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1. 发明申请

US20080160054A1 Novel elongase gene, and process for the preparation of polyunsaturated fatty acids 审中-公开
标题翻译：新型延伸酶基因，以及制备多不饱和脂肪酸的方法
公开(公告)号：US20080160054A1
公开(公告)日：2008-07-03
申请号：US11682269
申请日：2007-03-05
申请人： Ernst Heinz , Thorsten Zank , Ulrich Zahringer , Jens Lerchl , Andreas Renz
发明人： Ernst Heinz , Thorsten Zank , Ulrich Zahringer , Jens Lerchl , Andreas Renz
IPC分类号： A61K8/02 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , A23D7/00 , C12N5/02 , C12P21/04 , G01N33/53 , A61K36/00
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a novel elongase gene with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs.Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.
摘要翻译：本发明涉及具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7所示序列的新型延伸酶基因或其同源物，衍生物或类似物，其包含该基因或其同系物，衍生物和类似物，以及其用途。本发明还涉及包含具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7的延伸酶基因或其同源物，衍生物和类似物的载体或转基因生物。本发明还涉及单独使用延伸酶基因序列或与其它延伸酶和/或其它脂肪酸生物合成基因组合的用途。本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物和类似物的新型延伸酶基因。此外，本发明涉及一种制备多不饱和脂肪酸的方法，以及将DNA引入生产大量油，特别是具有高含量不饱和脂肪酸的油的生物体中的方法。此外，本发明涉及具有较高含量的具有至少两个双键的多不饱和脂肪酸的油和/或脂肪酸制剂和/或具有至少两个双键的具有较高含量的多不饱和脂肪酸的三酰基甘油制剂。

2. 发明申请

US20100021976A1 PRODUCTION OF POLYUNSATURATED FATTY ACIDS, NOVEL BIOSYNTHESIS GENES, AND NOVEL PLANT EXPRESSION CONSTRUCTS 有权
标题翻译：聚氧乙烯脂肪酸生产，新型生物基因和新型植物表达构造
公开(公告)号：US20100021976A1
公开(公告)日：2010-01-28
申请号：US12565799
申请日：2009-09-24
申请人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zahringer
发明人： Jens Lerchl , Andreas Renz , Ernst Heinz , Frederic Domergue , Ulrich Zahringer
IPC分类号： C12P7/64 , C12N15/53 , C12N15/74 , A01H5/00 , C12N5/10 , C12N1/00 , C12N1/19 , C12N15/82 , C12N15/85 , C12N15/81
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides having desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.
摘要翻译：本发明涉及生产具有至少两个双键的不饱和脂肪酸的方法。本发明还涉及编码在该方法中具有去饱和酶活性的多肽的核酸序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：11，并且用于产生转基因生物，优选地具有不饱和C18-，C20-或C22-脂肪酸的脂肪酸，油或脂质含量增加的转基因植物或转基因微生物及其同源物或衍生物，包括这些基因的基因构建体，以及它们单独使用或与多不饱和脂肪酸的生物合成基因组合使用。本发明还涉及用于种子特异性表达的多表达盒以及包含去饱和酶基因单独或与进一步去饱和酶和/或延伸酶基因或使用所述表达盒的同源物组合的载体或生物体。

3. 发明申请

US20060246556A1 Novel method for the production of polyunsaturated fatty acids 有权
标题翻译：用于生产多不饱和脂肪酸的新方法
公开(公告)号：US20060246556A1
公开(公告)日：2006-11-02
申请号：US10539891
申请日：2003-12-11
申请人： Johnathan Napier , Olga Sayanova , Colin Lazarus , Baoxiu Qi , Ernst Heinz , Thorsten Zank , Ulrich Zahringer
发明人： Johnathan Napier , Olga Sayanova , Colin Lazarus , Baoxiu Qi , Ernst Heinz , Thorsten Zank , Ulrich Zahringer
IPC分类号： C12P13/00 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22-fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9-elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Doosahexaenoic acid through the co-expression of a delta-8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants. The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1% by weight of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及一种用于特异性生产多不饱和ω-3和ω-6脂肪酸的改进方法和一种具有增加的不饱和脂肪酸含量，特别是ω-3和ω- 具有至少两个双键和20或22个碳原子链长的6种脂肪酸。本发明涉及转基因生物，优选转基因植物或转基因微生物的生产，其具有增加的含有C20-C22-脂肪酸的脂肪酸，油或脂质含量，其中Δ-5,7,8 ，10双键，分别由于诸如植物优选藻类如等鞭毛藻或小球虫的生物体的δ-8-去饱和酶和δ-9-脱氢酶的表达。此外，本发明涉及通过共同表达δ-8-去饱和酶，δ-9-延伸酶和δ-5的多不饱和脂肪酸如二十碳五烯酸，花生四烯酸，多糖五烯酸或多沙六酸，微生物或植物等生物体中的去饱和酶。本发明还涉及编码上述蛋白质的特定核酸序列与δ-8-去饱和酶，Δ-9-延伸酶或δ-5-去饱和酶活性，核酸构建体，载体和含有所述核酸的生物体的用途酸序列。本发明还涉及不饱和脂肪酸和甘油三酸酯，其具有增加的至少1重量％的不饱和脂肪酸的含量及其用途。

