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1. 发明授权

US09102667B2 N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease 有权
标题翻译：用于治疗心血管疾病的N-芳基氨基亚甲基苯并噻吩酮
公开(公告)号：US09102667B2
公开(公告)日：2015-08-11
申请号：US13980057
申请日：2012-01-18
申请人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
发明人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
IPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D409/12
CPC分类号： C07D417/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases: wherein E is S, O, or CH2, D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.
摘要翻译：本发明涉及用作治疗心血管疾病的药物的通式（I）的N-芳基氨基亚甲基苯并苯乙酮：其中E是S，O或CH 2，D是CH或NH，Ar是取代的苯基或萘基部分通过吸电子基团，未取代的杂芳基残基或被烷基或吸电子基团取代的杂芳基。

2. 发明申请

US20130289057A1 N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE 失效
标题翻译：用于治疗心血管疾病的N-亚氨基亚甲基苯并噻吩
公开(公告)号：US20130289057A1
公开(公告)日：2013-10-31
申请号：US13980057
申请日：2012-01-12
申请人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
发明人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
IPC分类号： C07D417/12 , C07D413/12 , C07D333/64 , C07D409/12
CPC分类号： C07D417/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases: wherein E is S, O, or CH2, D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.
摘要翻译：本发明涉及用作治疗心血管疾病的药物的通式（I）的N-芳基氨基亚甲基苯并苯乙酮：其中E是S，O或CH 2，D是CH或NH，Ar是取代的苯基或萘基部分通过吸电子基团，未取代的杂芳基残基或被烷基或吸电子基团取代的杂芳基。

3. 发明申请

US20090104177A1 PEPTIDES FOR INHIBITING THE INTERACTION OF PROTEIN KINASE A AND PROTEIN KINASE A ANCHOR PROTEINS 审中-公开
标题翻译：抑制蛋白激酶A和蛋白激酶相互作用的胶原蛋白锚定蛋白
公开(公告)号：US20090104177A1
公开(公告)日：2009-04-23
申请号：US11571117
申请日：2005-06-29
申请人： Enno Klussmann , Walter Rosenthal , Christian Hundsrucker
发明人： Enno Klussmann , Walter Rosenthal , Christian Hundsrucker
IPC分类号： A61K39/395 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06 , A01K67/027 , C12N9/99 , A61K31/7105 , C07K16/18 , A61K31/7088 , A61K38/00 , A61K35/12
CPC分类号： C07K14/47
摘要： The invention relates to a nucleic acid sequence encoding peptides which inhibit the interaction of protein kinase A (PKA) and protein kinase A anchor proteins (AKAP), to a host organism comprising said nucleic acid sequence and optionally expressing said peptides, to the use of said peptides and of said host organism in investigating diseases associated with said AKAP-PKA interaction, and to the use of said peptides as pharmaceutical agent for the treatment of such diseases.
摘要翻译：本发明涉及编码抑制蛋白激酶A（PKA）和蛋白激酶A锚蛋白（AKAP）与包含所述核酸序列并任选表达所述肽的宿主生物体相互作用的肽的核酸序列，以使用所述肽和所述宿主生物体在调查与所述AKAP-PKA相互作用相关的疾病中的用途以及所述肽作为药物用于治疗这些疾病的用途。

4. 发明申请

US20060154330A1 Akap18 delta, a novel splicing variant of a protein kinase a anchor protein and the use of the same 失效
标题翻译： Akap18 delta，一种蛋白激酶的锚定蛋白的新型剪接变体及其用途
公开(公告)号：US20060154330A1
公开(公告)日：2006-07-13
申请号：US10526768
申请日：2003-09-05
申请人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
发明人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to a nucleic acid sequence encoding a protein kinase A anchor portein, to the use of said nucleic acid sequence in a fusion protein, to a method of determining the interaction of said protein kinase A anchor protein with regulatory subunits of protein kinase A, and to a method of identifying cell-permeable substances.
摘要翻译：本发明涉及编码蛋白激酶A锚定蛋白的核酸序列，以使用融合蛋白中的所述核酸序列，确定所述蛋白激酶A锚定蛋白与蛋白激酶A的调控亚基的相互作用的方法以及鉴定细胞可渗透物质的方法。

