专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07666798B2 Method of making a micro-fluidic structure 有权
标题翻译：制造微流体结构的方法
公开(公告)号：US07666798B2
公开(公告)日：2010-02-23
申请号：US11440643
申请日：2006-05-24
申请人： Frank Bryant , Murray Robinson
发明人： Frank Bryant , Murray Robinson
IPC分类号： H01L21/465
CPC分类号： B81C1/00119 , B81B2203/0315 , B81C2201/0109
摘要： A microfabricated structure and method of making that includes forming a first layer of material on a substrate, forming patterned sacrificial material having a predetermined shape on the first layer of material, and forming a second layer of material over the first layer and the patterned sacrificial material, which is then removed to form an encapsulated cavity. Ideally, the first and second layers are formed of the same type material. A structural support layer can be added to the second layer. Openings can be formed in the cavity, and the cavities can be layered side by side, vertically stacked with interconnections via the openings, and a combination of both can be used to construct stacked arrays with interconnections throughout.
摘要翻译：微制造结构及其制造方法包括在基材上形成第一层材料，在第一层材料上形成具有预定形状的图案化牺牲材料，以及在第一层上形成第二层材料，并将图案化的牺牲材料，然后将其除去以形成封装的空腔。理想地，第一层和第二层由相同类型的材料形成。结构支撑层可以添加到第二层。可以在空腔中形成开口，并且空腔可以并排堆叠，通过开口垂直地堆叠有互连，并且两者的组合可以用于构造整个具有互连的堆叠阵列。

2. 发明授权

US07928520B2 Micro-fluidic structure 有权
标题翻译：微流体结构
公开(公告)号：US07928520B2
公开(公告)日：2011-04-19
申请号：US12686199
申请日：2010-01-12
申请人： Frank Bryant , Murray Robinson
发明人： Frank Bryant , Murray Robinson
IPC分类号： H01L21/465
CPC分类号： B81C1/00119 , B81B2203/0315 , B81C2201/0109
摘要： A microfabricated structure that includes a first layer of material on a substrate, and a second layer of material over the first layer that forms an encapsulated cavity, and a structural support layer added to the second layer. Openings can be formed in the cavity, and the cavities can be layered side by side, vertically stacked with interconnections via the openings, and a combination of both can be used to construct stacked arrays with interconnections throughout.
摘要翻译：一种微制造结构，其包括在基底上的第一层材料，以及在形成封装空腔的第一层上的第二材料层，以及添加到第二层的结构支撑层。可以在空腔中形成开口，并且空腔可以并排堆叠，通过开口垂直地堆叠有互连，并且两者的组合可以用于构造整个具有互连的堆叠阵列。

3. 发明申请

US20100109100A1 MICRO-FLUIDIC STRUCTURE 有权
标题翻译：微流体结构
公开(公告)号：US20100109100A1
公开(公告)日：2010-05-06
申请号：US12686199
申请日：2010-01-12
申请人： Frank Bryant , Murray Robinson
发明人： Frank Bryant , Murray Robinson
IPC分类号： H01L29/84
CPC分类号： B81C1/00119 , B81B2203/0315 , B81C2201/0109
摘要： A microfabricated structure that includes a first layer of material on a substrate, and a second layer of material over the first layer that forms an encapsulated cavity, and a structural support layer added to the second layer. Openings can be formed in the cavity, and the cavities can be layered side by side, vertically stacked with interconnections via the openings, and a combination of both can be used to construct stacked arrays with interconnections throughout.
摘要翻译：一种微制造结构，其包括在基底上的第一层材料，以及在形成封装空腔的第一层上的第二材料层，以及添加到第二层的结构支撑层。可以在空腔中形成开口，并且空腔可以并排堆叠，通过开口垂直地堆叠有互连，并且两者的组合可以用于构造整个具有互连的堆叠阵列。

4. 发明申请

US20070273728A1 Micro-fluidic structure and method of making 有权
标题翻译：微流体结构及其制备方法
公开(公告)号：US20070273728A1
公开(公告)日：2007-11-29
申请号：US11440643
申请日：2006-05-24
申请人： Frank Bryant , Murray Robinson
发明人： Frank Bryant , Murray Robinson
IPC分类号： B41J2/04
CPC分类号： B81C1/00119 , B81B2203/0315 , B81C2201/0109
摘要： A microfabricated structure and method of making that includes forming a first layer of material on a substrate, forming patterned sacrificial material having a predetermined shape on the first layer of material, and forming a second layer of material over the first layer and the patterned sacrificial material, which is then removed to form an encapsulated cavity. Ideally, the first and second layers are formed of the same type material. A structural support layer can be added to the second layer. Openings can be formed in the cavity, and the cavities can be layered side by side, vertically stacked with interconnections via the openings, and a combination of both can be used to construct stacked arrays with interconnections throughout.
摘要翻译：微制造结构及其制造方法包括在基材上形成第一层材料，在第一层材料上形成具有预定形状的图案化牺牲材料，以及在第一层上形成第二层材料，并将图案化的牺牲材料，然后将其除去以形成封装的空腔。理想地，第一层和第二层由相同类型的材料形成。结构支撑层可以添加到第二层。可以在空腔中形成开口，并且空腔可以并排堆叠，通过开口垂直地堆叠有互连，并且两者的组合可以用于构造整个具有互连的堆叠阵列。

5. 发明授权

US09345788B2 Reconstituted human breast tumor model 有权
公开(公告)号：US09345788B2
公开(公告)日：2016-05-24
申请号：US11170338
申请日：2005-06-28
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.

