和方法。本发明提供了用于通过纳米沉淀生产颗粒的微流体装置。本发明提供由本发明的微流体装置产生的高度均匀的颗粒组合物。

6. 发明申请

US20090074828A1 POLY(AMINO ACID) TARGETING MOIETIES 审中-公开
标题翻译：聚氨酯（AMINO ACID）瞄准动物
公开(公告)号：US20090074828A1
公开(公告)日：2009-03-19
申请号：US12098354
申请日：2008-04-04
申请人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
发明人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K47/42 , A61K31/135 , A61K31/337 , A61K38/16 , A61K31/4353 , A61K31/56 , A61K9/00 , C07K5/10 , A61P9/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译：本发明一般涉及聚合物和大分子，特别是涉及可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。本发明的其它方面涉及使用纳米颗粒文库的方法。

7. 发明授权

US09381477B2 Microfluidic synthesis of organic nanoparticles 有权
标题翻译：微流体合成有机纳米粒子
公开(公告)号：US09381477B2
公开(公告)日：2016-07-05
申请号：US12306249
申请日：2007-06-22
申请人： Rohit Karnik , Frank X. Gu , Pamela Basto , Chris Cannizzaro , Alireza Khademhosseini , Robert S. Langer , Omid C. Farokhzad
发明人： Rohit Karnik , Frank X. Gu , Pamela Basto , Chris Cannizzaro , Alireza Khademhosseini , Robert S. Langer , Omid C. Farokhzad
IPC分类号： B01L3/00 , G01N1/10 , B01F3/08 , A61K9/51 , A61K47/48 , B01F5/04 , B01F5/06 , B01F11/00 , B01F13/00 , B01J13/04 , B01J19/00 , B82Y30/00 , A61K9/16
CPC分类号： B01F3/0807 , A61K9/1694 , A61K9/5153 , A61K9/5192 , A61K47/48907 , A61K47/48915 , A61K47/6935 , A61K47/6937 , B01F5/0471 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F11/0071 , B01F13/0059 , B01F13/0062 , B01F2005/0621 , B01F2005/0636 , B01J13/04 , B01J19/0046 , B01J19/0093 , B01J2219/00162 , B01J2219/00164 , B01J2219/00459 , B01J2219/005 , B01J2219/0059 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00889 , B01J2219/0095 , B82Y30/00
摘要： The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
摘要翻译：本发明提供用于制备用于药物递送的颗粒（例如纳米颗粒）的微流体系统和方法。本发明提供了用于通过纳米沉淀生产颗粒的微流体装置。本发明提供由本发明的微流体装置产生的高度均匀的颗粒组合物。

8. 发明申请

US20110027172A1 DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION 审中-公开
标题翻译：用于药物和辐射的药物递送系统
公开(公告)号：US20110027172A1
公开(公告)日：2011-02-03
申请号：US12747040
申请日：2008-12-10
申请人： Zhuang Wang , Omid C. Farokhzad , Liangfang Zhang , Aleksandar Filip Radovic-Moreno , Frank X. Gu , Robert S. Langer
发明人： Zhuang Wang , Omid C. Farokhzad , Liangfang Zhang , Aleksandar Filip Radovic-Moreno , Frank X. Gu , Robert S. Langer
IPC分类号： A61K51/12 , A61K9/14 , A61K9/00 , A61P43/00
CPC分类号： A61K51/1255 , A61K31/337 , A61K47/6937
摘要： The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.
摘要翻译：本发明提供了用于递送药剂和放射性药剂的药物递送系统。药物递送系统可以特异性地靶向器官，组织，细胞，细胞外基质或细胞内区室。通常，药物递送系统是颗粒。还提供了包含本发明颗粒的药物组合物。本发明提供了制备和使用本发明的颗粒和药物组合物的方法。本发明的颗粒可用于治疗和诊断各种疾病，包括癌症。本发明的颗粒也可用于在体内追踪颗粒。

9. 发明授权

US08603532B2 Nanostructures for drug delivery 有权
标题翻译：用于药物输送的纳米结构
公开(公告)号：US08603532B2
公开(公告)日：2013-12-10
申请号：US13122615
申请日：2009-10-20
申请人： Stephen J. Lippard , Shanta Dhar , Omid C. Farokhzad , Frank X. Gu , Nagesh Kolishetti
发明人： Stephen J. Lippard , Shanta Dhar , Omid C. Farokhzad , Frank X. Gu , Nagesh Kolishetti
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： A61K9/48 , A61K9/143 , A61K31/555 , A61K33/24 , A61K47/48092 , A61K47/48869 , A61K47/48915 , A61K47/549 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
摘要翻译：本发明提供了可用于治疗患有癌症或有癌症发生危险的受试者的组合物，制剂，制剂，试剂盒和方法。本发明的一些实施方案可以包含包含多个包含铂（IV）治疗活性前体的颗粒的组合物。

10. 发明申请

US20110300219A1 NANOSTRUCTURES FOR DRUG DELIVERY 有权
标题翻译：用于药物递送的纳米结构
公开(公告)号：US20110300219A1
公开(公告)日：2011-12-08
申请号：US13122615
申请日：2009-10-20
申请人： Stephen J. Lippard , Shanta Dhar , Omid C. Farokhzad , Frank X. Gu , Nagesh Kolishetti
发明人： Stephen J. Lippard , Shanta Dhar , Omid C. Farokhzad , Frank X. Gu , Nagesh Kolishetti
IPC分类号： A61K9/14 , A61P35/00 , A61K39/00 , A61K33/00 , A61K31/282
CPC分类号： A61K9/48 , A61K9/143 , A61K31/555 , A61K33/24 , A61K47/48092 , A61K47/48869 , A61K47/48915 , A61K47/549 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
摘要翻译：本发明提供了可用于治疗患有癌症或有癌症发生危险的受试者的组合物，制剂，制剂，试剂盒和方法。本发明的一些实施方案可以包含包含多个包含铂（IV）治疗活性前体的颗粒的组合物。

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