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1. 发明授权

US5747338A Method and construct for screening for inhibitors of transcriptional activation 失效
标题翻译：用于筛选转录激活抑制剂的方法和构建
公开(公告)号：US5747338A
公开(公告)日：1998-05-05
申请号：US719577
申请日：1996-09-25
申请人： Klaus Giese , Jaime Escobedo
发明人： Klaus Giese , Jaime Escobedo
IPC分类号： C12Q1/68 , C12N5/10
CPC分类号： C12Q1/6897
摘要： A collision construct is provided that contains a first regulatory sequence containing a first promoter linked to a reporter gene which is also linked to a second regulatory sequence containing a second promoter such that the reporter gene is under regulatory control of the first promoter. The direction of transcription under the first promoter is opposite the direction of transcription under the second promoter and activation of the second promoter interferes with reporter gene activity. The collision construct is used to screen inhibitors of the second regulatory sequence and the second promoter whereby a functional inhibitor causes an enhanced signal of the reporter gene. Vectors, host cells and kits containing the collision construct are provided, as well as methods for producing the collision construct, the vectors and host cells, and methods for screening candidate inhibitors for their ability to inhibit target promoter activities.
摘要翻译：提供了一种碰撞构建体，其包含含有与报告基因连接的第一启动子的第一调控序列，其也与含有第二启动子的第二调控序列连接，使得报道基因处于第一启动子的调控下。第一启动子下的转录方向与第二启动子下的转录方向相反，第二启动子的活化会干扰报告基因的活性。碰撞构建体用于筛选第二调节序列和第二启动子的抑制剂，由此功能性抑制剂引起报告基因的增强的信号。提供载体，宿主细胞和含有碰撞构建体的试剂盒，以及用于产生碰撞构建体，载体和宿主细胞的方法以及用于筛选候选抑制剂以抑制靶启动子活性的能力的方法。

2. 发明授权

US06964868B1 Human genes and gene expression products II 失效
标题翻译：人类基因和基因表达产物二
公开(公告)号：US06964868B1
公开(公告)日：2005-11-15
申请号：US09297648
申请日：1999-01-28
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C07K14/47 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4748
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

3. 发明申请

US20050227917A1 Gene products differentially expressed in cancerous cells and their methods of use II 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法II
公开(公告)号：US20050227917A1
公开(公告)日：2005-10-13
申请号：US10779543
申请日：2004-02-12
申请人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
发明人： Lewis Williams , Jaime Escobedo , Michael Innis , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia Kennedy , David Pot , Altaf Kassam , George Lamson , Zhijun He , Elizabeth Scott , Guozhong Zhang , Theresa May , Doreen Sakamoto , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee Jones , Birgit Stache-Crain
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

4. 发明授权

US07122373B1 Human genes and gene expression products V 有权
标题翻译：人类基因和基因表达产物V
公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
IPC分类号： C12N5/10 , C12N15/63 , C12N15/11
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

5. 发明申请

US20070178527A1 Human platelet-derived growth factor receptors 审中-公开
标题翻译：人血小板衍生生长因子受体
公开(公告)号：US20070178527A1
公开(公告)日：2007-08-02
申请号：US11495096
申请日：2006-07-28
申请人： Lewis Williams , Jaime Escobedo
发明人： Lewis Williams , Jaime Escobedo
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/71
CPC分类号： C07K14/71 , G01N33/74 , G01N2333/49
摘要： DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.
摘要翻译：编码人血小板衍生生长因子受体（hPDGF-R）的DNA序列和包含编码可以分泌或并入哺乳动物细胞膜的受体的序列的表达构建体。提供了功能相当于野生型受体的肽片段，赋予缺乏受体的细胞对PDGF敏感的促有丝分裂反应。该构建体可用于增强细胞的PDGF应答，确定与PDGF结合相关的转导信号所涉及的区域，提供突变的类似物并评估药物的生理活性。还提供了包含PDGF受体序列的可溶性片段，包括与细胞内蛋白质相互作用的重要细胞内激酶插入序列。

6. 发明申请

US20070037147A1 Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
标题翻译：与致癌转化相关的内源性逆转录病毒多肽
公开(公告)号：US20070037147A1
公开(公告)日：2007-02-15
申请号：US10497786
申请日：2002-12-09
申请人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
发明人： Pablo Garcia , Stephen Hardy , Lewis Williams , Jaime Escobedo
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.
摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。这些蛋白质可用于癌症诊断和治疗，也是药物靶标。用于辅助治疗。鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

7. 发明申请

US20060039915A1 P-cadherin as a target for anti-cancer therapy 审中-公开
公开(公告)号：US20060039915A1
公开(公告)日：2006-02-23
申请号：US11264046
申请日：2005-11-01
申请人： Christoph Reinhard , Julie Klinger , Ann Jefferson , Jaime Escobedo , Fillipo Randazzo , Jill Winter , Robert Goodson , Weimin Qi
发明人： Christoph Reinhard , Julie Klinger , Ann Jefferson , Jaime Escobedo , Fillipo Randazzo , Jill Winter , Robert Goodson , Weimin Qi
IPC分类号： C12Q1/68 , A61K39/395
CPC分类号： C12N15/1138 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/73 , C07K2317/76 , C12N2310/11
摘要： Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P-cadherin antibodies. Also provided are screens for identifying anti-P-cadherin antibodies having therapeutic activity.

8. 发明申请

US20120308569A1 GENE PRODUCTS DIFFERENTIALLY EXPRESSED IN CANCEROUS CELLS 审中-公开
标题翻译：基因产物在CANCEROUS CELLS中显示不同
公开(公告)号：US20120308569A1
公开(公告)日：2012-12-06
申请号：US13491434
申请日：2012-06-07
申请人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K31/713 , C40B30/04 , A61P35/00 , G01N33/574 , C12Q1/68 , A61K39/395 , C12N5/09 , G01N33/566
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

9. 发明授权

US08221983B2 Gene products differentially expressed in cancerous cells 失效
标题翻译：在癌细胞中差异表达的基因产物
公开(公告)号：US08221983B2
公开(公告)日：2012-07-17
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

10. 发明申请

US20100233187A1 GENE PRODUCTS DIFFERENTIALLY EXPRESSED IN CANCEROUS CELLS 失效
标题翻译：基因产物在CANCEROUS CELLS中显示不同
公开(公告)号：US20100233187A1
公开(公告)日：2010-09-16
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K39/395 , C12N5/09 , C12Q1/68 , A61K31/713 , A61P35/00
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

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