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1. 发明申请

US20090177266A1 METHODS, SYSTEMS AND DEVICES FOR CARDIAC VALVE REPAIR 审中-公开
标题翻译：心脏瓣膜修复的方法，系统和装置
公开(公告)号：US20090177266A1
公开(公告)日：2009-07-09
申请号：US12398971
申请日：2009-03-05
申请人： Ferolyn T. Powell , Troy L. Thornton , Eric A. Goldfarb , Jan Komtebedde , Kent D. Dell , Pedro B. Lucatero , Francisco J. Valencia , Murli Srinivasan , Roger A. Goodgion , Sandra Saenz , Sylvia Wenchin Fan , Sylvester B. Lucatero , Yen C. Liao , John P. Madden , Jaime E. Sarabia
发明人： Ferolyn T. Powell , Troy L. Thornton , Eric A. Goldfarb , Jan Komtebedde , Kent D. Dell , Pedro B. Lucatero , Francisco J. Valencia , Murli Srinivasan , Roger A. Goodgion , Sandra Saenz , Sylvia Wenchin Fan , Sylvester B. Lucatero , Yen C. Liao , John P. Madden , Jaime E. Sarabia
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2457 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/29 , A61B2017/00243 , A61B2017/00783 , A61B2017/00876 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0435 , A61B2017/0445 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61F2/2412 , A61F2/2445 , A61F2/2454 , A61F2/246 , A61F2/2463 , A61F2/2478 , A61F2/2487 , A61F2210/009 , A61F2220/0016
摘要： Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.
摘要翻译：公开了用于心脏瓣膜的血管内修复的方法，系统和装置，特别是在收缩期间抑制血液从心室逆流的房室瓣膜。本文描述的程序可以使用从心脏远离病人的动脉或静脉血管引入心室的介入工具，引导件和辅助导管以及其他设备进行。介入工具和其他设备可以经皮引入，也可以通过手术切口引入，然后从远程访问位置通过脉管系统进入，直到达到心脏。

2. 发明申请

US20100298929A1 METHODS, SYSTEMS AND DEVICES FOR CARDIAC VALVE REPAIR 审中-公开
标题翻译：心脏瓣膜修复的方法，系统和装置
公开(公告)号：US20100298929A1
公开(公告)日：2010-11-25
申请号：US12690027
申请日：2010-01-19
申请人： Troy L. Thornton , Ferolyn T. Powell , Eric A. Goldfarb , Jan Komtebedde , Kent D. Dell , Pedro B. Lucatero , Francisco J. Valencia , Murli Srinivasan , Roger A. Goodgion , Sandra Saenz , Sylvia Erickson , Sylvester B. Lucatero , Yen C. Liao , John P. Madden , Jaime E. Sarabia
发明人： Troy L. Thornton , Ferolyn T. Powell , Eric A. Goldfarb , Jan Komtebedde , Kent D. Dell , Pedro B. Lucatero , Francisco J. Valencia , Murli Srinivasan , Roger A. Goodgion , Sandra Saenz , Sylvia Erickson , Sylvester B. Lucatero , Yen C. Liao , John P. Madden , Jaime E. Sarabia
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/0401 , A61B17/0487 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/083 , A61B17/29 , A61B17/295 , A61B2017/00243 , A61B2017/00477 , A61B2017/00783 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0419 , A61B2017/0427 , A61B2017/0435 , A61B2017/0441 , A61B2017/0445 , A61B2017/0454 , A61B2017/0464 , A61B2017/048 , A61B2017/0496 , A61B2017/0647 , A61B2017/12018 , A61B2017/22044 , A61F2/2412 , A61F2/2445 , A61F2/2454 , A61F2/2457 , A61F2/246 , A61F2/2463 , A61F2/2487 , A61F2002/249 , A61F2002/30079 , A61F2210/009 , A61F2220/0016 , A61F2250/0003 , A61F2250/0007
摘要： Disclosed are methods, systems, and devices for the endovascular repair of cardiac valves, particularly the atrioventricular valves which inhibit back flow of blood from a heart ventricle during contraction. The procedures described herein can be performed with interventional tools, guides and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart. The interventional tools and other equipment may be introduced percutaneously or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach the heart.
摘要翻译：公开了用于心脏瓣膜的血管内修复的方法，系统和装置，特别是在收缩期间抑制血液从心室逆流的房室瓣膜。本文描述的程序可以使用从心脏远离病人的动脉或静脉血管引入心室的介入工具，引导件和辅助导管以及其他设备进行。介入工具和其他设备可以经皮引入，也可以通过手术切口引入，然后从远程访问位置通过脉管系统进入，直到达到心脏。

