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1. 发明申请

US20130309249A1 MATERIALS AND METHODS FOR THE PROPHYLACTIC TREATMENT OF A PRE-MALIGNANT CONDITION 审中-公开
标题翻译：预防恶性疾病预防性治疗的材料与方法
公开(公告)号：US20130309249A1
公开(公告)日：2013-11-21
申请号：US13869796
申请日：2013-04-24
申请人： Charlotte Kuperwasser , Maja Sedic
发明人： Charlotte Kuperwasser , Maja Sedic
IPC分类号： A61K39/395 , A61K31/352 , A61K38/50 , A61K31/05 , A61K38/45 , A61K31/12 , A61K31/455
CPC分类号： A61K39/3955 , A61K31/05 , A61K31/12 , A61K31/352 , A61K31/455 , A61K38/45 , A61K38/50
摘要： Described herein are materials and methods for the prophylactic treatment of a pre-malignant condition, comprising administering a SIRT1 agonist to an individual whose genotype comprises one defective BRCA1 allele and one functional BRCA1 allele.
摘要翻译：本文描述了用于预防性治疗恶性前病症的材料和方法，包括向基因型包含一个缺陷型BRCA1等位基因和一个功能性BRCA1等位基因的个体施用SIRT1激动剂。

2. 发明授权

US08373017B2 Reconstituted human breast tumor model 有权
标题翻译：重建人乳腺肿瘤模型
公开(公告)号：US08373017B2
公开(公告)日：2013-02-12
申请号：US11296241
申请日：2005-12-06
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/00 , A01K67/027
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： Reconstituted human breast tumor models are disclosed. The models, which are incorporated into mice, provide actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain either: (a) a recombinant human oncogene and an SV40er; or (b) a recombinant human oncogene, a transgene or shRNA that inhibits the p53 pathway, and a transgene or shRNA that inhibits the Rb pathway.
摘要翻译：公开了重建的人乳腺肿瘤模型。结合到小鼠中的模型提供自发产生的实际肿瘤，从而模仿天然存在的乳腺癌。这些肿瘤是遗传性的，因为它们来源于植入宿主小鼠的人类乳腺上皮细胞发育的人类乳腺组织。在植入之前，乳腺上皮细胞被遗传修饰以包含：（a）重组人癌基因和SV40er; 或（b）重组人癌基因，抑制p53途径的转基因或shRNA，以及抑制Rb途径的转基因或shRNA。

3. 发明申请

US20060123493A1 Reconstituted human breast tumor model 审中-公开
标题翻译：重建人乳腺肿瘤模型
公开(公告)号：US20060123493A1
公开(公告)日：2006-06-08
申请号：US11006413
申请日：2004-12-07
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.
摘要翻译：公开了重构的人乳腺肿瘤模型。该模型被并入小鼠中，提供自发产生的实际肿瘤，从而模仿天然存在的乳腺癌。这些肿瘤是遗传性的，因为它们来源于植入宿主小鼠的人类乳腺上皮细胞发育的人类乳腺组织。在植入之前，乳腺上皮细胞被遗传修饰以含有重组人癌基因和SV40早期区域。

4. 发明申请

US20060161999A1 Reconstituted human breast tumor model 有权
公开(公告)号：US20060161999A1
公开(公告)日：2006-07-20
申请号：US11296241
申请日：2005-12-06
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： Reconstituted human breast tumor models are disclosed. The models, which are incorporated into mice, provide actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain either: (a) a recombinant human oncogene and an SV40er; or (b) a recombinant human oncogene, a transgene or shRNA that inhibits the p53 pathway, and a transgene or shRNA that inhibits the Rb pathway.

5. 发明申请

US20060123494A1 Reconstituted human breast tumor model 有权
公开(公告)号：US20060123494A1
公开(公告)日：2006-06-08
申请号：US11170338
申请日：2005-06-28
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.

6. 发明申请

US20050193432A1 Xenograft model of functional normal and malignant human breast tissues in rodents and methods thereof 审中-公开
标题翻译：啮齿动物功能正常和恶性人乳腺组织的异种移植模型及其方法
公开(公告)号：US20050193432A1
公开(公告)日：2005-09-01
申请号：US10990993
申请日：2004-11-17
申请人： Charlotte Kuperwasser , Robert Weinberg
发明人： Charlotte Kuperwasser , Robert Weinberg
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/00
摘要： The invention relates to an orthotopic xenograft rodent model in which the stromal and epithelial components of the reconstructed mammary gland are of human origin, and to methods of making the mouse. The invention also relates to methods of using the rodent, including methods of identifying agents or drugs that inhibits abnormal growth of human breast epithelial cells or that inhibit the formation of breast tumors or other hyperplastic growths.
摘要翻译：本发明涉及原位异种移植物啮齿动物模型，其中重建的乳腺的基质和上皮组分是人源的，以及制备小鼠的方法。本发明还涉及使用啮齿动物的方法，包括鉴定抑制人乳腺上皮细胞异常生长或抑制乳腺肿瘤或其他增生性生长形成的药剂或药物的方法。