5. 发明授权

US07863432B2 Nucleic acid molecules encoding AKAP18 delta, a splice variant of a protein kinase A anchor protein 失效
标题翻译：编码AKAP18δ的核酸分子，蛋白激酶A锚蛋白的剪接变体
公开(公告)号：US07863432B2
公开(公告)日：2011-01-04
申请号：US10526768
申请日：2003-09-05
申请人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
发明人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
IPC分类号： C07H21/04 , C12N15/63 , C12N1/20
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to polynucleotides which encode a protein kinase A anchor proteins (AKAP) and the use of such polynucleotides to generate AKAP polypeptides or fusion proteins containing AKAP proteins. The present invention also relates to methods of determining the interaction of AKAP proteins with regulatory subunits of protein kinase A and methods for identifying cell-permeable substances.
摘要翻译：本发明涉及编码蛋白激酶A锚蛋白（AKAP）的多核苷酸以及这种多核苷酸用于产生含有AKAP蛋白的AKAP多肽或融合蛋白的用途。本发明还涉及确定AKAP蛋白与蛋白激酶A的调控亚基的相互作用的方法以及用于鉴定细胞可渗透物质的方法。

6. 发明申请

US20090176773A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction 审中-公开
标题翻译： AKAP / PKA相互作用的非肽抑制剂
公开(公告)号：US20090176773A1
公开(公告)日：2009-07-09
申请号：US11914591
申请日：2006-05-18
申请人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
发明人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
IPC分类号： A61K31/536 , C07D207/44 , A61K31/40 , C07K16/44 , A01K67/027 , C12N5/00 , C07D265/30 , C07D241/04 , A61K31/5375 , A61K31/495 , C07D319/12 , A61K31/357 , C07D413/06 , A61K31/421 , C07D257/06 , A61K31/41 , C07D233/96 , A61K31/4166 , C07D211/82 , A61K31/44 , C07D413/10 , C07D407/12 , A61K31/5355 , A61P3/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P9/04 , A61P25/18 , A61P11/06 , A61P29/00 , A61P31/18
CPC分类号： C07C335/32 , C07C31/137 , C07C50/24 , C07C69/017 , C07C69/94 , C07C211/50 , C07C211/61 , C07C215/76 , C07C215/80 , C07C225/22 , C07C233/09 , C07C233/47 , C07C233/56 , C07C237/40 , C07C245/08 , C07C251/08 , C07C251/24 , C07C251/46 , C07C271/28 , C07C279/04 , C07C279/26 , C07C281/18 , C07C311/08 , C07C311/20 , C07C311/51 , C07C317/44 , C07C335/12 , C07C335/16 , C07C337/06 , C07C2601/14 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D213/42 , C07D231/12 , C07D277/40 , C07D277/54 , C07D277/68 , C07D295/135 , C07D333/64
摘要： The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
摘要翻译：本发明涉及调节，特别是抑制蛋白激酶A（PKA）和A激酶锚蛋白（AKAP）与包含所述非肽化合物或识别分子的宿主或靶生物的相互作用的非肽分子所述化合物，例如抗体或螯合剂。本发明还涉及药剂，特别是用于治疗与cAMP信号通路紊乱相关的疾病，特别是胰岛素性糖尿病，高渗，胰腺糖尿病，十二指肠溃疡，哮喘，心力衰竭，肥胖症，艾滋病，水肿，肝硬化，精神分裂症等。本发明还涉及本发明分子的用途。

7. 发明授权

US4889142A Smoking article and methods of making the same 失效
标题翻译：吸烟制品和制作方法
公开(公告)号：US4889142A
公开(公告)日：1989-12-26
申请号：US366203
申请日：1989-06-09
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： A24B15/28
CPC分类号： A24B15/28 , A24B15/282
摘要： The invention is for a multi-fold improvement for tobacco, including cigarettes, cigars, pipe smoking and other smoking devices by decreasing the health hazards thereof by:1. Replacing and/or reducing substantially all of the nitrate in cigarette paper by use of an oxidizing agent such as potassium permanganate.2. Improving the completeness of burning of the relatively poisonous and undesirable components of tar and smoke of cigarette smoke through addition of an oxidizing agent such as potassium permanganate to the cigarette.Using an oxidizing agent to render non-poisonous certain toxic components in smoking devices and materials including cigarettes, cigars, pipe tobacco and other plant derived ingredients useful and used for smoking.
摘要翻译：本发明是为了通过以下方式减少其健康危害来对烟草进行多重改进，包括香烟，雪茄，烟斗和其他吸烟装置：1.通过使用卷烟纸来替代和/或减少卷烟纸中的大部分硝酸盐氧化剂如高锰酸钾。 2.通过向香烟加入氧化剂如高锰酸钾，提高香烟烟雾焦油和烟雾中相对有毒和不良成分燃烧的完整性。使用氧化剂在吸烟装置和材料中产生无毒的某些有毒成分，包括香烟，雪茄，管烟草和其他有用和用于吸烟的植物衍生成分。