3. 发明申请

US20100022823A1 METHODS AND DEVICES FOR TISSUE GRASPING AND ASSESSMENT 有权
标题翻译：用于组织成像和评估的方法和装置
公开(公告)号：US20100022823A1
公开(公告)日：2010-01-28
申请号：US12575100
申请日：2009-10-07
申请人： Eric A. Goldfarb , Troy L. Thornton , Alfred H. Raschdorf , Jaime E. Sarabia , John P. Madden , Ferolyn T. Powell , Brian B. Martin , Sylvia Wen-Chin Fan , Jan Komtebedde , Yen C. Liao
发明人： Eric A. Goldfarb , Troy L. Thornton , Alfred H. Raschdorf , Jaime E. Sarabia , John P. Madden , Ferolyn T. Powell , Brian B. Martin , Sylvia Wen-Chin Fan , Jan Komtebedde , Yen C. Liao
IPC分类号： A61F2/24
CPC分类号： A61B17/29 , A61B17/0401 , A61B17/08 , A61B17/3478 , A61B2017/00243 , A61B2017/081 , A61B2017/22088 , A61B2017/22089 , A61B2017/22098 , A61B2017/2825 , A61B2017/2926 , A61B2017/2931 , A61B2017/306 , A61B2090/3908 , A61B2090/3925
摘要： Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.
摘要翻译：提供的装置，系统和方法用于稳定和抓握诸如瓣叶的组织，评估这些组织的抓握，近似和固定组织，以及评估组织的固定以治疗心脏瓣膜反流，特别是二尖瓣反流。

4. 发明授权

US07604646B2 Locking mechanisms for fixation devices and methods of engaging tissue 有权
标题翻译：固定装置的锁定机构和接合组织的方法
公开(公告)号：US07604646B2
公开(公告)日：2009-10-20
申请号：US11130818
申请日：2005-05-16
申请人： Eric A. Goldfarb , Jaime E. Sarabia , Alfred H. Raschdorf , John P. Madden
发明人： Eric A. Goldfarb , Jaime E. Sarabia , Alfred H. Raschdorf , John P. Madden
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the elements for locking the elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供设备，系统和方法用于组织近似和修复治疗部位。特别地，提供了固定装置，其包括一对元件，每个元件具有第一端，与第一端相对的自由端和用于接合组织的接合表面，第一端可在打开位置之间移动，其中自由端为间隔开和闭合位置，其中自由端与通常彼此面对的接合表面更靠近在一起。固定装置还包括联接到元件的锁定机构，用于将元件锁定就位。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放性外科手术，并可用于各种解剖学领域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。

5. 发明授权

US08343174B2 Locking mechanisms for fixation devices and methods of engaging tissue 有权
标题翻译：固定装置的锁定机构和接合组织的方法
公开(公告)号：US08343174B2
公开(公告)日：2013-01-01
申请号：US12554162
申请日：2009-09-04
申请人： Eric A. Goldfarb , Jaime E. Sarabia , Alfred H. Raschdorf , John P. Madden
发明人： Eric A. Goldfarb , Jaime E. Sarabia , Alfred H. Raschdorf , John P. Madden
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices and methods are provided for tissue approximation and repair. Fixation devices comprise a pair of elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices include a locking mechanism coupled to the elements for locking the elements in place. The devices and methods find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions. The invention is particularly useful in procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：提供了用于组织近似和修复的装置和方法。固定装置包括一对元件，每个元件具有第一端，与第一端相对的自由端和用于接合组织的接合表面，第一端可在打开位置之间移动，其中自由端间隔开，其中自由端与通常彼此面对的接合表面更靠近在一起。固定装置包括联接到元件的锁定机构，用于将元件锁定就位。这些装置和方法可用于各种治疗方法，包括血管内，微创和开放手术，可用于各种解剖区域。本发明在需要微创或血管内进入远程组织位置的方法中特别有用，其中使用的器械必须协商到治疗部位的长，窄和曲折的途径。

