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1. 发明授权

US08293193B2 Microfluidic component with a channel filled with nanotubes and method for its production 有权
标题翻译：具有填充纳米管的通道的微流体组件及其生产方法
公开(公告)号：US08293193B2
公开(公告)日：2012-10-23
申请号：US11918664
申请日：2006-05-11
申请人： Florence Ricoul , Nicolas Sarrut , Jean Dijon , Francoise Vinet
发明人： Florence Ricoul , Nicolas Sarrut , Jean Dijon , Francoise Vinet
IPC分类号： B01J19/00 , C23C16/00
CPC分类号： B01J19/0093 , B01F5/061 , B01F13/0059 , B01F13/0091 , B01F2005/0632 , B01F2005/0636 , B01J20/205 , B01J20/28007 , B01J20/281 , B01J2219/00783 , B01J2219/00846 , B01J2219/0086 , B01L3/5027 , B82Y30/00 , Y10T428/139
摘要： A microfluidic component comprises at least one channel (2) delineated by a top wall (6) and a bottom wall (3) and two opposite side walls (4, 5). The distance (P) between the top wall (6) and the bottom wall (3) of the channel (2) is greater than or equal to 25 micrometers and first and second sets of nanotubes (9a, 9b) are respectively borne by the two opposite side walls (4, 5) for the component to present a particularly high ratio between the contact surface and the available volume and a limited overall surface size. In addition, the distance between the two opposite side walls (4, 5) is about a few micrometers and preferably comprised between 3 and 5 micrometers.
摘要翻译：微流体部件包括由顶壁（6）和底壁（3）和两个相对的侧壁（4,5）所描绘的至少一个通道（2）。通道（2）的顶壁（6）和底壁（3）之间的距离（P）大于或等于25微米，第一组和第二组纳米管（9a，9b）分别由两个相对的侧壁（4,5）用于部件在接触表面和可用体积之间呈现特别高的比例以及有限的整个表面尺寸。另外，两个相对的侧壁（4,5）之间的距离约为几微米，优选地在3微米至5微米之间。

2. 发明申请

US20090060788A1 Microfluidic component with a channel filled with nanotubes and method for its production 有权
标题翻译：具有填充纳米管的通道的微流体组件及其生产方法
公开(公告)号：US20090060788A1
公开(公告)日：2009-03-05
申请号：US11918664
申请日：2006-05-11
申请人： Florence Ricoul , Nicolas Sarrut , Jean Dijon , Francoise Vinet
发明人： Florence Ricoul , Nicolas Sarrut , Jean Dijon , Francoise Vinet
IPC分类号： B01J19/00 , B44C1/22
CPC分类号： B01J19/0093 , B01F5/061 , B01F13/0059 , B01F13/0091 , B01F2005/0632 , B01F2005/0636 , B01J20/205 , B01J20/28007 , B01J20/281 , B01J2219/00783 , B01J2219/00846 , B01J2219/0086 , B01L3/5027 , B82Y30/00 , Y10T428/139
摘要： A microfluidic component comprises at least one channel (2) delineated by a top wall (6) and a bottom wall (3) and two opposite side walls (4, 5). The distance (P) between the top wall (6) and the bottom wall (3) of the channel (2) is greater than or equal to 25 micrometers and first and second sets of nanotubes (9a, 9b) are respectively borne by the two opposite side walls (4, 5) for the component to present a particularly high ratio between the contact surface and the available volume and a limited overall surface size. In addition, the distance between the two opposite side walls (4, 5) is about a few micrometers and preferably comprised between 3 and 5 micrometers.
摘要翻译：微流体部件包括由顶壁（6）和底壁（3）和两个相对的侧壁（4,5）所描绘的至少一个通道（2）。通道（2）的顶壁（6）和底壁（3）之间的距离（P）大于或等于25微米，第一组和第二组纳米管（9a，9b）分别由两个相对的侧壁（4,5）用于部件在接触表面和可用体积之间呈现特别高的比例以及有限的整个表面尺寸。另外，两个相对的侧壁（4,5）之间的距离约为几微米，优选地在3微米至5微米之间。

