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1. 发明申请

US20110129941A1 Method of Producing Polymeric Particles With Selected Size, Shape, Morphology and Composition 有权
标题翻译：生产选择尺寸，形状，形态和组成的聚合物颗粒的方法
公开(公告)号：US20110129941A1
公开(公告)日：2011-06-02
申请号：US11587251
申请日：2005-04-25
申请人： Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
发明人： Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
IPC分类号： B01J19/00
CPC分类号： C08J3/16 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61K9/5036 , B01F3/0807 , B01F5/0647 , B01F13/0062 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01J2219/00984 , B82Y10/00 , B82Y30/00 , Y10T436/2575
摘要： The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.
摘要翻译：本发明提供了一种用于制备具有预先设计的尺寸，形状，形态和组成的聚合物颗粒的方法和装置，更具体地，本发明使用微流体聚合反应器来生产聚合物颗粒。本文公开的本发明提供了一种用于制备具有预选形状的聚合物颗粒的方法。该方法包括将包含可控流速的可聚合组分的第一流体注入微流体通道并将具有受控流速的第二流体注射到第二流体与第一流体混合的微流体通道中，第二流体是不混溶的第一流体使得第一流体在微流体通道中形成液滴。微流体通道具有预选的尺寸以产生预选尺寸，形态和形状的液滴。微流体通道足够长，使得液滴在通道中具有足够长的停留时间，使得它们聚合或以其它方式硬化成预选尺寸和形状的液滴。

2. 发明授权

US08696952B2 Method of producing polymeric particles with selected size, shape, morphology and composition 有权
标题翻译：制备具有选定尺寸，形状，形态和组成的聚合物颗粒的方法
公开(公告)号：US08696952B2
公开(公告)日：2014-04-15
申请号：US11587251
申请日：2005-04-25
申请人： Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
发明人： Eugenia Kumacheva , Shengqing Xu , Zhihong Nie , Min Seok Seo , Patrick Cameron Lewis , Hong Zhang
IPC分类号： B01J19/00 , C08F2/00
CPC分类号： C08J3/16 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61K9/5036 , B01F3/0807 , B01F5/0647 , B01F13/0062 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01J2219/00984 , B82Y10/00 , B82Y30/00 , Y10T436/2575
摘要： The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.
摘要翻译：本发明提供了一种用于制备具有预先设计的尺寸，形状，形态和组成的聚合物颗粒的方法和装置，更具体地，本发明使用微流体聚合反应器来生产聚合物颗粒。本文公开的本发明提供了一种用于制备具有预选形状的聚合物颗粒的方法。该方法包括将包含可控流速的可聚合组分的第一流体注入微流体通道并将具有受控流速的第二流体注射到第二流体与第一流体混合的微流体通道中，第二流体是不混溶的第一流体使得第一流体在微流体通道中形成液滴。微流体通道具有预选的尺寸以产生预选尺寸，形态和形状的液滴。微流体通道足够长，使得液滴在通道中具有足够长的停留时间，使得它们聚合或以其它方式硬化成预选尺寸和形状的液滴。

3. 发明申请

US20070054119A1 Systems and methods of forming particles 审中-公开
标题翻译：形成颗粒的系统和方法
公开(公告)号：US20070054119A1
公开(公告)日：2007-03-08
申请号：US11368263
申请日：2006-03-03
申请人： Piotr Garstecki , Douglas Weibel , Irina Gitlin , Shoji Takeuchi , Shengqing Xu , Zhihong Nie , Min Seo , Patrick Lewis , Eugenia Kumacheva , Howard Stone , George Whitesides
发明人： Piotr Garstecki , Douglas Weibel , Irina Gitlin , Shoji Takeuchi , Shengqing Xu , Zhihong Nie , Min Seo , Patrick Lewis , Eugenia Kumacheva , Howard Stone , George Whitesides
IPC分类号： B32B1/00
CPC分类号： B01J19/0093 , B01F3/0807 , B01F13/0062 , B01J19/06 , B01J2219/00873 , B22F1/0007 , B22F9/06 , Y10T428/2982
摘要： The present invention generally relates to systems and methods of forming particles and, in certain aspects, to systems and methods of forming particles that are substantially monodisperse. Microfluidic systems and techniques for forming such particles are provided, for instance, particles may be formed using gellation, solidification, and/or chemical reactions such as cross-linking, polymerization, and/or interfacial polymerization reactions. In one aspect, the present invention is directed to a plurality of particles having an average dimension of less than about 500 micrometers and a distribution of dimensions such that no more than about 5% of the particles have a dimension greater than about 10% of the average dimension, which can be made via microfluidic systems. In one set of embodiments, at least some of the particles may comprise a metal, and in certain embodiments, at least some of the particles may comprise a magnetizable material. In another set of embodiments, at least some of the particles may be porous. In some embodiments, the invention includes non-spherical particles. Non-spherical particles may be formed, for example, by urging a fluidic droplet into a channel having a smallest dimension that is smaller than the diameter of a perfect mathematical sphere having a volume of the droplet, and solidifying the droplet, and/or by exposing at least a portion of a plurality of particles to an agent able to remove at least a portion of the particles.
摘要翻译：本发明一般涉及形成颗粒的系统和方法，并且在某些方面涉及形成基本上单分散的颗粒的体系和方法。提供了用于形成这种颗粒的微流体系统和技术，例如，可以使用凝胶化，固化和/或化学反应如交联，聚合和/或界面聚合反应形成颗粒。在一个方面，本发明涉及平均尺寸小于约500微米的多个颗粒和尺寸分布，使得不超过约5％的颗粒具有大于所述颗粒的约10％的尺寸平均尺寸，可以通过微流体系统进行。在一组实施方案中，至少一些颗粒可以包含金属，并且在某些实施方案中，至少一些颗粒可以包含可磁化材料。在另一组实施方案中，至少一些颗粒可以是多孔的。在一些实施方案中，本发明包括非球形颗粒。非球形颗粒可以例如通过将流体液滴推入具有小于具有液滴体积的完美数学球体的直径的最小尺寸的通道，和/或通过将多个颗粒的至少一部分暴露于能除去至少一部分颗粒的试剂。