6. 发明申请

US20160317843A9 INTEGRATED ABLATION AND MAPPING SYSTEM 审中-公开
公开(公告)号：US20160317843A9
公开(公告)日：2016-11-03
申请号：US13446552
申请日：2012-04-13
申请人： James W. Arenson , Thilaka Sumanaweera , John P. Madden
发明人： James W. Arenson , Thilaka Sumanaweera , John P. Madden
IPC分类号： A61N7/02
CPC分类号： A61N7/022 , A61B5/0422 , A61B5/061 , A61B5/1076 , A61B34/20 , A61B34/25 , A61B2017/00044 , A61B2018/00577 , A61B2018/00839
摘要： A system for ablating and mapping tissue comprises a stand alone tissue ablation system adapted to ablate the tissue, and a stand alone cardiac mapping system adapted to map the tissue. The ablation system is operably coupled with the cardiac mapping system such that mapping data from the cardiac mapping system is provided to the ablation system to create a graphical display of the tissue and the ablation system position relative to the tissue. Motion of the ablation system may be monitored and adjusted based on feedback provided by ablation system actuators as well as position sensors.

7. 发明申请

US20140046313A1 TISSUE NECROSIS METHODS AND APPARATUS 审中-公开
标题翻译：组织损伤方法和装置
公开(公告)号：US20140046313A1
公开(公告)日：2014-02-13
申请号：US13754268
申请日：2013-01-30
申请人： Michael J. Pederson , Patrick J. Phillips , John P. Madden , Michael J. Horzewski
发明人： Michael J. Pederson , Patrick J. Phillips , John P. Madden , Michael J. Horzewski
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B17/2202 , A61B17/3478 , A61B2017/22021 , A61B2018/00011 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61N7/022 , A61N2007/0043 , A61N2007/0052 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091 , A61N2007/0095
摘要： Apparatus and methods for creating tissue necrosis include an energy delivery apparatus that can be positioned adjacent a target treatment site such as a vessel without direct contact with the treatment site tissue. Collimated energy is then directed to the vessel to create necrotic regions in the tissue. Exemplary use in renal vessels creates necrotic regions in adjacent nerves which can alleviate hypertension in a patient.
摘要翻译：用于产生组织坏死的装置和方法包括能量输送装置，其能够定位在诸如血管的目标治疗部位附近而不与治疗部位组织直接接触。然后将准直的能量引导至血管以在组织中产生坏死区域。在肾血管中的示例性用途在相邻神经中产生可以减轻患者高血压的坏死区域。

8. 发明申请

US20130103064A1 INTEGRATED ABLATION AND MAPPING SYSTEM 审中-公开
标题翻译：综合排列和映射系统
公开(公告)号：US20130103064A1
公开(公告)日：2013-04-25
申请号：US13446552
申请日：2012-04-13
申请人： James W. Arenson , Thilaka Sumanaweera , John P. Madden
发明人： James W. Arenson , Thilaka Sumanaweera , John P. Madden
IPC分类号： A61N7/02
CPC分类号： A61N7/022 , A61B5/0422 , A61B5/061 , A61B5/1076 , A61B34/20 , A61B34/25 , A61B2017/00044 , A61B2018/00577 , A61B2018/00839
摘要： A system for ablating and mapping tissue comprises a stand alone tissue ablation system adapted to ablate the tissue, and a stand alone cardiac mapping system adapted to map the tissue. The ablation system is operably coupled with the cardiac mapping system such that mapping data from the cardiac mapping system is provided to the ablation system to create a graphical display of the tissue and the ablation system position relative to the tissue. Motion of the ablation system may be monitored and adjusted based on feedback provided by ablation system actuators as well as position sensors.
摘要翻译：用于消融和映射组织的系统包括适于消融组织的独立组织消融系统和适于映射组织的独立心脏图谱系统。消融系统与心脏测绘系统可操作地耦合，使得将来自心脏测绘系统的映射数据提供给消融系统以创建组织的图形显示和相对于组织的消融系统位置。可以基于由消融系统致动器以及位置传感器提供的反馈来监测和调整消融系统的运动。

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