8. 发明授权

US4205929A Slurry transport medium 失效
标题翻译：泥浆运输介质
公开(公告)号：US4205929A
公开(公告)日：1980-06-03
申请号：US888568
申请日：1978-03-20
申请人： Louis Schiffman , Walter Rosenthal
发明人： Louis Schiffman , Walter Rosenthal
IPC分类号： B65G53/30 , B65G53/04
CPC分类号： B65G53/30
摘要： This invention provides for an improvement in slurry transport systems, especially coal slurry lines. Instead of the usual use of fresh water resources which, in some geographic areas, are scarce for slurry transport, concentrated brine is used which is prepared from abundant salt water resources. Because of the higher density of this concentrated brine, it is a superior carrier of pulverized material. It dimishes the separation and settling tendency of slurry components during transport and particularly during shutdown. Other advantages in the use of concentrated brine include: freezing point depression which permits ease of transport during winter and at lower temperatures; dust suppression of stored coal; avoidance of spontaneous combustion of stored coal; inhibit freeze packing of dewatered pipeline coal; and diminished extent of corrosion in ferrous metal pipelines as compared to that which might occur with lower concentration brines. Important in the economy of the process is that the concentrated brine can be recycled. An inexpensive method for producing the concentrated brine is given.
摘要翻译：本发明提供了浆料输送系统，特别是煤浆管线的改进。而不是通常使用淡水资源，在某些地理区域稀缺的泥浆运输，使用浓缩的盐水，这是由丰富的盐水资源制成的。由于该浓缩盐水的密度较高，因此它是粉碎材料的优良载体。它在运输过程中特别是在关闭期间降低了浆料组分的分离和沉降趋势。使用浓缩盐水的其他优点包括：在冬季和较低温度下易于运输的凝固点凹陷; 贮存煤粉尘抑制; 避免储存煤的自燃; 抑制脱水管道煤的冷冻包装; 并且与较低浓度的盐水可能发生的情况相比，黑色金属管道的腐蚀程度减小。经济上重要的是浓缩的盐水可以回收利用。给出了生产浓缩盐水的廉价方法。

9. 发明授权

US4430092A Scavenging additive for leaded automotive fuel and method of using same 失效
标题翻译：含铅汽车燃料的清除添加剂及其使用方法
公开(公告)号：US4430092A
公开(公告)日：1984-02-07
申请号：US338556
申请日：1982-01-11
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： C10L1/10 , C10L1/14 , C10L1/20 , C10L1/30
CPC分类号： C10L1/103 , C10L1/14 , C10L1/201 , C10L1/306
摘要： A highly effective scavenging additive to a leaded automotive fuel which is substantially free of carcinogenic properties comprises tribromo methane or mixtures of tribromo methane and trichloro methane.
摘要翻译：基本上没有致癌性质的含铅汽车燃料的高效清除添加剂包括三溴甲烷或三溴甲烷和三氯甲烷的混合物。

10. 发明授权

US4252797A Corticosteroid calcium compositions and treatment of rheumatic diseases therewith 失效
标题翻译：皮质类固醇钙组合物和治疗风湿性疾病
公开(公告)号：US4252797A
公开(公告)日：1981-02-24
申请号：US058763
申请日：1979-07-19
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： A61K31/57 , A61K31/66 , A61K31/68
CPC分类号： A61K31/714 , A61K31/57 , A61K31/66 , Y10S514/825
摘要： A dosage composition of corticosteroids with calcium and optionally vitamins B12, C and/or D for treatment of arthritis and other rheumatic disease.
摘要翻译：具有钙和任选的维生素B12，C和/或D的皮质类固醇的剂量组合物用于治疗关节炎和其它风湿性疾病。

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