3. 发明申请

US20090084496A1 Method for fabricating a microfluidic component comprising at least one microchannel filled with nanostructures 有权
标题翻译：用于制造包含填充有纳米结构的至少一个微通道的微流体组分的方法
公开(公告)号：US20090084496A1
公开(公告)日：2009-04-02
申请号：US12230924
申请日：2008-09-08
申请人： Agnes Fonverne , Jean Dijon , Florence Ricoul , Emmanuelle Rouviere
发明人： Agnes Fonverne , Jean Dijon , Florence Ricoul , Emmanuelle Rouviere
IPC分类号： B32B38/00
CPC分类号： B81C1/00206 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00835 , B01J2219/00846 , B01J2219/00862 , B01J2219/00869 , B01J2219/00873 , B01L3/502707 , B01L3/502753 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B81B2201/058 , B81B2203/0338 , B81C2201/019 , B81C2203/038
摘要： A microfluidic component comprises at least one closed microchannel filled with nanostructures. The microchannel is produced by previously forming an opening delineating a bottom wall and two opposite side walls of the microchannel in a surface of a substrate. The nanostructures filling said microchannel are formed by in situ growth to constitute a layer of metallic catalyst deposited on said side walls and on said wall bottom. The microchannel is closed, before the nanostructures are formed, by sealing a protective cover onto said surface of the substrate. Sealing is obtained by formation of an eutectic compound between a material of the cover and the metal of the catalyst used for in situ growth of the nanostructures and deposited on the surface of the substrate designed to come into contact with the cover.
摘要翻译：微流体组分包括填充有纳米结构的至少一个闭合微通道。微通道预先形成在衬底的表面中描绘微通道的底壁和两个相对的侧壁的开口。填充所述微通道的纳米结构通过原位生长形成，以构成沉积在所述侧壁上和所述壁底上的金属催化剂层。在形成纳米结构之前，通过将保护盖密封在基材的所述表面上来封闭微通道。通过在盖的材料和用于纳米结构的原位生长的催化剂的金属之间形成共晶化合物并沉积在设计成与盖接触的基板的表面上来获得密封。

4. 发明授权

US08029863B2 Method for fabricating a microfluidic component comprising at least one microchannel filled with nanostructures 有权
标题翻译：用于制造包含填充有纳米结构的至少一个微通道的微流体组分的方法
公开(公告)号：US08029863B2
公开(公告)日：2011-10-04
申请号：US12230924
申请日：2008-09-08
申请人： Agnès Fonverne , Jean Dijon , Florence Ricoul , Emmanuelle Rouviere
发明人： Agnès Fonverne , Jean Dijon , Florence Ricoul , Emmanuelle Rouviere
IPC分类号： B32B38/00 , C23C16/00
CPC分类号： B81C1/00206 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00835 , B01J2219/00846 , B01J2219/00862 , B01J2219/00869 , B01J2219/00873 , B01L3/502707 , B01L3/502753 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B81B2201/058 , B81B2203/0338 , B81C2201/019 , B81C2203/038
摘要： A microfluidic component comprises at least one closed microchannel filled with nanostructures. The microchannel is produced by previously forming an opening delineating a bottom wall and two opposite side walls of the microchannel in a surface of a substrate. The nanostructures filling said microchannel are formed by in situ growth to constitute a layer of metallic catalyst deposited on said side walls and on said wall bottom. The microchannel is closed, before the nanostructures are formed, by sealing a protective cover onto said surface of the substrate. Sealing is obtained by formation of an eutectic compound between a material of the cover and the metal of the catalyst used for in situ growth of the nanostructures and deposited on the surface of the substrate designed to come into contact with the cover.
摘要翻译：微流体组分包括填充有纳米结构的至少一个闭合微通道。微通道预先形成在衬底的表面中描绘微通道的底壁和两个相对的侧壁的开口。填充所述微通道的纳米结构通过原位生长形成，以构成沉积在所述侧壁上和所述壁底上的金属催化剂层。在形成纳米结构之前，通过将保护盖密封在基材的所述表面上来封闭微通道。通过在盖的材料和用于纳米结构的原位生长的催化剂的金属之间形成共晶化合物并沉积在设计成与盖接触的基板的表面上来获得密封。