4. 发明授权

US08337778B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US08337778B2
公开(公告)日：2012-12-25
申请号：US12726223
申请日：2010-03-17
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

5. 发明授权

US06785214B2 Polymeric nanocomposite materials with a functional matrix and method of reading and writing thereto 失效
标题翻译：具有功能矩阵的聚合纳米复合材料及其读取和写入方法
公开(公告)号：US06785214B2
公开(公告)日：2004-08-31
申请号：US09726487
申请日：2000-12-01
申请人： Eugenia Kumacheva , Olga Kalinina
发明人： Eugenia Kumacheva , Olga Kalinina
IPC分类号： G11B700
CPC分类号： B01J13/02 , B01J13/18 , G03F7/0005 , G03F7/002 , G11B7/00455 , G11B7/0052
摘要： A nanocomposite material having a plurality of core particles formed of a core material. The core material has a first glass transition temperature. A shell encapsulates each core particle. The shell is formed of a shell material that has a second glass transition temperature less than the first glass transition temperature. When subjected to a temperature greater than the second glass transition temperature and less than the first glass transition temperature, the shells form a continuous matrix surrounding the core particles. The shell material includes a functional component that can be activated in response to an external excitation. This functional component can include either photosensitive, semiconductor, magnetic, piezoelectric or electro-active components just to mention a few. The different components may be chemically or physically bound to the shell or cores. These nanocomposite materials are used as storage media.
摘要翻译：一种纳米复合材料，其具有由核心材料形成的多个核心颗粒。芯材料具有第一玻璃化转变温度。壳体封装每个核心粒子。外壳由壳材料形成，其具有小于第一玻璃化转变温度的第二玻璃化转变温度。当受到大于第二玻璃化转变温度且小于第一玻璃化转变温度的温度时，壳形成围绕芯颗粒的连续基体。外壳材料包括可以响应于外部激发而被激活的功能部件。该功能组件可以包括光敏，半导体，磁性，压电或电活性组分，仅仅是提及一些。不同的组分可以化学或物理地结合到壳或核。这些纳米复合材料用作储存介质。

6. 发明授权

US06214500B1 Core and shell matrix compositions and processes 有权
标题翻译：核和壳基质组成和工艺
公开(公告)号：US06214500B1
公开(公告)日：2001-04-10
申请号：US09359565
申请日：1999-07-22
申请人： Eugenia Kumacheva , Jaan Noolandi , Olga Kalinina
发明人： Eugenia Kumacheva , Jaan Noolandi , Olga Kalinina
IPC分类号： G03C173
CPC分类号： B82Y10/00 , G11B7/00455 , G11B7/24 , G11B7/24044 , G11B7/244 , G11B7/245 , G11B7/26 , G11B2007/0009 , Y10S430/163
摘要： A composition including a matrix comprised of particles comprised of a core resin and a shell resin thereover, wherein the core resin contains a covalently bonded photosensitive compound, and wherein the shell resin is the continuous phase of the matrix.
摘要翻译：一种组合物，其包含由芯树脂和其上的壳树脂构成的颗粒构成的基体，其中所述芯树脂含有共价键合的感光性化合物，并且其中所述壳树脂为所述基质的连续相。