4. 发明申请

US20080075742A1 Compositions Comprising Fetal Hemoglobin and Bacterial Endotoxin and Optionally Additional Fetal Liver Components 有权
标题翻译：组成包括胎儿血红蛋白和细菌内毒素和任选额外的胎肝组成
公开(公告)号：US20080075742A1
公开(公告)日：2008-03-27
申请号：US10545500
申请日：2004-02-18
申请人： Otto Westphal , Josette Mottier Westphal , Alexander Westphal , Thierry Walli , Reginald Gorczynski , Silke Muller , Jean-Pierre Mach , Alfred Hartman , Wolfgang Bessler , Petra Hofmann , Ulrich Zahringer , Christian Alexander , Ulrich vor dem Esche , Artur J. Ulmer , Antonio Verdini
发明人： Otto Westphal , Josette Mottier Westphal , Alexander Westphal , Thierry Walli , Reginald Gorczynski , Silke Muller , Jean-Pierre Mach , Alfred Hartman , Wolfgang Bessler , Petra Hofmann , Ulrich Zahringer , Christian Alexander , Ulrich vor dem Esche , Artur J. Ulmer , Antonio Verdini
IPC分类号： A61K39/02 , A61K38/17 , A61P31/00 , A61P37/00 , A61P35/00 , A61K38/52
CPC分类号： A61K35/407 , A23L33/10 , A61K35/74 , A61K38/42 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.
摘要翻译：本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ链，以及任选地除了HbF之外存在于胎肝中的成分的新型免疫调节原理的药物组合物。组合物以药学上可接受的载体和/或稀释剂递送给人。根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出显着的协同生物医学活性。胎儿血红蛋白及其部分结构的生物医学效应令人惊奇地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。在口服施用组合物后，也观察到该生物医学活性。本发明的组合物发现了各种各样的应用，其具有共同的刺激免疫系统的作用，并且从对Th1型反应的Th2导向反应的细胞因子和趋化因子的极化反转。因此，提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

5. 发明授权

US07968103B2 Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components 有权
标题翻译：包含胎儿血红蛋白和细菌内毒素以及任选的额外的胎儿肝组分的组合物
公开(公告)号：US07968103B2
公开(公告)日：2011-06-28
申请号：US10545500
申请日：2004-02-18
申请人： Otto Westphal , Josette Westphal, legal representative , Alexander Westphal, legal representative , Thierry Walli , Reginald Gorczynski , Silke Muller , Jean-Pierre Mach , Alfred Hartman , Wolfgang Bessler , Petra Hofmann , Ulrich Zahringer , Christian Alexander , Ulrich vor dem Esche , Artur J. Ulmer , Antonio Verdini
发明人： Otto Westphal , Thierry Walli , Reginald Gorczynski , Silke Muller , Jean-Pierre Mach , Alfred Hartman , Wolfgang Bessler , Petra Hofmann , Ulrich Zahringer , Christian Alexander , Ulrich vor dem Esche , Artur J. Ulmer , Antonio Verdini
IPC分类号： A61K39/02 , A61K38/17 , A61P31/00
CPC分类号： A61K35/407 , A23L33/10 , A61K35/74 , A61K38/42 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.
摘要翻译：本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ-链以及除HbF之外存在于胎肝中的成分的新型免疫调节原理的药物组合物。组合物以药学上可接受的载体和/或稀释剂递送给人。根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出显着的协同生物医学活性。胎儿血红蛋白及其部分结构的生物医学效应令人惊奇地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。在口服施用组合物后，也观察到该生物医学活性。本发明的组合物发现了各种各样的应用，其具有共同的刺激免疫系统的作用，并且从对Th1型反应的Th2导向反应的细胞因子和趋化因子的极化反转。因此，提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

6. 发明授权

US5798343A 7-O-Carbamoylheptose derivatives, process for their production and their use in treating pseudomonas infections 失效
标题翻译： 7-O-氨基甲酰肝素衍生物，其生产方法及其在治疗假单胞菌感染中的应用
公开(公告)号：US5798343A
公开(公告)日：1998-08-25
申请号：US765970
申请日：1997-01-15
申请人： Ulrich Zahringer , Frank Beckmann , Hermann Moll
发明人： Ulrich Zahringer , Frank Beckmann , Hermann Moll
IPC分类号： C07H7/027 , A61K31/70 , A61K31/7012 , A61K31/7028 , A61P31/04 , C07H3/04 , C07H7/02 , C07H15/04 , A61K31/735 , C07H1/00 , C07H13/12
CPC分类号： C07H3/04 , C07H7/02 , G01N2333/21 , G01N2400/50
摘要： The invention describes 7-O-carbamoyl heptose derivatives of general formula (I) in which R is the substituent R.sup.1 or a group of general formula (II) in which R.sup.1 is a hydrogen atom, a methyl group or a suitable linker substituent suitable for a covalent coupling, a process for their production and their use in producing reagents and compositions for the diagnosis and therapy of pseudomona infections in humans and animals, and a screening process for their detection in Gram-negative bacteria. ##STR1##
摘要翻译： PCT No.PCT / EP95 / 02780 Sec。 371日期1997年1月15日 102（e）日期1997年1月15日PCT提交1995年7月14日PCT公布。出版物WO96 / 02550 日本特开1996年2月1日本发明描述了通式（I）的R-R为取代基R 1或通式（II）的基团，其中R 1为氢原子，甲基或适用于共价偶联的合适的连接体取代基，其制备方法及其在制备用于诊断和治疗人和动物中的假单胞菌感染的试剂和组合物中的应用，以及用于在革兰氏阴性细菌中检测的筛选方法。（I）（II）

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