6. 发明授权

US07622630B2 Chimeric cancer models 失效
标题翻译：嵌合癌症模型
公开(公告)号：US07622630B2
公开(公告)日：2009-11-24
申请号：US10570116
申请日：2004-08-27
申请人： Joerg Heyer , Murray Robinson , William Rideout, III , Ronald Depinho , Steven C. Clark , Yinghui Zhou , Tyler Jacks , Ronan C. O'Hagan
发明人： Joerg Heyer , Murray Robinson , William Rideout, III , Ronald Depinho , Steven C. Clark , Yinghui Zhou , Tyler Jacks , Ronan C. O'Hagan
IPC分类号： C12N15/00 , A01K67/00 , C12N5/06
CPC分类号： A01K67/0276 , A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C12N15/8509 , C12N2830/003
摘要： Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.
摘要翻译：公开了可用作诱导型自发癌症模型的嵌合非人哺乳动物。通过将一个或多个经遗传修饰的胚胎干细胞（ES）细胞引入早期胚胎，然后将操作的胚胎植入替代母体中获得非人类哺乳动物。 ES细胞含有重组癌基因，并且还可能含有遗传突变，其删除或灭活肿瘤抑制基因。不同类型癌症的模型是通过将遗传突变的不同组合引入引入早期胚胎的ES细胞来产生的。

7. 发明申请

US20050282150A1 Antibodies to cyclin E2 protein 失效
公开(公告)号：US20050282150A1
公开(公告)日：2005-12-22
申请号：US11192450
申请日：2005-07-28
申请人： Steven Coats , Michael Bass , Murray Robinson
发明人： Steven Coats , Michael Bass , Murray Robinson
IPC分类号： C12N15/09 , A61K48/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/00 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/573 , G01N33/574
CPC分类号： C12Q1/485 , A61K48/00 , C07K14/4738 , G01N33/573 , G01N33/57407 , G01N2333/91215 , G01N2500/02 , G01N2510/00
摘要： Disclosed are nucleic acid molecules encoding novel cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.

8. 发明申请

US20120231478A1 TIVOZANIB RESPONSE PREDICTION 审中-公开
标题翻译： TIVOZANIB反应预测
公开(公告)号：US20120231478A1
公开(公告)日：2012-09-13
申请号：US13502476
申请日：2010-06-03
申请人： Jie Lin , Bin Feng , Murray Robinson , Feng Jiang , Xiaojian Sun
发明人： Jie Lin , Bin Feng , Murray Robinson , Feng Jiang , Xiaojian Sun
IPC分类号： G01N33/566
CPC分类号： G01N33/57492 , C12Q1/6886 , G01N33/57407 , G01N2333/70596 , G01N2800/52
摘要： A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry.
摘要翻译：公开了一种诊断方法，用于预测人肿瘤是否敏感或对利托那尼治疗有抗药性（AV-951）。该方法基于来自肿瘤的组织样品中巨噬细胞含量的测量。巨噬细胞含量的测定可以基于巨噬细胞标记基因表达的分析，例如通过RNA分析或免疫组织化学。

9. 发明申请

US20080234304A1 N3-Pyridyl-Thiamine And Its Use In Cancer Treatments 审中-公开
标题翻译： N3-吡啶基硫胺素及其在癌症治疗中的应用
公开(公告)号：US20080234304A1
公开(公告)日：2008-09-25
申请号：US10594191
申请日：2005-03-23
申请人： Jeno Gyuris , Ronan C. O'Hagan , May Han , Murray Robinson , Solly Weiler
发明人： Jeno Gyuris , Ronan C. O'Hagan , May Han , Murray Robinson , Solly Weiler
IPC分类号： A61K31/51 , C12N5/00 , A61P43/00
CPC分类号： A61K31/4439
摘要： The invention provides methods using N3-pyridyl-thiamine compounds and pharmaceutical compositions comprising N3-pyridyl-thiamine, which are especially useful for preventing or reducing tumor growth in vivo. The invention is also directed to the benefits of reducing thiamine concentrations, e.g., by means of a thiamine reduced diet, as an effective step in a therapeutic regime for patients treated with N3-pyridyl-thiamine.
摘要翻译：本发明提供了使用N 3 - 吡啶基 - 硫胺素化合物的方法和包含N 3 - 吡啶基 - 硫胺素的药物组合物，其特别可用于预防或减少体内肿瘤生长。本发明还涉及降低硫胺素浓度的益处，例如通过硫胺素减少饮食，作为用N 3 - 吡啶基硫胺素治疗的患者的治疗方案的有效步骤。

10. 发明申请

US20070292948A1 Chimeric Cancer Models 失效
标题翻译：嵌合癌模型
公开(公告)号：US20070292948A1
公开(公告)日：2007-12-20
申请号：US10570116
申请日：2004-08-27
申请人： Joerg Heyer , Murray Robinson , William Rideout , Ronald Depinho , Steven Clark , Yinghui Zhou , Tyler Jacks
发明人： Joerg Heyer , Murray Robinson , William Rideout , Ronald Depinho , Steven Clark , Yinghui Zhou , Tyler Jacks
IPC分类号： C12N5/06 , A01K67/00 , C12N15/00
CPC分类号： A01K67/0276 , A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C12N15/8509 , C12N2830/003
摘要： Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.
摘要翻译：公开了可用作诱导型自发癌症模型的嵌合非人哺乳动物。通过将一个或多个经遗传修饰的胚胎干细胞（ES）细胞引入早期胚胎，然后将操作的胚胎植入替代母体中获得非人类哺乳动物。 ES细胞含有重组癌基因，并且还可能含有遗传突变，其删除或灭活肿瘤抑制基因。不同类型癌症的模型是通过将遗传突变的不同组合引入引入早期胚胎的ES细胞来产生的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式