5. 发明申请

US20110108424A1 DEVICE FOR SEPARATING BIOMOLECULES FROM A FLUID 审中-公开
标题翻译：从流体分离生物分子的装置
公开(公告)号：US20110108424A1
公开(公告)日：2011-05-12
申请号：US12991548
申请日：2009-05-05
申请人： Pierre Puget , Florence Ricoul
发明人： Pierre Puget , Florence Ricoul
IPC分类号： C25B7/00 , B82Y99/00
CPC分类号： G01N27/44791 , B01J20/205 , B01J20/28007 , B01L3/502707 , B01L3/502753 , B01L2300/0816 , B01L2300/0896 , B01L2400/0415 , B01L2400/086 , B82Y30/00
摘要： The device for separating biomolecules from a fluid comprises a microfluidic component provided with at least one microchannel having at least one of the walls supporting a plurality of nanotubes or nanowires. The component comprises at least one electrode electrically connected to at least a part of the nanotubes or nanowires and the device comprises means for applying a voltage between the electrode and the fluid. The nanotubes or nanowires are divided into several active areas in which the nanotubes or nanowires have a different density.
摘要翻译：用于从流体分离生物分子的装置包括提供有至少一个微通道的微流体组件，其具有支撑多个纳米管或纳米线的至少一个壁。该组件包括电连接到纳米管或纳米线的至少一部分的至少一个电极，并且该装置包括用于在电极和流体之间施加电压的装置。纳米管或纳米线被分成若干活性区域，其中纳米管或纳米线具有不同的密度。

6. 发明申请

US20080254448A1 Analysis Chip With Reference Range, Kits and Methods of Analysis 失效
标题翻译：具有参考范围，套件和分析方法的分析芯片
公开(公告)号：US20080254448A1
公开(公告)日：2008-10-16
申请号：US10584916
申请日：2004-12-23
申请人： Frédéric Ginot , Armelle Novelli-Rousseau , Frederic Mallard , Florence Ricoul
发明人： Frédéric Ginot , Armelle Novelli-Rousseau , Frederic Mallard , Florence Ricoul
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6837 , C12Q2545/101 , C12Q2545/113
摘要： Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several reference spots each arranged on said chip in a defined manner and independently of one another, each reference spot of this range comprising, immobilized on its surface and in a defined proportion P that is different and known for each spot relative to the other reference spots of said range: a probe reference molecule (PRM) permitting recognition and hybridization specifically to a defined target reference molecule (TRM), and/or an inert oligonucleotide molecule (IM) incapable of recognition and hybridization with said PRM, these molecules both being unable to immobilize said analyte or analytes. The method of the invention comprises the use of said chip with its reference range for analysis of said, at least one, analyte.
摘要翻译：至少一种分析物的分析芯片，所述芯片包含至少一个用于分析物特异性识别和固定的分析点; 和包括几个参考点的参考范围（G），每个参考点以规定的方式并且彼此独立地布置在所述芯片上，该范围的每个参考点包括固定在其表面上并以限定的比例P，每个点相对于所述范围的其它参考点：探针参考分子（PRM），其允许特异性地与定义的靶参考分子（TRM）的识别和杂交，和/或不能识别和杂交的惰性寡核苷酸分子（IM）所述PRM，这些分子都不能固定所述分析物或分析物。本发明的方法包括使用其参考范围用于分析所述至少一种分析物的所述芯片。

7. 发明授权

US08129113B2 Analysis chip with reference range, kits and methods of analysis 失效
标题翻译：分析芯片具有参考范围，套件和分析方法
公开(公告)号：US08129113B2
公开(公告)日：2012-03-06
申请号：US10584916
申请日：2004-12-23
申请人： Frédéric Ginot , Armelle Novelli-Rousseau , Frédéric Mallard , Florence Ricoul
发明人： Frédéric Ginot , Armelle Novelli-Rousseau , Frédéric Mallard , Florence Ricoul
IPC分类号： C07H21/04 , C12Q1/68 , C12M1/36
CPC分类号： C12Q1/6837 , C12Q2545/101 , C12Q2545/113
摘要： Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several reference spots each arranged on said chip in a defined manner and independently of one another, each reference spot of this range comprising, immobilized on its surface and in a defined proportion P that is different and known for each spot relative to the other reference spots of said range: a probe reference molecule (PRM) permitting recognition and hybridization specifically to a defined target reference molecule (TRM), and/or an inert oligonucleotide molecule (IM) incapable of recognition and hybridization with said PRM, these molecules both being unable to immobilize said analyte or analytes. The method of the invention comprises the use of said chip with its reference range for analysis of said, at least one, analyte.
摘要翻译：至少一种分析物的分析芯片，所述芯片包含至少一个用于分析物特异性识别和固定的分析点; 和包括几个参考点的参考范围（G），每个参考点以规定的方式并且彼此独立地布置在所述芯片上，该范围的每个参考点包括固定在其表面上并以限定的比例P，每个点相对于所述范围的其它参考点：探针参考分子（PRM），其允许特异性地与定义的靶参考分子（TRM）的识别和杂交，和/或不能识别和杂交的惰性寡核苷酸分子（IM）所述PRM，这些分子都不能固定所述分析物或分析物。本发明的方法包括使用其参考范围用于分析所述至少一种分析物的所述芯片。

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