7. 发明申请

US20100272651A1 METHOD FOR ASSESSING POTENTIAL FOR TUMOR DEVELOPMENT AND METASTASIS 审中-公开
标题翻译：用于评估肿瘤发生和分化潜力的方法
公开(公告)号：US20100272651A1
公开(公告)日：2010-10-28
申请号：US12764566
申请日：2010-04-21
申请人： Irene Georgakoudi , Derrick Hwu , Steven Boutrus , Charlotte Kuperwasser
发明人： Irene Georgakoudi , Derrick Hwu , Steven Boutrus , Charlotte Kuperwasser
IPC分类号： A61K49/00 , C12Q1/06
CPC分类号： A61K49/0097 , A61K49/0047 , G01N33/5017 , G01N33/5047 , G01N33/5088 , G01N33/5091 , G01N33/574 , G01N33/582 , G01N2800/50 , G01N2800/54 , G01N2800/56
摘要： The present invention generally provides methods for assessing the potential of tumor formation and/or metastasis using a combination (e.g., a ratio) of the number of circulating tumor cells and the number of circulating cells exhibiting autofluorescence within a selected wavelength region (e.g., red autofluorescence). In one aspect, it is directed to a method for providing likelihood of occurrence of a primary and/or a metastatic cancerous tumor in an animal, which comprises inoculating the animal with a plurality of cancer cells, determining a ratio of a number of cancer cells relative to a number of circulating indicator cells (e.g., immature leukocytes) that exhibit autofluorescence in the inoculated animal's blood and correlating the ratio to a likelihood that the animal will develop at least one primary and/or metastatic cancerous tumor, e.g., by way of assigning a probability for tumor development and/or metastasis based on the measured ratio. The method can also be utilized in human studies using, e.g., contrast agents to identify the circulating tumor cells.
摘要翻译：本发明通常提供使用组合（例如，比例）循环肿瘤细胞数量和在所选波长区域内显示自发荧光的循环细胞数量（例如红色）来评估肿瘤形成和/或转移的潜力的方法自发荧光）。一方面，涉及提供在动物中发生原发性和/或转移性癌性肿瘤的可能性的方法，其包括用多种癌细胞接种动物，确定多种癌细胞的比例相对于在接种的动物血液中显示自发荧光的多个循环指示细胞（例如未成熟白细胞），并将该比例与动物将发展至少一个原发性和/或转移性癌性肿瘤的可能性相关联，例如通过基于测量的比例分配肿瘤发展和/或转移的概率。该方法还可以用于使用例如造影剂的人类研究中鉴定循环肿瘤细胞。

8. 发明申请

US20070157330A1 Reconstituted human breast tumor model 审中-公开
标题翻译：重建人乳腺肿瘤模型
公开(公告)号：US20070157330A1
公开(公告)日：2007-07-05
申请号：US11716212
申请日：2007-03-08
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： C12N5/08 , A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2830/003
摘要： Reconstituted human breast tumor models are disclosed. The models, which are incorporated into mice, provide actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain either: (a) a recombinant human oncogene and an SV40er; or (b) a recombinant human oncogene, a transgene or shRNA that inhibits the p53 pathway, and a transgene or shRNA that inhibits the Rb pathway.
摘要翻译：公开了重建的人乳腺肿瘤模型。结合到小鼠中的模型提供自发产生的实际肿瘤，从而模仿天然存在的乳腺癌。这些肿瘤是遗传性的，因为它们来源于植入宿主小鼠的人类乳腺上皮细胞发育的人类乳腺组织。在植入之前，乳腺上皮细胞被遗传修饰以包含：（a）重组人癌基因和SV40er; 或（b）重组人癌基因，抑制p53途径的转基因或shRNA，以及抑制Rb途径的转基因或shRNA。

9. 发明授权

US09345788B2 Reconstituted human breast tumor model 有权
公开(公告)号：US09345788B2
公开(公告)日：2016-05-24
申请号：US11170338
申请日：2005-06-28
申请人： Min Wu , Charlotte Kuperwasser , Murray Robinson
发明人： Min Wu , Charlotte Kuperwasser , Murray Robinson
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： A61K49/0008 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N2510/04 , C12N2799/027
摘要： A reconstituted human breast tumor model is disclosed. The model, which is incorporated into mice, provides actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain a recombinant human oncogene and an SV40 early region.

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