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1. 发明申请

US20120308569A1 GENE PRODUCTS DIFFERENTIALLY EXPRESSED IN CANCEROUS CELLS 审中-公开
标题翻译：基因产物在CANCEROUS CELLS中显示不同
公开(公告)号：US20120308569A1
公开(公告)日：2012-12-06
申请号：US13491434
申请日：2012-06-07
申请人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. CHAN , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K31/713 , C40B30/04 , A61P35/00 , G01N33/574 , C12Q1/68 , A61K39/395 , C12N5/09 , G01N33/566
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

2. 发明授权

US08221983B2 Gene products differentially expressed in cancerous cells 失效
标题翻译：在癌细胞中差异表达的基因产物
公开(公告)号：US08221983B2
公开(公告)日：2012-07-17
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

3. 发明申请

US20100233187A1 GENE PRODUCTS DIFFERENTIALLY EXPRESSED IN CANCEROUS CELLS 失效
标题翻译：基因产物在CANCEROUS CELLS中显示不同
公开(公告)号：US20100233187A1
公开(公告)日：2010-09-16
申请号：US12725341
申请日：2010-03-16
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： A61K39/395 , C12N5/09 , C12Q1/68 , A61K31/713 , A61P35/00
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

4. 发明申请

US20100131432A1 Methods and compositions of molecular profiling for disease diagnostics 有权
标题翻译：用于疾病诊断的分子谱的方法和组成
公开(公告)号：US20100131432A1
公开(公告)日：2010-05-27
申请号：US12592065
申请日：2009-11-17
申请人： Giulia C. Kennedy , Bonnie H. Anderson , Darya I. Chudova , Eric T. Wang , Hui Wang , Moraima Pagan , Nusrat Robbee , Jonathan I. Wilde
发明人： Giulia C. Kennedy , Bonnie H. Anderson , Darya I. Chudova , Eric T. Wang , Hui Wang , Moraima Pagan , Nusrat Robbee , Jonathan I. Wilde
IPC分类号： G06Q90/00 , C12Q1/68 , G01N33/53 , C40B30/04 , C40B30/02 , C07H21/04 , C07K16/00 , C40B40/06 , C40B40/10
CPC分类号： C12Q1/6886 , A61B10/0096 , A61B10/0283 , A61B50/30 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/57407 , G06F19/20 , G06Q99/00
摘要： The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to gene expression product markers, alternative exon usage markers, and DNA polymorphisms associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.
摘要翻译：本发明涉及用于分子谱和癌症诊断的组合物，试剂盒和方法，包括但不限于基因表达产物标记，替代外显子使用标记和与癌症相关的DNA多态性。特别地，本发明提供了与甲状腺癌相关的分子谱，确定分子谱的方法和分析结果以提供诊断的方法。

5. 发明申请

US20090275734A1 Pancreatic Cancer Genes 失效
公开(公告)号：US20090275734A1
公开(公告)日：2009-11-05
申请号：US11929755
申请日：2007-10-30
申请人： Giulia C. Kennedy
发明人： Giulia C. Kennedy
IPC分类号： C07K16/30
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.

6. 发明授权

US06743602B1 Polynucleotides differentially expressed in adenocarcinomas, polypeptides encoded thereby, and methods of use thereof 失效
标题翻译：在腺癌中差异表达的多核苷酸，由此编码的多肽及其使用方法
公开(公告)号：US06743602B1
公开(公告)日：2004-06-01
申请号：US09626301
申请日：2000-07-25
申请人： Giulia C. Kennedy
发明人： Giulia C. Kennedy
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075
摘要： The present invention features human HX2004-6 polypeptide and nucleotide sequences encoding HX2004-6 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human HX2004-6 polypeptide. The present invention also relates to antibodies that bind specifically to a human HX2004-6 polypeptide. Further provided are diagnostic and screening methods using HX2004-6 polynucleotides and antibodies specific for HX2004-6 polypeptides.
摘要翻译：本发明的特征在于人HX2004-6多肽和编码HX2004-6多肽的核苷酸序列。在特定方面，多核苷酸是SEQ ID NO：1的核苷酸序列。在相关方面，本发明的特征在于包含编码人HX2004-6多肽的多核苷酸的表达载体和宿主细胞。本发明还涉及与人HX2004-6多肽特异性结合的抗体。还提供了使用HX2004-6多核苷酸和HX2004-6多肽特异性抗体的诊断和筛选方法。

