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1. 发明授权

US08309532B2 Therapeutic uses of inhibitors of RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US08309532B2
公开(公告)日：2012-11-13
申请号：US12803118
申请日：2010-06-17
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

2. 发明申请

US20110117102A1 Therapeutic uses of inhibitors of RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US20110117102A1
公开(公告)日：2011-05-19
申请号：US12803118
申请日：2010-06-17
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： A61K39/395 , A61K31/7088 , C07H21/02 , A61P27/06 , A61P11/00 , A61P27/02
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

3. 发明申请

US20110028532A1 Methods of treating eye diseases in diabetic patients 有权
标题翻译：治疗糖尿病患者眼部疾病的方法
公开(公告)号：US20110028532A1
公开(公告)日：2011-02-03
申请号：US12802527
申请日：2010-06-07
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： A61K31/713 , A61P27/02
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

4. 发明授权

US07741299B2 Therapeutic uses of inhibitors of RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US07741299B2
公开(公告)日：2010-06-22
申请号：US11207119
申请日：2005-08-16
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

5. 发明申请

US20130095117A1 THERAPEUTIC USES OF INHIBITORS OF RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US20130095117A1
公开(公告)日：2013-04-18
申请号：US13601554
申请日：2012-08-31
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： C07H21/02 , A61K45/06 , A61K31/713
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

6. 发明授权

US08168607B2 Methods of treating eye diseases in diabetic patients 有权
标题翻译：治疗糖尿病患者眼部疾病的方法
公开(公告)号：US08168607B2
公开(公告)日：2012-05-01
申请号：US12802527
申请日：2010-06-07
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： C12N15/11 , C07H21/04 , A61K31/70
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

7. 发明授权

US08642571B2 Therapeutic uses of inhibitors of RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US08642571B2
公开(公告)日：2014-02-04
申请号：US13601554
申请日：2012-08-31
申请人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
发明人： Elena Feinstein , Jorg Kaufmann , Klaus Giese
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/02 , A01K2217/058 , A01K2267/0362 , A61K31/713 , A61K39/39541 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2310/321 , A61K2300/00 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病和呼吸病症的新型分子，组合物，方法和用途。

8. 发明授权

US5747338A Method and construct for screening for inhibitors of transcriptional activation 失效
标题翻译：用于筛选转录激活抑制剂的方法和构建
公开(公告)号：US5747338A
公开(公告)日：1998-05-05
申请号：US719577
申请日：1996-09-25
申请人： Klaus Giese , Jaime Escobedo
发明人： Klaus Giese , Jaime Escobedo
IPC分类号： C12Q1/68 , C12N5/10
CPC分类号： C12Q1/6897
摘要： A collision construct is provided that contains a first regulatory sequence containing a first promoter linked to a reporter gene which is also linked to a second regulatory sequence containing a second promoter such that the reporter gene is under regulatory control of the first promoter. The direction of transcription under the first promoter is opposite the direction of transcription under the second promoter and activation of the second promoter interferes with reporter gene activity. The collision construct is used to screen inhibitors of the second regulatory sequence and the second promoter whereby a functional inhibitor causes an enhanced signal of the reporter gene. Vectors, host cells and kits containing the collision construct are provided, as well as methods for producing the collision construct, the vectors and host cells, and methods for screening candidate inhibitors for their ability to inhibit target promoter activities.
摘要翻译：提供了一种碰撞构建体，其包含含有与报告基因连接的第一启动子的第一调控序列，其也与含有第二启动子的第二调控序列连接，使得报道基因处于第一启动子的调控下。第一启动子下的转录方向与第二启动子下的转录方向相反，第二启动子的活化会干扰报告基因的活性。碰撞构建体用于筛选第二调节序列和第二启动子的抑制剂，由此功能性抑制剂引起报告基因的增强的信号。提供载体，宿主细胞和含有碰撞构建体的试剂盒，以及用于产生碰撞构建体，载体和宿主细胞的方法以及用于筛选候选抑制剂以抑制靶启动子活性的能力的方法。

9. 发明授权

US07795407B2 Metastatic breast and colon cancer regulated genes 失效
标题翻译：转移性乳腺癌和结肠癌调节基因
公开(公告)号：US07795407B2
公开(公告)日：2010-09-14
申请号：US11657337
申请日：2007-01-24
申请人： Hong Xin , Klaus Giese
发明人： Hong Xin , Klaus Giese
IPC分类号： C12N15/11
CPC分类号： C12N9/6478 , A61K38/00 , C07K14/4748 , C07K2319/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N2500/00
摘要： Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS:1-18, or a substantial portion thereof. One of the gene sequences encodes a novel aspartyl protease termed CSP56, which can be used to provide reagents and methods for determining which tumors are likely to metastasize and for suppressing metastases of these tumors. Clinicians can use this information to predict which tumors will metastasize to other organs and to provide relevant therapies to appropriate patients.
摘要翻译：已经发现和分离了SEQ ID NO：1-18所示的基因序列，并发现与乳腺癌和结肠癌细胞向其他器官的转移性扩散显着相关。提供了用于确定乳腺或结肠肿瘤转移风险的方法，其涉及确定来自肿瘤的组织样品是否表达由SEQ ID NO：1-18所示基因编码的多肽，或其主要部分。其中一个基因序列编码一种称为CSP56的新型天冬氨酰蛋白，可用于提供用于确定哪些肿瘤可能转移并抑制这些肿瘤转移的试剂和方法。临床医生可以使用这些信息来预测哪些肿瘤会转移到其他器官，并为适当的患者提供相关的治疗。

10. 发明授权

US07122373B1 Human genes and gene expression products V 有权
标题翻译：人类基因和基因表达产物V
公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C12N5/10 , C12N15/63 , C12N15/11
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

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