7. 发明申请

US20060257485A1 Method of producing hybrid polymer-inorganic materials 有权
标题翻译：混合聚合物 - 无机材料的制备方法
公开(公告)号：US20060257485A1
公开(公告)日：2006-11-16
申请号：US10548414
申请日：2004-03-10
申请人： Eugenia Kumacheva
发明人： Eugenia Kumacheva
IPC分类号： A61K9/14 , C08K3/22
CPC分类号： C08G83/001 , B82Y30/00 , C08J5/005
摘要： The present invention describes a new approach to producing hybrid composite materials with multiscale morphologies. We doped polymer submicrometer spheres with semiconductor or metal (e.g. CdS or Ag, respectively) nanoparticles and used these doped microspheres as the functional building blocks in production of hybrid periodically structured materials. The preparation of hybrid polymer particles included the following stages: (i) synthesis of monodisperse polymer microspheres, (ii) in-situ synthesis of the inorganic nanoparticles either on the surface, or in the bulk of the polymer beads, and (iii) encapsulation of hybrid microspheres with a hydrophobic shell. We demonstrated that by changing the composition of the polymer beads good control could be achieved over the size of the nanoparticles.
摘要翻译：本发明描述了生产具有多尺度形态的混合复合材料的新方法。我们用半导体或金属（例如分别为CdS或Ag）纳米颗粒掺杂聚合物亚微米球，并将这些掺杂的微球用作生产混合周期性结构材料的功能性结构单元。混合聚合物颗粒的制备包括以下阶段：（i）合成单分散聚合物微球体，（ii）在表面或大部分聚合物珠粒中原位合成无机纳米颗粒，和（iii）包封具有疏水壳的杂交微球。我们证明通过改变聚合物珠粒的组成，可以在纳米粒子的尺寸上实现良好的控制。

8. 发明申请

US20050172476A1 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US20050172476A1
公开(公告)日：2005-08-11
申请号：US11024228
申请日：2004-12-28
申请人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
发明人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04 , B01D61/42
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

9. 发明授权

US06846578B2 Method of colloid crystal growth on patterned surfaces 失效
标题翻译：在图案化表面上胶体晶体生长的方法
公开(公告)号：US06846578B2
公开(公告)日：2005-01-25
申请号：US10353071
申请日：2003-01-29
申请人： Eugenia Kumacheva , Edward H. Sargent , Robert Kori Golding , Mathieu Allard
发明人： Eugenia Kumacheva , Edward H. Sargent , Robert Kori Golding , Mathieu Allard
IPC分类号： C30B19/00 , C30B19/10 , C30B19/12 , B32B3/00 , C25D5/02
CPC分类号： C30B19/12 , C30B19/00 , C30B19/103 , C30B29/58 , Y10S428/926 , Y10S428/935 , Y10S977/951 , Y10T428/12063 , Y10T428/12472 , Y10T428/12993 , Y10T428/24802 , Y10T428/25 , Y10T428/254 , Y10T428/26 , Y10T428/265 , Y10T428/269
摘要： Method of synthesis of confined colloidal crystals using electrodeposition. The present invention provides a method of growing confined colloidal crystal structures using electrodeposition of monodispersed charged colloid spheres onto a substrate patterned with an array of electroconductive surface relief features on a surface of a substrate. In this approach, control over large-scale ordering is achieved via a planar pattern whose scale is on the order of tens of microns, a regime readily accessed through coarse lithography, laser micromachining, and holography.
摘要翻译：使用电沉积法合成胶体晶体的方法。本发明提供了一种使用单分散带电胶体球体电沉积到基板表面上具有导电表面浮雕特征阵列图案化的基板上的密闭胶体晶体结构的方法。在这种方法中，大规模排序的控制是通过一个尺度在几十微米级的平面图形来实现的，一种容易通过粗光刻，激光微加工和全息照相的方案。

10. 发明授权

US08236877B2 Method of producing hybrid polymer-inorganic materials 有权
公开(公告)号：US08236877B2
公开(公告)日：2012-08-07
申请号：US12911059
申请日：2010-10-25
申请人： Eugenia Kumacheva
发明人： Eugenia Kumacheva
IPC分类号： C08G83/00 , C08J3/05 , C08K3/22 , C08K9/10
CPC分类号： C08G83/001 , B82Y30/00 , C08J5/005
摘要： Hybrid composite materials with multiscale morphologies are formed by doping polymer submicrometer spheres with semiconductor or metal (e.g. CdS or Ag, respectively) nanoparticles and using these doped microspheres as functional building blocks in production of hybrid periodically structured materials. The preparation of hybrid polymer particles include the following stages: (i) synthesis of monodisperse polymer microspheres, (ii) in-situ synthesis of the inorganic nanoparticles either on the surface, or in the bulk with polymer beads, and (iii) encapsulation of hybrid microspheres with a hydrophobic shell.

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