7. 发明授权

US06262249B1 Pancreatic cancer genes 有权
标题翻译：胰腺癌基因
公开(公告)号：US06262249B1
公开(公告)日：2001-07-17
申请号：US09337171
申请日：1999-06-21
申请人： Giulia C. Kennedy
发明人： Giulia C. Kennedy
IPC分类号： C07H2104
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
摘要翻译：本发明提供了在癌症和发育异常中上调或下调的多核苷酸的DNA编码序列的技术。这些多核苷酸和编码的蛋白质或多肽可用于诊断或鉴定癌症和发育不良。上调多核苷酸和蛋白质的抑制剂可以减少癌症和发育异常的异常。增强下调多核苷酸的表达或将下调蛋白引入细胞可以降低癌症和发育不良的生长和/或异常特征。

8. 发明授权

US08323894B2 Methods of analysis of allelic imbalance 有权
标题翻译：等位基因不平衡分析方法
公开(公告)号：US08323894B2
公开(公告)日：2012-12-04
申请号：US13222851
申请日：2011-08-31
申请人： Giulia C Kennedy
发明人： Giulia C Kennedy
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2565/501
摘要： Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
摘要翻译：提供了用于鉴定印迹基因的方法。在另一个实施方案中，提供了用于鉴定和分析其表达显示等位基因不平衡的基因的方法。从作为两个或更多等位基因存在于基因组中的基因转录的表达产物可以通过与设计用于询问单个等位基因的阵列的杂交来区分。其转录产物存在的量与预期不同的基因是等位基因不平衡，印记和印记错误的候选者。

9. 发明申请

US20120220474A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS OF THYROID CONDITIONS 有权
标题翻译：用于诊断甲状腺条件的方法和组合物
公开(公告)号：US20120220474A1
公开(公告)日：2012-08-30
申请号：US13318751
申请日：2010-05-07
申请人： Giulia C. Kennedy , Bonnie H. Anderson , Darya I. Chudova , Eric T. Wang , Hui Wang , Moraima Pagan , Nusrat Rabbee , Jonathan I. Wilde
发明人： Giulia C. Kennedy , Bonnie H. Anderson , Darya I. Chudova , Eric T. Wang , Hui Wang , Moraima Pagan , Nusrat Rabbee , Jonathan I. Wilde
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.
摘要翻译：本发明涉及用于分子谱和癌症诊断的组合物，试剂盒和方法，包括但不限于与癌症相关的基因组DNA标记。特别地，本发明提供了与甲状腺癌相关的分子谱，确定分子谱的方法和分析结果以提供诊断的方法。

10. 发明授权

US07867731B2 HX2004-6 polypeptide expressed in cancerous cells 有权
标题翻译： HX2004-6多肽在癌细胞中表达
公开(公告)号：US07867731B2
公开(公告)日：2011-01-11
申请号：US10977087
申请日：2004-10-28
申请人： Christoph Reinhard , Anne Bennett Jefferson , Vivien W. Chan , Joerg Kaufmann , Hong Xin , Giulia C. Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
发明人： Christoph Reinhard , Anne Bennett Jefferson , Vivien W. Chan , Joerg Kaufmann , Hong Xin , Giulia C. Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
IPC分类号： C12P21/00 , C12P21/02 , C12N15/09 , C07K14/00 , C07K14/435
CPC分类号： G01N33/5005 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/723 , C12N9/1205 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/5008 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

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